Full Text Journal Articles by
Author Peter D R Higgins

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Efficacy of Ustekinumab in Crohn's Disease With and Without Concurrent Autoimmune Skin Disease.

Elena Fradkov, Jessica Sheehan, Kelly Cushing, Peter D R Higgins,

<h4>Background</h4>Approximately 33% of Crohn's disease (CD) patients have associated autoimmune skin disease. The pathophysiology of the latter frequently involves interleukin-12/interleukin-23 signaling pathways that may also impact gut inflammation. Ustekinumab is an anti-IL-12/23 FDA-approved biologic for psoriasis and inflammatory bowel disease. However, its relative efficacy has never been studied in CD ... Read more >>

Inflamm Bowel Dis (Inflammatory bowel diseases)
[2021, :]

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A Care Coordination Intervention Improves Symptoms But Not Charges in High-Risk Patients With Inflammatory Bowel Disease.

Jeffrey A Berinstein, Shirley A Cohen-Mekelburg, Gillian M Greenberg, Daniel Wray, Sameer K Berry, Sameer D Saini, A Mark Fendrick, Megan A Adams, Akbar K Waljee, Peter D R Higgins,

<h4>Background</h4>Inflammatory bowel disease (IBD) is associated with substantial symptom burden, variability in clinical outcomes, and high direct costs. We sought to determine if a care coordination-based strategy was effective at improving patient symptom burden and reducing healthcare costs for patients with IBD in the top quintile of predicted healthcare utilization ... Read more >>

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2021, :]

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Effect of ABT-263 on Intestinal Fibrosis in Human Myofibroblasts, Human Intestinal Organoids, and the Mouse Salmonella typhimurium Model.

Laura A Johnson, Eva S Rodansky, Anhdao Tran, Stephen G Collins, Kathryn A Eaton, Benjamin Malamet, Calen A Steiner, Sha Huang, Jason R Spence, Peter D R Higgins,

<h4>Background</h4>Intestinal fibrosis and subsequent intestinal obstruction are common complications of Crohn's disease (CD). Current therapeutics combat inflammation, but no pharmacological therapy exists for fibrostenotic disease. Pathological persistence of activated intestinal myofibroblasts is a key driver of fibrosis in CD. In other organ systems, BH-3 mimetic drugs that affect Bcl-2 apoptotic ... Read more >>

Inflamm Bowel Dis (Inflammatory bowel diseases)
[2021, :]

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Charting human development using a multi-endodermal organ atlas and organoid models.

Qianhui Yu, Umut Kilik, Emily M Holloway, Yu-Hwai Tsai, Christoph Harmel, Angeline Wu, Joshua H Wu, Michael Czerwinski, Charlie J Childs, Zhisong He, Meghan M Capeling, Sha Huang, Ian A Glass, Peter D R Higgins, Barbara Treutlein, Jason R Spence, J Gray Camp,

Organs are composed of diverse cell types that traverse transient states during organogenesis. To interrogate this diversity during human development, we generate a single-cell transcriptome atlas from multiple developing endodermal organs of the respiratory and gastrointestinal tract. We illuminate cell states, transcription factors, and organ-specific epithelial stem cell and mesenchyme ... Read more >>

Cell (Cell)
[2021, 184(12):3281-3298.e22]

Cited: 1 time

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Biomarkers for the Prediction and Diagnosis of Fibrostenosing Crohn's Disease: A Systematic Review.

Calen A Steiner, Jeffrey A Berinstein, Jeremy Louissaint, Peter D R Higgins, Jason R Spence, Carol Shannon, Cathy Lu, Ryan W Stidham, Joel G Fletcher, David H Bruining, Brian G Feagan, Vipul Jairath, Mark E Baker, Dominik Bettenworth, Florian Rieder, ,

<h4>Background and aims</h4>Intestinal strictures are a common complication of Crohn's disease (CD). Biomarkers of intestinal strictures would assist in their prediction, diagnosis, and monitoring. Herein we provide a comprehensive systematic review of studies assessing biomarkers that may predict or diagnose CD-associated strictures.<h4>Methods</h4>We performed a systematic review of PubMed, EMBASE, ISI ... Read more >>

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2021, :]

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Management of Crohn Disease-Reply.

Kelly Cushing, Peter D R Higgins,

JAMA (JAMA)
[2021, 325(17):1794-1795]

Cited: 0 times

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Tofacitinib for Biologic-Experienced Hospitalized Patients With Acute Severe Ulcerative Colitis: A Retrospective Case-Control Study.

Jeffrey A Berinstein, Jessica L Sheehan, Michael Dias, Elliot M Berinstein, Calen A Steiner, Laura A Johnson, Randolph E Regal, John I Allen, Kelly C Cushing, Ryan W Stidham, Shrinivas Bishu, Jami A R Kinnucan, Shirley A Cohen-Mekelburg, Akbar K Waljee, Peter D R Higgins,

<h4>Background & aims</h4>Despite rescue therapy, more than 30% of patients with acute severe ulcerative colitis (ASUC) require colectomy. Tofacitinib is a rapidly acting Janus kinase inhibitor with proven efficacy in ulcerative colitis. Tofacitinib may provide additional means for preventing colectomy in patients with ASUC.<h4>Methods</h4>A retrospective case-control study was performed evaluating ... Read more >>

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2021, 19(10):2112-2120.e1]

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Variations in Health Care Utilization Patterns Among Inflammatory Bowel Disease Patients at Risk for High Medical Service Utilization Enrolled in High Deductible Health Plans.

Jeffrey A Berinstein, Shirley A Cohen-Mekelburg, Calen A Steiner, Megan McLeod, Mohamed Noureldin, John I Allen, Jeffrey T Kullgren, Akbar K Waljee, Peter D R Higgins,

<h4>Background</h4>High-deductible health plans (HDHPs) are increasing in prevalence as a cost control device for slowing health care cost growth by reducing nonessential medical service utilization. High cost-sharing associated with HDHPs can lead to significant financial distress and worse disease outcomes. We hypothesize that chronic disease patients are delaying or foregoing ... Read more >>

Inflamm Bowel Dis (Inflammatory bowel diseases)
[2021, 27(6):771-778]

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Trends of 5-Aminosalicylate Medication Use in Patients With Crohn Disease.

Mohamed Noureldin, Shirley Cohen-Mekelburg, Asadullah Mahmood, Ryan Stidham, Peter D R Higgins, Shail Govani, Amar R Deshpande, Akbar K Waljee,

<h4>Background</h4>5-aminosalicylate (5-ASA) medications have a long history of use for the treatment of inflammatory bowel disease and continue to be widely prescribed today. The effectiveness of 5-ASAs in ulcerative colitis is clear; however, studies have shown little benefit for induction or maintenance treatment of Crohn disease (CD). We aimed to ... Read more >>

Inflamm Bowel Dis (Inflammatory bowel diseases)
[2021, 27(4):516-521]

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Management of Crohn Disease: A Review.

Kelly Cushing, Peter D R Higgins,

<h4>Importance</h4>Crohn disease, a chronic gastrointestinal inflammatory disease, is increasing in incidence and prevalence in many parts of the world. Uncontrolled inflammation leads to long-term complications, including fibrotic strictures, enteric fistulae, and intestinal neoplasia. Therefore, early and effective control of inflammation is of critical importance.<h4>Observations</h4>The optimal management approach for Crohn disease ... Read more >>

JAMA (JAMA)
[2021, 325(1):69-80]

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AXL Is a Potential Target for the Treatment of Intestinal Fibrosis.

Calen A Steiner, Eva S Rodansky, Laura A Johnson, Jeffrey A Berinstein, Kelly C Cushing, Sha Huang, Jason R Spence, Peter D R Higgins,

<h4>Background</h4>Fibrosis is the final common pathway to intestinal failure in Crohn's disease, but no medical therapies exist to treat intestinal fibrosis. Activated myofibroblasts are key effector cells of fibrosis in multiple organ systems, including the intestine. AXL is a receptor tyrosine kinase that has been implicated in fibrogenic pathways involving ... Read more >>

Inflamm Bowel Dis (Inflammatory bowel diseases)
[2021, 27(3):303-316]

Cited: 4 times

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Validation of models using basic parameters to differentiate intestinal tuberculosis from Crohn's disease: A multicenter study from Asia.

Julajak Limsrivilai, Choon Kin Lee, Piyapan Prueksapanich, Kamin Harinwan, Asawin Sudcharoen, Natcha Cheewasereechon, Satimai Aniwan, Pimsiri Sripongpan, Panu Wetwittayakhlang, Ananya Pongpaibul, Anapat Sanpavat, Nonthalee Pausawasdi, Phunchai Charatcharoenwitthaya, Peter D R Higgins, Siew Chien Ng,

<h4>Background</h4>Data on external validation of models developed to distinguish Crohn's disease (CD) from intestinal tuberculosis (ITB) are limited. This study aimed to validate and compare models using clinical, endoscopic, and/or pathology findings to differentiate CD from ITB.<h4>Methods</h4>Data from newly diagnosed ITB and CD patients were retrospectively collected from 5 centers ... Read more >>

PLoS One (PloS one)
[2020, 15(11):e0242879]

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Endoscopic and Histological Assessment, Correlation, and Relapse in Clinically Quiescent Ulcerative Colitis (MARQUEE).

Mark T Osterman, Frank I Scott, Franz F Fogt, Erin D Gilroy, Susan Parrott, Joseph Galanko, Raymond Cross, Alan Moss, Hans H Herfarth, Peter D R Higgins,

<h4>Objective</h4>It is difficult to predict relapse in quiescent ulcerative colitis (UC), but newer endoscopic and histological indices could improve this. This study aimed to determine in UC patients in clinical remission (1) the prevalence of active endoscopic and histological disease; (2) the correlation between endoscopic and histological scores; and (3) ... Read more >>

Inflamm Bowel Dis (Inflammatory bowel diseases)
[2021, 27(2):207-214]

Cited: 1 time

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Reply.

Jeffrey A Berinstein, Calen A Steiner, Peter D R Higgins,

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2021, 19(6):1303-1304]

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Efficacy and Outcome of Tofacitinib in Immune checkpoint Inhibitor Colitis.

Shrinivas Bishu, Joanna Melia, William Sharfman, Christopher D Lao, Leslie A Fecher, Peter D R Higgins,

Gastroenterology (Gastroenterology)
[2021, 160(3):932-934.e3]

Cited: 1 time

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Coronavirus Disease 2019 (COVID-19) Clinical Trial Oversight at a Major Academic Medical Center: Approach of Michigan Medicine.

Kayte Spector-Bagdady, Peter D R Higgins, Keith D Aaronson, Judy Birk, Kevin R Flaherty, Kevin S Gregg, Robert C Hyzy, Daniel R Kaul, Adam S Lauring, John C Magee, William J Meurer, Pauline K Park, Phillip Scott, Anna S Lok,

Clinicians, eager to offer the best care in the absence of guiding data, have provided patients with coronavirus disease 2019 (COVID-19) diverse clinical interventions. This usage has led to perceptions of efficacy of some interventions that, while receiving media coverage, lack robust evidence. Moving forward, randomized controlled clinical trials are ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, 71(16):2187-2190]

Cited: 7 times

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Mapping the relationships between inflammatory bowel disease and comorbid diagnoses to identify disease associations.

Akbar K Waljee, Mohamed Noureldin, Jeffrey A Berinstein, Shirley A Cohen-Mekelburg, Beth I Wallace, Kelly C Cushing, David A Hanauer, Toby P Keeney-Bonthrone, Brahmajee Nallamothu, Peter D R Higgins,

<h4>Background</h4>Massive amounts of patient data are captured daily in electronic medical records (EMR). Utilizing the power of such large data may help identify disease associations and generate hypotheses that can lead to a better understanding of disease associations and mechanisms. We aimed to comprehensively identify and validate associations between inflammatory ... Read more >>

Eur J Gastroenterol Hepatol (European journal of gastroenterology & hepatology)
[2020, 32(10):1341-1347]

Cited: 1 time

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Temporal Gut Microbial Changes Predict Recurrent Clostridiodes Difficile Infection in Patients With and Without Ulcerative Colitis.

Allen A Lee, Krishna Rao, Julajak Limsrivilai, Merritt Gillilland, Benjamin Malamet, Emily Briggs, Vincent B Young, Peter D R Higgins,

<h4>Background</h4>Ulcerative colitis (UC) carries an increased risk of primary and recurrent Clostridiodes difficile infection (rCDI), and CDI is associated with UC flares. We hypothesized that specific fecal microbial changes associate with UC flare and rCDI.<h4>Methods</h4>We conducted a prospective observational cohort study of 57 patients with UC and CDI, CDI only, ... Read more >>

Inflamm Bowel Dis (Inflammatory bowel diseases)
[2020, 26(11):1748-1758]

Cited: 2 times

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Association of Continuity of Care With Outcomes in US Veterans With Inflammatory Bowel Disease.

Shirley Cohen-Mekelburg, Sameer D Saini, Sarah L Krein, Timothy P Hofer, Beth I Wallace, John M Hollingsworth, Julie P W Bynum, Wyndy Wiitala, Jennifer Burns, Peter D R Higgins, Akbar K Waljee,

<h4>Importance</h4>Health care fragmentation is associated with inefficiency and worse outcomes. Continuity of care (COC) models were developed to address fragmentation.<h4>Objective</h4>To examine COC and selected outcomes in US veterans with inflammatory bowel disease (IBD).<h4>Design, setting, and participants</h4>This retrospective cohort study used the Veterans Health Administration (VHA) Corporate Data Warehouse to identify ... Read more >>

JAMA Netw Open (JAMA network open)
[2020, 3(9):e2015899]

Cited: 0 times

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Assessing Small Bowel Stricturing and Morphology in Crohn's Disease Using Semi-automated Image Analysis.

Ryan W Stidham, Binu Enchakalody, Akbar K Waljee, Peter D R Higgins, Stewart C Wang, Grace L Su, Ashish P Wasnik, Mahmoud Al-Hawary,

<h4>Background</h4>Evaluating structural damage using imaging is essential for the evaluation of small intestinal Crohn's disease (CD), but it is limited by potential interobserver variation. We compared the agreement of enterography-based bowel damage measurements collected by experienced radiologists and a semi-automated image analysis system.<h4>Methods</h4>Patients with small bowel CD undergoing a CT-enterography ... Read more >>

Inflamm Bowel Dis (Inflammatory bowel diseases)
[2020, 26(5):734-742]

Cited: 4 times

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Efficacy of Upadacitinib in a Randomized Trial of Patients With Active Ulcerative Colitis.

William J Sandborn, Subrata Ghosh, Julian Panes, Stefan Schreiber, Geert D'Haens, Satoshi Tanida, Jesse Siffledeen, Jeffrey Enejosa, Wen Zhou, Ahmed A Othman, Bidan Huang, Peter D R Higgins,

<h4>Background & aims</h4>We evaluated the efficacy and safety of upadacitinib, an oral selective inhibitor of Janus kinase 1, as induction therapy for ulcerative colitis (UC).<h4>Methods</h4>We performed a multicenter, double-blind, phase 2b study of 250 adults with moderately to severely active UC and an inadequate response, loss of response, or intolerance ... Read more >>

Gastroenterology (Gastroenterology)
[2020, 158(8):2139-2149.e14]

Cited: 10 times

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The Risk of SARS-CoV-2 in Immunosuppressed IBD Patients.

Peter D R Higgins, Siew Ng, Silvio Danese, Krishna Rao,

This is a rapid review of the risk of infection with SARS-CoV-2, the risk of symptomatic cases of COVID-19, and the severity of these cases in IBD patients. Guidance on how to manage IBD patients at risk for infection, and IBD patients after infection is provided. The prevention of infection ... Read more >>

Crohns Colitis 360 (Crohn's & colitis 360)
[2020, 2(2):otaa026]

Cited: 10 times

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Association of Household Pets, Common Dietary Factors, and Lifestyle Factors with Clostridium difficile Infection.

Jeffrey A Berinstein, Calen A Steiner, Katelin J Roth, Emily Briggs, Krishna Rao, Peter D R Higgins,

<h4>Background</h4>Clostridium difficile infection (CDI) is one of the most common hospital-acquired infections and is associated with significant morbidity and mortality. Since owning a cat or dog could enrich the gut microbiome, we hypothesized that it would be protective against CDI.<h4>Aims</h4>We conducted a survey study on patients tested for CDI in ... Read more >>

Dig Dis Sci (Digestive diseases and sciences)
[2021, 66(1):206-212]

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Prevalence and Effect of Intestinal Infections Detected by a PCR-Based Stool Test in Patients with Inflammatory Bowel Disease.

Julajak Limsrivilai, Zachary M Saleh, Laura A Johnson, Ryan W Stidham, Akbar K Waljee, Shail M Govani, Brian Gutermuth, Alexandra M Brown, Emily Briggs, Krishna Rao, Peter D R Higgins,

<h4>Background</h4>The advent of PCR-based stool testing has identified a greatly increased number of infectious agents in IBD, but their clinical significance is unknown.<h4>Aims</h4>To determine the infectious agent prevalence and the clinical significance of these infectious agents in IBD patients.<h4>Methods</h4>This cross-sectional study compared the prevalence of GI infections among IBD patients ... Read more >>

Dig Dis Sci (Digestive diseases and sciences)
[2020, 65(11):3287-3296]

Cited: 1 time

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Use of Accelerated Induction Strategy of Infliximab for Ulcerative Colitis in Hospitalized Patients at a Tertiary Care Center.

Shail M Govani, Jeffrey A Berinstein, Akbar K Waljee, Ryan W Stidham, Peter D R Higgins, Karin M Hardiman,

<h4>Background</h4>Infliximab can prevent colectomy in patients hospitalized with acute severe ulcerative colitis (ASUC). In cases of ASUC, fecal losses of infliximab may lead to low drug levels and reduced efficacy.<h4>Aim</h4>To determine 90-day colectomy risk and postoperative complications in patients receiving single-dose and accelerated induction of infliximab for ASUC.<h4>Methods</h4>We conducted a ... Read more >>

Dig Dis Sci (Digestive diseases and sciences)
[2020, 65(6):1800-1805]

Cited: 1 time

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