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Author Petros Isaakidis

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Tuberculosis preventive therapy for children and adolescents: an emergency response to the COVID-19 pandemic.

Erika Mohr-Holland, Bianca Douglas-Jones, Ivy Apolisi, Noluvo Ngambu, Shaheed Mathee, Rabia Cariem, Vanessa Mudaly, Colin Pfaff, Petros Isaakidis, Jennifer Furin, Anja Reuter,

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2021, 5(3):159-161]

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Treatment outcomes of children and adolescents receiving drug-resistant TB treatment in a routine TB programme, Mumbai, India.

Shubhangi Dhakulkar, Mrinalini Das, Narendra Sutar, Vikas Oswal, Daksha Shah, Shilpa Ravi, Dipa Vengurlekar, Vijay Chavan, Lorraine Rebello, Augusto C Meneguim, Aparna Iyer, Homa Mansoor, Stobdan Kalon, Shrikala Acharya, Gabriella Ferlazzo, Petros Isaakidis, Harshad P Thakur,

<h4>Background</h4>Childhood and adolescent drug-resistant TB (DR-TB) is one of the neglected infectious diseases. Limited evidence exists around programmatic outcomes of children and adolescents receiving DR-TB treatment. The study aimed to determine the final treatment outcomes, culture conversion rates and factors associated with unsuccessful treatment outcome in children and adolescents with ... Read more >>

PLoS One (PloS one)
[2021, 16(2):e0246639]

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Safety and effectiveness of an all-oral, bedaquiline-based, shorter treatment regimen for rifampicin-resistant tuberculosis in high HIV burden rural South Africa: a retrospective cohort analysis.

Ilse Tack, Asnake Dumicho, Liesbet Ohler, Altynay Shigayeva, Abera Balcha Bulti, Kenneth White, Mduduzi Mbatha, Jennifer Furin, Petros Isaakidis,

<h4>Background</h4>At the end of 2018, South Africa updated its all-oral regimen, to include bedaquiline (BDQ) and two months of linezolid (LZD) for all patients initiating the shorter 9 to 12 months regimen for rifampicin-resistant tuberculosis (RR-TB). We assessed a group of patients in rural KwaZulu-Natal for safety and effectiveness of ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

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One step forward: Successful end-of-treatment outcomes of drug-resistant TB patients who received concomitant bedaquiline and delamanid in Mumbai, India.

Mrinalini Das, Alpa Dalal, Chinmay Laxmeshwar, Shilpa Ravi, Fatima Mamnoon, Augusto C Meneguim, Roma Paryani, Taanya Mathur, Pramila Singh, Homa Mansoor, Stobdan Kalon, Farah Naz Hossain, Nathalie Lachenal, Sylvine Coutisson, Gabriella Ferlazzo, Petros Isaakidis,

<h4>Background</h4>Médecins Sans Frontières clinic in Mumbai, India has been providing concomitant Bedaquiline (BDQ) and Delamanid (DLM) in treatment regimen for patients with drug-resistant tuberculosis (DR-TB) and limited therapeutic options, referred from other healthcare institutions, since 2016. The study documents the end-of-treatment outcomes, culture-conversion rates, and serious adverse events (SAEs) during ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

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Preparedness of outpatient health facilities for ambulatory treatment with all-oral short DR-TB treatment regimens in Zhytomyr, Ukraine: a cross-sectional study.

Tinne Gils, Chinmay Laxmeshwar, Marve Duka, Khachatur Malakyan, Olga Valentinovna Siomak, Vitaly Stephanovich Didik, Natalia Lytvynenko, Yana Terleeva, Dmytri Donchuk, Petros Isaakidis,

<h4>Background</h4>Ukraine has a high burden of drug-resistant tuberculosis (DR-TB). Mental health problems, including alcohol use disorder, are common co-morbidities. One in five DR-TB patients has human immunodeficiency virus (HIV). As part of health reform, the country is moving from inpatient care to ambulatory primary care for tuberculosis (TB). In Zhytomyr ... Read more >>

BMC Health Serv Res (BMC health services research)
[2020, 20(1):890]

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Preparedness of outpatient health facilities for ambulatory treatment with all-oral short DR-TB treatment regimens in Zhytomyr, Ukraine: A cross-sectional study

Tinne Gils, Chinmay Laxmeshwar, Marve Duka, Khachatur Malakyan, Olga Valentinovna Siomak, Vitaly Stephanovich Didik, Natalia Lytvynenko, Yana Terleeva, Dimitri Donchuk, Petros Isaakidis,

<h4>Background: </h4> Ukraine has a high burden of drug-resistant tuberculosis (DR-TB). Mental health problems, including alcohol use disorder, are common co-morbidities. One in five DR-TB patients has human immunodeficiency virus (HIV). As part of health reform, the country is moving from inpatient care to ambulatory primary care for tuberculosis (TB). ... Read more >>

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Mortality in adults with multidrug-resistant tuberculosis and HIV by antiretroviral therapy and tuberculosis drug use: an individual patient data meta-analysis.

Gregory P Bisson, Mayara Bastos, Jonathon R Campbell, Didi Bang, James C Brust, Petros Isaakidis, Christoph Lange, Dick Menzies, Giovanni B Migliori, Jean W Pape, Domingo Palmero, Parvaneh Baghaei, Payam Tabarsi, Piret Viiklepp, Stalz Vilbrun, Jonathan Walsh, Suzanne M Marks,

<h4>Background</h4>HIV-infection is associated with increased mortality during multidrug-resistant tuberculosis treatment, but the extent to which the use of antiretroviral therapy (ART) and anti-tuberculosis medications modify this risk are unclear. Our objective was to evaluate how use of these treatments altered mortality risk in HIV-positive adults with multidrug-resistant tuberculosis.<h4>Methods</h4>We did an ... Read more >>

Lancet (Lancet (London, England))
[2020, 396(10248):402-411]

Cited: 1 time

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Partner Notification Approaches for Sex Partners and Children of Human Immunodeficiency Virus Index Cases in Côte d'Ivoire.

Marie-Huguette K A Kingbo, Petros Isaakidis, Arielle Lasry, Kudakwashe C Takarinda, Marcel Manzi, John Pringle, Flore Adjoua Konan, Jules NʼDraman, Nathalie Krou Danho, Armand K Abokon, Nicole Isabelle L Doumatey,

<h4>Background</h4>Four partner notification approaches were introduced in health facilities in Côte d'Ivoire to increase human immunodeficiency virus (HIV) testing uptake among the type of contacts (sex partners and biological children younger than 15 years). The study assessed the 4 approaches: client referral (index cases refer the contacts for HIV testing), ... Read more >>

Sex Transm Dis (Sexually transmitted diseases)
[2020, 47(7):450-457]

Cited: 1 time

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Correspondence regarding "Delamanid for rifampicin-resistant tuberculosis: a retrospective study from South Africa".

Erika Mohr-Holland, Anja Reuter, Jennifer Hughes, Johnny Daniels, Busisiwe Beko, Goodman Makhanda, Virginia De Avezedo, Yulene Kock, Helen Cox, Jennifer Furin, Laura Trivino Duran, Petros Isaakidis, Gabriella Ferlazzo,

Eur Respir J (The European respiratory journal)
[2020, 56(1):]

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Yield of Systematic Longitudinal Screening of Household Contacts of Pre-Extensively Drug Resistant (PreXDR) and Extensively Drug Resistant (XDR) Tuberculosis Patients in Mumbai, India.

Roma Haresh Paryani, Vivek Gupta, Pramila Singh, Madhur Verma, Sabira Sheikh, Reeta Yadav, Homa Mansoor, Stobdan Kalon, Sriram Selvaraju, Mrinalini Das, Chinmay Laxmeshwar, Gabriella Ferlazzo, Petros Isaakidis,

While risk of tuberculosis (TB) is high among household contacts (HHCs) of pre-extensively drug resistant (pre-XDR) TB and XDR-TB, data on yield of systematic longitudinal screening are lacking. We aim to describe the yield of systematic longitudinal TB contact tracing among HHCs of patients with pre-XDR-TB and XDR-TB. At the ... Read more >>

Trop Med Infect Dis (Tropical medicine and infectious disease)
[2020, 5(2):]

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Ambulatory management of pre- and extensively drug resistant tuberculosis patients with imipenem delivered through port-a-cath: A mixed methods study on treatment outcomes and challenges.

Vijay Vinayak Chavan, Alpa Dalal, Sharath Nagaraja, Pruthu Thekkur, Homa Mansoor, Augusto Meneguim, Roma Paryani, Pramila Singh, Stobdan Kalon, Mrinalini Das, Gabriella Ferlazzo, Petros Isaakidis,

<h4>Background</h4>Imipenem, an intravenous antibiotic is recommended for use in drug resistant tuberculosis (DR-TB) when an effective regimen with combination of other second line drugs is not possible. Though the treatment success rates with carbapenems are promising, the twice daily injection of Imipenem usually requires patients to be hospitalized. The Médecins ... Read more >>

PLoS One (PloS one)
[2020, 15(6):e0234651]

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Improving pediatric TB diagnosis in North Kivu (DR Congo), focusing on a clinical algorithm including targeted Xpert MTB/RIF on gastric aspirates.

Daan Van Brusselen, Erica Simons, Tony Luendo, Delphine Habarugira, Jimmy Ngowa, Nadine Neema Mitutso, Zakari Moluh, Mieke Steenssens, Rachelle Seguin, Hilde Vochten, Lucien Ngabo, Petros Isaakidis, Gabriella Ferlazzo,

Background:The incidence of tuberculosis (TB) in the Democratic Republic of the Congo (DRC) is 323/100,000. A context of civil conflict, internally displaced people and mining activities suggests a higher regional TB incidence in North Kivu. Médecins Sans Frontières (MSF) supports the General Reference Hospital of Masisi, North Kivu, covering a ... Read more >>

Confl Health (Conflict and health)
[2020, 14:26]

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'Only twice a year': a qualitative exploration of 6-month antiretroviral treatment refills in adherence clubs for people living with HIV in Khayelitsha, South Africa.

Claire Marriott Keene, Nompumelelo Zokufa, Emilie C Venables, Lynne Wilkinson, Risa Hoffman, Tali Cassidy, Leigh Snyman, Anna Grimsrud, Jacqueline Voget, Erin von der Heyden, Siphokazi Zide-Ndzungu, Vinayak Bhardwaj, Petros Isaakidis,

OBJECTIVE:Longer intervals between routine clinic visits and medication refills are part of patient-centred, differentiated service delivery (DSD). They have been shown to improve patient outcomes as well as optimise health services-vital as 'universal test-and-treat' targets increase numbers of HIV patients on antiretroviral treatment (ART). This qualitative study explored patient, healthcare ... Read more >>

BMJ Open (BMJ open)
[2020, 10(7):e037545]

Cited: 1 time

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Setting up a nurse-led model of care for management of hypertension and diabetes mellitus in a high HIV prevalence context in rural Zimbabwe: a descriptive study.

Marthe Frieden, Blessing Zamba, Nisbert Mukumbi, Patron T Mafaune, Brian Makumbe, Elizabeth Irungu, Virginia Moneti, Petros Isaakidis, Daniela Garone, Madhu Prasai,

BACKGROUND:In the light of the increasing burden of non-communicable diseases (NCDs) on health systems in low- and middle-income countries, particularly in Sub-Saharan Africa, context-adapted, cost-effective service delivery models are now required as a matter of urgency. We describe the experience of setting up and organising a nurse-led Diabetes Mellitus (DM) ... Read more >>

BMC Health Serv Res (BMC health services research)
[2020, 20(1):486]

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Routine viral load monitoring and enhanced adherence counselling at a public ART centre in Mumbai, India.

Chinmay Laxmeshwar, Shrikala Acharya, Mrinalini Das, Padmaja Keskar, Amar Pazare, Nayana Ingole, Preeti Mehta, Pooja Gori, Homa Mansoor, Stobdan Kalon, Pramila Singh, Taanya Mathur, Gabriella Ferlazzo, Petros Isaakidis,

BACKGROUND:Routine viral-load (VL) measurements along with enhanced adherence counselling (EAC) are recommended to achieve virological suppression among people living with HIV/AIDS (PLHA) on anti-retroviral therapy (ART). The Mumbai Districts AIDS Control Society along with Médecins Sans Frontières has provided routine VL measurements and EAC to PLHA on ART at King ... Read more >>

PLoS One (PloS one)
[2020, 15(5):e0232576]

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Setting up a nurse-led model of care for management of Hypertension and Diabetes Mellitus in a high HIV prevalence context in rural Zimbabwe: a descriptive study

Marthe Marie Frieden, Blessing Zamba, Nisbert Mukumbi, Patron Titsha Mafaune, Brian Makumbe, Elizabeth Irungu, Virginia Moneti, Petros Isaakidis, Daniela Garone, Madhu Janina Prasai,

<h4>Background: </h4> In the light of the increasing burden of non-communicable diseases (NCDs) on health systems in low- and middle-income countries, particularly in Sub-Saharan Africa, context-adapted, cost-effective service delivery models are now required as a matter of urgency. We describe the experience of setting up and organising a nurse-led Diabetes ... Read more >>

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Injectable-free regimens containing bedaquiline, delamanid, or both for adolescents with rifampicin-resistant tuberculosis in Khayelitsha, South Africa.

Erika Mohr-Holland, Anja Reuter, Jennifer Furin, Anthony Garcia-Prats, Virginia De Azevedo, Vanessa Mudaly, Yulene Kock, Laura Trivino-Duran, Petros Isaakidis, Jennifer Hughes,

Background:Limited data exist on the use of bedaquiline and delamanid in adolescents with rifampicin-resistant tuberculosis (RR-TB). We describe RR-TB treatment of adolescents (10-19 years) with injectable-free regimens containing these drugs in Khayelitsha, South Africa. Methods:This retrospective study included adolescents initiating injectable-free RR-TB treatment regimens containing bedaquiline and/or delamanid from February ... Read more >>

EClinicalMedicine (EClinicalMedicine)
[2020, 20:100290]

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Drug-associated adverse events in the treatment of multidrug-resistant tuberculosis: an individual patient data meta-analysis.

Zhiyi Lan, Nafees Ahmad, Parvaneh Baghaei, Linda Barkane, Andrea Benedetti, Sarah K Brode, James C M Brust, Jonathon R Campbell, Vicky Wai Lai Chang, Dennis Falzon, Lorenzo Guglielmetti, Petros Isaakidis, Russell R Kempker, Maia Kipiani, Liga Kuksa, Christoph Lange, Rafael Laniado-Laborín, Payam Nahid, Denise Rodrigues, Rupak Singla, Zarir F Udwadia, Dick Menzies, ,

<h4>Background</h4>Treatment of multidrug-resistant tuberculosis requires long-term therapy with a combination of multiple second-line drugs. These drugs are associated with numerous adverse events that can cause severe morbidity, such as deafness, and in some instances can lead to death. Our aim was to estimate the absolute and relative frequency of adverse ... Read more >>

Lancet Respir Med (The Lancet. Respiratory medicine)
[2020, 8(4):383-394]

Cited: 2 times

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Access to health services for men who have sex with men and transgender women in Beira, Mozambique: A qualitative study.

Farisai Gamariel, Petros Isaakidis, Ivan Alejandro Pulido Tarquino, José Carlos Beirão, Lucy O'Connell, Nordino Mulieca, Heitor Pedro Gatoma, Vasco Francisco Japissane Cumbe, Emilie Venables,

OBJECTIVES:HIV prevalence and incidence are higher among key populations including Men who have Sex with Men (MSM) and transgender women in low and middle income countries, when compared to the general population. Despite World Health Organisation guidelines on the provision of services to key populations recommending an evidence-based, culturally relevant ... Read more >>

PLoS One (PloS one)
[2020, 15(1):e0228307]

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GeneXpert and Community Health Workers Supported Patient Tracing for Tuberculosis Diagnosis in Conflict-Affected Border Areas in India.

Mrinalini Das, Dileep Pasupuleti, Srinivasa Rao, Stacy Sloan, Homa Mansoor, Stobdan Kalon, Farah Naz Hossain, Gabriella Ferlazzo, Petros Isaakidis,

Médecins Sans Frontières (MSF) has been providing diagnosis and treatment for patients with tuberculosis (TB) via mobile clinics in conflict-affected border areas of Chhattisgarh, India since 2009. The study objectives were to determine the proportion of patients diagnosed with TB and those who were lost-to-follow-up (LTFU) prior to treatment initiation ... Read more >>

Trop Med Infect Dis (Tropical medicine and infectious disease)
[2019, 5(1):]

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Breast Tuberculosis in Women: A Systematic Review.

Gianluca Quaglio, Damiano Pizzol, Petros Isaakidis, Arianna Bortolani, Francesca Tognon, Claudia Marotta, Francesco Di Gennaro, Giovanni Putoto, Piero L Olliaro,

Breast tuberculosis (TB) is rarely reported and poorly described. This review aims to update the existing literature on risk factors, clinical presentations, constitutional symptoms, diagnostic procedures, and medical and surgical treatments for breast TB. In all, 1,478 cases of breast TB were collected. Previous history of TB was reported in ... Read more >>

Am J Trop Med Hyg (The American journal of tropical medicine and hygiene)
[2019, 101(1):12-21]

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Bedaquiline and delamanid in combination for treatment of drug-resistant tuberculosis.

Erika Mohr, Gabriella Ferlazzo, Cathy Hewison, Virginia De Azevedo, Petros Isaakidis,

Lancet Infect Dis (The Lancet. Infectious diseases)
[2019, 19(5):470]

Cited: 2 times

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Treatment Outcomes in Global Systematic Review and Patient Meta-Analysis of Children with Extensively Drug-Resistant Tuberculosis.

Muhammad Osman, Elizabeth P Harausz, Anthony J Garcia-Prats, H Simon Schaaf, Brittany K Moore, Robert M Hicks, Jay Achar, Farhana Amanullah, Pennan Barry, Mercedes Becerra, Domnica I Chiotan, Peter C Drobac, Jennifer Flood, Jennifer Furin, Medea Gegia, Petros Isaakidis, Andrei Mariandyshev, Iveta Ozere, N Sarita Shah, Alena Skrahina, Elena Yablokova, James A Seddon, Anneke C Hesseling, ,

Extensively drug-resistant tuberculosis (XDR TB) has extremely poor treatment outcomes in adults. Limited data are available for children. We report on clinical manifestations, treatment, and outcomes for 37 children (<15 years of age) with bacteriologically confirmed XDR TB in 11 countries. These patients were managed during 1999-2013. For the 37 ... Read more >>

Emerg Infect Dis (Emerging infectious diseases)
[2019, 25(3):441-450]

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Are they there yet? Linkage of patients with tuberculosis to services for tobacco cessation and alcohol abuse - a mixed methods study from Karnataka, India.

Nagendra Navya, Kathiresan Jeyashree, Akshaya Kibballi Madhukeshwar, Tanu Anand, Abhay Subashrao Nirgude, Badarudeen Mohammad Nayarmoole, Petros Isaakidis,

BACKGROUND:Tobacco use and alcohol abuse are associated with higher risk of tuberculosis (TB) infection, progression to active TB and adverse treatment outcomes among patients with TB. Revised National Tuberculosis Control Programme (RNTCP) treatment guidelines (2016) require the documentation of tobacco and alcohol use among patients with TB and their linkage ... Read more >>

BMC Health Serv Res (BMC health services research)
[2019, 19(1):90]

Cited: 2 times

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Treatment correlates of successful outcomes in pulmonary multidrug-resistant tuberculosis: an individual patient data meta-analysis.

, Nafees Ahmad, Shama D Ahuja, Onno W Akkerman, Jan-Willem C Alffenaar, Laura F Anderson, Parvaneh Baghaei, Didi Bang, Pennan M Barry, Mayara L Bastos, Digamber Behera, Andrea Benedetti, Gregory P Bisson, Martin J Boeree, Maryline Bonnet, Sarah K Brode, James C M Brust, Ying Cai, Eric Caumes, J Peter Cegielski, Rosella Centis, Pei-Chun Chan, Edward D Chan, Kwok-Chiu Chang, Macarthur Charles, Andra Cirule, Margareth Pretti Dalcolmo, Lia D'Ambrosio, Gerard de Vries, Keertan Dheda, Aliasgar Esmail, Jennifer Flood, Gregory J Fox, Mathilde Fréchet-Jachym, Geisa Fregona, Regina Gayoso, Medea Gegia, Maria Tarcela Gler, Sue Gu, Lorenzo Guglielmetti, Timothy H Holtz, Jennifer Hughes, Petros Isaakidis, Leah Jarlsberg, Russell R Kempker, Salmaan Keshavjee, Faiz Ahmad Khan, Maia Kipiani, Serena P Koenig, Won-Jung Koh, Afranio Kritski, Liga Kuksa, Charlotte L Kvasnovsky, Nakwon Kwak, Zhiyi Lan, Christoph Lange, Rafael Laniado-Laborín, Myungsun Lee, Vaira Leimane, Chi-Chiu Leung, Eric Chung-Ching Leung, Pei Zhi Li, Phil Lowenthal, Ethel L Maciel, Suzanne M Marks, Sundari Mase, Lawrence Mbuagbaw, Giovanni B Migliori, Vladimir Milanov, Ann C Miller, Carole D Mitnick, Chawangwa Modongo, Erika Mohr, Ignacio Monedero, Payam Nahid, Norbert Ndjeka, Max R O'Donnell, Nesri Padayatchi, Domingo Palmero, Jean William Pape, Laura J Podewils, Ian Reynolds, Vija Riekstina, Jérôme Robert, Maria Rodriguez, Barbara Seaworth, Kwonjune J Seung, Kathryn Schnippel, Tae Sun Shim, Rupak Singla, Sarah E Smith, Giovanni Sotgiu, Ganzaya Sukhbaatar, Payam Tabarsi, Simon Tiberi, Anete Trajman, Lisa Trieu, Zarir F Udwadia, Tjip S van der Werf, Nicolas Veziris, Piret Viiklepp, Stalz Charles Vilbrun, Kathleen Walsh, Janice Westenhouse, Wing-Wai Yew, Jae-Joon Yim, Nicola M Zetola, Matteo Zignol, Dick Menzies,

<h4>Background</h4>Treatment outcomes for multidrug-resistant tuberculosis remain poor. We aimed to estimate the association of treatment success and death with the use of individual drugs, and the optimal number and duration of treatment with those drugs in patients with multidrug-resistant tuberculosis.<h4>Methods</h4>In this individual patient data meta-analysis, we searched MEDLINE, Embase, and ... Read more >>

Lancet (Lancet (London, England))
[2018, 392(10150):821-834]

Cited: 69 times

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