Full Text Journal Articles by
Author Penny L Berger

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Human prostate luminal cell differentiation requires NOTCH3 induction by p38-MAPK and MYC.

Sander B Frank, Penny L Berger, Mats Ljungman, Cindy K Miranti,

Many pathways dysregulated in prostate cancer are also involved in epithelial differentiation. To better understand prostate tumor initiation, we sought to investigate specific genes and mechanisms required for normal basal to luminal cell differentiation. Utilizing human prostate basal epithelial cells and an in vitro differentiation model, we tested the hypothesis ... Read more >>

J. Cell. Sci. (Journal of cell science)
[2017, 130(11):1952-1964]

Cited: 4 times

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Miz1, a Novel Target of ING4, Can Drive Prostate Luminal Epithelial Cell Differentiation.

Penny L Berger, Mary E Winn, Cindy K Miranti,

BACKGROUND:How prostate epithelial cells differentiate and how dysregulation of this process contributes to prostate tumorigenesis remain unclear. We recently identified a Myc target and chromatin reader protein, ING4, as a necessary component of human prostate luminal epithelial cell differentiation, which is often lost in primary prostate tumors. Furthermore, loss of ... Read more >>

Prostate (The Prostate)
[2017, 77(1):49-59]

Cited: 3 times

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Transient induction of ING4 by Myc drives prostate epithelial cell differentiation and its disruption drives prostate tumorigenesis.

Penny L Berger, Sander B Frank, Veronique V Schulz, Eric A Nollet, Mathew J Edick, Brittany Holly, Ting-Tung A Chang, Galen Hostetter, Suwon Kim, Cindy K Miranti,

The mechanisms by which Myc overexpression or Pten loss promotes prostate cancer development are poorly understood. We identified the chromatin remodeling protein, ING4, as a crucial switch downstream of Myc and Pten that is required for human prostate epithelial differentiation. Myc-induced transient expression of ING4 is required for the differentiation ... Read more >>

Cancer Res. (Cancer research)
[2014, 74(12):3357-3368]

Cited: 16 times

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