Full Text Journal Articles by
Author Per L Poulsen

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Esben Laugesen, Per L Poulsen,

J Hypertens (Journal of hypertension)
[2021, 39(5):1047-1048]

Cited: 0 times

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Invasive aortic pulse pressure is not superior to cuff pulse pressure in cardiovascular risk prediction.

Esben Laugesen, Søren T Knudsen, Klavs W Hansen, Niklas B Rossen, Lisette Okkels Jensen, Michael S Hansen, Lone K Andersen, Kristian K Thomsen, Hanne Søndergaard, Morten Böttcher, Bent Raungaard, Kevin K W Olesen, Michael Mæng, Hans Erik Bøtker, Per L Poulsen,

<h4>Objective</h4>Aortic pulse pressure (PP) represents the hemodynamic cardiac and cerebral burden more directly than cuff PP. The objective of this study was to investigate whether invasively measured aortic PP confers additional prognostic value beyond cuff PP for cardiovascular events and death. With increasing age, cuff PP progressively underestimates aortic PP. ... Read more >>

J Hypertens (Journal of hypertension)
[2021, 39(4):607-613]

Cited: 0 times

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Diabetes is not a risk factor for myocardial infarction in patients without coronary artery disease: A study from the Western Denmark Heart Registry.

Christine Gyldenkerne, Kevin Kw Olesen, Pernille G Thrane, Morten Madsen, Troels Thim, Morten Würtz, Lisette O Jensen, Bent Raungaard, Per L Poulsen, Hans E Bøtker, Michael Maeng,

<h4>Background</h4>Diabetes is considered a risk factor for myocardial infarction. However, we have previously found that diabetes was not a short-term risk factor for myocardial infarction in the absence of obstructive coronary artery disease.<h4>Methods</h4>We conducted a cohort study of patients undergoing coronary angiography from 2003 to 2012 and followed them by ... Read more >>

Diab Vasc Dis Res (Diabetes & vascular disease research)
[2020, 17(4):1479164120941809]

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Effect of 12 weeks continuous positive airway pressure on day and night arterial stiffness and blood pressure in patients with type 2 diabetes and obstructive sleep apnea: A randomized controlled trial.

Christoffer Krogager, Anne Margareta Banghøj, Per L Poulsen, Martin G Kirkegaard, Birger Thorsteinsson, Lise Tarnow, Klavs W Hansen, Esben Laugesen,

The objective of this study was to evaluate the effect of continuous positive airway pressure treatment on pulse wave velocity and blood pressure in patients with type 2 diabetes and obstructive sleep apnea. A randomized controlled study was performed, including 72 patients with type 2 diabetes and newly diagnosed obstructive ... Read more >>

J Sleep Res (Journal of sleep research)
[2020, 29(4):e12978]

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Risk stratification by assessment of coronary artery disease using coronary computed tomography angiography in diabetes and non-diabetes patients: a study from the Western Denmark Cardiac Computed Tomography Registry.

Kevin K W Olesen, Anders H Riis, Lene H Nielsen, Flemming H Steffensen, Bjarne L Nørgaard, Jesper M Jensen, Per L Poulsen, Troels Thim, Hans Erik Bøtker, Henrik T Sørensen, Michael Maeng,

<h4>Aims</h4>We examined whether severity of coronary artery disease (CAD) measured by coronary computed tomography angiography can be used to predict rates of myocardial infarction (MI) and death in patients with and without diabetes.<h4>Methods and results</h4>A cohort study of consecutive patients (n = 48 731) registered in the Western Denmark Cardiac Computed Tomography Registry ... Read more >>

Eur Heart J Cardiovasc Imaging (European heart journal cardiovascular Imaging)
[2019, 20(11):1271-1278]

Cited: 3 times

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Evaluation of interarm blood pressure differences using the Microlife WatchBP Office in a clinical setting.

Christoffer Krogager, Esben Laugesen, Niklas B Rossen, Per L Poulsen, Mogens Erlandsen, Klavs W Hansen,

<h4>Objective</h4>The aim of this study was to evaluate the usefulness of Microlife WatchBP Office and the effect of increasing the number of measurements in the clinical evaluation of systolic interarm difference (IAD).<h4>Patients and methods</h4>Office blood pressure was measured simultaneously on both arms in 339 patients (85% diabetic) using the Microlife ... Read more >>

Blood Press Monit (Blood pressure monitoring)
[2017, 22(3):161-165]

Cited: 1 time

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Effects of renal denervation on coronary flow reserve and forearm dilation capacity in patients with treatment-resistant hypertension. A randomized, double-blinded, sham-controlled clinical trial.

Morten Engholm, Jannik B Bertelsen, Ole N Mathiassen, Hans E Bøtker, Henrik Vase, Christian D Peters, Jesper N Bech, Niels H Buus, Anne P Schroeder, Hans Rickers, Klavs W Hansen, Per L Poulsen, Anne Kaltoft, Kent L Christensen,

<h4>Background</h4>Microvascular impairment is well documented in hypertension. We investigated the effect of renal sympathetic denervation (RDN) on cardiac and peripheral microvasculature in patients with treatment-resistant essential hypertension (TRH).<h4>Methods</h4>A randomized, single centre, double-blinded, sham-controlled clinical trial. Fifty-eight patients with TRH (ambulatory systolic BP (ASBP) ≥ 145mmHg) despite stable treatment were randomized ... Read more >>

Int J Cardiol (International journal of cardiology)
[2018, 250:29-34]

Cited: 2 times

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Effects of Renal Denervation on Insulin Sensitivity and Inflammatory Markers in Nondiabetic Patients with Treatment-Resistant Hypertension.

Ulla Kampmann, Ole N Mathiassen, Kent L Christensen, Niels H Buus, Mette Bjerre, Henrik Vase, Niels Møller, Anne Kaltoft, Per L Poulsen,

Increased sympathetic activity is important in the pathogenesis of hypertension and insulin resistance. Afferent signaling from the kidneys elevates the central sympathetic drive. We investigated the effect of catheter-based renal sympathetic denervation (RDN) on glucose metabolism, inflammatory markers, and blood pressure in nondiabetic patients with treatment-resistant hypertension. Eight subjects were ... Read more >>

J Diabetes Res (Journal of diabetes research)
[2017, 2017:6915310]

Cited: 2 times

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Increased high-risk coronary plaque burden is associated with arterial stiffness in patients with type 2 diabetes without clinical signs of coronary artery disease: a computed tomography angiography study.

Kristian L Funck, Esben Laugesen, Kristian Øvrehus, Jesper M Jensen, Bjarne L Nørgaard, Damini Dey, Troels K Hansen, Per L Poulsen,

<h4>Objectives</h4>Arterial stiffness and subclinical coronary atherosclerosis may yield valuable information on cardiovascular risk. We aimed to characterize coronary atherosclerosis in asymptomatic patients with type 2 diabetes and healthy controls and to investigate the association between baseline arterial stiffness and coronary plaque volumes after 5-year follow-up.<h4>Methods</h4>Data from 45 patients and 61 ... Read more >>

J Hypertens (Journal of hypertension)
[2017, 35(6):1235-1243]

Cited: 4 times

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Magnetic Resonance Neurography Visualizes Abnormalities in Sciatic and Tibial Nerves in Patients With Type 1 Diabetes and Neuropathy.

Michael Vaeggemose, Mirko Pham, Steffen Ringgaard, Hatice Tankisi, Niels Ejskjaer, Sabine Heiland, Per L Poulsen, Henning Andersen,

This study evaluates whether diffusion tensor imaging magnetic resonance neurography (DTI-MRN), T2 relaxation time, and proton spin density can detect and grade neuropathic abnormalities in patients with type 1 diabetes. Patients with type 1 diabetes (<i>n</i> = 49) were included-11 with severe polyneuropathy (sDPN), 13 with mild polyneuropathy (mDPN), and ... Read more >>

Diabetes (Diabetes)
[2017, 66(7):1779-1788]

Cited: 8 times

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The IGF system in patients with type 2 diabetes: associations with markers of cardiovascular target organ damage.

Rikke Hjortebjerg, Esben Laugesen, Pernille Høyem, Claus Oxvig, Brian Stausbøl-Grøn, Søren T Knudsen, Won Y Kim, Per L Poulsen, Troels K Hansen, Mette Bjerre, Jan Frystyk,

<h4>Objective</h4>Perturbations in the insulin-like growth factor (IGF) system may contribute to the accelerated cardiovascular disease (CVD) that occurs in patients with type 2 diabetes (T2D). However, it remains unknown whether the IGF system is also involved in the development of early, subclinical CVD. We characterised the IGF system in T2D ... Read more >>

Eur J Endocrinol (European journal of endocrinology)
[2017, 176(5):521-531]

Cited: 9 times

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Very poor agreement between routine outpatient clinic office and ambulatory blood pressure: time to improve an old hospital outpatient clinic routine?

Mark Reinhard, Per L Poulsen, Kent L Christensen,

<h4>Objective</h4>We investigated the agreement between elevated outpatient clinic office blood pressure (OC-OBP) as measured in the daily routine in our University Hospital Cardiology Outpatient Clinic and subsequent awake ambulatory blood pressure (AABP).<h4>Methods</h4>In all patients referred for ambulatory blood pressure monitoring from our Cardiology Outpatient Clinic, we identified OC-OBP and changes ... Read more >>

Blood Press Monit (Blood pressure monitoring)
[2016, 21(6):340-344]

Cited: 1 time

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Renal denervation in treatment-resistant essential hypertension. A randomized, SHAM-controlled, double-blinded 24-h blood pressure-based trial.

Ole N Mathiassen, Henrik Vase, Jesper N Bech, Kent L Christensen, Niels H Buus, Anne P Schroeder, Ole Lederballe, Hans Rickers, Ulla Kampmann, Per L Poulsen, Klavs W Hansen, Hans E Btker, Christian D Peters, Morten Engholm, Jannik B Bertelsen, Jens F Lassen, Sten Langfeldt, Gratien Andersen, Erling B Pedersen, Anne Kaltoft,

<h4>Background</h4>Renal denervation (RDN), treating resistant hypertension, has, in open trial design, been shown to lower blood pressure (BP) dramatically, but this was primarily with respect to office BP.<h4>Method</h4>We conducted a SHAM-controlled, double-blind, randomized, single-center trial to establish efficacy data based on 24-h ambulatory BP measurements (ABPM). Inclusion criteria were daytime ... Read more >>

J Hypertens (Journal of hypertension)
[2016, 34(8):1639-1647]

Cited: 33 times

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Reduced Subendocardial Viability Ratio Is Associated With Unfavorable Cardiovascular Risk Profile in Women With Short Duration of Type 2 Diabetes.

Esben Laugesen, Pernille Høyem, Jesper Fleischer, Indumathi Kumarathas, Søren T Knudsen, Klavs W Hansen, Jens Sandahl Christiansen, Troels K Hansen, Per L Poulsen,

<h4>Background</h4>The pathophysiological perturbations underlying the unfavorable cardiovascular prognosis in women with type 2 diabetes (T2DM) remain elusive. Low subendocardial viability ratio (SEVR), an index of myocardial oxygen supply and demand, has been associated with intermediate cardiovascular risk markers and cardiovascular mortality in various populations. However, whether SEVR is associated with ... Read more >>

Am J Hypertens (American journal of hypertension)
[2016, 29(10):1165-1172]

Cited: 7 times

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Diffusion tensor imaging MR neurography for the detection of polyneuropathy in type 1 diabetes.

Michael Vaeggemose, Mirko Pham, Steffen Ringgaard, Hatice Tankisi, Niels Ejskjaer, Sabine Heiland, Per L Poulsen, Henning Andersen,

<h4>Purpose</h4>To evaluate if diffusion tensor imaging MR neurography (DTI-MRN) can detect lesions of peripheral nerves in patients with type 1 diabetes.<h4>Materials and methods</h4>Eleven type 1 diabetic patients with polyneuropathy (DPN), 10 type 1 diabetic patients without polyneuropathy (nDPN), and 10 healthy controls (HC) were investigated with a 3T MRI scanner. ... Read more >>

J Magn Reson Imaging (Journal of magnetic resonance imaging : JMRI)
[2017, 45(4):1125-1134]

Cited: 11 times

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Invasively Measured Aortic Systolic Blood Pressure and Office Systolic Blood Pressure in Cardiovascular Risk Assessment: A Prospective Cohort Study.

Esben Laugesen, Søren T Knudsen, Klavs W Hansen, Niklas B Rossen, Lisette Okkels Jensen, Michael G Hansen, Henrik Munkholm, Kristian K Thomsen, Hanne Søndergaard, Morten Bøttcher, Bent Raungaard, Morten Madsen, Adam Hulman, Daniel Witte, Hans Erik Bøtker, Per L Poulsen,

Aortic systolic blood pressure (BP) represents the hemodynamic cardiac and cerebral burden more directly than office systolic BP. Whether invasively measured aortic systolic BP confers additional prognostic value beyond office BP remains debated. In this study, office systolic BP and invasively measured aortic systolic BP were recorded in 21 908 patients ... Read more >>

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2016, 68(3):768-774]

Cited: 2 times

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The solitary sellar plasmacytoma: a diagnostic challenge.

Anne Soejbjerg, Suzan Dyve, Steen Baerentzen, Georg Thorsell, Per L Poulsen, Jens O L Jorgensen, Ulla Kampmann,

<h4>Unlabelled</h4>Solitary sellar plasmacytomas are exceedingly rare and difficult to distinguish from other pituitary tumors. We report a case of a 62-year-old woman presenting with blurred vision of the right eye and tenderness of the right temporal region, which was interpreted as temporal arteritis. MRI revealed a pituitary mass lesion (20mm×14mm×17mm) ... Read more >>

Endocrinol Diabetes Metab Case Rep (Endocrinology, diabetes & metabolism case reports)
[2016, 2016:160031]

Cited: 4 times

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Combined Insulin Deficiency and Endotoxin Exposure Stimulate Lipid Mobilization and Alter Adipose Tissue Signaling in an Experimental Model of Ketoacidosis in Subjects With Type 1 Diabetes: A Randomized Controlled Crossover Trial.

Mads Svart, Ulla Kampmann, Thomas Voss, Steen B Pedersen, Mogens Johannsen, Nikolaj Rittig, Per L Poulsen, Thomas S Nielsen, Niels Jessen, Niels Møller,

Most often, diabetic ketoacidosis (DKA) in adults results from insufficient insulin administration and acute infection. DKA is assumed to release proinflammatory cytokines and stress hormones that stimulate lipolysis and ketogenesis. We tested whether this perception of DKA can be reproduced in an experimental human model by using combined insulin deficiency ... Read more >>

Diabetes (Diabetes)
[2016, 65(5):1380-1386]

Cited: 4 times

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Unmasking sarcoidosis following surgery for Cushing disease.

Jon E F Diernaes, Anette Bygum, Per L Poulsen,

We present a patient with Cushing disease apparently suppressing sarcoidosis, which was unmasked following surgical resection of a pituitary adrenocorticotropin (ACTH)-producing microadenoma. Case report and a short review of the literature published in this area. A 46-year-old Caucasian woman presented with symptoms of hypercortisolism such as progressive weight gain, Cushingoid ... Read more >>

Dermatoendocrinol (Dermato-endocrinology)
[2016, 8(1):e983688]

Cited: 1 time

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Low Physical Activity Is Associated With Increased Arterial Stiffness in Patients Recently Diagnosed With Type 2 Diabetes.

Kristian L Funck, Esben Laugesen, Pernille Høyem, Jesper Fleischer, Simon L Cichosz, Jens S Christiansen, Troels K Hansen, Per L Poulsen,

<h4>Aims</h4>Several studies have indicated that low physical activity is associated with increased risk of cardiovascular disease (CVD) and all-cause mortality among patients with diabetes. The association between physical activity and subclinical cardiovascular changes preceding clinical events remains to be elucidated. We investigated the relationship between physical activity and arterial stiffness, ... Read more >>

Am J Hypertens (American journal of hypertension)
[2016, 29(7):882-888]

Cited: 10 times

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Morning blood pressure surge and target organ damage in newly diagnosed type 2 diabetic patients: a cross sectional study.

Johanne M Lyhne, Esben Laugesen, Pernille Høyem, Simon Cichosz, Jens S Christiansen, Søren T Knudsen, Klavs W Hansen, Troels K Hansen, Per L Poulsen,

<h4>Background</h4>Type 2 diabetic patients display significantly higher incidence of cardiovascular (CV) events including stroke compared to non-diabetics. Morning blood pressure surge (MBPS) and blunted systolic night-day (SND) ratio have been associated with CV events in hypertensive patients. No studies have evaluated MBPS in newly diagnosed diabetic patients or studied the ... Read more >>

BMC Endocr Disord (BMC endocrine disorders)
[2015, 15:77]

Cited: 9 times

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Assessment of central blood pressure in patients with type 2 diabetes: a comparison between SphygmoCor and invasively measured values.

Esben Laugesen, Niklas B Rossen, Christian D Peters, Michael Mæng, Eva Ebbehøj, Søren T Knudsen, Klavs W Hansen, Hans E Bøtker, Per L Poulsen,

<h4>Background</h4>The SphygmoCor is used for noninvasive assessment of ascending aortic blood pressure (BP). However, the validity of the SphygmoCor transfer function has not been tested in an exclusively type 2 diabetic patient sample. Calibration with systolic (SBP) and diastolic (DBP) brachial BP has previously been associated with substantial imprecision of ... Read more >>

Am J Hypertens (American journal of hypertension)
[2014, 27(2):169-176]

Cited: 9 times

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Reproducibility of pulse wave analysis and pulse wave velocity in patients with type 2 diabetes.

Esben Laugesen, Niklas B Rossen, Pernille Høyem, Jens S Christiansen, Søren T Knudsen, Klavs W Hansen, Troels K Hansen, Per L Poulsen,

<h4>Aims</h4>Patients with type 2 diabetes have increased arterial stiffness and a high incidence of cardiovascular disease compared with non-diabetics. Arterial stiffness and central waveforms can be assessed by carotid-femoral pulse wave velocity (PWV) and pulse wave analysis (PWA) using the SphygmoCor device. These methods can potentially improve cardiovascular risk stratification ... Read more >>

Scand J Clin Lab Invest (Scandinavian journal of clinical and laboratory investigation)
[2013, 73(5):428-435]

Cited: 3 times

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Carotid-femoral pulse wave velocity is associated with cerebral white matter lesions in type 2 diabetes.

Esben Laugesen, Pernille Høyem, Brian Stausbøl-Grøn, Anders Mikkelsen, Samuel Thrysøe, Mogens Erlandsen, Jens S Christiansen, Søren T Knudsen, Klavs W Hansen, Won Y Kim, Troels K Hansen, Per L Poulsen,

<h4>Objective</h4>Patients with type 2 diabetes have a high incidence of cardiovascular events including stroke. Increased arterial stiffness (AS) predicts cardiovascular events in the general population. Cerebral white matter lesions (WMLs) are associated with an increased risk of stroke. It is unknown whether AS in patients with type 2 diabetes is ... Read more >>

Diabetes Care (Diabetes care)
[2013, 36(3):722-728]

Cited: 23 times

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Ambulatory arterial stiffness index: a composite index reflecting arterial stiffness, blood pressure variability and patients' diurnal cycle.

Esben Laugesen, Mogens Erlandsen, Søren T Knudsen, Klavs W Hansen, Per L Poulsen,

J Hypertens (Journal of hypertension)
[2011, 29(11):2278-2279]

Cited: 5 times

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