Full Text Journal Articles by
Author Peter Ahnert


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A biomathematical model of immune response and barrier function in mice with pneumococcal lung infection.

Sibylle Schirm, Peter Ahnert, Sarah Berger, Geraldine Nouailles, Sandra-Maria Wienhold, Holger Müller-Redetzky, Norbert Suttorp, Markus Loeffler, Martin Witzenrath, Markus Scholz,

Pneumonia is one of the leading causes of death worldwide. The course of the disease is often highly dynamic with unforeseen critical deterioration within hours in a relevant proportion of patients. Besides antibiotic treatment, novel adjunctive therapies are under development. Their additive value needs to be explored in preclinical and ... Read more >>

PLoS One (PloS one)
[2020, 15(12):e0243147]

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Identification of New, Functionally Relevant Mutations in the Coding Regions of the Human Fos and Jun Proto-Oncogenes in Rheumatoid Arthritis Synovial Tissue.

René Huber, Sandra Augsten, Holger Kirsten, Roland Zell, Axel Stelzner, Hansjörg Thude, Thorsten Eidner, Bruno Stuhlmüller, Peter Ahnert, Raimund W Kinne,

In rheumatoid arthritis (RA), the expression of many pro-destructive/pro-inflammatory proteins depends on the transcription factor AP-1. Therefore, our aim was to analyze the presence and functional relevance of mutations in the coding regions of the AP-1 subunits of the fos and jun family in peripheral blood (PB) and synovial membranes ... Read more >>

Life (Basel) (Life (Basel, Switzerland))
[2020, 11(1):]

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Dynamics of cytokines, immune cell counts and disease severity in patients with community-acquired pneumonia - Unravelling potential causal relationships.

Maciej Rosolowski, Volker Oberle, Peter Ahnert, Petra Creutz, Martin Witzenrath, Michael Kiehntopf, Markus Loeffler, Norbert Suttorp, Markus Scholz,

<h4>Background</h4>Community acquired pneumonia (CAP) is a severe and often rapidly deteriorating disease. To better understand its dynamics and potential causal relationships, we analyzed time series data of cytokines, blood and clinical parameters in hospitalized CAP patients.<h4>Methods</h4>Time series data of 10 circulating cytokines, blood counts and clinical parameters were related to ... Read more >>

Cytokine (Cytokine)
[2020, 136:155263]

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Molecular analyses of glioblastoma stem-like cells and glioblastoma tissue.

Marco Wallenborn, Li-Xin Xu, Holger Kirsten, Leili Rohani, Daniela Rudolf, Peter Ahnert, Christian Schmidt, Ronny M Schulz, Mandy Richter, Wolfgang Krupp, Wolf Mueller, Adiv A Johnson, Jürgen Meixensberger, Heidrun Holland,

Glioblastoma is a common, malignant brain tumor whose disease incidence increases with age. Glioblastoma stem-like cells (GSCs) are thought to contribute to cancer therapy resistance and to be responsible for tumor initiation, maintenance, and recurrence. This study utilizes both SNP array and gene expression profiling to better understand GSCs and ... Read more >>

PLoS One (PloS one)
[2020, 15(7):e0234986]

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[Self-reported infections in the German National Cohort (GNC) in the context of the current research landscape].

Max J Hassenstein, Ghazal Aarabi, Peter Ahnert, Heiko Becher, Claus-Werner Franzke, Julia Fricke, Gérard Krause, Stephan Glöckner, Cornelia Gottschick, André Karch, Yvonne Kemmling, Tobias Kerrinnes, Berit Lange, Rafael Mikolajczyk, Alexandra Nieters, Jördis J Ott, Wolfgang Ahrens, Klaus Berger, Claudia Meinke-Franze, Sylvia Gastell, Kathrin Günther, Karin Halina Greiser, Bernd Holleczek, Johannes Horn, Lina Jaeschke, Annika Jagodzinski, Lina Jansen, Carmen Jochem, Karl-Heinz Jöckel, Rudolf Kaaks, Lilian Krist, Oliver Kuß, Susan Langer, Nicole Legath, Michael Leitzmann, Wolfgang Lieb, Markus Loeffler, Nina Mangold, Karin B Michels, Christa Meisinger, Nadia Obi, Tobias Pischon, Tamara Schikowski, Sabine Schipf, Matthias B Schulze, Andreas Stang, Sabina Waniek, Kerstin Wirkner, Stefan N Willich, Stefanie Castell,

<h4>Background</h4>Infectious diseases continue to play an important role for disease perception, health-economic considerations and public health in Germany. In recent years, infectious diseases have been linked to the development of non-communicable diseases. Analyses of the German National Cohort (GNC) may provide deeper insights into this issue and pave the way ... Read more >>

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz (Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz)
[2020, 63(4):404-414]

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Neutralizing Complement C5a Protects Mice with Pneumococcal Pulmonary Sepsis.

Holger Müller-Redetzky, Ute Kellermann, Sandra-Maria Wienhold, Birgitt Gutbier, Jasmin Lienau, Katharina Hellwig, Katrin Reppe, Eleftheria Letsiou, Thomas Tschernig, Markus Scholz, Peter Ahnert, Christian Maasch, Kai Hoehlig, Sven Klussmann, Axel Vater, Theresa C Firsching, Judith Hoppe, Norbert Suttorp, Martin Witzenrath,

BACKGROUND:Community-acquired pneumonia and associated sepsis cause high mortality despite antibiotic treatment. Uncontrolled inflammatory host responses contribute to the unfavorable outcome by driving lung and extrapulmonary organ failure. The complement fragment C5a holds significant proinflammatory functions and is associated with tissue damage in various inflammatory conditions. The authors hypothesized that C5a ... Read more >>

Anesthesiology (Anesthesiology)
[2020, 132(4):795-807]

Cited: 2 times

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HLA Class II Allele Analyses Implicate Common Genetic Components in Type 1 and Non-Insulin-Treated Type 2 Diabetes.

Thomas Jacobi, Lucas Massier, Nora Klöting, Katrin Horn, Alexander Schuch, Peter Ahnert, Christoph Engel, Markus Löffler, Ralph Burkhardt, Joachim Thiery, Anke Tönjes, Michael Stumvoll, Matthias Blüher, Ilias Doxiadis, Markus Scholz, Peter Kovacs,

CONTEXT:Common genetic susceptibility may underlie the frequently observed co-occurrence of type 1 and type 2 diabetes in families. Given the role of HLA class II genes in the pathophysiology of type 1 diabetes, the aim of the present study was to test the association of high density imputed human leukocyte ... Read more >>

J Clin Endocrinol Metab (The Journal of clinical endocrinology and metabolism)
[2020, 105(3):]

Cited: 1 time

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Markov State Modelling of Disease Courses and Mortality Risks of Patients with Community-Acquired Pneumonia.

Jens Przybilla, Peter Ahnert, Holger Bogatsch, Frank Bloos, Frank M Brunkhorst, SepNet Critical Care Trials Group, Progress Study Group, Michael Bauer, Markus Loeffler, Martin Witzenrath, Norbert Suttorp, Markus Scholz,

Community-acquired pneumonia (CAP) is one of the most frequent infectious diseases worldwide, with high lethality. Risk evaluation is well established at hospital admission, and re-evaluation is advised for patients at higher risk. However, severe disease courses may develop from all levels of severity. We propose a stochastic continuous-time Markov model ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(2):]

Cited: 0 times

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Association of proteome and metabolome signatures with severity in patients with community-acquired pneumonia.

Manuela Gesell Salazar, Sophie Neugebauer, Tim Kacprowski, Stephan Michalik, Peter Ahnert, Petra Creutz, Maciej Rosolowski, , Markus Löffler, Michael Bauer, Norbert Suttorp, Michael Kiehntopf, Uwe Völker,

A combined OMICS screening approach of human plasma and serum was used to characterize protein and metabolome signatures displaying association to severity of Community-acquired pneumonia (CAP). 240 serum and BD P100 EDTA plasma samples from patients diagnosed with CAP, collected during the day of enrolment to the hospital, were analyzed ... Read more >>

J Proteomics (Journal of proteomics)
[2020, 214:103627]

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Copy number variants in lipid metabolism genes are associated with gallstones disease in men.

Eduardo Pérez-Palma, Bernabé I Bustos, Dennis Lal, Stephan Buch, Lorena Azocar, Mohammad Reza Toliat, Wolfgang Lieb, Andre Franke, Sebastian Hinz, Greta Burmeister, Witigo von Shönfels, Clemens Schafmayer, Peter Ahnert, Henry Völzke, Uwe Völker, Georg Homuth, Markus M Lerch, Klaus Puschel, Rodrigo A Gutiérrez, Jochen Hampe, Peter Nürnberg, Juan Francisco Miquel, Giancarlo V De Ferrari,

Gallstones Disease (GSD) is one of the most common digestive diseases requiring hospitalization and surgical procedures in the world. GSD has a high prevalence in populations with European or Amerindian ancestry (10-20%) and the influence of genetic factors is broadly acknowledged. However, known genetic variants do not entirely explain the ... Read more >>

Eur J Hum Genet (European journal of human genetics : EJHG)
[2020, 28(2):264-273]

Cited: 0 times

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Sequential organ failure assessment score is an excellent operationalization of disease severity of adult patients with hospitalized community acquired pneumonia - results from the prospective observational PROGRESS study.

Peter Ahnert, Petra Creutz, Katrin Horn, Fabian Schwarzenberger, Michael Kiehntopf, Hamid Hossain, Michael Bauer, Frank Martin Brunkhorst, Konrad Reinhart, Uwe Völker, Trinad Chakraborty, Martin Witzenrath, Markus Löffler, Norbert Suttorp, Markus Scholz, ,

<h4>Background</h4>CAP (Community acquired pneumonia) is frequent, with a high mortality rate and a high burden on health care systems. Development of predictive biomarkers, new therapeutic concepts, and epidemiologic research require a valid, reproducible, and quantitative measure describing CAP severity.<h4>Methods</h4>Using time series data of 1532 patients enrolled in the PROGRESS study, ... Read more >>

Crit Care (Critical care (London, England))
[2019, 23(1):110]

Cited: 4 times

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Central neurocytoma: SNP array analyses, subtel FISH, and review of the literature.

Caroline Sander, Marco Wallenborn, Vivian Pascal Brandt, Peter Ahnert, Vera Reuschel, Christan Eisenlöffel, Wolfgang Krupp, Jürgen Meixensberger, Heidrun Holland,

The central neurocytoma (CN) is a rare brain tumor with a frequency of 0.1-0.5% of all brain tumors. According to the World Health Organization classification, it is a benign grade II tumor with good prognosis. However, some CN occur as histologically "atypical" variant, combined with increasing proliferation and poor clinical ... Read more >>

Pathol Res Pract (Pathology, research and practice)
[2019, 215(7):152397]

Cited: 1 time

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Association of Human FOS Promoter Variants with the Occurrence of Knee-Osteoarthritis in a Case Control Association Study.

René Huber, Holger Kirsten, Annu Näkki, Dirk Pohlers, Hansjörg Thude, Thorsten Eidner, Matthias Heinig, Korbinian Brand, Peter Ahnert, Raimund W Kinne,

Our aim was to analyse (i) the presence of single nucleotide polymorphisms (SNPs) in the <i>JUN</i> and <i>FOS</i> core promoters in patients with rheumatoid arthritis (RA), knee-osteoarthritis (OA), and normal controls (NC); (ii) their functional influence on <i>JUN</i>/<i>FOS</i> transcription levels; and (iii) their associations with the occurrence of RA or ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2019, 20(6):]

Cited: 2 times

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Attenuated PDGF signaling drives alveolar and microvascular defects in neonatal chronic lung disease.

Prajakta Oak, Tina Pritzke, Isabella Thiel, Markus Koschlig, Daphne S Mous, Anita Windhorst, Noopur Jain, Oliver Eickelberg, Kai Foerster, Andreas Schulze, Wolfgang Goepel, Tobias Reicherzer, Harald Ehrhardt, Robbert J Rottier, Peter Ahnert, Ludwig Gortner, Tushar J Desai, Anne Hilgendorff,

Neonatal chronic lung disease (nCLD) affects a significant number of neonates receiving mechanical ventilation with oxygen-rich gas (MV-O<sub>2</sub>). Regardless, the primary molecular driver of the disease remains elusive. We discover significant enrichment for SNPs in the PDGF-Rα gene in preterms with nCLD and directly test the effect of PDGF-Rα haploinsufficiency ... Read more >>

EMBO Mol Med (EMBO molecular medicine)
[2017, 9(11):1504-1520]

Cited: 6 times

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Comparing performance of modern genotype imputation methods in different ethnicities.

Nab Raj Roshyara, Katrin Horn, Holger Kirsten, Peter Ahnert, Markus Scholz,

A variety of modern software packages are available for genotype imputation relying on advanced concepts such as pre-phasing of the target dataset or utilization of admixed reference panels. In this study, we performed a comprehensive evaluation of the accuracy of modern imputation methods on the basis of the publicly available ... Read more >>

Sci Rep (Scientific reports)
[2016, 6:34386]

Cited: 12 times

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Body surface assessment with 3D laser-based anthropometry: reliability, validation, and improvement of empirical surface formulae.

Andreas Kuehnapfel, Peter Ahnert, Markus Loeffler, Markus Scholz,

<h4>Purpose</h4>Body surface area is a physiological quantity relevant for many medical applications. In clinical practice, it is determined by empirical formulae. 3D laser-based anthropometry provides an easy and effective way to measure body surface area but is not ubiquitously available. We used data from laser-based anthropometry from a population-based study ... Read more >>

Eur J Appl Physiol (European journal of applied physiology)
[2017, 117(2):371-380]

Cited: 1 time

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PROGRESS - prospective observational study on hospitalized community acquired pneumonia.

Peter Ahnert, Petra Creutz, Markus Scholz, Hartwig Schütte, Christoph Engel, Hamid Hossain, Trinad Chakraborty, Michael Bauer, Michael Kiehntopf, Uwe Völker, Sven Hammerschmidt, Markus Loeffler, Norbert Suttorp, ,

<h4>Background</h4>Community acquired pneumonia (CAP) is a high incidence disease resulting in about 260,000 hospital admissions per year in Germany, more than myocardial infarction or stroke. Worldwide, CAP is the most frequent infectious disease with high lethality ranging from 1.2 % in those 20-29 years old to over 10 % in patients older ... Read more >>

BMC Pulm Med (BMC pulmonary medicine)
[2016, 16(1):108]

Cited: 4 times

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Novel Anthropometry Based on 3D-Bodyscans Applied to a Large Population Based Cohort.

Henry Löffler-Wirth, Edith Willscher, Peter Ahnert, Kerstin Wirkner, Christoph Engel, Markus Loeffler, Hans Binder,

Three-dimensional (3D) whole body scanners are increasingly used as precise measuring tools for the rapid quantification of anthropometric measures in epidemiological studies. We analyzed 3D whole body scanning data of nearly 10,000 participants of a cohort collected from the adult population of Leipzig, one of the largest cities in Eastern ... Read more >>

PLoS One (PloS one)
[2016, 11(7):e0159887]

Cited: 17 times

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Association, characterisation and meta-analysis of SNPs linked to general reading ability in a German dyslexia case-control cohort.

Bent Müller, Arndt Wilcke, Ivonne Czepezauer, Peter Ahnert, Johannes Boltze, Holger Kirsten, ,

Dyslexia is a severe disorder in the acquisition of reading and writing. Several studies investigated the role of genetics for reading, writing and spelling ability in the general population. However, many of the identified SNPs were not analysed in case-control cohorts. Here, we investigated SNPs previously linked to reading or ... Read more >>

Sci Rep (Scientific reports)
[2016, 6:27901]

Cited: 7 times

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Reliability of 3D laser-based anthropometry and comparison with classical anthropometry.

Andreas Kuehnapfel, Peter Ahnert, Markus Loeffler, Anja Broda, Markus Scholz,

Anthropometric quantities are widely used in epidemiologic research as possible confounders, risk factors, or outcomes. 3D laser-based body scans (BS) allow evaluation of dozens of quantities in short time with minimal physical contact between observers and probands. The aim of this study was to compare BS with classical manual anthropometric ... Read more >>

Sci Rep (Scientific reports)
[2016, 6:26672]

Cited: 13 times

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A Biomathematical Model of Pneumococcal Lung Infection and Antibiotic Treatment in Mice.

Sibylle Schirm, Peter Ahnert, Sandra Wienhold, Holger Mueller-Redetzky, Geraldine Nouailles-Kursar, Markus Loeffler, Martin Witzenrath, Markus Scholz,

Pneumonia is considered to be one of the leading causes of death worldwide. The outcome depends on both, proper antibiotic treatment and the effectivity of the immune response of the host. However, due to the complexity of the immunologic cascade initiated during infection, the latter cannot be predicted easily. We ... Read more >>

PLoS One (PloS one)
[2016, 11(5):e0156047]

Cited: 5 times

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The LIFE-Adult-Study: objectives and design of a population-based cohort study with 10,000 deeply phenotyped adults in Germany.

Markus Loeffler, Christoph Engel, Peter Ahnert, Dorothee Alfermann, Katrin Arelin, Ronny Baber, Frank Beutner, Hans Binder, Elmar Brähler, Ralph Burkhardt, Uta Ceglarek, Cornelia Enzenbach, Michael Fuchs, Heide Glaesmer, Friederike Girlich, Andreas Hagendorff, Madlen Häntzsch, Ulrich Hegerl, Sylvia Henger, Tilman Hensch, Andreas Hinz, Volker Holzendorf, Daniela Husser, Anette Kersting, Alexander Kiel, Toralf Kirsten, Jürgen Kratzsch, Knut Krohn, Tobias Luck, Susanne Melzer, Jeffrey Netto, Matthias Nüchter, Matthias Raschpichler, Franziska G Rauscher, Steffi G Riedel-Heller, Christian Sander, Markus Scholz, Peter Schönknecht, Matthias L Schroeter, Jan-Christoph Simon, Ronald Speer, Julia Stäker, Robert Stein, Yve Stöbel-Richter, Michael Stumvoll, Attila Tarnok, Andrej Teren, Daniel Teupser, Francisca S Then, Anke Tönjes, Regina Treudler, Arno Villringer, Alexander Weissgerber, Peter Wiedemann, Silke Zachariae, Kerstin Wirkner, Joachim Thiery,

<h4>Background</h4>The LIFE-Adult-Study is a population-based cohort study, which has recently completed the baseline examination of 10,000 randomly selected participants from Leipzig, a major city with 550,000 inhabitants in the east of Germany. It is the first study of this kind and size in an urban population in the eastern part ... Read more >>

BMC Public Health (BMC public health)
[2015, 15:691]

Cited: 89 times

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The role of HPV RNA transcription, immune response-related gene expression and disruptive TP53 mutations in diagnostic and prognostic profiling of head and neck cancer.

Gunnar Wichmann, Maciej Rosolowski, Knut Krohn, Markus Kreuz, Andreas Boehm, Anett Reiche, Ulrike Scharrer, Dirk Halama, Julia Bertolini, Ulrike Bauer, Dana Holzinger, Michael Pawlita, Jochen Hess, Christoph Engel, Dirk Hasenclever, Markus Scholz, Peter Ahnert, Holger Kirsten, Alexander Hemprich, Christian Wittekind, Olf Herbarth, Friedemann Horn, Andreas Dietz, Markus Loeffler, ,

Stratification of head and neck squamous cell carcinomas (HNSCC) based on HPV16 DNA and RNA status, gene expression patterns, and mutated candidate genes may facilitate patient treatment decision. We characterize head and neck squamous cell carcinomas (HNSCC) with different HPV16 DNA and RNA (E6*I) status from 290 consecutively recruited patients ... Read more >>

Int J Cancer (International journal of cancer)
[2015, 137(12):2846-2857]

Cited: 53 times

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Dissecting the genetics of the human transcriptome identifies novel trait-related trans-eQTLs and corroborates the regulatory relevance of non-protein coding loci†.

Holger Kirsten, Hoor Al-Hasani, Lesca Holdt, Arnd Gross, Frank Beutner, Knut Krohn, Katrin Horn, Peter Ahnert, Ralph Burkhardt, Kristin Reiche, Jörg Hackermüller, Markus Löffler, Daniel Teupser, Joachim Thiery, Markus Scholz,

Genetics of gene expression (eQTLs or expression QTLs) has proved an indispensable tool for understanding biological pathways and pathomechanisms of trait-associated SNPs. However, power of most genome-wide eQTL studies is still limited. We performed a large eQTL study in peripheral blood mononuclear cells of 2112 individuals increasing the power to ... Read more >>

Hum Mol Genet (Human molecular genetics)
[2015, 24(16):4746-4763]

Cited: 37 times

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Three gangliogliomas: results of GTG-banding, SKY, genome-wide high resolution SNP-array, gene expression and review of the literature.

Li-Xin Xu, Heidrun Holland, Holger Kirsten, Peter Ahnert, Wolfgang Krupp, Manfred Bauer, Ralf Schober, Wolf Mueller, Dominik Fritzsch, Jürgen Meixensberger, Ronald Koschny,

According to the World Health Organization gangliogliomas are classified as well-differentiated and slowly growing neuroepithelial tumors, composed of neoplastic mature ganglion and glial cells. It is the most frequent tumor entity observed in patients with long-term epilepsy. Comprehensive cytogenetic and molecular cytogenetic data including high-resolution genomic profiling (single nucleotide polymorphism ... Read more >>

Neuropathology (Neuropathology : official journal of the Japanese Society of Neuropathology)
[2015, 35(2):148-157]

Cited: 2 times

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