Full Text Journal Articles by
Author Philip Floyd

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Predicting the Solubility Advantage of Amorphous Drugs: Effect of pH.

Peter J Skrdla, Philip D Floyd, Philip C Dell'Orco,

The solubility enhancement generated by an amorphous phase over its crystalline counterpart is unaffected by the pH of the solution (at fixed ionic strength and temperature), even for a drug containing ionizable moieties, provided that both the ionized and neutral species generated through dissolution of the solids remain dissolved. ... Read more >>

J Pharm Sci (Journal of pharmaceutical sciences)
[2020, 109(4):1627-1629]

Cited: 0 times

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Modeling Recrystallization Kinetics Following the Dissolution of Amorphous Drugs.

Peter J Skrdla, Philip D Floyd, Philip C Dell'Orco,

Amorphous phases are frequently employed to overcome the solubility limitation that is nowadays commonplace in developmental small-molecule drugs intended for oral administration. However, since the solubility enhancement has finite longevity (it is a "kinetic solubility" effect), characterizing its duration (i.e., the so-called "parachute" effect) can be important for optimizing a ... Read more >>

Mol Pharm (Molecular pharmaceutics)
[2020, 17(1):219-228]

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Predicting the solubility enhancement of amorphous drugs and related phenomena using basic thermodynamic principles and semi-empirical kinetic models.

Peter J Skrdla, Philip D Floyd, Philip C Dell'Orco,

The accurate prediction of the solubility enhancement offered by neat amorphous drugs and amorphous solid dispersions, over their crystalline (API) counterparts, has been discussed in several landmark works dating back at least two decades. Against this backdrop, an assessment of the current state-of-the-art for rigorously, yet simply (circumventing computational methods), ... Read more >>

Int J Pharm (International journal of pharmaceutics)
[2019, 567:118465]

Cited: 0 times

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Predicted amorphous solubility and dissolution rate advantages following moisture sorption: Case studies of indomethacin and felodipine.

Peter J Skrdla, Philip D Floyd, Philip C Dell'Orco,

Water is often readily absorbed by amorphous compounds, lowering their glass transition temperature (T<sub>g</sub>) and facilitating their recrystallization (via nucleation-and-growth). At the same time, the increase in moisture content translates to a decrease in both the thermodynamic solubility and intrinsic dissolution rate, as compared to the corresponding dry (pure) amorphous ... Read more >>

Int J Pharm (International journal of pharmaceutics)
[2019, 555:100-108]

Cited: 2 times

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The amorphous state: first-principles derivation of the Gordon-Taylor equation for direct prediction of the glass transition temperature of mixtures; estimation of the crossover temperature of fragile glass formers; physical basis of the "Rule of 2/3".

Peter J Skrdla, Philip D Floyd, Philip C Dell'Orco,

Predicting the glass transition temperature (T<sub>g</sub>) of mixtures has applications that span across industries and scientific disciplines. By plotting experimentally determined T<sub>g</sub> values as a function of the glass composition, one can usually apply the Gordon-Taylor (G-T) equation to determine the slope, k, which subsequently can be used in T<sub>g</sub> ... Read more >>

Phys Chem Chem Phys (Physical chemistry chemical physics : PCCP)
[2017, 19(31):20523-20532]

Cited: 1 time

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Practical Estimation of Amorphous Solubility Enhancement Using Thermoanalytical Data: Determination of the Amorphous/Crystalline Solubility Ratio for Pure Indomethacin and Felodipine.

Peter J Skrdla, Philip D Floyd, Philip C Dell'orco,

Use of amorphous phases can mitigate the low in vivo exposures of poorly soluble, crystalline active pharmaceutical ingredients. However, it remains challenging to accurately predict the solubility enhancement offered even by a pure amorphous phase relative to the crystalline form. In this work, a methodology is presented that allows estimation of ... Read more >>

J Pharm Sci (Journal of pharmaceutical sciences)
[2016, 105(9):2625-2630]

Cited: 4 times

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Analytical characterization of an orally-delivered peptide pharmaceutical product.

Wayne P Kelley, Shujun Chen, Philip D Floyd, Ping Hu, Shiva G Kapsi, Alireza S Kord, Mingjiang Sun, Frederick G Vogt,

The characterization of orally-delivered peptide pharmaceuticals presents several challenges to analytical methods in comparison to characterization of conventional small-molecule drugs. These challenges include the analysis and characterization of difficult-to-separate impurities, secondary structure, the amorphous solid-state form, and the integrity of enteric-coated drug delivery systems. This work presents the multidisciplinary analytical ... Read more >>

Anal Chem (Analytical chemistry)
[2012, 84(10):4357-4372]

Cited: 5 times

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Insulin prohormone processing, distribution, and relation to metabolism in Aplysia californica.

P D Floyd, L Li, S S Rubakhin, J V Sweedler, C C Horn, I Kupfermann, V Y Alexeeva, T A Ellis, N C Dembrow, K R Weiss, F S Vilim,

The first Aplysia californica insulin gene is characterized and its proteolytic processing from prohormone to final peptides elucidated using a combination of biochemical and mass spectrometric methods. Aplysia insulin (AI) is one of the largest insulins found, with a molecular weight of 9146 Da, and an extended A chain compared ... Read more >>

J Neurosci (The Journal of neuroscience : the official journal of the Society for Neuroscience)
[1999, 19(18):7732-7741]

Cited: 67 times

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