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Author Peter C Ford

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Dinitrosyl Iron Complexes (DNICs). From Spontaneous Assembly to Biological Roles.

Daniela R Truzzi, Nathalia M Medeiros, Ohara Augusto, Peter C Ford,

Dinitrosyl iron complexes (DNICs) are spontaneously and rapidly generated in cells. Their assembly requires nitric oxide (NO), biothiols, and nonheme iron, either labile iron or iron-sulfur clusters. Despite ubiquitous detection by electron paramagnetic resonance in NO-producing cells, the DNIC's chemical biology remains only partially understood. In this Forum Article, we ... Read more >>

Inorg Chem (Inorganic chemistry)
[2021, :]

Cited: 0 times

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Nitric Oxide Dioxygenation by O2 Adducts of Manganese Porphyrins.

Tigran S Kurtikyan, Vardan A Hayrapetyan, Astghik A Hovhannisyan, Garik G Martirosyan, Gohar Sh Hovhannisyan, Alexei V Iretskii, Peter C Ford,

We describe here nitric oxide dioxygenation (NOD) by the dioxygen manganese porphyrin adducts Mn(Por)(η<sup>2</sup>-O<sub>2</sub>) (Por<sup>2-</sup> = the <i>meso</i>-tetra-phenyl or <i>meso</i>-tetra-<i>p</i>-tolylporphyrinato dianions, TPP<sup>2-</sup> and TTP<sup>2-</sup>). The Mn(Por)(η<sup>2</sup>-O<sub>2</sub>) was assembled by adding O<sub>2</sub> to sublimed layers of Mn<sup>II</sup>(Por). When NO was introduced and the temperature was slowly raised from 80 to 120 ... Read more >>

Inorg Chem (Inorganic chemistry)
[2020, 59(23):17224-17233]

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The solution chemistry of nitric oxide and other reactive nitrogen species.

Peter C Ford, Katrina M Miranda,

In this article we discuss the fundamental chemical and physical properties of NO and related nitrogen oxides (NO<sub>2</sub><sup>-</sup>, NO<sub>2</sub>, N<sub>2</sub>O<sub>3</sub>, etc.) under solution conditions relevant to mammalian biology. ... Read more >>

Nitric Oxide (Nitric oxide : biology and chemistry)
[2020, 103:31-46]

Cited: 2 times

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Chelating and Bridging Roles of 2-(2-Pyridyl)benzimidazole and Bis(diphenylphosphino)acetylene in Stabilizing a Cyclic Tetranuclear Platinum(II) Complex.

S Masoud Nabavizadeh, Fatemeh Niroomand Hosseini, Fatemeh Niknam, Peyman Hamidizadeh, S Jafar Hoseini, Peter C Ford, Mahdi M Abu-Omar,

The reaction of complex [Pt(Me)(DMSO)(pbz)], 1, (pbz = 2-(2-pyridyl)benzimidazolate) with [PtMe(Cl)(DMSO)2], B, followed by addition of bis(diphenylphosphino)acetylene (dppac), gave the novel tetranuclear platinum complex [Pt4Me4(μ-dppac)2(pbz)2Cl2], 2, bearing both the pbz and dppac ligands. In this structure, the pbz ligands are both chelating and bridging to stabilize the tetraplatinum framework. The ... Read more >>

Inorg Chem (Inorganic chemistry)
[2019, 58(21):14608-14616]

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Dynamics of Dinitrosyl Iron Complex (DNIC) Formation with Low Molecular Weight Thiols.

Daniela R Truzzi, Ohara Augusto, Alexei V Iretskii, Peter C Ford,

Dinitrosyl iron complexes (DNICs) are ubiquitous in mammalian cells and tissues producing nitric oxide (NO) and have been argued to play key physiological and pathological roles. Nonetheless, the mechanism and dynamics of DNIC formation in aqueous media remain only partially understood. Here, we report a stopped-flow kinetics and density functional ... Read more >>

Inorg Chem (Inorganic chemistry)
[2019, 58(19):13446-13456]

Cited: 1 time

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Near-Infrared and Visible Photoactivation to Uncage Carbon Monoxide from an Aqueous-Soluble PhotoCORM.

Qin Jiang, Yingzi Xia, Jacob Barrett, Alexander Mikhailovsky, Guang Wu, Daqi Wang, Pengfei Shi, Peter C Ford,

Multiphoton excitation allows one to access high energy excited states and perform valuable tasks in biological systems using tissue penetrating near-infrared (NIR) light. Here, we describe new photoactive manganese tricarbonyl complexes incorporating the ligand 4'-p-N,N-bis(2-hydroxyethyl)amino-benzyl-2,2':6',2″-terpyridine (TPYOH), which can serve as an antenna for two photon NIR excitation. Solutions of Mn(CO)<sub>3</sub>(TPYOH)X ... Read more >>

Inorg Chem (Inorganic chemistry)
[2019, 58(16):11066-11075]

Cited: 3 times

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Thiyl radicals are co-products of dinitrosyl iron complex (DNIC) formation.

Daniela R Truzzi, Ohara Augusto, Peter C Ford,

Thiyl radicals are detected by EPR as co-products of dinitrosyl iron complex (DNIC) formation. In demonstrating that DNIC formation generates RS˙ in a NO rich environment, these results provide a novel route for S-nitroso thiol formation. ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2019, 55(62):9156-9159]

Cited: 1 time

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Nitric Oxide Uncaging from a Hydrophobic Chromium(III) PhotoNORM: Visible and Near-Infrared Photochemistry in Biocompatible Polymer Disks.

Po-Ju Huang, John V Garcia, Aidan Fenwick, Guang Wu, Peter C Ford,

Devices consisting of polymer disks (PDs) of optically clear or translucent, medical-grade silicone loaded with a new hydrophobic, oxygen-stable, photoactivated nitric oxide-releasing moiety (photoNORM) are described. The photoNORM is the new <i>O</i>-nitrito chromium(III) complex <i>trans-</i>[Cr(PetA)(ONO)<sub>2</sub>](BF<sub>4</sub>) (PetA = 5,14-dimethyl-7,12-diphenyl-1,4,8,11-tetraaza-cyclotetradecane), of which the synthesis, X-ray crystal structure, and solution-phase photochemistry are described. ... Read more >>

ACS Omega (ACS omega)
[2019, 4(5):9181-9187]

Cited: 2 times

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Correction to Dinuclear PhotoCORMs: Dioxygen-Assisted Carbon Monoxide Uncaging from Long-Wavelength-Absorbing Metal-Metal-Bonded Carbonyl Complexes.

Zhi Li, Agustin E Pierri, Po-Ju Huang, Guang Wu, Alexei V Iretskii, Peter C Ford,

Inorg Chem (Inorganic chemistry)
[2018, 57(10):6191]

Cited: 0 times

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Six-Coordinate Nitrato Complexes of Iron Porphyrins with Trans S-Donor Ligands.

Tigran S Kurtikyan, Gurgen M Gulyan, Hayk S Minasyan, Astghik A Hovhannisyan, Peter C Ford,

The reaction of dimethyl sulfide (DMS) and tetrahydrothiophene (THT) with thin, amorphous layers of the nitrato complexes Fe(Por)(η2-O2NO) (Por = meso-tetraphenylporphyrinato dianion or meso-tetra- p-tolylporphyrinato dianion) at low temperature leads to formation of the corresponding six-coordinate complexes Fe(Por)(L)(η1-ONO2) (L = DMS, THT) as characterized by Fourier transform infrared and optical ... Read more >>

Inorg Chem (Inorganic chemistry)
[2018, 57(9):4795-4798]

Cited: 0 times

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Photoactivated in Vitro Anticancer Activity of Rhenium(I) Tricarbonyl Complexes Bearing Water-Soluble Phosphines.

Sierra C Marker, Samantha N MacMillan, Warren R Zipfel, Zhi Li, Peter C Ford, Justin J Wilson,

Fifteen water-soluble rhenium compounds of the general formula [Re(CO)<sub>3</sub>(NN)(PR<sub>3</sub>)]<sup>+</sup>, where NN is a diimine ligand and PR<sub>3</sub> is 1,3,5-triaza-7-phosphaadamantane (PTA), tris(hydroxymethyl)phosphine (THP), or 1,4-diacetyl-1,3,7-triaza-5-phosphabicylco[3.3.1]nonane (DAPTA), were synthesized and characterized by multinuclear NMR spectroscopy, IR spectroscopy, and X-ray crystallography. The complexes bearing the THP and DAPTA ligands exhibit triplet-based luminescence in ... Read more >>

Inorg Chem (Inorganic chemistry)
[2018, 57(3):1311-1331]

Cited: 20 times

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Correction to "A Luminescent and Biocompatible PhotoCORM".

Agustin E Pierri, Alessia Pallaoro, Guang Wu, Peter C Ford,

J Am Chem Soc (Journal of the American Chemical Society)
[2018, 140(1):525]

Cited: 1 time

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Biological Thiols and Carbon Disulfide: The Formation and Decay of Trithiocarbonates under Physiologically Relevant Conditions.

Maykon Lima Souza, Anthony W DeMartino, Peter C Ford,

Carbon disulfide is an environmental toxin, but there are suggestions in the literature that it may also have regulatory and/or therapeutic roles in mammalian physiology. Thiols or thiolates would be likely biological targets for an electrophile, such as CS<sub>2</sub>, and in this context, the present study examines the dynamics of ... Read more >>

ACS Omega (ACS omega)
[2017, 2(10):6535-6543]

Cited: 0 times

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Uncaging carbon disulfide. Delivery platforms for potential pharmacological applications: a mechanistic approach.

Anthony W DeMartino, Maykon Lima Souza, Peter C Ford,

We describe the kinetics of the formation and decay of a series of dithiocarbamates under physiological conditions. The goal is to provide a toolbox of compounds that release CS<sub>2</sub> by well-defined kinetics in such media. Carbon disulfide is a known environmental toxin, but there is fragmentary evidence suggesting that CS<sub>2</sub> ... Read more >>

Chem Sci (Chemical science)
[2017, 8(10):7186-7196]

Cited: 3 times

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Photochemical studies of cis-[Ru(bpy)2(4-bzpy)(CO)](PF6)2 and cis-[Ru(bpy)2(4-bzpy)(Cl)](PF6): Blue light-induced nucleobase binding.

Aurideia P de Sousa, Edinilton M Carvalho, Javier Ellena, Eduardo H S Sousa, Jackson R de Sousa, Luiz G F Lopes, Peter C Ford, Alda K M Holanda,

The ruthenium(II) compounds cis-[Ru(bpy)<sub>2</sub>(4-bzpy)(CO)](PF<sub>6</sub>)<sub>2</sub> (I) and cis-[Ru(bpy)<sub>2</sub>(4-bzpy)(Cl)](PF<sub>6</sub>) (II) (4-bzpy=4-benzoylpyridine, bpy=2,2'-bipyridine) were synthesized and characterized by spectroscopic and electrochemical techniques. The crystal structure of II was determined by X-ray diffraction. The photochemical behavior of I in aqueous solution shows that irradiation with ultraviolet light (365nm) releases both CO and 4-bzpy leading ... Read more >>

J Inorg Biochem (Journal of inorganic biochemistry)
[2017, 173:144-151]

Cited: 2 times

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Dinuclear PhotoCORMs: Dioxygen-Assisted Carbon Monoxide Uncaging from Long-Wavelength-Absorbing Metal-Metal-Bonded Carbonyl Complexes.

Zhi Li, Agustin E Pierri, Po-Ju Huang, Guang Wu, Alexei V Iretskii, Peter C Ford,

We describe a new strategy for triggering the photochemical release of caged carbon monoxide (CO) in aerobic media using long-wavelength visible and near-infrared (NIR) light. The dinuclear rhenium-manganese carbonyl complexes (CO)<sub>5</sub>ReMn(CO)<sub>3</sub>(L), where L = phenanthroline (1), bipyridine (2), biquinoline (3), or phenanthrolinecarboxaldehyde (4), each show a strong metal-metal-bond-to-ligand (σ<sub>MM</sub> → ... Read more >>

Inorg Chem (Inorganic chemistry)
[2017, 56(11):6094-6104]

Cited: 8 times

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Carbon disulfide. Just toxic or also bioregulatory and/or therapeutic?

Anthony W DeMartino, David F Zigler, Jon M Fukuto, Peter C Ford,

The overview presented here has the goal of examining whether carbon disulfide (CS<sub>2</sub>) may play a role as an endogenously generated bioregulator and/or has therapeutic value. The neuro- and reproductive system toxicity of CS<sub>2</sub> has been documented from its long-term use in the viscose rayon industry. CS<sub>2</sub> is also used ... Read more >>

Chem Soc Rev (Chemical Society reviews)
[2017, 46(1):21-39]

Cited: 14 times

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Six-Coordinate Ferrous Nitrosyl Complex FeII(TTP)(PMe3)(NO) (TTP = meso-Tetra-p-tolylporphyrinato Dianion).

Tigran S Kurtikyan, Astghik A Hovhannisyan, Peter C Ford,

Low-temperature in situ Fourier transform infrared and UV-vis measurements show that trimethylphosphine (PMe<sub>3</sub>) reacts with microporous layers of Fe<sup>II</sup>(TTP)(NO) (TTP = meso-tetra-p-tolylporphyrinato dianion; NO = nitric oxide) to form the previously unknown six-coordinate complex Fe<sup>II</sup>(TTP)(PMe<sub>3</sub>)(NO). Upon warming this compound to room temperature in the presence of excess phosphine, the NO ... Read more >>

Inorg Chem (Inorganic chemistry)
[2016, 55(19):9517-9520]

Cited: 0 times

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From curiosity to applications. A personal perspective on inorganic photochemistry.

Peter C Ford,

Over the past several decades, the photochemistry and photophysics of transition metal compounds has blossomed from a relatively niche topic to a major research theme. Applications arising from the elucidation of the fundamental principles defining this field now range from probing the rates and mechanisms of small molecules with metalloproteins ... Read more >>

Chem Sci (Chemical science)
[2016, 7(5):2964-2986]

Cited: 2 times

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Near-IR mediated intracellular uncaging of NO from cell targeted hollow gold nanoparticles.

Elizabeth S Levy, Demosthenes P Morales, John V Garcia, Norbert O Reich, Peter C Ford,

We demonstrate modulation of nitric oxide release in solution and in human prostate cancer cells from a thiol functionalized cupferron (TCF) absorbed on hollow gold nanoshells (HGNs) using near-infrared (NIR) light. NO release from the TCF-HGN conjugates occurs through localized surface heating due to NIR excitation of the surface plasmon. ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2015, 51(100):17692-17695]

Cited: 3 times

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Syntheses and properties of phosphine-substituted ruthenium(II) polypyridine complexes with nitrogen oxides.

Go Nakamura, Mio Kondo, Meredith Crisalli, Sze Koon Lee, Akane Shibata, Peter C Ford, Shigeyuki Masaoka,

Four novel phosphine-substituted ruthenium(ii) polypyridine complexes with nitrogen oxides-trans(P,NO2)-[Ru(trpy)(Pqn)(NO2)]PF6 (trans-NO2), cis(P,NO2)-[Ru(trpy)(Pqn)(NO2)]PF6 (cis-NO2), [Ru(trpy)(dppbz)(NO2)]PF6 (PP-NO2), and cis(P,NO)-[Ru(trpy)(Pqn)(NO)](PF6)3 (cis-NO)-were synthesised (trpy = 2,2':6',2''-terpyridine, Pqn = 8-(diphenylphosphanyl)quinoline, and dppbz = 1,2-bis(diphenylphosphanyl)benzene). The influence of the number and position of the phosphine group(s) on the electronic structure of these complexes was investigated using single-crystal ... Read more >>

Dalton Trans (Dalton transactions (Cambridge, England : 2003))
[2015, 44(39):17189-17200]

Cited: 2 times

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Photoreactivity of a quantum dot-ruthenium nitrosyl conjugate.

Lilian Pereira Franco, Simone Aparecida Cicillini, Juliana Cristina Biazzotto, Marco A Schiavon, Alexander Mikhailovsky, Peter Burks, John Garcia, Peter C Ford, Roberto Santana da Silva,

We describe the use of cadmium telluride quantum dots (CdTe QDs) as antennas for the photosensitization of nitric oxide release from a ruthenium nitrosyl complex with visible light excitation. The CdTe QDs were capped with mercaptopropionic acid to make them water-soluble, and the ruthenium nitrosyl complex was cis-[Ru(NO)(4-ampy)(bpy)2](3+) (Ru-NO; bpy ... Read more >>

J Phys Chem A (The journal of physical chemistry. A)
[2014, 118(51):12184-12191]

Cited: 6 times

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Dinitrosyl iron complexes with cysteine. Kinetics studies of the formation and reactions of DNICs in aqueous solution.

José Clayston Melo Pereira, Alexei V Iretskii, Rui-Min Han, Peter C Ford,

Kinetics studies provide mechanistic insight regarding the formation of dinitrosyl iron complexes (DNICs) now viewed as playing important roles in the mammalian chemical biology of the ubiquitous bioregulator nitric oxide (NO). Reactions in deaerated aqueous solutions containing FeSO4, cysteine (CysSH), and NO demonstrate that both the rates and the outcomes ... Read more >>

J Am Chem Soc (Journal of the American Chemical Society)
[2015, 137(1):328-336]

Cited: 13 times

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A photoCORM nanocarrier for CO release using NIR light.

Agustin E Pierri, Po-Ju Huang, John V Garcia, James G Stanfill, Megan Chui, Guang Wu, Nanfeng Zheng, Peter C Ford,

A water-soluble nanocarrier for a photo-activated CO releasing moiety (photoCORM) that can be triggered with NIR excitation is described. This has an upconversion nanoparticle core encapsulated by an amphiphilic polymer imparting both water solubility and a hydrophobic interior containing the photoCORM trans-Mn(bpy)(PPh3)2(CO)2. Such an ensemble offers a unique strategy for ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2015, 51(11):2072-2075]

Cited: 41 times

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Catalytic conversion of nonfood woody biomass solids to organic liquids.

Katalin Barta, Peter C Ford,

This Account outlines recent efforts in our laboratories addressing a fundamental challenge of sustainability chemistry, the effective utilization of biomass for production of chemicals and fuels. Efficient methods for converting renewable biomass solids to chemicals and liquid fuels would reduce society's dependence on nonrenewable petroleum resources while easing the atmospheric ... Read more >>

Acc Chem Res (Accounts of chemical research)
[2014, 47(5):1503-1512]

Cited: 47 times

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