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Late recurrence in birdshot chorioretinopathy.

Arash Maleki, Sydney Look-Why, Ambika Manhapra, Soheila Asgari, Andrew M Philip, Peter Y Chang, Stephen D Anesi, C Stephen Foster,

<h4>Objective</h4>To compare the demographic, clinical, ancillary testing, and multimodal imaging characteristics of birdshot chorioretinopathy (BSCR) patients with late recurrence and birdshot patients with durable remission.<h4>Patients and methods</h4>This was a retrospective observational case series. The above-mentioned parameters were studied in BSCR patients with late recurrence (group 1) and BSCR patients with ... Read more >>

Can J Ophthalmol (Canadian journal of ophthalmology. Journal canadien d'ophtalmologie)
[2021, :]

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ACUTE MYOCARDITIS WITH CARDIOGENIC SHOCK AND MULTIPLE ORGAN FAILURE, FOLLOWED BY BILATERAL PANUVEITIS MASQUERADING AS ENDOGENOUS ENDOPHTHALMITIS, DUE TO TOXOPLASMA GONDII IN AN IMMUNOCOMPETENT PATIENT.

Artur Filipowicz, Mircea N Coca, Barbra M Blair, Peter Y Chang,

<h4>Purpose</h4>To report a case of systemic and ocular toxoplasmosis in an immunocompetent patient, who developed myocarditis with resulting cardiogenic shock and multiple organ failure, followed by bilateral panuveitis masquerading as endogenous endophthalmitis.<h4>Methods</h4>Single case report with images.<h4>Results</h4>A 59-year-old man with a history of monoclonal gammopathy of undetermined significance and associated scleromyxedema ... Read more >>

Retin Cases Brief Rep (Retinal cases & brief reports)
[2021, 15(5):575-580]

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Outcomes of Artificial Intelligence Volumetric Assessment of Kidneys and Renal Tumors for Preoperative Assessment of Nephron-Sparing Interventions.

Roozbeh Houshyar, Justin Glavis-Bloom, Thanh-Lan Bui, Chantal Chahine, Michelle D Bardis, Alexander Ushinsky, Hanna Liu, Param Bhatter, Elliott Lebby, Dylann Fujimoto, William Grant, Karen Tran-Harding, Jaime Landman, Daniel S Chow, Peter D Chang,

<b><i>Background:</i></b> Renal-cell carcinoma is the most common kidney cancer and the 13th most common cause of cancer death worldwide. Partial nephrectomy and percutaneous ablation, increasingly utilized to treat small renal masses and preserve renal parenchyma, require precise preoperative imaging interpretation. We sought to develop and evaluate a convolutional neural network ... Read more >>

J Endourol (Journal of endourology)
[2021, 35(9):1411-1418]

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Prospective Multicenter Comparison of Open and Robotic Radical Prostatectomy: The PROST-QA/RP2 Consortium.

Peter Chang, Andrew A Wagner, Meredith M Regan, Joseph A Smith, Christopher S Saigal, Mark S Litwin, Jim C Hu, Matthew R Cooperberg, Peter R Carroll, Eric A Klein, Adam S Kibel, Gerald L Andriole, Misop Han, Alan W Partin, David P Wood, Catrina M Crociani, Thomas K Greenfield, Dattatraya Patil, Larry A Hembroff, Kyle Davis, Linda Stork, Daniel E Spratt, John T Wei, Martin G Sanda,

<h4>Purpose</h4>To evaluate the comparative effectiveness of robot-assisted laparoscopic prostatectomy (RALP) and open radical prostatectomy (ORP) in a multicenter study.<h4>Materials and methods</h4>We evaluated men with localized prostate cancer at eleven high-volume academic medical centers in the United States from the PROST-QA (2003-2006) and the PROST-QA/RP2 cohorts (2010-2013) with a pre-specified goal ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000002176]

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Ruxolitinib Combined with Gemcitabine against Cholangiocarcinoma Growth via the JAK2/STAT1/3/ALDH1A3 Pathway.

Shin-Yi Chung, Yi-Ping Hung, Yi-Ru Pan, Yu-Chan Chang, Chiao-En Wu, Dennis Shin-Shian Hsu, Peter Mu-Hsin Chang, Meng-Lun Lu, Chi-Ying F Huang, Yeu Su, Michael Hsiao, Chun-Nan Yeh, Ming-Huang Chen,

Cholangiocarcinoma is the most common primary malignant tumor of the bile duct. The current standard first-line treatment for advanced or metastatic cholangiocarcinoma is gemcitabine and cisplatin. However, few effective treatment choices exist for refractory cholangiocarcinoma, and additional therapeutic drugs are urgently required. Our previous work demonstrated that the ALDH isoform ... Read more >>

Biomedicines (Biomedicines)
[2021, 9(8):]

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Clinical Implications of Bone Bruise Patterns Accompanying Anterior Cruciate Ligament Tears.

Patrick Ward, Peter Chang, Logan Radtke, Robert H Brophy,

<h4>Background</h4>Anterior cruciate ligament (ACL) tears are common injuries; they are often associated with concomitant injuries to other structures in the knee, including bone bruises. While there is limited evidence that bone bruises are associated with slightly worse clinical outcomes, the implications of bone bruises for the articular cartilage and the ... Read more >>

Sports Health (Sports health)
[2021, :19417381211029583]

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APPLICATION OF ADJUNCTIVE TOPICAL MITOMYCIN-C IN SCLEROSTOMY REVISION FOR REFRACTORY IDIOPATHIC UVEAL EFFUSION SYNDROME.

Ivy Zhu, Zeeshan Haq, Mohsin H Ali, Peter Y Chang, Sarwar Zahid, William F Mieler,

<h4>Background/purpose</h4>To describe the use of topical mitomycin-C in sclerostomy revision for recalcitrant idiopathic uveal effusion syndrome.<h4>Methods</h4>A 50-year-old healthy man presented with painless, gradual vision loss in the right eye. He underwent multimodal retinal imaging with wide-field fundus photography, spectral domain optical coherence tomography, and B-scan and A-scan ultrasonography. He was ... Read more >>

Retin Cases Brief Rep (Retinal cases & brief reports)
[2021, 15(4):339-343]

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Reducing postoperative opioid pill prescribing via a quality improvement approach.

Kristian D Stensland, Peter Chang, David Jiang, David Canes, Aaron Berkenwald, Adrian Waisman, Kortney Robinson, Gabriel Brat, Catrina Crociani, Kyle Mcanally, Sarah Hyde, Brian Holliday, Jodi Mechaber, Analesa Baraka, Alireza Moinzadeh, Andrew A Wagner,

<h4>Background</h4>The opioid epidemic has been fueled by prescribing unnecessary quantities of opioid pills for postoperative use. While evidence mounts that postoperative opioids can be reduced or eliminated, implementing such changes within various institutions can be met with many barriers to adoption.<h4>Objective</h4>To address excess opioid prescribing within our institutions, we applied ... Read more >>

Int J Qual Health Care (International journal for quality in health care : journal of the International Society for Quality in Health Care)
[2021, 33(3):]

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Validity of Research Based on Public Data in Sports Medicine: A Quantitative Assessment of Anterior Cruciate Ligament Injuries in the National Football League.

Paul M Inclan, Peter S Chang, Christina D Mack, Gary S Solomon, Robert H Brophy, Richard Y Hinton, Kurt P Spindler, Allen K Sills, Matthew J Matava,

<h4>Background</h4>Numerous researchers have leveraged publicly available Internet sources to publish publicly obtained data (POD) studies concerning various orthopaedic injuries in National Football League (NFL) players.<h4>Purpose</h4>To provide a comprehensive systematic review of all POD studies regarding musculoskeletal injuries in NFL athletes and to use anterior cruciate ligament (ACL) injuries in NFL ... Read more >>

Am J Sports Med (The American journal of sports medicine)
[2021, :3635465211015435]

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Exposure-Response Relationships for Efficacy and Safety of Filgotinib and its metabolite GS-829845 in Subjects with Rheumatoid Arthritis Based on Phase 2 and Phase 3 Studies

Amy Meng, Kacey Anderson, Cara Nelson, Liyun Ni, Shu-Min Chuang, Francesco Bellanti, Peter Chang, Craig Comisar, Brian Kearney, Beatrix Bartok, Anita Mathias,

<h4>Aims: </h4>:Filgotinib is a potent, oral, JAK1-preferential inhibitor for the treatment of rheumatoid arthritis (RA). This report describes exposure-response (ER) analyses of filgotinib for dose confirmation based on three Phase 3 and two Phase 2 studies in moderate to severe RA patients. <h4>Methods:</h4> The PK exposures used in ER analyses ... Read more >>

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Ruxolitinib Combined with Gemcitabine against Cholangiocarcinoma Growth via the jak2/stat1/3/aldh1a3 Pathway

Shin-Yi Chung, Yi-Ping Hung, Yi-Ru Pan, Yu-Chan Chang, Chiao-En Wu, Dennis Shin-Shian Hsu, Peter Mu-Hsin Chang, Meng-Lun Lu, Chi-Ying Huang, Yeu Su, Michael Hsiao, Chun-Nan Yeh, Ming-Huang Chen,

Cholangiocarcinoma is the most common primary malignant tumor of the bile duct. The current standard first-line treatment for advanced or metastatic cholangiocarcinoma is gemcitabine and cisplatin. However, few effective treatment choices exist for refractory cholangiocarcinoma, and additional therapeutic drugs are urgently required. Our previous work demonstrated that the ALDH isoform ... Read more >>

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The brain transcriptome of the wolf spider, Schizocosa ocreata.

Daniel Stribling, Peter L Chang, Justin E Dalton, Christopher A Conow, Malcolm Rosenthal, Eileen Hebets, Rita M Graze, Michelle N Arbeitman,

<h4>Objectives</h4>Arachnids have fascinating and unique biology, particularly for questions on sex differences and behavior, creating the potential for development of powerful emerging models in this group. Recent advances in genomic techniques have paved the way for a significant increase in the breadth of genomic studies in non-model organisms. One growing ... Read more >>

BMC Res Notes (BMC research notes)
[2021, 14(1):236]

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Differentiation of Milk and Whey Protein Concentrates by Microbiome Profiling Using 16S Metagenomics.

Christopher M Thompson, Quanyin Gao, Peter Chang, Gary Swanson,

<h4>Background</h4>Protein powder identification presents a challenge in quality control. There is current deliberation of the specificity of methods for the identification of milk proteins, and the consensus identification method of whey protein from the United States Pharmacopeia Food Chemical Codex relies on a combined analysis of the testing of ash, ... Read more >>

J AOAC Int (Journal of AOAC International)
[2021, 104(3):757-764]

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Tongue conservation treatment for oral tongue squamous cell carcinoma with induction chemotherapy, surgery, and risk-adapted adjuvant therapy: A phase II trial.

Tsung-Lun Lee, Pei-Yin Wei, Muh-Hwa Yang, Peter Mu-Hsin Chang, Ling-Wei Wang, Shyh-Kuan Tai,

<h4>Background</h4>To assess the feasibility of tongue conservation treatment with induction chemotherapy (ICT), tongue conservation surgery, and risk-adapted postoperative adjuvant therapy in oral tongue squamous cell carcinoma (OTSCC).<h4>Methods</h4>Patients with newly diagnosed OTSCC cT2-4 N0-2 M0 were recruited. The ICT with a regimen of docetaxel, cisplatin, and oral tegafur/uracil (DCU) was administrated every ... Read more >>

Cancer Rep (Hoboken) (Cancer reports (Hoboken, N.J.))
[2021, :e1456]

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Identification and Localization of Endotracheal Tube on Chest Radiographs Using a Cascaded Convolutional Neural Network Approach.

Su Kara, Jake Y Akers, Peter D Chang,

Rapid and accurate assessment of endotracheal tube (ETT) location is essential in the intensive care unit (ICU) setting, where timely identification of a mispositioned support device may prevent significant patient morbidity and mortality. This study proposes a series of deep learning-based algorithms which together iteratively identify and localize the position ... Read more >>

J Digit Imaging (Journal of digital imaging)
[2021, 34(4):898-904]

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The impact of pretreatment PSA on risk stratification in men with Gleason 6 prostate cancer: Implications for active surveillance.

Sina Monfared, Aaron Fleishman, Ruslan Korets, Peter Chang, Andrew Wagner, Glenn Bubley, Irving Kaplan, Aria F Olumi, Boris Gershman,

<h4>Background</h4>There are limited data to support the safety of active surveillance in men with favorable-intermediate risk prostate cancer due only to a prostate specific antigen (PSA) above 10 ng/ml. We therefore evaluated the impact of pretreatment PSA on risk-stratification in men with Gleason 6 prostate cancer.<h4>Methods</h4>We identified men aged 18 ... Read more >>

Urol Oncol (Urologic oncology)
[2021, :]

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Validation of a Triplex Quantitative Polymerase Chain Reaction Assay for Detection and Quantification of Traditional Protein Sources, Pisum sativum L. and Glycine max (L.) Merr., in Protein Powder Mixtures.

Adam C Faller, Dhivya Shanmughanandhan, Subramanyam Ragupathy, Yanjun Zhang, Zhengfei Lu, Peter Chang, Gary Swanson, Steven G Newmaster,

Several botanicals have been traditionally used as protein sources, including the leguminous <i>Pisum sativum</i> L. and <i>Glycine max</i> (L.) Merr. While a rich history exists of cultivating these plants for their whole, protein-rich grain, modern use as powdered supplements present a new challenge in material authentication. The absence of clear ... Read more >>

Front Plant Sci (Frontiers in plant science)
[2021, 12:661770]

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Segmentation of the Prostate Transition Zone and Peripheral Zone on MR Images with Deep Learning.

Michelle Bardis, Roozbeh Houshyar, Chanon Chantaduly, Karen Tran-Harding, Alexander Ushinsky, Chantal Chahine, Mark Rupasinghe, Daniel Chow, Peter Chang,

Purpose To develop a deep learning model to delineate the transition zone (TZ) and peripheral zone (PZ) of the prostate on MR images. Materials and Methods This retrospective study was composed of patients who underwent a multiparametric prostate MRI and an MRI/transrectal US fusion biopsy between January 2013 and May ... Read more >>

Radiol Imaging Cancer (Radiology. Imaging cancer)
[2021, 3(3):e200024]

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Treatment of Noninfectious Retinal Vasculitis Using Subcutaneous Repository Corticotropin Injection.

Stephen D Anesi, Peter Y Chang, Arash Maleki, Andrew Stephenson, Alyssa Montieth, Artur Filipowicz, Sarah Syeda, Soheila Asgari, Marisa Walsh, Jamie Lynne Metzinger, C Stephen Foster,

<h4>Purpose</h4>To show whether subcutaneous repository corticotropin injection (RCI, Acthar® Gel, a repository corticotropin injection, can be an effective potential therapeutic agent for noninfectious retinal vasculitis.<h4>Methods</h4>Patients with active retinal vasculitis were followed with serial ultra-wide-field fluorescein angiograms and treated with 80 units of subcutaneous repository corticotropin injection twice weekly.<h4>Results</h4>Primary outcome of ... Read more >>

J Ophthalmic Vis Res (Journal of ophthalmic & vision research)
[2021, 16(2):219-233]

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Validation of a Deep Learning Tool in the Detection of Intracranial Hemorrhage and Large Vessel Occlusion.

Joel McLouth, Sebastian Elstrott, Yasmina Chaibi, Sarah Quenet, Peter D Chang, Daniel S Chow, Jennifer E Soun,

<b>Purpose:</b> Recently developed machine-learning algorithms have demonstrated strong performance in the detection of intracranial hemorrhage (ICH) and large vessel occlusion (LVO). However, their generalizability is often limited by geographic bias of studies. The aim of this study was to validate a commercially available deep learning-based tool in the detection of ... Read more >>

Front Neurol (Frontiers in neurology)
[2021, 12:656112]

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Using Preoperative Pelvic Floor Assessment to Predict Early Return of Continence after Robotic Radical Prostatectomy.

Alison Levy, Aaron Fleishman, Max Jackson, Adrian Waisman, Marianne Chan, Allison Kleeman, Catrina Crociani, Kyle McAnally, Jenna Leader, Marysa Warnhoff, David Jiang, Andrew Wagner, Peter Chang,

<h4>Objective</h4>To evaluate whether pre-operative pelvic floor physical therapy (PFPT) parameters may predict early return of urinary continence after RP. While long-term urinary continence is eventually achieved in most patients who undergo radical prostatectomy (RP), predicting when patients will become continent is challenging. Prior studies aiming to predict return of post-operative ... Read more >>

Urology (Urology)
[2021, 155:160-164]

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Clinical features, visual outcome, and poor prognostic factors in occlusive retinal vasculitis.

Miaoli Lin, Stephen D Anesi, Peter Y Chang, Laura Eggenschwiler, Ambika Manhapra, Marisa Walsh, C Stephen Foster,

<h4>Objective</h4>To investigate the clinical features, treatment, and visual outcome of occlusive retinal vasculitis (ORV), with a focal analysis on prognostic factors associated with poor visual outcome.<h4>Methods</h4>We conducted a retrospective cohort study in patients diagnosed with ORV with at least 6 months of follow-up. Demographic data, ocular features, best corrected visual ... Read more >>

Can J Ophthalmol (Canadian journal of ophthalmology. Journal canadien d'ophtalmologie)
[2021, :]

Cited: 1 time

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Early response to psychological treatment for eating disorders: A systematic review and meta-analysis.

Peter G R Y Chang, Jaime Delgadillo, Glenn Waller,

Early response is a well-established predictor of positive outcomes at the end of psychological treatments for common mental disorders. There is some prior evidence that this conclusion also applies to eating disorders, including three meta-analyses, but no moderators of that relationship have been identified. However, a number of further papers ... Read more >>

Clin Psychol Rev (Clinical psychology review)
[2021, 86:102032]

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Assessment of Cumulative Incidence and Severity of Primary Open-Angle Glaucoma Among Participants in the Ocular Hypertension Treatment Study After 20 Years of Follow-up.

Michael A Kass, Dale K Heuer, Eve J Higginbotham, Richard K Parrish, Cheryl L Khanna, James D Brandt, Joern B Soltau, Chris A Johnson, John L Keltner, Julia B Huecker, Bradley S Wilson, Lei Liu, J Phillip Miller, Harry A Quigley, Mae O Gordon, ,

<h4>Importance</h4>Ocular hypertension is an important risk factor for the development of primary open-angle glaucoma (POAG). Data from long-term follow-up can be used to inform the management of patients with ocular hypertension.<h4>Objective</h4>To determine the cumulative incidence and severity of POAG after 20 years of follow-up among participants in the Ocular Hypertension ... Read more >>

JAMA Ophthalmol (JAMA ophthalmology)
[2021, :]

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Erratum: Ultralow-input single-tube linked-read library method enables short-read second-generation sequencing systems to routinely generate highly accurate and economical long-range sequencing information.

Zhoutao Chen, Long Pham, Tsai-Chin Wu, Guoya Mo, Yu Xia, Peter L Chang, Devin Porter, Tan Phan, Huu Che, Hao Tran, Vikas Bansal, Justin Shaffer, Pedro Belda-Ferre, Greg Humphrey, Rob Knight, Pavel Pevzner, Son Pham, Yong Wang, Ming Lei,

Genome Res (Genome research)
[2021, 31(5):934]

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