Full Text Journal Articles by
Author Philip V Peplow

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MicroRNAs as disease progression biomarkers and therapeutic targets in experimental autoimmune encephalomyelitis model of multiple sclerosis.

Bridget Martinez, Philip V Peplow,

Multiple sclerosis is an autoimmune neurodegenerative disease of the central nervous system characterized by pronounced inflammatory infiltrates entering the brain, spinal cord and optic nerve leading to demyelination. Focal demyelination is associated with relapsing-remitting multiple sclerosis, while progressive forms of the disease show axonal degeneration and neuronal loss. The tests ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(10):1831-1837]

Cited: 0 times

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Protective effects of pharmacological therapies in animal models of multiple sclerosis: a review of studies 2014-2019.

Bridget Martinez, Philip V Peplow,

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. The disability caused by inflammatory demyelination clinically dominates the early stages of relapsing-remitting MS and is reversible. Once there is considerable loss of axons, MS patients enter a secondary progressive stage. Disease-modifying drugs currently in use for ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(7):1220-1234]

Cited: 0 times

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MicroRNAs as biomarkers of diabetic retinopathy and disease progression.

Bridget Martinez, Philip V Peplow,

Diabetes mellitus, together with its complications, has been increasing in prevalence worldwide. Its complications include cardiovascular disease (e.g., myocardial infarction, stroke), neuropathy, nephropathy, and eye complications (e.g., glaucoma, cataracts, retinopathy, and macular edema). In patients with either type 1 or type 2 diabetes mellitus, diabetic retinopathy is the leading cause ... Read more >>

Neural Regen Res (Neural regeneration research)
[2019, 14(11):1858-1869]

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MicroRNAs as diagnostic and therapeutic tools for Alzheimer's disease: advances and limitations.

Bridget Martinez, Philip V Peplow,

Alzheimer's disease (AD) is the most common age-related, progressive neurodegenerative disease. It is characterized by memory loss and cognitive decline and responsible for most cases of dementia in the elderly. Late-onset or sporadic AD accounts for > 95% of cases, with age at onset > 65 years. Currently there are ... Read more >>

Neural Regen Res (Neural regeneration research)
[2019, 14(2):242-255]

Cited: 9 times

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Neuroprotection by immunomodulatory agents in animal models of Parkinson's disease.

Bridget Martinez, Philip V Peplow,

Parkinson's disease (PD) is an age-related neurodegenerative disease for which the characteristic motor symptoms emerge after an extensive loss of dopamine containing neurons. The cell bodies of these neurons are present in the substantia nigra, with the nerve terminals being in the striatum. Both innate and adaptive immune responses may ... Read more >>

Neural Regen Res (Neural regeneration research)
[2018, 13(9):1493-1506]

Cited: 6 times

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MicroRNAs as diagnostic markers and therapeutic targets for traumatic brain injury.

Bridget Martinez, Philip V Peplow,

Traumatic brain injury (TBI) is characterized by primary damage to the brain from the external mechanical force and by subsequent secondary injury due to various molecular and pathophysiological responses that eventually lead to neuronal cell death. Secondary brain injury events may occur minutes, hours, or even days after the trauma, ... Read more >>

Neural Regen Res (Neural regeneration research)
[2017, 12(11):1749-1761]

Cited: 9 times

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MicroRNAs in Parkinson's disease and emerging therapeutic targets.

Bridget Martinez, Philip V Peplow,

Parkinson's disease (PD) is the second most common age-related neurodegenerative disorder, with the clinical main symptoms caused by a loss of dopaminergic neurons in the substantia nigra, corpus striatum and brain cortex. Over 90% of patients with PD have sporadic PD and occur in people with no known family history ... Read more >>

Neural Regen Res (Neural regeneration research)
[2017, 12(12):1945-1959]

Cited: 12 times

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Blood microRNAs as potential diagnostic markers for hemorrhagic stroke.

Bridget Martinez, Philip V Peplow,

Proper medical treatment of a stroke victim relies on accurate and rapid differentiation between ischemic and hemorrhagic stroke, which in current practice is performed by computerized tomography (CT) or magnetic resonance imaging (MRI) scans. A panel of microRNAs could be an extremely useful clinical tool for distinguishing between hemorrhagic and ... Read more >>

Neural Regen Res (Neural regeneration research)
[2017, 12(1):13-18]

Cited: 4 times

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Blood microRNAs as potential diagnostic and prognostic markers in cerebral ischemic injury.

Bridget Martinez, Philip V Peplow,

MicroRNAs are a family of small, genome-encoded endogenous RNAs that are transcribed but are not translated into proteins. They serve essential roles in virtually every aspect of brain function, including neurogenesis, neural development, and cellular responses leading to changes in synaptic plasticity. They are also implicated in neurodegeneration and neurological ... Read more >>

Neural Regen Res (Neural regeneration research)
[2016, 11(9):1375-1378]

Cited: 8 times

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Treatment of insulin resistance by acupuncture: a review of human and animal studies.

Bridget Martinez, Philip V Peplow,

Numerous experimental studies have demonstrated that acupuncture can correct various metabolic disorders such as hyperglycaemia, overweight, hyperphagia, hyperlipidaemia, inflammation, altered activity of the sympathetic nervous system, and insulin signalling defects, all of which contribute to the development of insulin resistance.To review human and animal studies investigating acupuncture as a treatment ... Read more >>

Acupunct Med (Acupuncture in medicine : journal of the British Medical Acupuncture Society)
[2016, 34(4):310-319]

Cited: 8 times

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Prevention and protection against cerebral ischemic injury using acupuncture.

Philip V Peplow, Bridget Martinez,

Neural Regen Res (Neural regeneration research)
[2016, 11(4):559-560]

Cited: 1 time

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Differential Effect of Electroacupuncture on Inflammatory Adipokines in Two Rat Models of Obesity.

Jacqueline J T Liaw, Philip V Peplow,

Chronic inflammation is known to be associated with visceral obesity and insulin resistance which are characterized by altered levels of production of pro- and anti-inflammatory adipokines. The dysregulation of the production of inflammatory adipokines and their functions in obese individuals leads to a state of chronic low-grade inflammation and may ... Read more >>

J Acupunct Meridian Stud (Journal of acupuncture and meridian studies)
[2016, 9(4):183-190]

Cited: 3 times

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Topical Issue: Acu-obesity and Diabetes.

Philip V Peplow,

J Acupunct Meridian Stud (Journal of acupuncture and meridian studies)
[2016, 9(3):107-108]

Cited: 0 times

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Electroacupuncture treatment of insulin resistance in diabetes mellitus.

Philip V Peplow,

Acupunct Med (Acupuncture in medicine : journal of the British Medical Acupuncture Society)
[2015, 33(5):347-349]

Cited: 4 times

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Effect of Electroacupuncture on Inflammation in the Obese Zucker Fatty Rat Model of Metabolic Syndrome.

Jacqueline J T Liaw, Philip V Peplow,

Chronic inflammation is known to be associated with visceral obesity and insulin resistance and is characterized by altered levels of production of adipokines such as tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), IL-6, leptin, and adiponectin. Metabolic syndrome (MetS) is a major and escalating public health and clinical challenge worldwide, and ... Read more >>

J Acupunct Meridian Stud (Journal of acupuncture and meridian studies)
[2016, 9(2):73-79]

Cited: 4 times

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Neuroimmunomodulatory effects of transcranial laser therapy combined with intravenous tPA administration for acute cerebral ischemic injury.

Philip V Peplow,

At present, the only FDA approved treatment for ischemic strokes is intravenous administration of tissue plasminogen activator within 4.5 hours of stroke onset. Owing to this brief window only a small percentage of patients receive tissue plasminogen activator. Transcranial laser therapy has been shown to be effective in animal models ... Read more >>

Neural Regen Res (Neural regeneration research)
[2015, 10(8):1186-1190]

Cited: 7 times

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Effects of Electroacupuncture on Pro-/Anti-inflammatory Adipokines in Serum and Adipose Tissue in Lean and Diet-induced Obese Rats.

Jacqueline J T Liaw, Philip V Peplow,

The effects of electroacupuncture (EA) on pro-/anti-inflammatory cytokines and blood glucose (BG) in lean and obese Long Evans rats were investigated. Group 1 and Group 3 had five lean and seven obese rats, respectively, and received EA at the Zhongwan/Guanyuan acupoints on Day 1, Day 3, Day 5, Day 8, ... Read more >>

J Acupunct Meridian Stud (Journal of acupuncture and meridian studies)
[2016, 9(2):65-72]

Cited: 2 times

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Repeated electroacupuncture: an effective treatment for hyperglycemia in a rat model.

Philip V Peplow, Gabrielle T Z McLean,

The effect of electroacupuncture (EA) in lowering blood glucose (BG) in eight fasted male obese Zucker diabetic rats aged 21-24 weeks was investigated. Group 1 (n = 4) received no EA and Group 2 (n = 4) received EA at the Zhongwan and Guanyuan acupoints on Day 1, Day 3, Day 6, Day 8, ... Read more >>

J Acupunct Meridian Stud (Journal of acupuncture and meridian studies)
[2015, 8(2):71-76]

Cited: 1 time

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Defining a therapeutic window for laser irradiation (810 nm) applied to the inguinal region to ameliorate diabetes in diabetic mice.

Philip V Peplow, G David Baxter,

OBJECTIVE: The purpose of this study was to determine a therapeutic window of antidiabetic effect by laser irradiating the left inguinal region of diabetic mice (810 nm 20.4 and 40.8 J/cm(2)) for 7 days. BACKGROUND DATA: Irradiation of 810 nm 10.2 J/cm(2) to the left inguinal region of diabetic mice for 7 days significantly ... Read more >>

Photomed Laser Surg (Photomedicine and laser surgery)
[2014, 32(9):500-504]

Cited: 2 times

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Growth factor- and cytokine-stimulated endothelial progenitor cells in post-ischemic cerebral neovascularization.

Philip V Peplow,

Endothelial progenitor cells are resident in the bone marrow blood sinusoids and circulate in the peripheral circulation. They mobilize from the bone marrow after vascular injury and home to the site of injury where they differentiate into endothelial cells. Activation and mobilization of endothelial progenitor cells from the bone marrow ... Read more >>

Neural Regen Res (Neural regeneration research)
[2014, 9(15):1425-1429]

Cited: 13 times

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Repeated electroacupuncture in obese Zucker diabetic fatty rats: adiponectin and leptin in serum and adipose tissue.

Philip V Peplow,

Fasted, male, obese, Zucker, diabetic fatty rats aged 10-16 weeks were anesthetized with 1% halothane in nitrous oxide-oxygen (3:1) on alternate weekdays over 2 weeks. Group 1 (n = 4) did not receive electroacupuncture (controls); Group 2 (n = 4) received electroacupuncture using the Zhongwan and the Guanyuan acupoints; Group 3 (n = 4) received electroacupuncture ... Read more >>

J Acupunct Meridian Stud (Journal of acupuncture and meridian studies)
[2015, 8(2):66-70]

Cited: 4 times

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Influence of growth factors and cytokines on angiogenic function of endothelial progenitor cells: a review of in vitro human studies.

Philip V Peplow,

Growth factors and cytokines released at sites of injury and inflammation play an important role in stimulating endothelial progenitor cell (EPC) migration to these sites. A comparative analysis of the literature shows under neutral in vitro conditions (pH 7.4), several growth factors and cytokines influenced favorably indices of EPC angiogenic ... Read more >>

Growth Factors (Growth factors (Chur, Switzerland))
[2014, 32(3-4):83-116]

Cited: 17 times

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Testing infrared laser phototherapy (810 nm) to ameliorate diabetes: irradiation on body parts of diabetic mice.

Philip V Peplow, G David Baxter,

BACKGROUND AND OBJECTIVES: Irradiation of left flank of genetic diabetic mice with 660 nm wavelength laser, 100 mW, 20 seconds/day for 7 days did not significantly alter blood plasma glucose compared to nonirradiated controls. Infrared light would provide for a greater amount of photoenergy penetrating the skin and muscle. Genetic diabetic mice were ... Read more >>

Lasers Surg Med (Lasers in surgery and medicine)
[2013, 45(4):240-245]

Cited: 2 times

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Repeated application of electroacupuncture ameliorates hyperglycemia in obese Zucker diabetic fatty rats.

Philip V Peplow, Soo Min Han,

Electroacupuncture (EA) was investigated for lowering the blood glucose (BG) in fasting male obese Zucker fatty diabetic (ZDF) rats aged 10-17 weeks. Anesthesia provided satisfactory chemical restraint to enable repeated EA. Animals in Groups 1, 2 and 3 were anesthetized on Days 1, 3, 5, 8, 10 and 12. Group ... Read more >>

J Acupunct Meridian Stud (Journal of acupuncture and meridian studies)
[2014, 7(1):1-5]

Cited: 3 times

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A review of the influence of growth factors and cytokines in in vitro human keratinocyte migration.

Philip V Peplow, Marissa P Chatterjee,

OBJECTIVE: Keratinocyte migration from the wound edge is a crucial step in the reepithelization of cutaneous wounds. Growth factors and cytokines, released from cells that invade the wound matrix, play an important role, and several in vitro assays have been performed to elucidate this. The purposes of this study were ... Read more >>

Cytokine (Cytokine)
[2013, 62(1):1-21]

Cited: 36 times

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