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Author Peter Jezzard

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Intrinsic excitation-inhibition imbalance affects medial prefrontal cortex differently in autistic men versus women.

Stavros Trakoshis, Pablo Martínez-Cañada, Federico Rocchi, Carola Canella, Wonsang You, Bhismadev Chakrabarti, Amber Nv Ruigrok, Edward T Bullmore, John Suckling, Marija Markicevic, Valerio Zerbi, , Anthony J Bailey, Simon Baron-Cohen, Patrick F Bolton, Edward T Bullmore, Sarah Carrington, Marco Catani, Bhismadev Chakrabarti, Michael C Craig, Eileen M Daly, Sean Cl Deoni, Christine Ecker, Francesca Happé, Julian Henty, Peter Jezzard, Patrick Johnston, Derek K Jones, Meng-Chuan Lai, Michael V Lombardo, Anya Madden, Diane Mullins, Clodagh M Murphy, Declan Gm Murphy, Greg Pasco, Amber Nv Ruigrok, Susan A Sadek, Debbie Spain, Rose Stewart, John Suckling, Sally J Wheelwright, Steven C Williams, Simon Baron-Cohen, Alessandro Gozzi, Meng-Chuan Lai, Stefano Panzeri, Michael V Lombardo,

Excitation-inhibition (E:I) imbalance is theorized as an important pathophysiological mechanism in autism. Autism affects males more frequently than females and sex-related mechanisms (e.g., X-linked genes, androgen hormones) can influence E:I balance. This suggests that E:I imbalance may affect autism differently in males versus females. With a combination of in-silico modeling ... Read more >>

Elife (eLife)
[2020, 9:]

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Matt Bernstein, Editor-in-Chief Emeritus.

Peter Jezzard,

Magn Reson Med (Magnetic resonance in medicine)
[2020, 83(1):11]

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Improving PCASL at ultra-high field using a VERSE-guided parallel transmission strategy.

Yan Tong, Peter Jezzard, Thomas W Okell, William T Clarke,

PURPOSE:To improve the labeling efficiency of pseudo-continuous arterial spin labeling (PCASL) at 7T using parallel transmission (pTx). METHODS:Five healthy subjects were scanned on an 8-channel-transmit 7T human MRI scanner. Time-of-flight (TOF) angiography was acquired to identify regions of interest (ROIs) around the 4 major feeding arteries to the brain, and ... Read more >>

Magn Reson Med (Magnetic resonance in medicine)
[2020, 84(2):777-786]

Cited: 1 time

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Navigator-based reacquisition and estimation of motion-corrupted data: Application to multi-echo spin echo for carotid wall MRI.

Robert Frost, Luca Biasiolli, Linqing Li, Katherine Hurst, Mohammad Alkhalil, Robin P Choudhury, Matthew D Robson, Aaron T Hess, Peter Jezzard,

PURPOSE:To assess whether artifacts in multi-slice multi-echo spin echo neck imaging, thought to be caused by brief motion events such as swallowing, can be corrected by reacquiring corrupted central k-space data and estimating the remainder with parallel imaging. METHODS:A single phase-encode line (ky = 0, phase-encode direction anteroposterior) navigator echo ... Read more >>

Magn Reson Med (Magnetic resonance in medicine)
[2020, 83(6):2026-2041]

Cited: 1 time

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The advantages of radial trajectories for vessel-selective dynamic angiography with arterial spin labeling.

Eleanor S K Berry, Peter Jezzard, Thomas W Okell,

OBJECTIVES:To demonstrate the advantages of radial k-space trajectories over conventional Cartesian approaches for accelerating the acquisition of vessel-selective arterial spin labeling (ASL) dynamic angiograms, which are conventionally time consuming to acquire. MATERIALS AND METHODS:Vessel-encoded pseudocontinuous ASL was combined with time-resolved balanced steady-state free precession (bSSFP) and spoiled gradient echo (SPGR) ... Read more >>

MAGMA (Magma (New York, N.Y.))
[2019, 32(6):643-653]

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The advantages of radial trajectories for vessel-selective dynamic angiography with arterial spin labeling

Eleanor Berry, Peter Jezzard, Thomas Okell,

Abstract Object To demonstrate the advantages of radial k-space trajectories over conventional Cartesian approaches for accelerating the acquisition of vessel-selective arterial spin labeling (ASL) dynamic angiograms, which are conventionally time-consuming to acquire. Materials and Methods Vessel-encoded pseudocontinuous ASL was combined with time-resolved balanced steady-state free precession (bSSFP) and spoiled gradient ... Read more >>

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Determining T2 relaxation time and stroke onset relationship in ischaemic stroke within apparent diffusion coefficient-defined lesions. A user-independent method for quantifying the impact of stroke in the human brain.

Michael J Knight, Robin A Damion, Bryony L McGarry, Rose Bosnell, Kimmo T Jokivarsi, Olli H J Gröhn, Peter Jezzard, George W J Harston, Davide Carone, James Kennedy, Salwa El-Tawil, Jennifer Elliot, Keith W Muir, Philip Clatworthy, Risto A Kauppinen,

Background and Objective:In hyperacute ischaemic stroke, T2 of cerebral water increases with time. Quantifying this change may be informative of the extent of tissue damage and onset time. Our objective was to develop a user-unbiased method to measure the effect of cerebral ischaemia on T2 to study stroke onset time-dependency ... Read more >>

Biomed Spectrosc Imaging (Biomedical spectroscopy and imaging)
[2019, 8(1-2):11-28]

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Measurement of collateral perfusion in acute stroke: a vessel-encoded arterial spin labeling study.

Thomas W Okell, George W J Harston, Michael A Chappell, Fintan Sheerin, James Kennedy, Peter Jezzard,

Collateral perfusion is important for sustaining tissue viability in acute ischemic stroke. Conventional techniques for its visualization are invasive, require contrast agents and demonstrate collateral vessels, rather than measuring perfusion directly. In this study we utilize a non-invasive, non-contrast magnetic resonance imaging (MRI)-based method to directly quantify collateral perfusion in ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):8181]

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Off-resonance correction for pseudo-continuous arterial spin labeling using the optimized encoding scheme.

Eleanor S K Berry, Peter Jezzard, Thomas W Okell,

Pseudo-continuous arterial spin labeling (PCASL) MRI has become a popular tool for non-invasive perfusion imaging and angiography. However, it suffers from sensitivity to off-resonance effects within the labeling plane, which can be exacerbated at high field or in the presence of metallic implants, leading to spatially varying signal loss and ... Read more >>

Neuroimage (NeuroImage)
[2019, 199:304-312]

Cited: 2 times

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Volume-localized measurement of oxygen extraction fraction in the brain using MRI.

Caitlin O'Brien, Thomas W Okell, Mark Chiew, Peter Jezzard,

PURPOSE:T2 -relaxation-under-spin-tagging (TRUST) is an MR technique for the non-invasive assessment of whole-brain cerebral oxygen extraction fraction (OEF), through measurement of the venous blood T2 relaxation time in the sagittal sinus. A key limitation of TRUST, however, is the lack of spatial specificity of the measurement. We sought to develop ... Read more >>

Magn Reson Med (Magnetic resonance in medicine)
[2019, 82(4):1412-1423]

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Quantifying T 2 relaxation time changes within lesions defined by apparent diffusion coefficient in grey and white matter in acute stroke patients.

Robin A Damion, Michael J Knight, Bryony L McGarry, Rose Bosnell, Peter Jezzard, George Wj Harston, Davide Carone, James Kennedy, Salwa El-Tawil, Jennifer Elliot, Keith W Muir, Philip Clatworthy, Risto A Kauppinen,

The apparent diffusion coefficient (ADC) of cerebral water, as measured by diffusion MRI, rapidly decreases in ischaemia, highlighting a lesion in acute stroke patients. The MRI T 2 relaxation time changes in ischaemic brain such that T 2 in ADC lesions may be informative of the extent of tissue damage, ... Read more >>

Phys Med Biol (Physics in medicine and biology)
[2019, 64(9):095016]

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A Noninvasive Comparison Study between Human Gliomas with IDH1 and IDH2 Mutations by MR Spectroscopy.

Xin Shen, Natalie L Voets, Sarah J Larkin, Nick de Pennington, Puneet Plaha, Richard Stacey, James S O McCullagh, Christopher J Schofield, Stuart Clare, Peter Jezzard, Tom Cadoux-Hudson, Olaf Ansorge, Uzay E Emir,

The oncogenes that are expressed in gliomas reprogram particular pathways of glucose, amino acids, and fatty acid metabolism. Mutations in isocitrate dehydrogenase genes (IDH1/2) in diffuse gliomas are associated with abnormally high levels of 2-hydroxyglutarate (2-HG) levels. The aim of this study was to determine whether metabolic reprogramming associated with ... Read more >>

Metabolites (Metabolites)
[2019, 9(2):]

Cited: 2 times

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A Noninvasive Comparison Study between Human Gliomas with IDH1 and IDH2 Mutations by MR Spectroscopy

Xin Shen, Natalie Voets, Sarah Larkin, Nick de Pennington, Richard Stacey, Puneet Plaha, James McCullagh, Christopher Schofield, Stuart Clare, Peter Jezzard, Tom Cadoux-Hudson, Olaf Ansorge, Uzay Emir,

The oncogenes that are expressed in gliomas reprogram particular pathways of glucose, amino acid, and fatty acid metabolism. Mutations in isocitrate dehydrogenase genes (IDH1/2) in diffuse gliomas are associated with abnormally high levels of 2-hydroxyglutarate (2-HG) levels. The aim of this study was to determine whether metabolic reprogramming associated with ... Read more >>

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Visualizing artery-specific blood flow patterns above the circle of Willis with vessel-encoded arterial spin labeling.

Thomas W Okell, Meritxell Garcia, Michael A Chappell, James V Byrne, Peter Jezzard,

PURPOSE:To establish the feasibility of using vessel-encoded pseudocontinuous arterial spin labeling (VEPCASL) for noninvasive vascular territory imaging (VTI) and artery-specific dynamic angiography of a large number of arterial branches above the circle of Willis within a clinically feasible scan time. METHODS:3D time-of-flight angiography was used to select a labeling plane ... Read more >>

Magn Reson Med (Magnetic resonance in medicine)
[2019, 81(3):1595-1604]

Cited: 2 times

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Neural self-representation in autistic women and association with 'compensatory camouflaging'.

Meng-Chuan Lai, Michael V Lombardo, Bhismadev Chakrabarti, Amber Nv Ruigrok, Edward T Bullmore, John Suckling, Bonnie Auyeung, Francesca Happé, Peter Szatmari, Simon Baron-Cohen, ,

Prior work has revealed sex/gender-dependent autistic characteristics across behavioural and neural/biological domains. It remains unclear whether and how neural sex/gender differences are related to behavioural sex/gender differences in autism. Here, we examined whether atypical neural responses during mentalizing and self-representation are sex/gender-dependent in autistic adults and explored whether 'camouflaging' (acting ... Read more >>

Autism (Autism : the international journal of research and practice)
[2019, 23(5):1210-1223]

Cited: 5 times

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Metabolite-cycled density-weighted concentric rings k-space trajectory (DW-CRT) enables high-resolution 1 H magnetic resonance spectroscopic imaging at 3-Tesla.

Adam Steel, Mark Chiew, Peter Jezzard, Natalie L Voets, Puneet Plaha, Michael Albert Thomas, Charlotte J Stagg, Uzay E Emir,

Magnetic resonance spectroscopic imaging (MRSI) is a promising technique in both experimental and clinical settings. However, to date, MRSI has been hampered by prohibitively long acquisition times and artifacts caused by subject motion and hardware-related frequency drift. In the present study, we demonstrate that density weighted concentric ring trajectory (DW-CRT) ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):7792]

Cited: 1 time

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Quantitative blood flow measurement in rat brain with multiphase arterial spin labelling magnetic resonance imaging.

James R Larkin, Manon A Simard, Alexandre A Khrapitchev, James A Meakin, Thomas W Okell, Martin Craig, Kevin J Ray, Peter Jezzard, Michael A Chappell, Nicola R Sibson,

Cerebral blood flow is an important parameter in many diseases and functional studies that can be accurately measured in humans using arterial spin labelling (ASL) MRI. However, although rat models are frequently used for preclinical studies of both human disease and brain function, rat CBF measurements show poor consistency between ... Read more >>

J. Cereb. Blood Flow Metab. (Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism)
[2019, 39(8):1557-1569]

Cited: 5 times

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Dual regression physiological modeling of resting-state EPI power spectra: Effects of healthy aging.

Olivia Viessmann, Harald E Möller, Peter Jezzard,

Aging and disease-related changes in the arteriovasculature have been linked to elevated levels of cardiac cycle-induced pulsatility in the cerebral microcirculation. Functional magnetic resonance imaging (fMRI), acquired fast enough to unalias the cardiac frequency contributions, can be used to study these physiological signals in the brain. Here, we propose an ... Read more >>

Neuroimage (NeuroImage)
[2019, 187:68-76]

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A comparison of 2-hydroxyglutarate detection at 3 and 7 T with long-TE semi-LASER.

Adam Berrington, Natalie L Voets, Sarah J Larkin, Nick de Pennington, James Mccullagh, Richard Stacey, Christopher J Schofield, Peter Jezzard, Stuart Clare, Tom Cadoux-Hudson, Puneet Plaha, Olaf Ansorge, Uzay E Emir,

Abnormally high levels of the 'oncometabolite' 2-hydroxyglutarate (2-HG) occur in many grade II and III gliomas, and correlate with mutations in the genes of isocitrate dehydrogenase (IDH) isoforms. In vivo measurement of 2-HG in patients, using magnetic resonance spectroscopy (MRS), has largely been carried out at 3 T, yet signal overlap ... Read more >>

NMR Biomed (NMR in biomedicine)
[2018, 31(3):]

Cited: 3 times

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Arterial spin labeling for the measurement of cerebral perfusion and angiography.

Peter Jezzard, Michael A Chappell, Thomas W Okell,

Arterial spin labeling (ASL) is an MRI technique that was first proposed a quarter of a century ago. It offers the prospect of non-invasive quantitative measurement of cerebral perfusion, making it potentially very useful for research and clinical studies, particularly where multiple longitudinal measurements are required. However, it has suffered ... Read more >>

J. Cereb. Blood Flow Metab. (Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism)
[2018, 38(4):603-626]

Cited: 6 times

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Density-weighted concentric rings k-space trajectory for 1 H magnetic resonance spectroscopic imaging at 7 T.

Mark Chiew, Wenwen Jiang, Brian Burns, Peder Larson, Adam Steel, Peter Jezzard, M Albert Thomas, Uzay E Emir,

It has been shown that density-weighted (DW) k-space sampling with spiral and conventional phase encoding trajectories reduces spatial side lobes in magnetic resonance spectroscopic imaging (MRSI). In this study, we propose a new concentric ring trajectory (CRT) for DW-MRSI that samples k-space with a density that is proportional to a ... Read more >>

NMR Biomed (NMR in biomedicine)
[2018, 31(1):]

Cited: 2 times

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Cardiac cycle-induced EPI time series fluctuations in the brain: Their temporal shifts, inflow effects and T2∗ fluctuations.

Olivia Viessmann, Harald E Möller, Peter Jezzard,

The cardiac-induced arterial pressure wave causes changes in cerebral blood flow velocities and volumes that affect the signals in echo-planar imaging (EPI). Using single-echo EPI time series data, acquired fast enough to unalias the cardiac frequency, we found that the cardiac cycle-induced signal fluctuations are delayed differentially in different brain ... Read more >>

Neuroimage (NeuroImage)
[2017, 162:93-105]

Cited: 1 time

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Consensus statement on current and emerging methods for the diagnosis and evaluation of cerebrovascular disease.

Manus J Donahue, Eric Achten, Petrice M Cogswell, Frank-Erik De Leeuw, Colin P Derdeyn, Rick M Dijkhuizen, Audrey P Fan, Rashid Ghaznawi, Jeremy J Heit, M Arfan Ikram, Peter Jezzard, Lori C Jordan, Eric Jouvent, Linda Knutsson, Richard Leigh, David S Liebeskind, Weili Lin, Thomas W Okell, Adnan I Qureshi, Charlotte J Stagg, Matthias Jp van Osch, Peter Cm van Zijl, Jennifer M Watchmaker, Max Wintermark, Ona Wu, Greg Zaharchuk, Jinyuan Zhou, Jeroen Hendrikse,

Cerebrovascular disease (CVD) remains a leading cause of death and the leading cause of adult disability in most developed countries. This work summarizes state-of-the-art, and possible future, diagnostic and evaluation approaches in multiple stages of CVD, including (i) visualization of sub-clinical disease processes, (ii) acute stroke theranostics, and (iii) characterization ... Read more >>

J. Cereb. Blood Flow Metab. (Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism)
[2018, 38(9):1391-1417]

Cited: 7 times

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Sex differences in frontal lobe connectivity in adults with autism spectrum conditions.

E A Zeestraten, M C Gudbrandsen, E Daly, M T de Schotten, M Catani, F Dell'Acqua, M-C Lai, A N V Ruigrok, M V Lombardo, B Chakrabarti, S Baron-Cohen, C Ecker, , D G M Murphy, M C Craig,

Autism spectrum conditions (ASC) are more prevalent in males than females. The biological basis of this difference remains unclear. It has been postulated that one of the primary causes of ASC is a partial disconnection of the frontal lobe from higher-order association areas during development (that is, a frontal 'disconnection ... Read more >>

Transl Psychiatry (Translational psychiatry)
[2017, 7(4):e1090]

Cited: 5 times

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A purpose-built neck coil for black-blood DANTE-prepared carotid artery imaging at 7T.

Konstantinos Papoutsis, Linqing Li, Jamie Near, Stephen Payne, Peter Jezzard,

Atherosclerotic plaques in the bifurcation of the carotid arteries can pose a significant health risk due to possible plaque rupture and subsequent stroke. The assessment of plaques, and evaluation of the risk they pose, can be performed with Black-Blood (BB) vessel wall magnetic resonance imaging. However, resolution at standard clinical ... Read more >>

Magn Reson Imaging (Magnetic resonance imaging)
[2017, 40:53-61]

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