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Nicholas H Chakiryan, Aaron Dahmen, Marco Bandini, Filippo Pederzoli, Laura Marandino, Maarten Albersen, Eduard Roussel, Yao Zhu, Ding-Wei Ye, Antonio A Ornellas, Mario Catanzaro, Oliver W Hakenberg, Axel Heidenreich, Friederike Haidl, Nick Watkin, Michael Ager, Jad Chahoud, Alberto Briganti, Roberto Salvioni, Francesco Montorsi, Andrea Necchi, Philippe E Spiess,

J Urol (The Journal of urology)
[2021, 206(4):969]

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Identifying the Optimal Number of Neoadjuvant Chemotherapy Cycles in Patients with Muscle Invasive Bladder Cancer.

David D'Andrea, Peter C Black, Homayoun Zargar, Colin P Dinney, Francesco Soria, Michael S Cookson, Jeffrey S Montgomery, Wassim Kassouf, Marc A Dall'Era, Srikala S Sridhar, John S McGrath, Jonathan L Wright, Andrew C Thorpe, Jeff M Holzbeierlein, Diego M Carrión, Ettore Di Trapani, Trinity J Bivalacqua, Scott North, Daniel A Barocas, Yair Lotan, Petros Grivas, Andrew J Stephenson, Bas W van Rhijn, Siamak Daneshmand, Philippe E Spiess, Shahrokh F Shariat,

<h4>Purpose</h4>We investigated the pathological response rates and survival associated with 3 vs 4 cycles of cisplatin-based neoadjuvant chemotherapy (NAC) in patients with cT2-4N0M0 muscle invasive bladder cancer.<h4>Materials and methods</h4>In this cohort study we analyzed clinical data of 828 patients treated with NAC and radical cystectomy between 2000 and 2020. A ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000002190]

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Contrasting genomic profiles from metastatic sites, primary tumors, and liquid biopsies of advanced prostate cancer.

Andrea Necchi, Vito Cucchiara, Petros Grivas, Gennady Bratslavsky, Joseph Jacob, Philippe E Spiess, Ethan S Sokol, Jonathan Keith Killian, Douglas Lin, Shakti Ramkissoon, Richard S P Huang, Russell W Madison, Jeffrey M Venstrom, Alexa B Schrock, Natalie Danziger, Brennan Decker, Ole Gjoerup, Ryon P Graf, Geoffrey R Oxnard, Hanna Tukachinsky, Jeffrey S Ross,

<h4>Background</h4>This study assessed the contrasting genomic profiles from the primary tumors (PTs), metastatic (MET) sites, and circulating tumor DNA (ctDNA) of patients with prostate cancer (PC).<h4>Methods</h4>A total of 1294 PC tissue specimens and 2462 ctDNA specimens underwent hybrid capture-based comprehensive genomic profiling (CGP). Specimens included tissue from PTs; MET biopsies ... Read more >>

Cancer (Cancer)
[2021, :]

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Impact of radiation therapy on perineal urethrostomy for penile cancer.

Peter A S Johnstone, Hielke M de Vries, Juan Chipollini, G Daniel Grass, Franklin Boyd, Fernando Korkes, Maarten Albersen, Eduard Roussel, Yao Zhu, Ding-Wei Ye, Viraj Master, Thien-Linh Le, Asif Muneer, Oscar R Brouwer, Philippe E Spiess,

<h4>Objective</h4>A lack of demonstrated clinical benefit precludes radiotherapy (RT) from being recommended for pN1/pN2 penile cancer (PeCa) lesions; but it may be recommended in case of extranodal (pN3) disease or for positive resection margins. Perineal urethrostomy (PU) is a technique of urinary diversion in patients with PeCa requiring total or ... Read more >>

Clin Transl Radiat Oncol (Clinical and translational radiation oncology)
[2021, 30:84-87]

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Association of age with response to preoperative chemotherapy in patients with muscle-invasive bladder cancer.

David D'Andrea, Peter C Black, Homayoun Zargar, Kamran Zargar-Shoshtari, Francesco Soria, Adrian S Fairey, Laura S Mertens, Colin P Dinney, Maria C Mir, Laura-Maria Krabbe, Michael S Cookson, Niels-Erik Jacobsen, Jeffrey S Montgomery, Nikhil Vasdev, Evan Y Yu, Evanguelos Xylinas, Nicholas J Campain, Wassim Kassouf, Marc A Dall'Era, Jo-An Seah, Cesar E Ercole, Simon Horenblas, Srikala S Sridhar, John S McGrath, Jonathan Aning, Jonathan L Wright, Andrew C Thorpe, Todd M Morgan, Jeff M Holzbeierlein, Trinity J Bivalacqua, Scott North, Daniel A Barocas, Yair Lotan, Petros Grivas, Andrew J Stephenson, Jay B Shah, Bas W van Rhijn, Siamak Daneshmand, Philippe E Spiess, Shahrokh F Shariat,

<h4>Purpose</h4>To assess the association of patient age with response to preoperative chemotherapy in patients with muscle-invasive bladder cancer (MIBC).<h4>Materials and methods</h4>We analyzed data from 1105 patients with MIBC. Patients age was evaluated as continuous variable and stratified in quartiles. Pathologic objective response (pOR; ypT0-Ta-Tis-T1N0) and pathologic complete response (pCR; ypT0N0), ... Read more >>

World J Urol (World journal of urology)
[2021, :]

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Geospatial Cellular Distribution of Cancer-Associated Fibroblasts Significantly Impacts Clinical Outcomes in Metastatic Clear Cell Renal Cell Carcinoma.

Nicholas H Chakiryan, Gregory J Kimmel, Youngchul Kim, Joseph O Johnson, Noel Clark, Ali Hajiran, Andrew Chang, Ahmet M Aydin, Logan Zemp, Esther Katende, Jad Chahoud, Meghan C Ferrall-Fairbanks, Philippe E Spiess, Natasha Francis, Michelle Fournier, Jasreman Dhillon, Jong Y Park, Liang Wang, James J Mulé, Philipp M Altrock, Brandon J Manley,

Cancer-associated fibroblasts (CAF) are highly prevalent cells in the tumor microenvironment in clear cell renal cell carcinoma (ccRCC). CAFs exhibit a pro-tumor effect in vitro and have been implicated in tumor cell proliferation, metastasis, and treatment resistance. Our objective is to analyze the geospatial distribution of CAFs with proliferating and ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(15):]

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Patterns of Recurrence following Inguinal Lymph Node Dissection for Penile Cancer: Optimizing Surveillance Strategies.

Nicholas H Chakiryan, Aaron Dahmen, Marco Bandini, Filippo Pederzoli, Laura Marandino, Maarten Albersen, Eduard Roussel, Yao Zhu, Ding-Wei Ye, Antonio A Ornellas, Mario Catanzaro, Oliver W Hakenberg, Axel Heidenreich, Friederike Haidl, Nick Watkin, Michael Ager, Jad Chahoud, Alberto Briganti, Roberto Salvioni, Francesco Montorsi, Andrea Necchi, Philippe E Spiess,

<h4>Purpose</h4>Our primary objective is to detail the incidence, site, and timing of penile squamous cell carcinoma (pSCC) recurrence after inguinal lymph node dissection (ILND).<h4>Materials and methods</h4>We performed a retrospective analysis of 551 patients who underwent ILND for pSCC from 2000 to 2017. The primary outcome was pSCC recurrence after ILND. ... Read more >>

J Urol (The Journal of urology)
[2021, 206(4):960-969]

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Outcomes of perineal urethrostomy for penile cancer: A 20-year international multicenter experience.

Hielke M de Vries, Juan Chipollini, Julio Slongo, Franklin Boyd, Fernando Korkes, Maarten Albersen, Eduard Roussel, Yao Zhu, Ding-Wei Ye, Viraj Master, Thien-Linh Le, Peter A Johnstone, Asif Muneer, Oscar R Brouwer, Philippe E Spiess,

<h4>Purpose</h4>Perineal urethrostomy (PU) is often the definitive form of urinary diversion in patients with locally-advanced or anatomically unfavorable penile cancer (PC) requiring total penectomy. Here, we report post-operative PU-related complications and PU stenosis rates after total penectomy with PU in a large multicenter cohort of PC patients.<h4>Methods</h4>We retrospectively reviewed the ... Read more >>

Urol Oncol (Urologic oncology)
[2021, 39(8):500.e9-500.e13]

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Pretreatment Risk Stratification for Endoscopic Kidney-sparing Surgery in Upper Tract Urothelial Carcinoma: An International Collaborative Study.

Beat Foerster, Mohammad Abufaraj, Surena F Matin, Mounsif Azizi, Mohit Gupta, Wei-Ming Li, Thomas Seisen, Timothy Clinton, Evanguelos Xylinas, M Carmen Mir, Donald Schweitzer, Andrea Mari, Shoji Kimura, Marco Bandini, Romain Mathieu, Ja H Ku, Gautier Marcq, Georgi Guruli, Markus Grabbert, Anna K Czech, Tim Muilwijk, Armin Pycha, David D'Andrea, Firas G Petros, Philippe E Spiess, Trinity Bivalacqua, Wen-Jeng Wu, Morgan Rouprêt, Laura-Maria Krabbe, Kees Hendricksen, Shin Egawa, Alberto Briganti, Marco Moschini, Vivien Graffeille, Wassim Kassouf, Riccardo Autorino, Axel Heidenreich, Piotr Chlosta, Steven Joniau, Francesco Soria, Phillip M Pierorazio, Shahrokh F Shariat,

<h4>Background</h4>Several groups have proposed features to identify low-risk patients who may benefit from endoscopic kidney-sparing surgery in upper tract urothelial carcinoma (UTUC).<h4>Objective</h4>To evaluate standard risk stratification features, develop an optimal model to identify ≥pT2/N+ stage at radical nephroureterectomy (RNU), and compare it with the existing unvalidated models.<h4>Design, setting, and participants</h4>This ... Read more >>

Eur Urol (European urology)
[2021, 80(4):507-515]

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Preoperative immunonutrition and carbohydrate loading associated with improved bowel function after radical cystectomy.

Sephalie Y Patel, Nathaniel Trona, Brandon Alford, Jose M Laborde, Youngchul Kim, Roger Li, Brandon J Manley, Scott M Gilbert, Wade J Sexton, Philippe E Spiess, Michael A Poch,

<h4>Background</h4>Preoperative malnourishment has been consistently associated with poor outcomes after radical cystectomy and other major abdominal surgeries. Most enhanced recovery after surgery (ERAS) studies have examined preoperative nutrition and its relationship to outcomes after gastrointestinal surgery. Although numerous studies have demonstrated the benefits of using an ERAS protocol, this study ... Read more >>

Nutr Clin Pract (Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition)
[2021, :]

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Prevalence of Preoperative Iron Deficiency Anemia: A Case Series Among Patients Undergoing Radical Cystectomy.

Sephalie Y Patel, Timothy E Kubal, Roger Li, Brandon J Manley, Scott M Gilbert, Wade J Sexton, Philippe E Spiess, David Boulware, Michael A Poch,

Anemia occurs in a significant group of patients with bladder cancer before radical cystectomy. Iron deficiency is a readily identifiable cause of anemia, which can be treated before surgery. The proportion of patients with bladder cancer with iron deficiency anemia is unknown. Laboratory and clinical outcomes were collected on 47 ... Read more >>

A A Pract (A&A practice)
[2021, 15(5):e01477]

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Correlating Immune Cell Infiltration Patterns with Recurrent Somatic Mutations in Advanced Clear Cell Renal Cell Carcinoma.

Nicholas H Chakiryan, Ali Hajiran, Youngchul Kim, Ahmet M Aydin, Logan Zemp, Esther Katende, Jonathan Nguyen, Wenyi Fan, Chia-Ho Cheng, Neale Lopez-Blanco, Jad Chahoud, Philippe E Spiess, Michelle Fournier, Jasreman Dhillon, Liang Wang, Carlos Moran-Segura, James Mulé, Dongliang Du, Sean J Yoder, Anders Berglund, Jamie K Teer, Brandon J Manley,

<h4>Background</h4>Clear cell renal cell carcinoma (ccRCC) tumors have low frequencies of genetic alterations compared with other malignancies, but very high levels of immune cell infiltration and favorable response rates to immunotherapy. Currently, the interplay between specific ccRCC somatic mutations and immune infiltration pattern is unclear.<h4>Objective</h4>To analyze the associations between common ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

Cited: 2 times

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Real-World Survival Outcomes Associated With First-Line Immunotherapy, Targeted Therapy, and Combination Therapy for Metastatic Clear Cell Renal Cell Carcinoma.

Nicholas H Chakiryan, Da David Jiang, Kyle A Gillis, Elizabeth Green, Ali Hajiran, Lee Hugar, Logan Zemp, Jingsong Zhang, Rohit K Jain, Jad Chahoud, Philippe E Spiess, Wade Sexton, Scott M Gilbert, Brandon J Manley,

<h4>Importance</h4>Clinical trials have shown an overall survival (OS) benefit associated with first-line immunotherapy (IT) and combination targeted therapy (TT) and IT regimens compared with TT among patients with metastatic clear cell renal cell carcinoma (RCC). Generalizability of these findings in a real-world cohort outside of a clinical trial setting is ... Read more >>

JAMA Netw Open (JAMA network open)
[2021, 4(5):e2111329]

Cited: 1 time

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Salvage therapy for localized recurrences of penile cancer.

Ava Saidian, Brian Ceballos, Andrea Necchi, Adam S Baumgarten, Philippe E Spiess,

<h4>Purpose of review</h4>To review the current literature and guidelines regarding salvage therapy for local and regional recurrence of primary penile cancer.<h4>Recent findings</h4>While invasive surgical management has not significantly changed, penile sparing treatments (PSTs) may have a promising role in the management of local recurrence. Penile sparing surgeries do appear to ... Read more >>

Curr Opin Urol (Current opinion in urology)
[2021, 31(3):214-219]

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Editorial Comment.

Aaron Dahmen, Philippe E Spiess,

J Urol (The Journal of urology)
[2021, 206(2):362-363]

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Spatial clustering of CD68+ tumor associated macrophages with tumor cells is associated with worse overall survival in metastatic clear cell renal cell carcinoma.

Nicholas H Chakiryan, Gregory J Kimmel, Youngchul Kim, Ali Hajiran, Ahmet M Aydin, Logan Zemp, Esther Katende, Jonathan Nguyen, Neale Lopez-Blanco, Jad Chahoud, Philippe E Spiess, Michelle Fournier, Jasreman Dhillon, Liang Wang, Carlos Moran-Segura, Asmaa El-Kenawi, James Mulé, Philipp M Altrock, Brandon J Manley,

Immune infiltration is typically quantified using cellular density, not accounting for cellular clustering. Tumor-associated macrophages (TAM) activate oncogenic signaling through paracrine interactions with tumor cells, which may be better reflected by local cellular clustering than global density metrics. Using multiplex immunohistochemistry and digital pathologic analysis we quantified cellular density and ... Read more >>

PLoS One (PloS one)
[2021, 16(4):e0245415]

Cited: 1 time

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Patient-Reported Outcomes in Clinical Trials Leading to Cancer Immunotherapy Drug Approvals From 2011 to 2018: A Systematic Review.

Houssein Safa, Monica Tamil, Philippe E Spiess, Brandon Manley, Julio Pow-Sang, Scott M Gilbert, Firas Safa, Brian D Gonzalez, Laura B Oswald, Adele Semaan, Adi Diab, Jad Chahoud,

<h4>Background</h4>Patient-reported outcomes (PROs) promote patient centeredness in clinical trials; however, in the field of rapidly emerging and clinically impressive immunotherapy, data on PROs are limited.<h4>Methods</h4>We systematically identified all immunotherapy approvals from 2011 through 2018 and assessed the analytic tools and reporting quality of associated PRO reports. For randomized clinical trials ... Read more >>

J Natl Cancer Inst (Journal of the National Cancer Institute)
[2021, 113(5):532-542]

Cited: 2 times

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Novel Classification for Upper Tract Urothelial Carcinoma to Better Risk-stratify Patients Eligible for Kidney-sparing Strategies: An International Collaborative Study.

Gautier Marcq, Beat Foerster, Mohammad Abufaraj, Surena F Matin, Mounsif Azizi, Mohit Gupta, Wei-Ming Li, Thomas Seisen, Timothy Clinton, Evanguelos Xylinas, M Carmen Mir, Donald Schweitzer, Andrea Mari, Shoji Kimura, Marco Bandini, Romain Mathieu, Ja H Ku, Georgi Guruli, Markus Grabbert, Anna K Czech, Tim Muilwijk, Armin Pycha, David D'Andrea, Firas G Petros, Philippe E Spiess, Trinity Bivalacqua, Wen-Jeng Wu, Morgan Rouprêt, Laura-Maria Krabbe, Kees Hendricksen, Shin Egawa, Alberto Briganti, Marco Moschini, Vivien Graffeille, Riccardo Autorino, Patricia John, Axel Heidenreich, Piotr Chlosta, Steven Joniau, Francesco Soria, Phillip M Pierorazio, Shahrokh F Shariat, Wassim Kassouf,

<h4>Background</h4>The European Association of Urology risk stratification dichotomizes patients with upper tract urothelial carcinoma (UTUC) into two risk categories.<h4>Objective</h4>To evaluate the predictive value of a new classification to better risk stratify patients eligible for kidney-sparing surgery (KSS).<h4>Design, setting, and participants</h4>This was a retrospective study including 1214 patients from 21 centers ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Intermediate- and high-risk nonmuscle invasive bladder cancer: Where do we stand?

Giuseppe Basile, Filippo Pederzoli, Marco Bandini, Daniele Raggi, Andrea Gallina, Andrea Salonia, Alberto Briganti, Francesco Montorsi, Philippe E Spiess, Andrea Necchi,

<h4>Introduction</h4>The standard of care for intermediate- and high-risk non-muscle invasive bladder cancer (NMIBC) patients is transurethral resection of bladder tumor followed by intravesical adjuvant immunotherapy with Bacillus Calmette-Guerin (BCG). However, a non-negligible portion of patients is doomed to fail BCG-therapy and, consequently, undergo radical cystectomy as only treatment option available. ... Read more >>

Urol Oncol (Urologic oncology)
[2021, :]

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Current practice patterns of society of urologic oncology members in performing inguinal lymph node staging/therapy for penile cancer: A survey study.

Nicholson Marilin, Viraj A Master, Curtis A Pettaway, Philippe E Spiess,

<h4>Objectives</h4>Inguinal lymph node (ILN) staging and therapeutic procedures are important for the diagnosis and management of suspected Inguinal lymph node metastasis in the setting of penile cancer. Morbidity associated with inguinal lymph node dissection (ILND) and the lack of standardization in its perioperative management are both significant. In this study, ... Read more >>

Urol Oncol (Urologic oncology)
[2021, 39(7):439.e9-439.e15]

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Revolutionizing care for rare genitourinary tumours.

Andrea Necchi, Filippo Pederzoli, Marco Bandini, Philippe E Spiess,

Nat Rev Urol (Nature reviews. Urology)
[2021, 18(2):69-70]

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Expansion of tumor-infiltrating lymphocytes (TIL) from penile cancer patients.

Ahmet Murat Aydin, MacLean Hall, Brittany L Bunch, Holly Branthoover, Zachary Sannasardo, Amy Mackay, Matthew Beatty, Amod A Sarnaik, John E Mullinax, Philippe E Spiess, Shari Pilon-Thomas,

Penile cancer is a rare but highly lethal cancer, and therapeutic options for patients presenting with lymph nodal disease are very limited. Adoptive cell therapy (ACT) using tumor-infiltrating lymphocytes (TIL) was shown to provide durable objective response in patients with metastatic melanoma and TIL have been expanded from solid tumors ... Read more >>

Int Immunopharmacol (International immunopharmacology)
[2021, 94:107481]

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Reliability of Serum Tumor Marker Measurement to Diagnose Recurrence in Patients with Clinical Stage I Nonseminomatous Germ Cell Tumors Undergoing Active Surveillance: A Systematic Review.

Nicholas H Chakiryan, Aaron Dahmen, Vito Cucchiara, Alberto Briganti, Francesco Montorsi, Andrea Salonia, Philippe E Spiess, Andrea Necchi,

<h4>Purpose</h4>Men with nonseminomatous germ cell tumors of the testicle without evidence of residual disease after radical orchiectomy (clinical stage I) are increasingly managed with active surveillance. The guideline-recommended cornerstones of surveillance are conventional serum tumor markers and computerized tomography. The reliability of serum tumor markers as a tool to diagnose ... Read more >>

J Urol (The Journal of urology)
[2021, 205(6):1569-1576]

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Penile cancer.

Anita Thomas, Andrea Necchi, Asif Muneer, Marcos Tobias-Machado, Anna Thi Huyen Tran, Anne-Sophie Van Rompuy, Philippe E Spiess, Maarten Albersen,

Penile squamous cell carcinoma (PSCC) is a rare cancer with orphan disease designation and a prevalence of 0.1-1 per 100,000 men in high-income countries, but it constitutes up to 10% of malignancies in men in some African, Asian and South American regions. Risk factors for PSCC include the absence of ... Read more >>

Nat Rev Dis Primers (Nature reviews. Disease primers)
[2021, 7(1):11]

Cited: 5 times

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Should Upper-tract Urothelial Carcinoma and Bladder Carcinoma Be Treated the Same or Different?

Rohit K Jain, Jeffery S Ross, Andrea Necchi, Philippe E Spiess,

Eur Urol Oncol (European urology oncology)
[2021, 4(2):180-181]

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