Full Text Journal Articles by
Author Peter Schwenkreis


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Somatosensory dysfunction in patients with posttraumatic headache: A systematic review.

Julia Jessen, Özüm S Özgül, Oliver Höffken, Peter Schwenkreis, Martin Tegenthoff, Elena K Enax-Krumova,

<h4>Objectives</h4>Aim of the review is to summarize the knowledge about the sensory function and pain modulatory systems in posttraumatic headache and discuss its possible role in patients with posttraumatic headache.<h4>Background</h4>Posttraumatic headache is the most common complication after traumatic brain injury, and significantly impacts patients' quality of life. Even though it ... Read more >>

Cephalalgia (Cephalalgia : an international journal of headache)
[2021, :3331024211030496]

Cited: 0 times

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Chances and Challenges of Registry-Based Pharmacovigilance in Multiple Sclerosis: Lessons Learnt from the Implementation of the Multicenter REGIMS Registry.

Alexandra Simbrich, Jasmine Thibaut, Laura Khil, Stanislav Maximov, Heinz Wiendl, Klaus Berger, ,

The long-term and potential rare side effects of new immunomodulating drugs for the treatment of multiple sclerosis (MS) are often not well known. Spontaneous case report systems of adverse drug effects are a valuable source in pharmacovigilance, but have several limitations. Primary data collections within registries allow a comprehensive analysis ... Read more >>

Drug Saf (Drug safety)
[2021, 44(1):7-15]

Cited: 1 time

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The use of exoskeletons in the occupational context for primary, secondary, and tertiary prevention of work-related musculoskeletal complaints.

Benjamin Steinhilber, Tessy Luger, Peter Schwenkreis, Stefan Middeldorf, Hartmut Bork, Bernhard Mann, Alexander von Glinski, Thomas A Schildhauer, Stephan Weiler, Martin Schmauder, Kai Heinrich, Gabriele Winter, Gerhard Schnalke, Peter Frener, Ralf Schick, Sascha Wischniewski, Matthias Jäger,

OCCUPATIONAL APPLICATIONS This guideline includes 20 recommendations and four key statements that achieved consensus or strong consensus regarding the application of exoskeletons in the workplace for the prevention of musculoskeletal complaints and diseases, the general use and implementation of exoskeletons, and recommendations for risk assessment. The guideline is intended for ... Read more >>

IISE Trans Occup Ergon Hum Factors (IISE transactions on occupational ergonomics and human factors)
[2020, 8(3):132-144]

Cited: 0 times

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Dabigatran for Prevention of Stroke after Embolic Stroke of Undetermined Source.

Hans-Christoph Diener, Ralph L Sacco, J Donald Easton, Christopher B Granger, Richard A Bernstein, Shinichiro Uchiyama, Jörg Kreuzer, Lisa Cronin, Daniel Cotton, Claudia Grauer, Martina Brueckmann, Marina Chernyatina, Geoffrey Donnan, José M Ferro, Martin Grond, Bernd Kallmünzer, Jerzy Krupinski, Byung-Chul Lee, Robin Lemmens, Jaime Masjuan, Miroslav Odinak, Jeffrey L Saver, Peter D Schellinger, Danilo Toni, Kazunori Toyoda, ,

<h4>Background</h4>Cryptogenic strokes constitute 20 to 30% of ischemic strokes, and most cryptogenic strokes are considered to be embolic and of undetermined source. An earlier randomized trial showed that rivaroxaban is no more effective than aspirin in preventing recurrent stroke after a presumed embolic stroke from an undetermined source. Whether dabigatran ... Read more >>

N Engl J Med (The New England journal of medicine)
[2019, 380(20):1906-1917]

Cited: 77 times

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A Randomized and Controlled Crossover Study Investigating the Improvement of Walking and Posture Functions in Chronic Stroke Patients Using HAL Exoskeleton - The HALESTRO Study (HAL-Exoskeleton STROke Study).

Matthias Sczesny-Kaiser, Rebecca Trost, Mirko Aach, Thomas A Schildhauer, Peter Schwenkreis, Martin Tegenthoff,

<b>Background:</b> The exoskeleton HAL (hybrid assistive limb) has proven to improve walking functions in spinal cord injury and chronic stroke patients when using it for body-weight supported treadmill training (BWSTT). Compared with other robotic devices, it offers the possibility to initiate movements actively. Previous studies on stroke patients did not ... Read more >>

Front Neurosci (Frontiers in neuroscience)
[2019, 13:259]

Cited: 11 times

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Safety and efficacy of rasagiline as an add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a randomised, double-blind, parallel-group, placebo-controlled, phase 2 trial.

Albert C Ludolph, Joachim Schuster, Johannes Dorst, Luc Dupuis, Jens Dreyhaupt, Jochen H Weishaupt, Jan Kassubek, Ulrike Weiland, Susanne Petri, Thomas Meyer, Julian Grosskreutz, Berthold Schrank, Matthias Boentert, Alexander Emmer, Andreas Hermann, Daniel Zeller, Johannes Prudlo, Andrea S Winkler, Torsten Grehl, Michael T Heneka, Siw Wollebæk Johannesen, Bettina Göricke, ,

BACKGROUND:Rasagiline, a monoamine oxidase B inhibitor with neuroprotective potential in Parkinson's disease, has shown a disease-modifying effect in the SOD1-Gly93Ala low-expressing mouse model of amyotrophic lateral sclerosis, both alone and in combination with riluzole. We sought to test whether or not rasagiline 1 mg/day can prolong survival in patients with ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2018, 17(8):681-688]

Cited: 10 times

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Hybrid Assistive Limb Exoskeleton HAL in the Rehabilitation of Chronic Spinal Cord Injury: Proof of Concept; the Results in 21 Patients.

Oliver Jansen, Dennis Grasmuecke, Renate C Meindl, Martin Tegenthoff, Peter Schwenkreis, Matthias Sczesny-Kaiser, Martin Wessling, Thomas A Schildhauer, Christian Fisahn, Mirko Aach,

<h4>Introduction</h4>The use of mobile exoskeletons is becoming more and more common in the field of spinal cord injury (SCI) rehabilitation. The hybrid assistive limb (HAL) exoskeleton provides a tailored support depending on the patient's voluntary drive.<h4>Materials and methods</h4>After a pilot study in 2014 that included 8 patients with chronic SCI, ... Read more >>

World Neurosurg (World neurosurgery)
[2018, 110:e73-e78]

Cited: 12 times

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Functional Outcome of Neurologic-Controlled HAL-Exoskeletal Neurorehabilitation in Chronic Spinal Cord Injury: A Pilot With One Year Treatment and Variable Treatment Frequency.

Oliver Jansen, Thomas A Schildhauer, Renate C Meindl, Martin Tegenthoff, Peter Schwenkreis, Matthias Sczesny-Kaiser, Dennis Grasmücke, Christian Fisahn, Mirko Aach,

Study Design:Longitudinal prospective study. Objectives:Whether 1-year HAL-BWSTT of chronic spinal cord injured patients can improve independent ambulated mobility further as a function of training frequency, after an initial 3-month training period. Methods:Eight patients with chronic SCI were enrolled. They initially received full standard physical therapy and neurorehabilitation in the acute/subacute ... Read more >>

Global Spine J (Global spine journal)
[2017, 7(8):735-743]

Cited: 6 times

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Polarity-Specific Cortical Effects of Transcranial Direct Current Stimulation in Primary Somatosensory Cortex of Healthy Humans.

Robert Rehmann, Matthias Sczesny-Kaiser, Melanie Lenz, Tomasz Gucia, Annika Schliesing, Peter Schwenkreis, Martin Tegenthoff, Oliver Höffken,

Transcranial direct current stimulation (tDCS) is a non-invasive stimulation method that has been shown to modulate the excitability of the motor and visual cortices in human subjects in a polarity dependent manner in previous studies. The aim of our study was to investigate whether anodal and cathodal tDCS can also ... Read more >>

Front Hum Neurosci (Frontiers in human neuroscience)
[2016, 10:208]

Cited: 5 times

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[Neurological diseases after lightning strike : Lightning strikes twice].

K M Gruhn, Frauke Knossalla, Peter Schwenkreis, Uwe Hamsen, Thomas A Schildhauer, Martin Tegenthoff, Matthias Sczesny-Kaiser,

Lightning strikes rarely occur but 85 % of patients have lightning-related neurological complications. This report provides an overview about different modes of energy transfer and neurological conditions related to lightning strikes. Moreover, two case reports demonstrate the importance of interdisciplinary treatment and the spectrum of neurological complications after lightning strikes. ... Read more >>

Nervenarzt (Der Nervenarzt)
[2016, 87(6):623-628]

Cited: 1 time

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Repetitive Transcranial Direct Current Stimulation Induced Excitability Changes of Primary Visual Cortex and Visual Learning Effects-A Pilot Study.

Matthias Sczesny-Kaiser, Katharina Beckhaus, Hubert R Dinse, Peter Schwenkreis, Martin Tegenthoff, Oliver Höffken,

Studies on noninvasive motor cortex stimulation and motor learning demonstrated cortical excitability as a marker for a learning effect. Transcranial direct current stimulation (tDCS) is a non-invasive tool to modulate cortical excitability. It is as yet unknown how tDCS-induced excitability changes and perceptual learning in visual cortex correlate. Our study ... Read more >>

Front Behav Neurosci (Frontiers in behavioral neuroscience)
[2016, 10:116]

Cited: 10 times

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HAL® exoskeleton training improves walking parameters and normalizes cortical excitability in primary somatosensory cortex in spinal cord injury patients.

Matthias Sczesny-Kaiser, Oliver Höffken, Mirko Aach, Oliver Cruciger, Dennis Grasmücke, Renate Meindl, Thomas A Schildhauer, Peter Schwenkreis, Martin Tegenthoff,

<h4>Background</h4>Reorganization in the sensorimotor cortex accompanied by increased excitability and enlarged body representations is a consequence of spinal cord injury (SCI). Robotic-assisted bodyweight supported treadmill training (BWSTT) was hypothesized to induce reorganization and improve walking function.<h4>Objective</h4>To assess whether BWSTT with hybrid assistive limb® (HAL®) exoskeleton affects cortical excitability in the ... Read more >>

J Neuroeng Rehabil (Journal of neuroengineering and rehabilitation)
[2015, 12:68]

Cited: 28 times

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TMS and drugs revisited 2014.

Ulf Ziemann, Janine Reis, Peter Schwenkreis, Mario Rosanova, Antonio Strafella, Radwa Badawy, Florian Müller-Dahlhaus,

The combination of pharmacology and transcranial magnetic stimulation to study the effects of drugs on TMS-evoked EMG responses (pharmaco-TMS-EMG) has considerably improved our understanding of the effects of TMS on the human brain. Ten years have elapsed since an influential review on this topic has been published in this journal ... Read more >>

Clin Neurophysiol (Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology)
[2015, 126(10):1847-1868]

Cited: 176 times

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Impact of locomotion training with a neurologic controlled hybrid assistive limb (HAL) exoskeleton on neuropathic pain and health related quality of life (HRQoL) in chronic SCI: a case study (.).

Oliver Cruciger, Thomas A Schildhauer, Renate C Meindl, Martin Tegenthoff, Peter Schwenkreis, Mustafa Citak, Mirko Aach,

Chronic neuropathic pain (CNP) is a common condition associated with spinal cord injury (SCI) and has been reported to be severe, disabling and often treatment-resistant and therefore remains a clinical challenge for the attending physicians. The treatment usually includes pharmacological and/or nonpharmacological approaches. Body weight supported treadmill training (BWSTT) and ... Read more >>

Disabil Rehabil Assist Technol (Disability and rehabilitation. Assistive technology)
[2016, 11(6):529-534]

Cited: 14 times

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Locomotion training using voluntary driven exoskeleton (HAL) in acute incomplete SCI.

Oliver Cruciger, Martin Tegenthoff, Peter Schwenkreis, Thomas A Schildhauer, Mirko Aach,

Neurology (Neurology)
[2014, 83(5):474]

Cited: 18 times

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Synergistic effects of noradrenergic modulation with atomoxetine and 10 Hz repetitive transcranial magnetic stimulation on motor learning in healthy humans.

Matthias Sczesny-Kaiser, Alica Bauknecht, Oliver Höffken, Martin Tegenthoff, Hubert R Dinse, Dirk Jancke, Klaus Funke, Peter Schwenkreis,

<h4>Background</h4>Repetitive transcranial magnetic stimulation (rTMS) is able to induce changes in neuronal activity that outlast stimulation. The underlying mechanisms are not completely understood. They might be analogous to long-term potentiation or depression, as the duration of the effects seems to implicate changes in synaptic plasticity. Norepinephrine (NE) has been shown ... Read more >>

BMC Neurosci (BMC neuroscience)
[2014, 15:46]

Cited: 5 times

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Voluntary driven exoskeleton as a new tool for rehabilitation in chronic spinal cord injury: a pilot study.

Mirko Aach, Oliver Cruciger, Matthias Sczesny-Kaiser, Oliver Höffken, Renate Ch Meindl, Martin Tegenthoff, Peter Schwenkreis, Yoshiyuki Sankai, Thomas A Schildhauer,

<h4>Background context</h4>Treadmill training after traumatic spinal cord injury (SCI) has become an established therapy to improve walking capabilities. The hybrid assistive limb (HAL) exoskeleton has been developed to support motor function and is tailored to the patients' voluntary drive.<h4>Purpose</h4>To determine whether locomotor training with the exoskeleton HAL is safe and ... Read more >>

Spine J (The spine journal : official journal of the North American Spine Society)
[2014, 14(12):2847-2853]

Cited: 72 times

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Complex regional pain syndrome: more than a peripheral disease.

Annika Reinersmann, Christoph Maier, Peter Schwenkreis, Melanie Lenz,

SUMMARY At early stages, complex regional pain syndrome (CRPS) is clinically characterized by damage of peripheral tissues and nerves (edema, activation of osteoblasts, hyperalgesia to blunt pressure). These signs are the result of a dysbalance of pro- and anti-inflammatory cytokines, which normalizes approximately 6 months after the beginning of the disease, ... Read more >>

Pain Manag (Pain management)
[2013, 3(6):495-502]

Cited: 13 times

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Complex regional pain syndrome type I affects brain structure in prefrontal and motor cortex.

Burkhard Pleger, Bogdan Draganski, Peter Schwenkreis, Melanie Lenz, Volkmar Nicolas, Christoph Maier, Martin Tegenthoff,

The complex regional pain syndrome (CRPS) is a rare but debilitating pain disorder that mostly occurs after injuries to the upper limb. A number of studies indicated altered brain function in CRPS, whereas possible influences on brain structure remain poorly investigated. We acquired structural magnetic resonance imaging data from CRPS ... Read more >>

PLoS One (PloS one)
[2014, 9(1):e85372]

Cited: 23 times

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Convulsive syncope after single-pulse TMS.

Matthias Sczesny-Kaiser, Oliver Höffken, Martin Tegenthoff, Peter Schwenkreis,

Brain Stimul (Brain stimulation)
[2013, 6(5):830]

Cited: 2 times

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Influence of (S)-ketamine on human motor cortex excitability.

Oliver Höffken, Ida S Haussleiter, Andrea Westermann, Jörn Lötsch, Christoph Maier, Martin Tegenthoff, Peter Schwenkreis,

Previous studies demonstrated a reduction of motor cortical excitability through pharmacological NMDA receptor blockage. Interestingly, subanesthetic doses of racemic ketamine, a non-competitive NMDA receptor antagonist, had no effects on intracortical excitability evoked by transcranial magnetic stimulation. In this study, we aimed to substantiate these findings by using the more active ... Read more >>

Exp Brain Res (Experimental brain research)
[2013, 225(1):47-53]

Cited: 5 times

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Influence of parameter settings on paired-pulse-suppression in somatosensory evoked potentials: a systematic analysis.

Oliver Höffken, Janina Tannwitz, Melanie Lenz, Matthias Sczesny-Kaiser, Martin Tegenthoff, Peter Schwenkreis,

<h4>Objective</h4>Paired-pulse somatosensory evoked potentials (SEPs) are a common tool to investigate excitability in the human somatosensory cortex. Comparing literature about paired-pulse SEP, there is no standard set of stimulation parameters, while little is known about the influence of stimulation parameters on paired-pulse suppression.<h4>Methods</h4>We analyzed changes of paired-pulse ratios by varying ... Read more >>

Clin Neurophysiol (Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology)
[2013, 124(3):574-580]

Cited: 15 times

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Pain-associated mild sensory deficits without hyperalgesia in chronic non-neuropathic pain.

Andrea Westermann, Anne-Kathrin Rönnau, Elena Krumova, Sabrina Regeniter, Peter Schwenkreis, Roman Rolke, Rolf-Detlef Treede, Helmut Richter, Christoph Maier,

<h4>Objectives</h4>A mixture of sensory loss and gain is a hallmark of neuropathic pain. But hypesthesia and hyperalgesia also occur with experimentally induced acute pain. Here, we assessed sensory profiles in chronic non-neuropathic pain (osteoarthritis, OA) using the quantitative sensory testing (QST) protocol of the German Research Network on Neuropathic Pain ... Read more >>

Clin J Pain (The Clinical journal of pain)
[2011, 27(9):782-789]

Cited: 26 times

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Central mechanisms during fatiguing muscle exercise in muscular dystrophy and fibromyalgia syndrome: a study with transcranial magnetic stimulation.

Peter Schwenkreis, Michael Voigt, Monika Hasenbring, Martin Tegenthoff, Matthias Vorgerd, Rudolf A Kley,

<h4>Introduction</h4>The aim of this study was to apply paired-pulse transcranial magnetic stimulation (TMS) to assess intracortical inhibition (ICI) during fatiguing muscle exercise in healthy humans and patients with muscular dystrophy (MD) and fibromyalgia syndrome (FMS) to obtain insight into differential central mechanisms.<h4>Methods</h4>We studied 23 patients with MD, 16 patients with ... Read more >>

Muscle Nerve (Muscle & nerve)
[2011, 43(4):479-484]

Cited: 15 times

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Cortical disinhibition occurs in chronic neuropathic, but not in chronic nociceptive pain.

Peter Schwenkreis, Andrea Scherens, Anne-Kathrin Rönnau, Oliver Höffken, Martin Tegenthoff, Christoph Maier,

<h4>Background</h4>The aim of this study was to examine the relationship between chronic neuropathic pain after incomplete peripheral nerve lesion, chronic nociceptive pain due to osteoarthritis, and the excitability of the motor cortex assessed by transcranial magnetic stimulation (TMS). Hence in 26 patients with neuropathic pain resulting from an isolated incomplete ... Read more >>

BMC Neurosci (BMC neuroscience)
[2010, 11:73]

Cited: 49 times

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