Full Text Journal Articles by
Author Peter M Rothwell

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Risk of stroke in relation to degree of asymptomatic carotid stenosis: a population-based cohort study, systematic review, and meta-analysis.

Dominic P J Howard, Liam Gaziano, Peter M Rothwell, ,

<h4>Background</h4>There is uncertainty around which patients with asymptomatic carotid stenosis should be offered surgical intervention. Although stroke rates were unrelated to the degree of stenosis in the medical-treatment-only groups in previous randomised trials, this could simply reflect recruitment bias and there has been no systematic analysis of a stenosis-risk association ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2021, 20(3):193-202]

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Body Mass Index and Arterial Stiffness Are Associated With Greater Beat-to-Beat Blood Pressure Variability After Transient Ischemic Attack or Minor Stroke.

Alastair J S Webb, Amy Lawson, Sara Mazzucco, Linxin Li, Peter M Rothwell, ,

<h4>Background and purpose</h4>Blood pressure variability (BPV) from beat to beat is associated with an increased risk of cardiovascular events and enables rapid assessment of BPV, but the underlying causes of elevated BPV are unclear.<h4>Methods</h4>In consecutive patients within 4 to 6 weeks of transient ischemic attack or nondisabling stroke (OXVASC [Oxford ... Read more >>

Stroke (Stroke)
[2021, :STROKEAHA120031179]

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Prevalence, prognosis, and treatment of atherosclerotic intracranial stenosis in Caucasians.

Robert Hurford, Peter M Rothwell,

<h4>Background</h4>Intracranial atherosclerotic stenosis is a highly prevalent cause of stroke worldwide with important ethnic disparities. Widely considered to be a common cause of stroke in Asian and Afro-Caribbean populations, relatively less is known about the burden and significance of intracranial atherosclerotic stenosis in Caucasians.<h4>Aims</h4>We aim to highlight recent insights and ... Read more >>

Int J Stroke (International journal of stroke : official journal of the International Stroke Society)
[2020, :1747493020974461]

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Progression of Beat-to-Beat Blood Pressure Variability Despite Best Medical Management.

Alastair J S Webb, Amy Lawson, Karolina Wartolowska, Sara Mazzucco, Peter M Rothwell,

Beat-to-beat variability in blood pressure (BP) is associated with recurrent stroke despite good control of hypertension. However, no study has identified rates of progression of beat-to-beat BP variability (BPV), its determinants, or which patient groups are particularly affected, limiting understanding of its potential as a treatment target. In consecutive patients ... Read more >>

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2021, 77(1):193-201]

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Impact of multimorbidity on risk and outcome of stroke: Lessons from chronic kidney disease.

Dearbhla M Kelly, Peter M Rothwell,

With both an aging population and greater post-stroke survival, multimorbidity is a growing healthcare challenge, affecting over 40% of stroke patients, and rising rapidly and predictably with increasing age. Commonly defined as the co-occurrence of two or more chronic conditions, multimorbidity burden is a strong adverse prognostic factor, associated with ... Read more >>

Int J Stroke (International journal of stroke : official journal of the International Stroke Society)
[2020, :1747493020975250]

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Age and sex distribution of beat-to-beat blood pressure variability after transient ischemic attack and minor stroke: A population-based study.

Alastair Js Webb, Amy Lawson, Sara Mazzucco, Linxin Li, Peter M Rothwell,

<h4>Background</h4>Beat-to-beat blood pressure variability is associated with increased stroke risk but its importance at different ages is unclear.<h4>Aims</h4>To determine the age-sex distribution of blood pressure variability in patients with transient ischemic stroke or minor stroke.<h4>Methods</h4>In consecutive patients within six weeks of transient ischemic stroke or non-disabling stroke (Oxford Vascular Study), ... Read more >>

Int J Stroke (International journal of stroke : official journal of the International Stroke Society)
[2020, :1747493020971905]

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Physiological determinants of residual cerebral arterial pulsatility on best medical treatment after TIA or minor stroke.

Alastair Js Webb, Amy Lawson, Linxin Li, Sara Mazzucco, Peter M Rothwell, ,

Cerebral arterial pulsatility is strongly associated with cerebral small vessel disease and lacunar stroke yet its dependence on central versus local haemodynamic processes is unclear. In a population-based study of patients on best medical managment, 4-6 weeks after a TIA or non-disabling stroke, arterial stiffness and aortic systolic, diastolic and pulse ... Read more >>

J Cereb Blood Flow Metab (Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism)
[2020, :271678X20969984]

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Prevalence, predictors and prognosis of incidental intracranial aneurysms in patients with suspected TIA and minor stroke: a population-based study and systematic review.

Robert Hurford, Isabel Taveira, Wilhelm Kuker, Peter M Rothwell, ,

<h4>Introduction</h4>Unruptured intracranial aneurysms (UIAs) are common incidental imaging findings, but there are few data in patients with transient ischaemic attack (TIA)/stroke. The frequency of UIA might be higher due to shared risk factors, but rupture risk might be reduced by intensive secondary prevention. We determined the prevalence and prognosis of ... Read more >>

J Neurol Neurosurg Psychiatry (Journal of neurology, neurosurgery, and psychiatry)
[2020, :]

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Increasing Blood Pressure Variability Predicts Poor Functional Outcome Following Acute Stroke.

Karen Ob Appiah, Mintu Nath, Lisa Manning, William J Davison, Sara Mazzucco, Linxin Li, F Potter John, Peter M Rothwell, Ronney B Panerai, Victoria J Haunton, Thompson G Robinson,

<h4>Introduction</h4>Increasing blood pressure variability has been reported following acute stroke, but there is uncertainty about how best to measure it and about the impact on prognosis following acute ischaemic stroke and transient ischaemic attack.<h4>Methods</h4>Enhanced casual blood pressure and ambulatory blood pressure monitoring were completed at baseline (≤48 h post symptom onset). ... Read more >>

J Stroke Cerebrovasc Dis (Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association)
[2021, 30(1):105466]

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Five-Year Prognosis After TIA or Minor Ischemic Stroke in Asian and Non-Asian Populations.

Takao Hoshino, Shinichiro Uchiyama, Lawrence K S Wong, Kazuo Kitagawa, Hugo Charles, Julien Labreuche, Philippa C Lavallée, Gregory W Albers, Louis R Caplan, Geoffrey A Donnan, José M Ferro, Michael G Hennerici, Carlos Molina, Peter M Rothwell, P Gabriel Steg, Pierre-Jean Touboul, Éric Vicaut, Pierre Amarenco, ,

<h4>Objective</h4>To determine long-term vascular outcomes of Asian patients who experienced TIA or minor ischemic stroke and to compare the outcomes of Asian patients with those of non-Asian patients, in the context of modern guideline-based prevention strategies.<h4>Methods</h4>This is a subanalysis of the TIAregistry.org project, in which 3,847 patients (882 from Asian ... Read more >>

Neurology (Neurology)
[2021, 96(1):e54-e66]

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Reliability, reproducibility and validity of dynamic cerebral autoregulation in a large cohort with transient ischaemic attack or minor stroke.

Yun-Kai Lee, Peter M Rothwell, Stephen J Payne, Alastair J S Webb,

<h4>Objective</h4>Cerebral autoregulation (CA) is critical to maintenance of cerebral perfusion but its relevance to the risk of stroke and dementia has been under-studied due to small study sizes and a lack of consensus as to the optimal method of measurement. We determined the reliability and reproducibility of multiple CA indices ... Read more >>

Physiol Meas (Physiological measurement)
[2020, 41(9):095002]

Cited: 2 times

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Etiological Subtypes of Transient Ischemic Attack and Ischemic Stroke in Chronic Kidney Disease: Population-Based Study.

Dearbhla M Kelly, Linxin Li, Peter M Rothwell, ,

BACKGROUND AND PURPOSE:Chronic kidney disease (CKD) is strongly associated with stroke risk, but the mechanisms underlying this association are unclear and might be informed by subtype-specific analyses. However, few studies have reported stroke subtypes in CKD according to established classification systems, such as the TOAST (Trial of ORG 10172 in ... Read more >>

Stroke (Stroke)
[2020, 51(9):2786-2794]

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Associations of blood biomarkers with glomerular filtration rate in patients with TIA and stroke: population-based study.

Dearbhla M Kelly, Linxin Li, Annette I Burgess, Deborah L Poole, Julia M Duerden, Peter M Rothwell,

<h4>Background and purpose</h4>Non-traditional risk factors such as chronic inflammation, oxidative stress and thrombogenic factors are believed to contribute to the excess stroke risk in chronic kidney disease (CKD) by triggering vascular injury and endothelial dysfunction. We aimed to determine how well a panel of biomarkers representative of these factors would ... Read more >>

Stroke Vasc Neurol (Stroke and vascular neurology)
[2020, :]

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An International Report on the Adaptations of Rapid Transient Ischaemic Attack Pathways During the COVID-19 Pandemic.

Andy Lim, Shaloo Singhal, Philippa Lavallee, Pierre Amarenco, Peter M Rothwell, Gregory Albers, Mukul Sharma, Robert Brown, Annemarei Ranta, Mohana Maddula, Timothy Kleinig, Jesse Dawson, Mitchell S V Elkind, Maria Guarino, Shelagh B Coutts, Benjamin Clissold, Henry Ma, Thanh Phan,

<h4>Background</h4>This report aims to describe changes that centres providing transient ischaemic attack (TIA) pathway services have made to stay operational in response to the SARS-CoV-2 pandemic.<h4>Methods</h4>An international cross-sectional description of the adaptions of TIA pathways between 30<sup>th</sup> March and 6<sup>th</sup> May 2020. Experience was reported from 18 centres with rapid ... Read more >>

J Stroke Cerebrovasc Dis (Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association)
[2020, 29(11):105228]

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Prognosis of Asymptomatic Intracranial Stenosis in Patients With Transient Ischemic Attack and Minor Stroke.

Robert Hurford, Frank J Wolters, Linxin Li, Kui Kai Lau, Wilhelm Küker, Peter M Rothwell,

<h4>Importance</h4>Asymptomatic intracranial stenosis (ICS) is a frequent finding on imaging results, particularly in the assessment of acute stroke. Although the management of symptomatic ICS is informed by randomized trials, to our knowledge there are few data on the prevalence and prognosis of asymptomatic ICS in patients with stroke and transient ... Read more >>

JAMA Neurol (JAMA neurology)
[2020, 77(8):947-954]

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Antiplatelet Treatment to Prevent Early Recurrent Stroke.

Peter M Rothwell,

N Engl J Med (The New England journal of medicine)
[2020, 383(3):276-278]

Cited: 1 time

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Prognosis of Cryptogenic Stroke With Patent Foramen Ovale at Older Ages and Implications for Trials: A Population-Based Study and Systematic Review.

Sara Mazzucco, Linxin Li, Peter M Rothwell,

Importance:Patent foramen ovale (PFO) closure may prevent recurrent stroke after cryptogenic transient ischemic attack (TIA) or stroke (TIA/stroke) in patients aged 60 years or younger. Patent foramen ovale is associated with cryptogenic stroke in the older population, but risk of recurrence is unknown. Data on prognosis of patients receiving medical ... Read more >>

JAMA Neurol (JAMA neurology)
[2020, :]

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Extended short-term follow-up for a trial of treatment of unruptured arteriovenous malformations.

Peter M Rothwell,

Lancet Neurol (The Lancet. Neurology)
[2020, 19(7):558-559]

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Weights for ordinal analyses of the modified Rankin Scale in stroke trials: A population-based cohort study.

Aravind Ganesh, Ramon Luengo-Fernandez, Sarah T Pendlebury, Peter M Rothwell, ,

<h4>Background</h4>Ordinal/shift analyses of ordered measures like the modified Rankin Scale(mRS) are underused as primary trial outcomes for neurological disorders - despite statistical advantages - potentially hindered by poor clinical interpretability versus dichotomies, and by valuing state-transitions equally (linear scale). Weighted ordinal analyses incorporating step-changes at key transitions might have greater ... Read more >>

EClinicalMedicine (EClinicalMedicine)
[2020, 23:100415]

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The Characteristics of Patients With Possible Transient Ischemic Attack and Minor Stroke in the Hunter and Manning Valley Regions, Australia (the INSIST Study).

Shinya Tomari, Parker Magin, Daniel Lasserson, Debbie Quain, Jose M Valderas, Helen M Dewey, P Alan Barber, Neil J Spratt, Dominique A Cadilhac, Valery L Feigin, Peter M Rothwell, Hossein Zareie, Carlos Garcia-Esperon, Andrew Davey, Nashwa Najib, Milton Sales, Christopher R Levi,

<b>Background:</b> Transient ischemic attack (TIA) and minor stroke (TIAMS) are risk factors for stroke recurrence. Some TIAMS may be preventable by appropriate primary prevention. We aimed to recruit "possible-TIAMS" patients in the INternational comparison of Systems of care and patient outcomes In minor Stroke and TIA (INSIST) study. <b>Methods:</b> A ... Read more >>

Front Neurol (Frontiers in neurology)
[2020, 11:383]

Cited: 1 time

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Prevalence, predictors, and prognosis of symptomatic intracranial stenosis in patients with transient ischaemic attack or minor stroke: a population-based cohort study.

Robert Hurford, Frank J Wolters, Linxin Li, Kui Kai Lau, Wilhelm Küker, Peter M Rothwell, ,

<h4>Background</h4>Symptomatic intracranial stenosis was perceived to convey a high risk of recurrent stroke, but two previous trials (SAMMPRIS and VISSIT) did not show superiority of intracranial stenosis stenting over intensive medical management alone. These findings were partly due to a lower than expected risk of recurrent stroke without stenting, possibly ... Read more >>

Lancet Neurol (The Lancet. Neurology)
[2020, 19(5):413-421]

Cited: 2 times

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Blood Pressure-Lowering Profiles and Clinical Effects of Angiotensin Receptor Blockers Versus Calcium Channel Blockers.

Maria H Mehlum, Knut Liestøl, Sverre E Kjeldsen, Torgeir B Wyller, Stevo Julius, Peter M Rothwell, Giuseppe Mancia, Gianfranco Parati, Michael A Weber, Eivind Berge,

Blood pressure-lowering drugs have different blood pressure-lowering profiles. We studied if differences in blood pressure mean and variability can explain the differences in risks of cardiovascular events and death among 15 245 high-risk hypertensive patients randomized to valsartan or amlodipine and followed for 4.2 years in the VALUE trial (Valsartan ... Read more >>

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2020, 75(6):1584-1592]

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Serial Shunt Evaluation Reveals Limitations of Contemporary Screening Studies for Patent Foramen Ovale.

Pok-Tin Tang, Thomas Cahill, Peter M Rothwell, Oliver J Ormerod, Matthew J Daniels,

JACC Cardiovasc Interv (JACC. Cardiovascular interventions)
[2020, 13(10):1269-1270]

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Author response: Prognostic value of "tissue-based" definitions of TIA and minor stroke: Population-based study.

Robert Hurford, Linxin Li, Nicola Lovett, Magdalena Kubiak, Wilhelm Kuker, Peter M Rothwell,

Neurology (Neurology)
[2020, 94(15):680-681]

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Global Stroke Statistics 2019.

Joosup Kim, Tharshanah Thayabaranathan, Geoffrey A Donnan, George Howard, Virginia J Howard, Peter M Rothwell, Valery Feigin, Bo Norrving, Mayowa Owolabi, Jeyaraj Pandian, Liping Liu, Dominique A Cadilhac, Amanda G Thrift,

BACKGROUND:Data on stroke epidemiology and availability of hospital-based stroke services around the world are important for guiding policy decisions and healthcare planning. AIMS:To provide the most current incidence, mortality and case-fatality data on stroke and describe current availability of stroke units around the world by country. METHODS:We searched multiple databases ... Read more >>

Int J Stroke (International journal of stroke : official journal of the International Stroke Society)
[2020, 15(8):819-838]

Cited: 5 times

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