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Kidney health for everyone everywhere-from prevention to detection and equitable access to care.

Philip Kam-Tao Li, Guillermo Garcia-Garcia, Siu-Fai Lui, Sharon Andreoli, Winston Wing-Shing Fung, Anne Hradsky, Latha Kumaraswami, Vassilios Liakopoulos, Ziyoda Rakhimova, Gamal Saadi, Luisa Strani, Ifeoma Ulasi, Kamyar Kalantar-Zadeh, ,

Kidney Int. (Kidney international)
[2020, 97(2):226-232]

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Kidney Health for Everyone Everywhere-From Prevention to Detection and Equitable Access to Care.

Philip Kam-Tao Li, Guillermo Garcia-Garcia, Siu-Fai Lui, Sharon Andreoli, Winston Wing-Shing Fung, Anne Hradsky, Latha Kumaraswami, Vassilios Liakopoulos, Ziyoda Rakhimova, Gamal Saadi, Luisa Strani, Ifeoma Ulasi, Kamyar Kalantar-Zadeh, ,

The global burden of chronic kidney disease (CKD) is increasing with a projection of becoming the fifth leading cause of years of life lost globally by 2040. CKD is a major cause of catastrophic health expenditure. The costs of dialysis and transplantation consume up to 3% of the entire annual ... Read more >>

J Ren Care (Journal of renal care)
[2020, 46(1):4-12]

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Kidney health for everyone everywhere - from prevention to detection and equitable access to care.

Philip Kam-Tao Li, Guillermo Garcia-Garcia, Siu-Fai Lui, Sharon Andreoli, Winston Wing-Shing Fung, Anne Hradsky, Latha Kumaraswami, Vassilios Liakopoulos, Ziyoda Rakhimova, Gamal Saadi, Luisa Strani, Ifeoma Ulasi, Kamyar Kalantar-Zadeh,

The global burden of chronic kidney disease (CKD) is rapidly increasing with a projection of becoming the 5th most common cause of years of life lost globally by 2040. Aggravatingly, CKD is a major cause of catastrophic health expenditure. The costs of dialysis and transplantation consume up to 3% of ... Read more >>

Clin. Nephrol. (Clinical nephrology)
[2020, 93(3):111-122]

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Kidney health for everyone, everywhere: from prevention to detection and equitable access to care.

Philip K-T Li, Guillermo Garcia-Garcia, Siu-Fai Lui, Sharon Andreoli, Winston W-S Fung, Anne Hradsky, Latha Kumaraswami, Vassilios Liakopoulos, Ziyoda Rakhimova, Gamal Saadi, Luisa Strani, Ifeoma Ulasi, Kamyar Kalantar-Zadeh, ,

Intern Med J (Internal medicine journal)
[2020, 50(2):145-150]

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Author Correction: Metabolomic Changes of Human Proximal Tubular Cell Line in High Glucose Environment.

Pascal Zhongping Wei, Winston Wing-Shing Fung, Jack Kit-Chung Ng, Ka-Bik Lai, Cathy Choi-Wan Luk, Kai Ming Chow, Philip Kam-Tao Li, Cheuk Chun Szeto,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):1733]

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Establishing a Core Outcome Set for Peritoneal Dialysis: Report of the SONG-PD (Standardized Outcomes in Nephrology-Peritoneal Dialysis) Consensus Workshop.

Karine E Manera, David W Johnson, Jonathan C Craig, Jenny I Shen, Talia Gutman, Yeoungjee Cho, Angela Yee-Moon Wang, Edwina A Brown, Gillian Brunier, Jie Dong, Tony Dunning, Rajnish Mehrotra, Saraladevi Naicker, Roberto Pecoits-Filho, Jeffrey Perl, Martin Wilkie, Allison Tong, ,

Outcomes reported in randomized controlled trials in peritoneal dialysis (PD) are diverse, are measured inconsistently, and may not be important to patients, families, and clinicians. The Standardized Outcomes in Nephrology-Peritoneal Dialysis (SONG-PD) initiative aims to establish a core outcome set for trials in PD based on the shared priorities of ... Read more >>

Am. J. Kidney Dis. (American journal of kidney diseases : the official journal of the National Kidney Foundation)
[2020, 75(3):404-412]

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Helper-assisted continuous ambulatory peritoneal dialysis: Does the choice of helper matter?

Jack Kit-Chung Ng, Gordon Chun-Kau Chan, Kai Ming Chow, Winston Fung, Wing-Fai Pang, Man-Ching Law, Chi Bon Leung, Philip Kam-Tao Li, Cheuk Chun Szeto,

BACKGROUND:There is an increasing number of elderly patients on continuous ambulatory peritoneal dialysis (CAPD) who could not perform dialysis exchange themselves and require assistance. We examine the outcome of Chinese CAPD patients who required helper-assisted dialysis and compare the outcome between different types of helper. METHODS:We reviewed 133 incident patients ... Read more >>

Perit Dial Int (Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis)
[2020, 40(1):34-40]

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The efficacy of managing fluid overload in chronic peritoneal dialysis patients by a structured nurse-led intervention protocol.

Man Ching Law, Bonnie Ching-Ha Kwan, Janny Suk-Fun Fung, Kai Ming Chow, Jack K C Ng, Wing-Fai Pang, Phyllis Mei-Shan Cheng, Chi Bon Leung, , Cheuk Chun Szeto,

BACKGROUND:Extracellular volume overload is a common problem in peritoneal dialysis (PD) patients and is associated with excessive mortality. We determine the effectiveness of treating PD patients with extracellular volume overload by a structured nurse-led intervention program. METHODS:The hydration status of PD patients was screened by bioimpedance spectroscopy (BIS). Fluid overload ... Read more >>

BMC Nephrol (BMC nephrology)
[2019, 20(1):454]

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Urinary mitochondrial DNA level as a biomarker of tissue injury in non-diabetic chronic kidney diseases.

Zhongping Wei, Bonnie Ching-Ha Kwan, Kai Ming Chow, Phyllis Mei-Shan Cheng, Cathy Choi-Wan Luk, Ka-Bik Lai, Philip Kam-Tao Li, Cheuk Chun Szeto,

BACKGROUND:Urinary mitochondrial DNA (mtDNA) fragment level has been proposed as a biomarker of chronic kidney disease (CKD). In this study, we determine the relation between urinary mtDNA level and rate of renal function deterioration in non-diabetic CKD. METHODS:We recruited 102 non-diabetic CKD patients (43 with kidney biopsy that showed non-specific ... Read more >>

BMC Nephrol (BMC nephrology)
[2018, 19(1):367]

Cited: 1 time

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Metabolomic Changes of Human Proximal Tubular Cell Line in High Glucose Environment.

Pascal Zhongping Wei, Winston Wing-Shing Fung, Jack Kit-Chung Ng, Ka-Bik Lai, Cathy Choi-Wan Luk, Kai Ming Chow, Philip Kam-Tao Li, Cheuk Chun Szeto,

Hyperglycemia causes mitochondrial damage renal tubular cells, which contribute to the progression of diabetic kidney disease. However, the metabolic aberration of renal tubular cells in an hyperglycemic milieu has not been fully elucidated. In this study, human proximal renal tubular cell line (HK-2 cell) are incubated in glucose and mannitol ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):16617]

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Relationship between Plasma Endocan Level and Clinical Outcome of Chinese Peritoneal Dialysis Patients.

Peter Yam-Kau Poon, Jack Kit-Chung Ng, Winston Wing-Shing Fung, Kai-Ming Chow, Bonnie Ching-Ha Kwan, Philip Kam-Tao Li, Cheuk-Chun Szeto,

BACKGROUND:Endocan is associated with endothelial dysfunction. In peritoneal dialysis (PD) patients, cardiovascular disease is a common cause of mortality. We examined the relationship between serum endocan level and clinical outcome of PD patients. METHODS:We recruited 193 new PD patients (118 males, mean age 58.8 ± 11.6 years). Serum endocan levels ... Read more >>

Kidney Blood Press. Res. (Kidney & blood pressure research)
[2019, 44(5):1259-1270]

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Straight Versus Coiled Peritoneal Dialysis Catheters: A Randomized Controlled Trial.

Kai Ming Chow, Steve Siu Man Wong, Jack Kit Chung Ng, Yuk Lun Cheng, Chi Bon Leung, Wing Fai Pang, Winston Wing Shing Fung, Cheuk Chun Szeto, Philip Kam Tao Li,

RATIONALE & OBJECTIVE:Despite a recent meta-analysis favoring straight catheters, the clinical benefits of straight versus coiled peritoneal dialysis catheters remain uncertain. We conducted a randomized controlled study to compare the complication rates associated with these 2 types of double-cuffed peritoneal dialysis catheters. STUDY DESIGN:Multicenter, open-label, randomized, controlled trial. SETTING & ... Read more >>

Am. J. Kidney Dis. (American journal of kidney diseases : the official journal of the National Kidney Foundation)
[2020, 75(1):39-44]

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GFR Slope as a Surrogate End Point for Kidney Disease Progression in Clinical Trials: A Meta-Analysis of Treatment Effects of Randomized Controlled Trials.

Lesley A Inker, Hiddo J L Heerspink, Hocine Tighiouart, Andrew S Levey, Josef Coresh, Ron T Gansevoort, Andrew L Simon, Jian Ying, Gerald J Beck, Christoph Wanner, Jürgen Floege, Philip Kam-Tao Li, Vlado Perkovic, Edward F Vonesh, Tom Greene,

BACKGROUND:Surrogate end points are needed to assess whether treatments are effective in the early stages of CKD. GFR decline leads to kidney failure, but regulators have not approved using differences in the change in GFR from the beginning to the end of a randomized, controlled trial as an end point ... Read more >>

J. Am. Soc. Nephrol. (Journal of the American Society of Nephrology : JASN)
[2019, 30(9):1735-1745]

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Beware of drug interaction between tigecycline and tacrolimus.

Kai Ming Chow, Wing Fai Pang, Gordon Chun Kau Chan, Chi Bon Leung, Cheuk Chun Szeto, Philip Kam Tao Li,

Nephrology (Carlton) (Nephrology (Carlton, Vic.))
[2020, 25(1):99-100]

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Peritoneal Dialysis-Associated Peritonitis.

Cheuk-Chun Szeto, Philip Kam-Tao Li,

Peritonitis is a common and severe complication in peritoneal dialysis (PD). Detailed recommendations on the prevention and treatment of PD-associated peritonitis have been published by the International Society for Peritoneal Dialysis (ISPD), but there is a substantial variation in clinical practice among dialysis units. Prophylactic antibiotics administered before PD catheter ... Read more >>

Clin J Am Soc Nephrol (Clinical journal of the American Society of Nephrology : CJASN)
[2019, 14(7):1100-1105]

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Burden, access, and disparities in kidney disease.

Deidra C Crews, Aminu K Bello, Gamal Saadi, , ,

Nefrologia (Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia)
[2020, 40(1):4-11]

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Urinary miRNA profile for the diagnosis of IgA nephropathy.

Cheuk-Chun Szeto, Gang Wang, Jack Kit-Chung Ng, Bonnie Ching-Ha Kwan, Fernand Mac-Moune Lai, Kai-Ming Chow, Cathy Choi-Wan Luk, Ka-Bik Lai, Philip Kam-Tao Li,

BACKGROUND:IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. Urinary micro-RNA (miRNA) level is increasingly reported to as non-invasive markers of various kidney diseases. We aim to identify urinary miRNA targets for the diagnosis of IgAN. METHODS:In the development cohort, we performed complete miRNA profiling of urinary sediment in ... Read more >>

BMC Nephrol (BMC nephrology)
[2019, 20(1):77]

Cited: 1 time

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Clinical practice guidelines for the provision of renal service in Hong Kong: Accreditation of Renal Unit.

Philip Kam-Tao Li, Bonnie Ching-Ha Kwan, Andrew Kui-Man Wong,

Nephrology (Carlton) (Nephrology (Carlton, Vic.))
[2019, 24 Suppl 1:130-132]

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Burden, Access, and Disparities in Kidney Disease.

Deidra C Crews, Aminu K Bello, Gamal Saadi, ,

Kidney Int Rep (Kidney international reports)
[2019, 4(3):372-379]

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Effect of Erythropoiesis-Stimulating Agent Therapy in Patients Receiving Palliative Care of Chronic Kidney Disease.

Kai Ming Chow, Cheuk Chun Szeto, Agnes Shin Man Choy, Jack Kit Chung Ng, Alice Ka Wai Mok, Chi Bon Leung, Philip Kam Tao Li,

BACKGROUND:Despite the increasing use of erythropoiesis-stimulating agent (ESA) in patients receiving dialysis, few studies have examined the benefits of ESA for patients with chronic kidney disease receiving palliative care. OBJECTIVE:We designed a retrospective observational study to evaluate the effect of ESA in treating anemia of renal disease among adult patients ... Read more >>

Am J Hosp Palliat Care (The American journal of hospice & palliative care)
[2019, 36(8):718-721]

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Clinical practice guidelines for the provision of renal service in Hong Kong: Peritoneal Dialysis.

Cheuk Chun Szeto, Wai Kei Lo, Philip Kam-Tao Li,

Nephrology (Carlton) (Nephrology (Carlton, Vic.))
[2019, 24 Suppl 1:27-40]

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Burden, access, and disparities in kidney disease.

Deidra C Crews, Aminu K Bello, Gamal Saadi, ,

Kidney Int. (Kidney international)
[2019, 95(2):242-248]

Cited: 2 times

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Reprint of: Burden, access, and disparities in kidney disease.

Deidra C Crews, Aminu K Bello, Gamal Saadi, ,

Nephrol. Ther. (Nephrologie & therapeutique)
[2019, 15(1):3-8]

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Fluid management and bioimpedance study in peritoneal dialysis.

Jack Kit-Chung Ng, Philip Kam-Tao Li,

PURPOSE OF REVIEW:Maintaining euvolaemia is an essential yet challenging objective in management of patients on peritoneal dialysis. Optimal method to assess volume status remains to be determined. In this review, we will discuss the risk factors and clinical outcomes of fluid overload in PD patients, and examine the role of ... Read more >>

Curr. Opin. Nephrol. Hypertens. (Current opinion in nephrology and hypertension)
[2019, 28(1):58-64]

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Peritoneal protein clearance predicts mortality in peritoneal dialysis patients.

Wanhong Lu, Wing-Fai Pang, Li Jin, Huixian Li, Kai Ming Chow, Bonnie Ching-Ha Kwan, Chi Bon Leung, Philip Kam-Tao Li, Cheuk Chun Szeto,

BACKGROUND:Peritoneal protein clearance has been suggested to be a marker of peritoneal inflammation and systemic endothelial dysfunction. METHODS:We enrolled 711 consecutive incident PD patients. Baseline peritoneal protein clearance and other clinical information were reviewed. All patients were followed for at least 1 year for all-cause and cardiovascular mortality. RESULTS:The average PD ... Read more >>

Clin. Exp. Nephrol. (Clinical and experimental nephrology)
[2019, 23(4):551-560]

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