Full Text Journal Articles by
Author Philip George

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Colectomy Incidence Rates in Five-Year Data From the Observational Postmarketing Ulcerative Colitis Study of Originator Infliximab.

Julián Panés, James O Lindsay, Niels Teich, Stefan Lindgren, Jean-Frédéric Colombel, Heather Ann Flynn, Susan Huyck, Ruji Yao, George Philip, Walter Reinisch,

<h4>Background</h4>This analysis of the Observational Postmarketing Ulcerative Colitis Study examined incidence rates of colectomy in patients with ulcerative colitis who received originator infliximab (IFX) or conventional therapies (ConvRx) as per their treating physician.<h4>Methods</h4>Cox proportional hazards models compared time to colectomy for both treatment groups. A secondary analysis examined colectomy incidence ... Read more >>

Inflamm Bowel Dis (Inflammatory bowel diseases)
[2021, 27(12):1963-1967]

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Physiologic Variants of Cardiac Conduction (Aberration, Gap, Supernormal Conduction).

William M Miles, Philip George,

Wide QRS complexes during supraventricular rhythms can be caused by fixed bundle branch block, functional (intermittent) bundle branch block, preexcitation, or toxic/metabolic causes. Functional bundle branch block can be caused by long-short aberrancy (usually physiologic), or acceleration/deceleration dependent aberrancy (usually pathologic). Electrocardiogram criteria have been proposed to differentiate aberration from ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, 13(4):607-624]

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Chimeric antigen receptor T-cells in New Zealand: challenges and opportunities.

Robert Weinkove, Philip George, Myra Ruka, Tia Huia Haira, Giulia Giunti,

Chimeric antigen receptor (CAR) T-cells are a personalised cell and gene therapy for cancer that are becoming an international standard of care for some refractory B-cell leukaemias, non-Hodgkin lymphomas and myeloma. A single CAR T-cell administration can result in durable complete response for some recipients. Domestic CAR T-cell manufacturing capability ... Read more >>

N Z Med J (The New Zealand medical journal)
[2021, 134(1542):96-108]

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What has changed in orthodontic patient care between the two surges of the COVID-19 pandemic? A thematic analysis.

Elbe Peter, Monisha J, Baiju Rm, Suja Ani G, Sreela Ls, George Philip,

<h4>Background and aim</h4>The coronavirus disease 2019 (COVID-19) has brought new challenges to every specialty and orthodontics is no exception. Currently, there seems no way other than to mitigate the risk and proceed with routine orthodontic treatment. The aim of the present study was to conduct a qualitative inquiry into the ... Read more >>

J Orthod (Journal of orthodontics)
[2021, :14653125211043883]

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Low-Molecular-Weight Heparin Anti-Xa Guided Reversal of Apixaban With Prothrombin Complex Concentrate in a Patient on Hemodialysis.

Christina M Brummett, James S Dingman, George J Philip, David A Moran, Brian W Gilbert,

The growing use of oral factor Xa (FXa) inhibitors in patients with chronic kidney disease (CKD), particularly the recent increased use of apixaban in patients with end-stage renal disease (ESRD), has created a new dilemma in the already controversial topic of oral FXa inhibitor reversal. With the limited availability of ... Read more >>

J Pharm Pract (Journal of pharmacy practice)
[2021, :8971900211044288]

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Correction to: Impact of Body Mass Index (BMI) on perioperative outcomes following minimally invasive retromuscular abdominal wall reconstruction: a comparative analysis.

Alex Addo, Richard Lu, Andrew Broda, Philip George, Nick Huerta, Adrian Park, H Reza Zahiri, Igor Belyansky,

Surg Endosc (Surgical endoscopy)
[2021, 35(10):5803]

Cited: 3 times

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Thromboelastography utilization for dabigatran reversal in a patient with acute kidney injury.

Brian W Gilbert, M Jacob Ott, George J Philip,

<h4>Purpose</h4>This case report describes utilization of thromboelastography (TEG) in the setting of an acute major bleed in a patient on dabigatran who had concomitant acute kidney injury.<h4>Summary</h4>An 80-year-old female presented to the emergency department after a fall with complaints of pain in her knee, shoulder, and hip. Her medical history ... Read more >>

Am J Health Syst Pharm (American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists)
[2021, 78(15):1382-1384]

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Long-term Tolerability and Efficacy of Golimumab in Active Non-Radiographic Axial Spondyloarthritis: Results From Open-Label Extension.

Désirée van der Heijde, Maxime Dougados, Walter P Maksymowych, Gina Bergman, Sean P Curtis, Anjela Tzontcheva, Susan Huyck, George Philip, Joachim Sieper,

<h4>Objectives</h4>We report the open-label extension (OLE) of the GO-AHEAD study evaluating the long-term efficacy and safety of golimumab (GLM) in patients with non-radiographic axial spondyloarthritis (nr-axSpA).<h4>Methods</h4>Patients (both GLM- and placebo [PBO]-treated in the double-blind phase) received GLM 50 mg every 4 weeks during the OLE (36-week treatment; additional 8-week safety follow-up; GLM/GLM ... Read more >>

Rheumatology (Oxford) (Rheumatology (Oxford, England))
[2021, :]

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Bilateral total conservative parotidectomy: a tale behind an aesthetic surgery.

Jeyashanth Riju, Philip George, Konduru Vidya, Amit Jiwan Tirkey,

Any facial swelling is associated with stress for the patient due to cosmesis. Especially when one has bilateral symmetrical enlarged parotids, having exhausted all available conservative management, surgery becomes the last resort; which in such cases pose specific challenges. A 29-year-old man presented with problems of bilateral symmetrical enlarged parotid ... Read more >>

BMJ Case Rep (BMJ case reports)
[2020, 13(12):]

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Erratum to "Cardiovascular Considerations for the Internist and Hospitalist in the COVID-19 Era" AmJMed, 133(11); 1254-1261.

Michael R Massoomi, R David Anderson, Mustafa M Ahmed, Osama Dasa, Philip George, William M Miles, Juan M Aranda, Carl J Pepine,

Am J Med (The American journal of medicine)
[2021, 134(4):555]

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Patients with ineffective esophageal motility benefit from laparoscopic antireflux surgery.

Alex Addo, Philip George, H Reza Zahiri, Adrian Park,

<h4>Background</h4>Gastroesophageal reflux disease (GERD) is a common chronic disorder of the gastrointestinal tract, affecting more than 50% of Americans. The development of GERD may be associated with ineffective esophageal motility (IEM). The impact of esophageal motility on outcomes post laparoscopic antireflux surgery (LARS), including quality of life (QOL), remains to ... Read more >>

Surg Endosc (Surgical endoscopy)
[2021, 35(8):4459-4468]

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Impact of Body Mass Index (BMI) on perioperative outcomes following minimally invasive retromuscular abdominal wall reconstruction: a comparative analysis.

Alex Addo, Richard Lu, Andrew Broda, Philip George, Nick Huerta, Adrian Park, H Reza Zahiri, Igor Belyansky,

<h4>Background</h4>Morbidity and recurrence rates are higher in obese patients undergoing open abdominal wall reconstruction (AWR). Historically, body mass index (BMI) ≥ 40 has served as a relative contraindication to open AWR. The purpose of this study is to evaluate the impact of minimally invasive surgery (MIS) on outcomes after AWR for higher ... Read more >>

Surg Endosc (Surgical endoscopy)
[2021, 35(10):5796-5802]

Cited: 1 time

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Hybrid versus open retromuscular abdominal wall repair: early outcomes.

Alex Addo, Richard Lu, Andrew Broda, Philip George, H Reza Zahiri, Igor Belyansky,

<h4>Background</h4>The hybrid approach to abdominal wall reconstruction (AWR) for abdominal wall hernias combines minimally invasive posterior component separation and retromuscular dissection with open fascial closure and mesh implantation. This combination may enhance patient outcomes and recovery compared to the open approach alone. The purpose of this study is to evaluate ... Read more >>

Surg Endosc (Surgical endoscopy)
[2021, 35(10):5593-5598]

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Management of the Thyroid Gland in Papillary Carcinoma of the Thyroglossal Cyst: A Case Report.

Philip George, Suresh Mani, Ramesh Babu Telugu, Rajiv Charles Michael,

Carcinoma arising in a thyroglossal cyst is rare. We present a case of anterior neck swelling diagnosed to be thyroglossal cyst clinically which turns out to be a papillary carcinoma arising in thyroglossal cyst. She underwent sistrunk procedure with total thyroidectomy and diseasefree on follow up evaluation. Even though preoperative ... Read more >>

JNMA J Nepal Med Assoc (JNMA; journal of the Nepal Medical Association)
[2020, 58(227):497-500]

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A Call for Engagement with the Surgical Patient.

Philip George, Alex Addo, Ian Brooks, Adrian Park,

Surg Innov (Surgical innovation)
[2020, 27(4):317-319]

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Cardiovascular Considerations for the Internist and Hospitalist in the COVID-19 Era.

Michael R Massoomi, R David Anderson, Mustafa M Ahmed, Osama Dasa, Philip George, William M Miles, Juan M Aranda, Carl J Pepine,

It is clear that existing cardiovascular disease is a major risk factor for COVID-19 and related adverse outcomes. In addition to acute respiratory syndrome, a large cohort also develop myocardial or vascular dysfunction, in part from inflammation and renin angiotensin system activation with increased sympathetic outflow, cardiac arrhythmias, ischemia, heart ... Read more >>

Am J Med (The American journal of medicine)
[2020, 133(11):1254-1261]

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The Association of Human Papillomavirus in Benign and Malignant Laryngeal Lesions-a Pilot Study.

Philip George, Suresh Mani, Priya Abraham, Rajiv C Michael,

Various etiological factors have been described in laryngeal carcinogenesis. Tobacco and alcohol play a major role in the development of laryngeal cancers. However, recently there has been an overshadowing of association of human papillomavirus infection in laryngeal cancers. The aim of this study is to assess the prevalence of human ... Read more >>

Indian J Surg Oncol (Indian journal of surgical oncology)
[2021, 12(2):306-310]

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Challenges in determining minor head trauma risks in patients on DOACs.

Brian W Gilbert, Brady Dively, Jacob A Reeder, George J Philip,

Am J Emerg Med (The American journal of emergency medicine)
[2021, 42:233-234]

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B-cell prolymphocytic leukaemia with a t(4;14) FGFR3/IGH translocation: response to ibrutinib.

Philip George, Angela Brown, Robert Weinkove,

Pathology (Pathology)
[2020, 52(4):491-492]

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Validation of a hierarchical algorithm to define chronic liver disease and cirrhosis etiology in administrative healthcare data.

George Philip, Maya Djerboua, David Carlone, Jennifer A Flemming,

BACKGROUND AND AIMS:Chronic liver disease (CLD) and cirrhosis are leading causes of death globally with the burden of disease rising significantly over the past several decades. Defining the etiology of liver disease is important for understanding liver disease epidemiology, healthcare planning, and outcomes. The aim of this study was to ... Read more >>

PLoS One (PloS one)
[2020, 15(2):e0229218]

Cited: 1 time

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The Effect of Low-Carbohydrate and Low-Fat Diets on Pain in Individuals with Knee Osteoarthritis.

Larissa J Strath, Catherine D Jones, Alan Philip George, Shannon L Lukens, Shannon A Morrison, Taraneh Soleymani, Julie L Locher, Barbara A Gower, Robert E Sorge,

<h4>Objective</h4>Osteoarthritis is the most prominent form of arthritis, affecting approximately 15% of the population in the United States. Knee osteoarthritis (KOA) has become one of the leading causes of disability in older adults. Besides knee replacement, there are no curative treatments for KOA, so persistent pain is commonly treated with ... Read more >>

Pain Med (Pain medicine (Malden, Mass.))
[2020, 21(1):150-160]

Cited: 2 times

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Immune surveillance in clinical regression of pre-invasive squamous cell lung cancer

Adam Pennycuick, Vitor Teixeira, Khalid AbdulJabbar, Shan Ahmed Raza, Tom Lund, Ayse Akarca, Rachel Rosenthal, Christodoulos Pipinikas, Henry Lee-Six, Deepak Chandrasekharan, Robert Hynds, Kate Gowers, Jake Henry, Celine Denais, Mary Falzon, Sophia Antoniou, Pascal Durrenberger, Andrew Furness, Bernadette Carroll, Ricky Thakrar, Philip George, Teresa Marafioti, Charles Swanton, Christina Thirlwell, Peter Campbell, Yinyin Yuan, Sergio Quezada, Nicholas McGranahan, Sam Janes,

Before squamous cell lung cancer develops, pre-cancerous lesions can be found in the airways. From longitudinal monitoring, we know that only half of such lesions become cancer, whereas a third spontaneously regress. While recent studies have described the presence of an active immune response in high-grade lesions, the mechanisms underpinning ... Read more >>

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Five-year Safety Data From OPUS, a European Observational Safety Registry for Adults With Ulcerative Colitis Treated With Originator Infliximab [Remicade®] or Conventional Therapy.

Julián Panés, James O Lindsay, Niels Teich, Stefan Lindgren, Jean-Frédéric Colombel, Freddy Cornillie, Heather Ann Flynn, Susan Huyck, Paul Stryszak, Ruji Yao, George Philip, Walter Reinisch,

<h4>Background and aims</h4>The Observational Postmarketing Ulcerative colitis Study [OPUS] was conducted to obtain the first long-term [5 years] safety data assessing treatment with originator infliximab versus conventional therapies in patients with ulcerative colitis [UC] in real-world clinical practice.<h4>Methods</h4>The OPUS registry was a prospective, non-randomised, observational study that measured adverse events ... Read more >>

J Crohns Colitis (Journal of Crohn's & colitis)
[2019, 13(9):1148-1157]

Cited: 3 times

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Early Dose Optimisation of Golimumab in Nonresponders to Induction Treatment for Ulcerative Colitis Is Effective and Supported by Pharmacokinetic Data.

George Philip, Freddy Cornillie, J Omoniyi Adedokun, Richard Melsheimer, Paul Rutgeerts, Jean-Frédéric Colombel, Colleen Marano,

<h4>Background and aims</h4>In nonresponders to golimumab induction for ulcerative colitis, we assessed clinical response rates and golimumab serum concentrations when the 100-mg dose was used early in the course of maintenance.<h4>Methods</h4>This post-hoc analysis of golimumab maintenance dosing [in the PURSUIT-M study] examined clinical outcomes and golimumab concentrations in early [Week ... Read more >>

J Crohns Colitis (Journal of Crohn's & colitis)
[2019, 13(10):1257-1264]

Cited: 2 times

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Soluble human Suppression of Tumorigenicity 2 is associated with endoscopic activity in patients with moderate-to-severe ulcerative colitis treated with golimumab.

Fernando Magro, Susana Lopes, Marco Silva, Rosa Coelho, Francisco Portela, Diogo Branquinho, Luís Correia, Samuel Fernandes, Marília Cravo, Paulo Caldeira, Helena Tavares de Sousa, Marta Patita, Paula Lago, Jaime Ramos, Joana Afonso, Isabel Redondo, Patrícia Machado, George Philip, Joanne Lopes, Fátima Carneiro,

<h4>Background</h4>Suppressor of Tumorigenicity 2 (ST2) is an IL33 receptor detected in the mucosa and serum of ulcerative colitis (UC) patients. We evaluated soluble ST2 (sST2) as a surrogate biomarker of disease outcome and therapeutic response, in moderate-to-severe UC patients treated with golimumab.<h4>Methods</h4>We conducted an open-label single-arm multicentre prospective study. At ... Read more >>

Therap Adv Gastroenterol (Therapeutic advances in gastroenterology)
[2019, 12:1756284819869141]

Cited: 1 time

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