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Gastrointestinal disseminated histoplasmosis in HIV-infected patients: A descriptive and comparative study.

Mathieu Nacher, Audrey Valdes, Antoine Adenis, Romain Blaizot, Philippe Abboud, Magalie Demar, Félix Djossou, Loïc Epelboin, Caroline Misslin, Balthazar Ntab, Dominique Louvel, Kinan Drak Alsibai, Pierre Couppié,

Disseminated histoplasmosis is one the main AIDS-defining opportunistic infections in HIV-infected patients, notably in Latin America. The non-specific and proteiform clinical presentation leads to diagnostic delays that may lead to fatal outcomes. This retrospective multicentric study aimed to describe the frequency and manifestations of gastrointestinal histoplasmosis in French Guiana, and ... Read more >>

PLoS Negl Trop Dis (PLoS neglected tropical diseases)
[2021, 15(1):e0009050]

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Risk Factors for Mortality among HIV-Infected Patients with Disseminated Histoplasmosis.

Mathieu Nacher, Kinan Drak Alsibai, Audrey Valdes, Romain Blaizot, Philippe Abboud, Magalie Demar, Félix Djossou, Loïc Epelboin, Caroline Misslin, Balthazar Ntab, Antoine Adenis, Pierre Couppié,

Identifying prognostic factors is important in order to guide the choice of first-line therapy for disseminated histoplasmosis. Our objective was to identify factors associated with death among a cohort of 330 patients compiled over 34 years of clinical practice in French Guiana. Survival analysis was performed with death as the ... Read more >>

J Fungi (Basel) (Journal of fungi (Basel, Switzerland))
[2020, 6(4):]

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Hemophagocytic Lymphohistiocytosis During HIV Infection in Cayenne Hospital 2012-2015: First Think Histoplasmosis.

Duc Nguyen, Mathieu Nacher, Loic Epelboin, Alessia Melzani, Magalie Demar, Denis Blanchet, Romain Blaizot, Kinan Drak Alsibai, Philippe Abboud, Félix Djossou, Pierre Couppié, Antoine Adenis,

<b>Introduction:</b> Haemophagocytic Lymphohistiocytosis (HLH), during HIV infection is a rare complication with a poor prognosis. There are few data on HLH within the Amazon region. The objective was to describe epidemiological, clinical and therapeutic features of HIV-related HLH in French Guiana. <b>Methods:</b> A retrospective analysis of adult HIV patients at ... Read more >>

Front Cell Infect Microbiol (Frontiers in cellular and infection microbiology)
[2020, 10:574584]

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A Review of Diagnostic Methods and Results for HIV-associated Disseminated Histoplasmosis: Shouldn’t We be Involving Pathologists More Systematically?

Mathieu Nacher, Audrey Valdes, Antoine Adenis, Philippe Abboud, Magalie Demar, Felix Djossou, Loic Epelboin, Caroline Misslin, Denis Blanchet, Pierre Couppie, Kinan Drak Alsibai,

<h4>Background: </h4> . Disseminated histoplasmosis is a major killer of HIV-infected persons in Latin America. Antigen detection, fungal culture, or Polymerase Chain Reaction are often not available, but cytology and histology are usually present in most hospitals and may represent an important diagnostic alternative. In this study, we review 34 ... Read more >>

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Heterogeneity of Clinical Presentations and Paraclinical Explorations to Diagnose Disseminated Histoplasmosis in Patients with Advanced HIV: 34 Years of Experience in French Guiana.

Mathieu Nacher, Audrey Valdes, Antoine Adenis, Romain Blaizot, Philippe Abboud, Magalie Demar, Félix Djossou, Loïc Epelboin, Kinan Drak Alsibai, Caroline Misslin, Balthazar Ntab, Pierre Couppié,

We aimed to describe the ways patients with disseminated histoplasmosis-a multifaceted and often lethal disease-present themselves and are explored. A retrospective, observational, multicentric study spanned the period between 1 January 1981 and 1 October 2014. Principal component analysis was performed for the sampling sites and for the clinical signs and ... Read more >>

J Fungi (Basel) (Journal of fungi (Basel, Switzerland))
[2020, 6(3):]

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Disseminated Histoplasmosis in HIV-Infected Patients: A Description of 34 Years of Clinical and Therapeutic Practice.

Mathieu Nacher, Audrey Valdes, Antoine Adenis, Romain Blaizot, Philippe Abboud, Magalie Demar, Félix Djossou, Loïc Epelboin, Caroline Misslin, Balthazar Ntab, Kinan Drak Alsibai, Pierre Couppié,

Disseminated histoplasmosis is the main AIDS-defining infection of French Guiana. We aim to describe our therapeutic experience for 349 patients with disseminated histoplasmosis between 1 January 1981 and 10 January 2014 in French Guiana. Survival, delays for treatment initiation, duration of induction therapy, and associated initial treatments are described. The ... Read more >>

J Fungi (Basel) (Journal of fungi (Basel, Switzerland))
[2020, 6(3):]

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What is AIDS in the Amazon and the Guianas in the 90-90-90 era?

Mathieu Nacher, Antoine Adenis, Basma Guarmit, Aude Lucarelli, Denis Blanchet, Magalie Demar, Felix Djossou, Philippe Abboud, Loïc Epelboin, Pierre Couppié,

<h4>Introduction</h4>In the past decade, new diagnostic methods and strategies have appeared, HIV testing efforts and the generalization of antiretroviral therapy may have influenced the number of opportunistic diagnoses and mortality of HIV-infected patients. To test this hypothesis we compiled data on the top opportunistic infections and causes of early death ... Read more >>

PLoS One (PloS one)
[2020, 15(7):e0236368]

Cited: 2 times

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HIV patients dying on anti-tuberculosis treatment: are undiagnosed infections still a problem in French Guiana?

Mathieu Nacher, Antoine Adenis, Philippe Abboud, Felix Djossou, Magalie Demar, Loïc Epelboin, Pierre Couppié,

<h4>Objective</h4>Despite scaling-up testing and antiretroviral treatment in Latin America, advanced HIV remains a significant public health problem. The objective of the present study was look for historical risk factors for death in French Guiana's HIV cohort taking into account the immunological status, the main opportunistic infections, and their treatment. A ... Read more >>

BMC Res Notes (BMC research notes)
[2020, 13(1):209]

Cited: 1 time

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What is AIDS in the Amazon and the Guianas in the 90-90-90 era?

Mathieu Nacher, Antoine Adenis, Basma Guarmit, Aude Lucarelli, Denis Blanchet, Magalie Demar, Felix Djossou, Philippe Abboud, Loïc Epelboin, Pierre Couppié,

<h4>Introduction</h4> In the past decade, new diagnostic methods and strategies have appeared, HIV testing efforts and the generalization of antiretroviral therapy may have influenced the number of opportunistic diagnoses and mortality of HIV-infected patients. To test this hypothesis we compiled data on the top opportunistic infections and causes of early ... Read more >>

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HIV patients dying on anti-tuberculosis treatment: are undiagnosed infections still a problem in French Guiana?

mathieu nacher, Antoine Adenis, Philippe Abboud, Felix Djossou, Magalie Demar, Loïc Epelboin, Pierre Couppié,

<h4>Objective: </h4> Despite scaling-up testing and antiretroviral treatment in Latin America, advanced HIV remains a significant public health problem. The objective of the present study was look for historical risk factors for death in French Guiana’s HIV cohort taking into account the immunological status, the main opportunistic infections, and their ... Read more >>

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Relations between influenza, dengue outbreaks, and subsequent bacterial sepsis in French Guiana: a time series analysis

Claire Cropet, Philippe Abboud, Emilie Mosnier, Loïc Epelboin, Félix Djossou, Ward Schrooten, Milko Sobesky, mathieu nacher,

<h4>Objective: </h4> Influenza has been shown to increase the risk for severe bacterial infection, in the tropics the seasonality of influenza epidemics is less marked and this may not be the case. Dengue is often followed by prolonged asthenia and some physicians hypothesized increased susceptibility to infections based on anecdotal ... Read more >>

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Emergence of Plasmodium vivax Resistance to Chloroquine in French Guiana.

Lise Musset, Christophe Heugas, Richard Naldjinan, Denis Blanchet, Pascal Houze, Philippe Abboud, Béatrice Volney, Gaëlle Walter, Yassamine Lazrek, Loïc Epelboin, Stephane Pelleau, Pascal Ringwald, Eric Legrand, Magalie Demar, Félix Djossou,

In South America, Plasmodium vivax resistance to chloroquine was recently reported in Brazil and Bolivia. The objective of this study was to collect data on chloroquine resistance in French Guiana by associating a retrospective evaluation of therapeutic efficacy with an analysis of recurrent parasitemia from any patients. Patients with P. ... Read more >>

Antimicrob Agents Chemother (Antimicrobial agents and chemotherapy)
[2019, 63(11):]

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Estimation of the duration between HIV seroconversion and HIV diagnosis in different population groups in French Guiana: Strategic information to reduce the proportion of undiagnosed infections.

Mathieu Nacher, Antoine Adenis, Florence Huber, Edouard Hallet, Philippe Abboud, Emilie Mosnier, Bastien Bideau, Christian Marty, Aude Lucarelli, Vanessa Morel, François Lacapère, Loïc Epelboin, Pierre Couppié,

<h4>Background</h4>Given the great efforts put into the strategic objective of reducing the proportion of HIV-infected patients that are undiagnosed, the aim of the present study was to review the temporal trends between 1997 and 2016 for median estimates of infection duration and median CD4 count at diagnosis for the main ... Read more >>

PLoS One (PloS one)
[2018, 13(6):e0199267]

Cited: 2 times

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Primaquine 30 mg/day versus 15 mg/day during 14 days for the prevention of Plasmodium vivax relapses in adults in French Guiana: a historical comparison.

Audrey Valdes, Loic Epelboin, Emilie Mosnier, Gaelle Walter, Guillaume Vesin, Philippe Abboud, Alessia Melzani, Denis Blanchet, Nicaise Blaise, Mathieu Nacher, Magalie Demar, Felix Djossou,

<h4>Background</h4>The preventive treatment of Plasmodium vivax relapse recommended by the World Health Organization is primaquine at a dose of 15 mg/day for 14 days, except for malaria cases from Asia and Oceania. Since 2006, CDC recommends the use of primaquine at 30 mg/day for 14 days. In France, all cases of malaria due to ... Read more >>

Malar J (Malaria journal)
[2018, 17(1):237]

Cited: 2 times

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Fatal case of chikungunya and concomitant thrombotic thrombocytopenic purpura in French Guiana during air flight medical evacuation.

Loïc Epelboin, Bastien Bidaud, Emilie Mosnier, Paul Le Turnier, Guillaume Vesin, Gaëlle Walter, Philippe Abboud, Stéphanie Houcke, Maïa Forgues, Gérald Egmann, Alain Stepanian, Félix Djossou,

Thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy associated to severe ADAMTS13 deficiency. It has been linked to various viral infections. Among arboviruses, only Crimean-Congo haemorrhagic fever and dengue fever have been linked to this severe disease. We report the first documented case of TTP concomitant to Chikungunya virus infection. ... Read more >>

J Travel Med (Journal of travel medicine)
[2017, 24(5):]

Cited: 5 times

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A Large Outbreak of Thiamine Deficiency Among Illegal Gold Miners in French Guiana.

Emilie Mosnier, Florence Niemetzky, Juliette Stroot, Vincent Pommier de Santi, Paul Brousse, Basma Guarmit, Denis Blanchet, Muriel Ville, Philippe Abboud, Felix Djossou, Mathieu Nacher,

From September 2013 to July 2014, several gold miners working in the tropical forest consulted the Maripasoula Health Center in French Guiana for edema and findings consistent with right-sided cardiac failure. Of the 42 cases of beriberi that were diagnosed, one patient died. The laboratory and clinical investigation demonstrated vitamin ... Read more >>

Am J Trop Med Hyg (The American journal of tropical medicine and hygiene)
[2017, 96(5):1248-1252]

Cited: 5 times

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A predictive score for hypotension in patients with confirmed dengue fever in Cayenne Hospital, French Guiana.

Félix Djossou, Guillaume Vesin, Narcisse Elenga, Magalie Demar, Loïc Epelboin, Gaëlle Walter, Philippe Abboud, Thierry Le-Guen, Dominique Rousset, Brigitte Moreau, Aba Mahamat, Denis Malvy, Mathieu Nacher,

<h4>Background</h4>Identifying patients at risk of developing severe dengue is challenging. The objective of the present study was to determine the incidence of hypotension and its predictive factors during the Dengue 2 epidemic in 2013.<h4>Methods</h4>In 2013, a longitudinal study was performed using data from all confirmed cases of dengue seen in ... Read more >>

Trans R Soc Trop Med Hyg (Transactions of the Royal Society of Tropical Medicine and Hygiene)
[2016, 110(12):705-713]

Cited: 1 time

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Epidemiological assessment of the severity of dengue epidemics in French Guiana.

Claude Flamand, Camille Fritzell, Christelle Prince, Philippe Abboud, Vanessa Ardillon, Luisiane Carvalho, Magalie Demar, Rachida Boukhari, Martine Papaix-Puech, Narcisse Elenga, Dominique Rousset, Séverine Matheus, Mathieu Nacher, Philippe Quenel, Félix Djossou,

<h4>Background</h4>Dengue fever is the most important arboviral infection that affects humans, particularly in tropical and subtropical regions. Here, we provide the first comprehensive overview of the severity of dengue epidemics in French Guiana.<h4>Methodology/principal findings</h4>We monitored hospitalized cases between 2008 and 2013. Detailed clinical features and biological parameters were collected on ... Read more >>

PLoS One (PloS one)
[2017, 12(2):e0172267]

Cited: 8 times

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Incidence and predictive factors of transaminase elevation in patients consulting for dengue fever in Cayenne Hospital, French Guiana.

Félix Djossou, Guillaume Vesin, Gaelle Walter, Loïc Epelboin, Emilie Mosnier, Bastien Bidaud, Philippe Abboud, Antoine Okandze, Severine Mattheus, Narcisse Elenga, Magalie Demar, Denis Malvy, Mathieu Nacher,

<h4>Background</h4>The objective of the study was to determine the incidence of transaminase elevation during dengue, and its predictive factors.<h4>Methods</h4>In 2013, a longitudinal study was performed using data from all cases of dengue seen in Cayenne Hospital. Cox proportional modeling was used. Signs of major transaminase elevation were defined as an ... Read more >>

Trans R Soc Trop Med Hyg (Transactions of the Royal Society of Tropical Medicine and Hygiene)
[2016, 110(2):134-140]

Cited: 4 times

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Q Fever in French Guiana: Tip of the Iceberg or Epidemiological Exception?

Loïc Epelboin, Mathieu Nacher, Aba Mahamat, Vincent Pommier de Santi, Alain Berlioz-Arthaud, Carole Eldin, Philippe Abboud, Sébastien Briolant, Emilie Mosnier, Margarete do Socorro Mendonça Gomes, Stephen G Vreden, Magalie Pierre-Demar, Marcus Lacerda, Didier Raoult, Elba Regina Sampaio de Lemos, Félix Djossou,

PLoS Negl Trop Dis (PLoS neglected tropical diseases)
[2016, 10(5):e0004598]

Cited: 10 times

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Combined antiparasitic treatment for neurocysticercosis.

Aba Mahamat, Philippe Abboud, Magalie Demar, Daniel JeanBourquin, Félix Djossou,

Lancet Infect Dis (The Lancet. Infectious diseases)
[2015, 15(3):264-265]

Cited: 0 times

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AIDS-related Pneumocystis jirovecii genotypes in French Guiana.

Solène Le Gal, Denis Blanchet, Céline Damiani, Paul Guéguen, Michèle Virmaux, Philippe Abboud, Geneviève Guillot, Stéphane Kérangart, Cédric Merle, Enrique Calderon, Anne Totet, Bernard Carme, Gilles Nevez,

The study described Pneumocystis jirovecii (P. jirovecii) multilocus typing in seven AIDS patients living in French Guiana (Cayenne Hospital) and seven immunosuppressed patients living in Brest, metropolitan France (Brest Hospital). Archival P. jirovecii specimens were examined at the dihydropteroate synthase (DHPS) locus using a PCR-RFLP technique, the internal transcribed spacer ... Read more >>

Infect Genet Evol (Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases)
[2015, 29:60-67]

Cited: 6 times

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Comparison between emerging Q fever in French Guiana and endemic Q fever in Marseille, France.

Sophie Edouard, Aba Mahamat, Magalie Demar, Philippe Abboud, Felix Djossou, Didier Raoult,

Q fever is an emergent disease in French Guiana. We compared the incidence clinical and serologic profiles between patients from Cayenne, French Guiana and Marseille in metropolitan France during a four-year period. The annual incidence of diagnosed acute Q fever was significantly higher in Cayenne (17.5/100,000) than in Marseille (1.9/100,000) ... Read more >>

Am J Trop Med Hyg (The American journal of tropical medicine and hygiene)
[2014, 90(5):915-919]

Cited: 15 times

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Histoplasmosis or tuberculosis in HIV-infected patients in the amazon: what should be treated first?

Mathieu Nacher, Antoine Adenis, Emilie Sambourg, Florence Huber, Philippe Abboud, Loïc Epelboin, Emilie Mosnier, Vincent Vantilcke, Julie Dufour, Félix Djossou, Magalie Demar, Pierre Couppié,

PLoS Negl Trop Dis (PLoS neglected tropical diseases)
[2014, 8(12):e3290]

Cited: 9 times

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Q fever in French Guiana.

Carole Eldin, Aba Mahamat, Magalie Demar, Philippe Abboud, Félix Djossou, Didier Raoult,

Coxiella burnetii, the causative agent of Q fever, is present worldwide. Recent studies have shown that this bacterium is an emerging pathogen in French Guiana and has a high prevalence (24% of community-acquired pneumonia). In this review, we focus on the peculiar epidemiology of Q fever in French Guiana. We ... Read more >>

Am J Trop Med Hyg (The American journal of tropical medicine and hygiene)
[2014, 91(4):771-776]

Cited: 14 times

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