Full Text Journal Articles by
Author Perihan A Elzahhar

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Challenging inflammatory process at molecular, cellular and in vivo levels via some new pyrazolyl thiazolones.

Perihan A Elzahhar, Rana A Alaaeddine, Rasha Nassra, Azza Ismail, Hala F Labib, Mohamed G Temraz, Ahmed S F Belal, Ahmed F El-Yazbi,

The work reported herein describes the synthesis of a new series of anti-inflammatory pyrazolyl thiazolones. In addition to COX-2/15-LOX inhibition, these hybrids exerted their anti-inflammatory actions through novel mechanisms. The most active compounds possessed COX-2 inhibitory activities comparable to celecoxib (IC<sub>50</sub> values of 0.09-0.14 µM) with significant 15-LOX inhibitory activities (IC<sub>50</sub>s ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2021, 36(1):669-684]

Cited: 0 times

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The Emerging Role of COX-2, 15-LOX and PPARγ in Metabolic Diseases and Cancer: An Introduction to Novel Multi-target Directed Ligands (MTDLs).

Rana A Alaaeddine, Perihan A Elzahhar, Ibrahim AlZaim, Wassim Abou-Kheir, Ahmed S F Belal, Ahmed F El-Yazbi,

Emerging evidence supports an intertwining framework for the involvement of different inflammatory pathways in a common pathological background for a number of disorders. Of importance are pathways involving arachidonic acid metabolism by cyclooxygenase-2 (COX-2) and 15-lipoxygenase (15-LOX). Both enzyme activities and their products are implicated in a range of pathophysiological ... Read more >>

Curr Med Chem (Current medicinal chemistry)
[2021, 28(11):2260-2300]

Cited: 2 times

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Expanding the anticancer potential of 1,2,3-triazoles via simultaneously targeting Cyclooxygenase-2, 15-lipoxygenase and tumor-associated carbonic anhydrases.

Perihan A Elzahhar, Shrouk M Abd El Wahab, Mohamed Elagawany, Hoda Daabees, Ahmed S F Belal, Ahmed F El-Yazbi, Ali H Eid, Rana Alaaeddine, Rehab R Hegazy, Rasha M Allam, Maged W Helmy, Bahaa Elgendy, Andrea Angeli, Soad A El-Hawash, Claudiu T Supuran,

Cancer is a multifactorial disorder involving multiplicity of interrelated signaling pathways and molecular targets. To that end, a multi-target design strategy was adopted to develop some 1,2,3-triazoles hybridized with some pharmacophoric anticancer fragments, as first-in-class simultaneous inhibitors of COX-2, 15-LOX and tumor associated carbonic anhydrase enzymes. Results revealed that compounds ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2020, 200:112439]

Cited: 3 times

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Novel pyrazine based anti-tubercular agents: Design, synthesis, biological evaluation and in silico studies.

Nayera W Hassan, Manal N Saudi, Yasser S Abdel-Ghany, Azza Ismail, Perihan A Elzahhar, Dharmarajan Sriram, Rasha Nassra, Marwa M Abdel-Aziz, Soad A El-Hawash,

TB continues to be a leading health threat despite the availability of powerful anti-TB drugs. We report herein the design and synthesis of various hybrid molecules comprising pyrazine scaffold and various formerly identified anti-mycobacterial moieties. Thirty-one compounds were screened in vitro for their activity against Mycobacterium tuberculosis H37Rv strain using ... Read more >>

Bioorg Chem (Bioorganic chemistry)
[2020, 96:103610]

Cited: 3 times

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Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase.

Ehab D AlFadly, Perihan A Elzahhar, Anna Tramarin, Salwa Elkazaz, Hossam Shaltout, Marwa M Abu-Serie, Jana Janockova, Ondrej Soukup, Doaa A Ghareeb, Ahmed F El-Yazbi, Rim W Rafeh, Nour-Mounira Z Bakkar, Firas Kobeissy, Isabel Iriepa, Ignacio Moraleda, Manal N S Saudi, Manuela Bartolini, Ahmed S F Belal,

Neuroinflammation and cholinergic deficit are key detrimental processes involved in Alzheimer's disease. Hence, in the search for novel and effective treatment strategies, the multi-target-directed ligand paradigm was applied to the rational design of two series of new hybrids endowed with anti-inflammatory and anticholinesterase activity via triple targeting properties, namely able ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2019, 167:161-186]

Cited: 7 times

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Shooting three inflammatory targets with a single bullet: Novel multi-targeting anti-inflammatory glitazones.

Perihan A Elzahhar, Rana Alaaeddine, Tamer M Ibrahim, Rasha Nassra, Azza Ismail, Benjamin S K Chua, Rebecca L Frkic, John B Bruning, Nadja Wallner, Tilo Knape, Andreas von Knethen, Hala Labib, Ahmed F El-Yazbi, Ahmed S F Belal,

In search for effective multi-targeting drug ligands (MTDLs) to address low-grade inflammatory changes of metabolic disorders, we rationally designed some novel glitazones-like compounds. This was achieved by incorporating prominent pharmacophoric motifs from previously reported COX-2, 15-LOX and PPARγ ligands. Challenging our design with pre-synthetic docking experiments on PPARγ showed encouraging ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2019, 167:562-582]

Cited: 6 times

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Anti-leishmanial click modifiable thiosemicarbazones: Design, synthesis, biological evaluation and in silico studies.

Mohamed G Temraz, Perihan A Elzahhar, Alaa El-Din A Bekhit, Adnan A Bekhit, Hala F Labib, Ahmed S F Belal,

Leishmaniasis is a devastating tropical disease with limited therapeutic options. Depending on recently reported active anti-leishmanial compounds, we designed and synthesized a series of click modifiable 1,2,3-triazole and thiosemicarbazone hybrids. Most of the synthesized compounds showed comparable to superior activity to a well-established anti-leishmanial drug miltefosine. Compounds 2 and 10a ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2018, 151:585-600]

Cited: 6 times

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Design and synthesis of some new 2,3'-bipyridine-5-carbonitriles as potential anti-inflammatory/antimicrobial agents.

Perihan A Elzahhar, Salwa Elkazaz, Raafat Soliman, Alaa A El-Tombary, Hossam A Shaltout, Ibrahim M El-Ashmawy, Abeer E Abdel Wahab, Soad A El-Hawash,

<h4>Aim</h4>Inflammation may cause accumulation of fluid in the injured area, which may promote bacterial growth. Other reports disclosed that non-steroidal anti-inflammatory drugs may enhance progression of bacterial infection.<h4>Results</h4>This work describes synthesis of new series of 2,3'-bipyridine-5-carbonitriles as structural analogs of etoricoxib, linked at position-6 to variously substituted thio or oxo ... Read more >>

Future Med Chem (Future medicinal chemistry)
[2017, 9(12):1413-1450]

Cited: 1 time

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Design, synthesis and antimicrobial evaluation of methyl pyridyl-2,4- dioxobutanoates and some new derived ring systems.

Perihan A S Elzahhar, Raafat Soliman, Soad A M El-Hawash, Hanan M A Ragab, Amal M Youssef, Abeer E Abdel Wahab,

This work describes the synthesis of new series of compounds derived from methyl pyridyl- 2,4-dioxobutanoates that contain pyridine ring attached to substituted bioactive heterocyclic moieties in order to investigate their preliminary in vitro antibacterial and antifungal activities. The results revealed that most of the tested compounds exhibited significant activity against ... Read more >>

Med Chem (Medicinal chemistry (Shariqah (United Arab Emirates)))
[2015, 11(4):407-414]

Cited: 1 time

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Design, synthesis and biological screening of some pyridinylpyrazole and pyridinylisoxazole derivatives as potential anti-inflammatory, analgesic, antipyretic and antimicrobial agents.

Soad A M El-Hawash, Raafat Soliman, Amal M Youssef, Hanan M A Ragab, Perihan A S Elzahhar, Ibrahim M El-Ashmawey, Abeer E Abdel Wahab, Iman A Shaat,

A series of substituted pyridinylpyrazole (or isoxazole) derivatives were synthesized and evaluated for their anti-inflammatory (AI) activity using formalin-induced paw edema bioassays. Their inhibitory activities of cyclooxygenase-1 and cyclooxygenase-2 (COX-1 and COX-2) were also determined. The analgesic activity of the same compounds was evaluated using rat-tail withdrawal technique. Their antipyretic ... Read more >>

Med Chem (Medicinal chemistry (Shariqah (United Arab Emirates)))
[2014, 10(3):318-338]

Cited: 2 times

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