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Hypervalent iodine(iii)-promoted rapid cascade reaction for the synthesis of unsymmetric azo compounds.

Jiabin Shen, Jun Xu, Qing Zhu, Pengfei Zhang,

A rapid three-component cascade reaction for the synthesis of unsymmetric azo compounds via a radical activation strategy has been reported. Various aryldiazonium salts and unactivated alkenes are well compatible, providing the corresponding products in good to excellent yields. This strategy gives an efficient and practical solution for the synthesis of ... Read more >>

Org Biomol Chem (Organic & biomolecular chemistry)
[2021, 19(14):3119-3123]

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Combinatorial nanodroplet platform for screening antibiotic combinations.

Hui Li, Pengfei Zhang, Kuangwen Hsieh, Tza-Huei Wang,

The emergence and spread of multidrug resistant bacterial strains and concomitant dwindling of effective antibiotics pose worldwide healthcare challenges. To address these challenges, advanced engineering tools are developed to personalize antibiotic treatments by speeding up the diagnostics that is critical to prevent antibiotic misuse and overuse and make full use ... Read more >>

Lab Chip (Lab on a chip)
[2022, :]

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Genetic Diversity and Structure of Core Collection of Huangqi (Astragalus) Developed by Genomic Simple Sequence Repeat Markers

Fanshu Gong, Yaping Geng, Pengfei Zhang, Feng Zhang, Xinfeng Fan, Yaling Liu,

Huangqi ( Astragalus ) is a versatile herb that possesses several therapeutic effects against a variety of diseases, especially lung diseases. The aim of this study was to establish a core collection of Astragalus germplasm resources based on molecular 10 SSR markers. Based on 380 samples of Astragalus collected from ... Read more >>

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Albumin-Consolidated AIEgens for Boosting Glioma and Cerebrovascular NIR-II Fluorescence Imaging.

Duyang Gao, Yaxi Li, Yayun Wu, Yu Liu, Dehong Hu, Simin Liang, Jiuling Liao, Min Pan, Pengfei Zhang, Kai Li, Xin Liu, Hairong Zheng, Zonghai Sheng,

The application of an exogenous polymer matrix to construct aggregation-induced emission (AIE) nanoprobes promotes the utility of AIE luminogens (AIEgens) in diagnosing brain diseases. However, the limited fluorescence (FL) and low active-targeting abilities of AIE-based nanoprobes impede their imaging application. Here, we employed endogenous albumin as an effective matrix to ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2022, :]

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α-Functionalization of ketones promoted by sunlight and heterogeneous catalysis in the aqueous phase.

Lei He, Chenfeng Liang, Yani Ouyang, Lin Li, Yirui Guo, Pengfei Zhang, Wanmei Li,

Herein, a protocol that combines heterogeneous catalysis and solar photocatalysis for the regioselective α-substitution of asymmetric ketones with quinoxalinones has been reported. The result indicates that the reaction is more likely to occur on the α-carbon. This strategy provides a green and efficient way for the α-functionalization of ketones. A ... Read more >>

Org Biomol Chem (Organic & biomolecular chemistry)
[2022, :]

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Targeting ZFP64/GAL-1 axis promotes therapeutic effect of nab-paclitaxel and reverses immunosuppressive microenvironment in gastric cancer.

Mengxuan Zhu, Pengfei Zhang, Shan Yu, Cheng Tang, Yan Wang, Zhenbin Shen, Weidong Chen, Tianshu Liu, Yuehong Cui,

<h4>Background</h4>Chemoresistance is a main obstacle in gastric cancer (GC) treatment, but its molecular mechanism still needs to be elucidated. Here, we aim to reveal the underlying mechanisms of nanoparticle albumin-bound paclitaxel (nab-paclitaxel) resistance in GC.<h4>Methods</h4>We performed RNA sequencing (RNA-seq) on samples from patients who were resistant or sensitive to nab-paclitaxel, ... Read more >>

J Exp Clin Cancer Res (Journal of experimental & clinical cancer research : CR)
[2022, 41(1):14]

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Direct Z-scheme MgIn2S4/TiO2 heterojunction for enhanced photocathodic protection of metals under visible light.

Hong Li, Xingqiang Cui, Weizhe Song, Zhanyuan Yang, Yanhui Li, Pengfei Zhang, Zongmin Zheng, Yuqi Wang, Junru Li, Fubin Ma,

To improve the photocathodic protection performance of traditional TiO2 photoanodes for metals, constructing a Z-scheme heterojunction is one of the most promising and creative strategies. Herein, we fabricated a novel Z-scheme MgIn2S4 nanosheets/TiO2 nanotube nanocomposite through anodization and hydrothermal method. The optimized Z-scheme MgIn2S4/TiO2 nanocomposites exhibited stronger visible light absorption, ... Read more >>

Nanotechnology (Nanotechnology)
[2022, :]

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Visible light-driven oxidative coupling of dibenzylamine and substituted anilines with a 2D WSe2 nanomesh material.

Kejie Chai, Yifeng Shi, Yanqiong Wang, Peijie Zou, Qingrong Yuan, Weiming Xu, Pengfei Zhang,

A novel 2D WSe2 nanomesh material was synthesized with a 3D SBA-15 mesoporous material via a nanocasting strategy. The formation of the 2D sheet-like nanomesh structure of WSe2 inside a 3D confined pore space is mainly attributed to the synergistic effect arising from the crystal self-limitation growth caused by the ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(42):21869-21878]

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Functionalized quinoxalinones as privileged structures with broad-ranging pharmacological activities.

Xiaoying Jiang, Kaiyu Wu, Renren Bai, Pengfei Zhang, Yi Zhang,

Quinoxalinones are a class of heterocyclic compounds which attract extensive attention owing to their potential in the field of organic synthesis and medicinal chemistry. During the past few decades, many new synthetic strategies toward the functionalization of quinoxalinone based scaffolds have been witnessed. Regrettably, there are only a few reports ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2022, 229:114085]

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Unraveling three-dimensional chromatin structural dynamics during spermatogonial differentiation.

Yi Zheng, Lingkai Zhang, Long Jin, Pengfei Zhang, Fuyuan Li, Ming Guo, Qiang Gao, Yao Zeng, Mingzhou Li, Wenxian Zeng,

Spermatogonial stem cells (SSCs) are able to undergo both self-renewal and differentiation. Unlike self-renewal, which replenishes the SSC and progenitor pool, differentiation is an irreversible process committing cells to meiosis. While the preparations for meiotic events in differentiating spermatogonia (Di-SG) are likely to be accompanied by alterations in chromatin structure, ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2021, :101559]

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Proportions of Beneficial Factors in MLR, NLR, PLR and D-dimer in Preoperative Peripheral Blood of Patients With Early Stage Lung Cancer as Predictors of Patient Survival After Surgery

jun wang, huawei li, ran xu, tong lu, jiaying zhao, Pengfei zhang, lidong qu, Shengqiang zhang, Jida guo, Linyou zhang,

<h4>Objective: </h4> The purpose of this paper is to predict the following items. preoperative baseline monocyte-to-lymphocyte ratio (MLR)、neutrophil-to-lymphocyte ratio (NLR) Platura-to-lymphocyte ratio (PLR) and dimeric fibrin fragment D (D-dimer) associated with clinical outcome in patients with Early Lung Cancer (LC).MethodsWe performed a retrospective analysis of 376 patients with LC. Progression-free ... Read more >>

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Switched alternative splicing events as attractive features in lung squamous cell carcinoma.

Boxue He, Cong Wei, Qidong Cai, Pengfei Zhang, Shuai Shi, Xiong Peng, Zhenyu Zhao, Wei Yin, Guangxu Tu, Weilin Peng, Yongguang Tao, Xiang Wang,

<h4>Background</h4>Alternative splicing (AS) plays important roles in transcriptome and proteome diversity. Its dysregulation has a close affiliation with oncogenic processes. This study aimed to evaluate AS-based biomarkers by machine learning algorithms for lung squamous cell carcinoma (LUSC) patients.<h4>Method</h4>The Cancer Genome Atlas (TCGA) database and TCGA SpliceSeq database were utilized. After ... Read more >>

Cancer Cell Int (Cancer cell international)
[2022, 22(1):5]

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Spatiotemporal Control of Molecular Cascade Reactions by a Reconfigurable DNA Origami Domino Array.

Sisi Fan, Bin Ji, Yan Liu, Kexuan Zou, Zhijin Tian, Bin Dai, Daxiang Cui, Pengfei Zhang, Yonggang Ke, Jie Song,

Inspired by efficient biomolecular reactions in the cell, versatile DNA nanostructures have been explored for manipulating the spatial position and regulating reactions at the molecular level. Spatially controlled arrangement of molecules on the artificial scaffolds generally leads to enhanced reaction activities. Especially, the rich toolset of dynamic DNA nanostructures provides ... Read more >>

Angew Chem Int Ed Engl (Angewandte Chemie (International ed. in English))
[2021, :e202116324]

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Prevalence, Antimicrobial Resistance, and Molecular Characteristics of Staphylococcus aureus and Methicillin-Resistant Staphylococcus aureus from Retail Ice Cream in Shaanxi Province, China.

Pengfei Zhang, Xinyu Liu, Meng Zhang, Mingying Kou, Guanhong Chang, Yangli Wan, Xu Xu, Fuqian Ruan, Yeru Wang, Xin Wang,

<i>Staphylococcus aureus (S. aureus)</i> is one of the major opportunistic foodborne pathogens as well as a source of human and animal infections. As surveillance of <i>S. aureus</i> and methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) is limited in ice cream, a total of 240 ice cream samples were collected from three cities in ... Read more >>

Foodborne Pathog Dis (Foodborne pathogens and disease)
[2021, :]

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Inserting Menthoxytriazine into Poly(ethylene terephthalate) for Inhibiting Microbial Adhesion.

Pengfei Zhang, Jiyu Li, Mei Yang, Lifei Huang, Fanqiang Bu, Zixu Xie, Guofeng Li, Xing Wang,

Antimicrobial modification of poly(ethylene terephthalate) (PET) is effective in preventing the adhesion and growth of microorganisms on its surface. However, few methods are available to modify PET directly at its backbone to impart the antimicrobial effect. Herein, menthoxytriazine-modified PET (PMETM) based on the stereochemical antimicrobial strategy was reported. This novel ... Read more >>

ACS Biomater Sci Eng (ACS biomaterials science & engineering)
[2021, :]

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Zearalenone Exposure Triggered Cecal Physical Barrier Injury through the TGF-β1/Smads Signaling Pathway in Weaned Piglets.

Pengfei Zhang, Changwei Jing, Ming Liang, Shuzhen Jiang, Libo Huang, Ning Jiao, Yang Li, Weiren Yang,

This study aims to investigate the effects of exposure to different dosages of zearalenone (ZEA) on cecal physical barrier functions and its mechanisms based on the TGF-β1/Smads signaling pathway in weaned piglets. Thirty-two weaned piglets were allotted to four groups and fed a basal diet supplemented with ZEA at 0, ... Read more >>

Toxins (Basel) (Toxins)
[2021, 13(12):]

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China's Public Health Policies in Response to COVID-19: From an "Authoritarian" Perspective.

Jinghua Gao, Pengfei Zhang,

<b>Background:</b> China is generally regarded internationally as an "authoritarian" state. Traditional definitions have assigned many negative connotations surrounding the term of authoritarian. We realize that it might not be considered value-neutral in other countries. But authoritarian in the Chinese context emphasizes more on centralized decision making, collectivism, coordinating all activities ... Read more >>

Front Public Health (Frontiers in public health)
[2021, 9:756677]

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Endophytic Bacterial and Fungal Community Compositions in Different Organs of Ginseng (Panax Ginseng)

Zhenjie Fan, Shuiming Xiao, Haoyu Hu, Pengfei Zhang, Jing Chao, Shuai Guo, Dianyun Hou, Jiang Xu,

Panax ginseng ( Panax ginseng C. A. Mey.) is a perennial herb of the genus ginseng, which is used as medicine with dried roots and rhizomes. With the deepening of research on ginseng, the chemical components and pharmacological effects of ginseng have gradually been discovered. Endophytes are beneficial to host ... Read more >>

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Combating Antimicrobial Resistance via Single-Cell Diagnostic Technologies Powered by Droplet Microfluidics.

Kuangwen Hsieh, Kathleen E Mach, Pengfei Zhang, Joseph C Liao, Tza-Huei Wang,

ConspectusAntimicrobial resistance is a global threat that if left unchecked could lead to 10 million annual mortalities by 2050. One factor contributing to the rise of multi-drug-resistant (MDR) pathogens is the reliance on traditional culture-based pathogen identification (ID) and antimicrobial susceptibility testing (AST) that typically takes several days. This delay ... Read more >>

Acc Chem Res (Accounts of chemical research)
[2022, 55(2):123-133]

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Metabolitin-based molecular drug delivery by targeting GPR158 in glioblastoma

Huashan Zhao, Wen Zhu, Jingwei Li, Jinju Lin, Xiaohua Lei, Pengfei Zhang, Jian Zhang,

Glioblastoma multiforme (GBM) is a lethal form of intracranial tumor. One of the obstacles to treat GBM is the blood-brain barrier which limit the transportation of drugs into the tumor site. Here, based on our previous study on metabolitin (MTL) and osteocalcin, we generated a molecular drug delivery system that ... Read more >>

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Altered brain functional network dynamics in classic trigeminal neuralgia: a resting-state functional magnetic resonance imaging study.

Pengfei Zhang, Yanli Jiang, Guangyao Liu, Jiao Han, Jun Wang, Laiyang Ma, Wanjun Hu, Jing Zhang,

Accumulating studies have indicated a wide range of brain alterations with respect to the structure and function of classic trigeminal neuralgia (CTN). Given the dynamic nature of pain experience, the exploration of temporal fluctuations in interregional activity covariance may enhance the understanding of pain processes in the brain. The present ... Read more >>

J Headache Pain (The journal of headache and pain)
[2021, 22(1):147]

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Philanthropic Motives of China's Celebrities in Media Representation: From an Impression Management Perspective.

Jinghua Gao, Pengfei Zhang,

<b>Background:</b> In China, celebrities, represented by entertainment and sports personalities, are often involved in charitable activities to assist the party-state in solving social problems. Although previous research has addressed the manifestation of prosocial behavior by Chinese celebrities, altruistic engagements have rarely been theorized from the perspective of impression management. <b>Methods:</b> ... Read more >>

Front Psychol (Frontiers in psychology)
[2021, 12:759671]

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Deeply-Dyed Nanobead System Based Lateral Flow Assay for Rapid Point-of-Care Drug Testing

Lingzhi Fan, Jianbing Wu, Jing Yang, Fugang Li, Wannian Yan, Fei Tan, Madeline Zhang, Mohamed Draz, Huanxing Han, Pengfei Zhang,

Point-of-care test (POCT), which allows for rapid and sensitive screening of drugs abuse, is essential and can significantly reduce the clinical, economic and social impact of the opioid crisis worldwide. However, the traditional gold nanoparticle-based lateral flow immunoassay strip is not sensitive enough for detection of trace drugs in hair ... Read more >>

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Photo-Induced Cross-Dehydrogenative Alkylation of Heteroarenes with Alkanes under Aerobic Conditions.

Jun Xu, Heng Cai, Jiabin Shen, Chao Shen, Jie Wu, Pengfei Zhang, Xiaogang Liu,

We report a Minisci-type cross-dehydrogenative alkylation in an aerobic atmosphere using abundant and inexpensive cerium chloride as a photocatalyst and air as an oxidant. This photoreaction exhibits excellent tolerance to functional groups and is suitable for both heteroarene and alkane substrates under mild conditions, generating the corresponding products in moderate-to-good ... Read more >>

J Org Chem (The Journal of organic chemistry)
[2021, 86(24):17816-17832]

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Quality of public health insurance and individuals' consumption structure upgrades: evidence from China.

Pengfei Zhang, Jinghua Gao,

<h4>Background</h4>The aim of this study was to investigate the relationship between the quality of public health insurance and individuals' consumption structure upgrades in China.<h4>Methods</h4>This study was conducted using data from a population of 6430 Chinese individuals aged 18 to 70 y from the 2017 Chinese Social Survey. We used multiple ... Read more >>

Health Econ Rev (Health economics review)
[2021, 11(1):45]

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