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Geography and ethnicity related variation in the Chinese human milk serum proteome.

Lina Zhang, Ying Ma, Zhenyu Yang, Shan Jiang, Jun Liu, Kasper A Hettinga, Jianqiang Lai, Peng Zhou,

Human milk provides a range of nutrients and bioactive components, which can support the growth and development of infants. However, human milk composition may change due to geographic and ethnic variation. This study investigated the variation of the Chinese human milk serum proteome based on mothers with different ethnicities living ... Read more >>

Food Funct (Food & function)
[2019, 10(12):7818-7827]

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Stable unmethylated DNA demarcates expressed genes and their cis-regulatory space in plant genomes

Peter Crisp, Alexandre Marand, Jaclyn Noshay, Peng Zhou, Zefu Lu, Robert Schmitz, Nathan Springer,

Abstract The genomic sequences of crops continue to be produced at a frenetic pace. However, it remains challenging to develop complete annotations of functional genes and regulatory elements in these genomes. Here, we explore the potential to use DNA methylation profiles to develop more complete annotations. Using leaf tissue in ... Read more >>

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Pathogenesis of SARS-CoV-2 in transgenic mice expressing human angiotensin-converting enzyme 2.

Ren-Di Jiang, Mei-Qin Liu, Ying Chen, Chao Shan, Yi-Wu Zhou, Xu-Rui Shen, Qian Li, Lei Zhang, Yan Zhu, Hao-Rui Si, Qi Wang, Juan Min, Xi Wang, Wei Zhang, Bei Li, Hua-Jun Zhang, Ralph S. Baric, Peng Zhou, Xing-Lou Yang, Zheng-Li Shi,

A SARS-CoV-2 hACE2 transgenic mouse infection model recapitulates a number of infection symptoms and pathology in COVID-19 patients. Pre-exposure to SARS-CoV-2 was able to protect mice from severe pneumonia. ... Read more >>

Cell (Cell)
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Cis-regulatory elements within TEs can influence expression of nearby maize genes

Jaclyn Noshay, Alexandre Marand, Sarah Anderson, Peng Zhou, Maria Katherine Mejia Guerra, Zefu Lu, Christine O’Connor, Peter Crisp, Candice Hirsch, Robert Schmitz, Nathan Springer,

Abstract Transposable elements (TEs) have the potential to create regulatory variation both through disruption of existing DNA regulatory elements and through creation of novel DNA regulatory elements. In a species with a large genome, such as maize, the many TEs interspersed with genes creates opportunities for significant allelic variation due ... Read more >>

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Evaluation of the immune response in conventionally weaned pigs infected with porcine deltacoronavirus.

Donghong Zhao, Xiang Gao, Peng Zhou, Liping Zhang, Yongguang Zhang, Yonglu Wang, Xinsheng Liu,

Although porcine deltacoronavirus (PDCoV) is a significant pandemic threat in the swine population and has caused significant economic losses, information regarding the immune response in conventionally weaned pigs infected with PDCoV is scarce. Hence, the immune response in conventionally weaned pigs infected with PDCoV was assessed after challenge and rechallenge. ... Read more >>

Arch. Virol. (Archives of virology)
[2020, :]

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Comparative aroma and taste profiles of oil furu (soybean curd) fermented with different mucor strains.

Guanmian Wei, Joe M Regenstein, Xiaoming Liu, Peng Zhou,

The effects of different mucor strains (Mucor racemosus, Actinomucor, and Mucor wutungkiao) on aroma and taste profiles based on proteolysis, lipolysis, and their catabolism in oil furu were studied. Gas chromatography-mass spectrometry and relative odor activity were used to monitor the changes of key volatile compounds and the differences in ... Read more >>

J. Food Sci. (Journal of food science)
[2020, :]

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Early Awake Prone and Lateral Position in Non-intubated Severe and Critical Patients with COVID-19 in Wuhan: A Respective Cohort Study

Wei Dong, Yiping Gong, Juan Feng, Lang Bai, Haomiao Qing, Peng Zhou, Yu Du, Junchen Zhu, Shanling Xu,

Background Previous studies suggest applying prone position (PP) and lateral position (LP) in patients with severe acute respiratory distress syndrome (ARDS) for their efficacy in improving oxygenation and lung recruitment.This paper aims to share clinical experiences and outcome of using PP and LP in combination with oxygen therapy (OT) and ... Read more >>

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Clinical and Genetic Analyses of 38 Chinese Patients with Peutz-Jeghers Syndrome.

Bo-Da Wu, Yong-Jun Wang, Liang-Liang Fan, Hui Huang, Peng Zhou, Mei Yang, Xiao-Liu Shi,

Background Peutz-Jeghers syndrome (PJS) is a rare autosomal dominant inherited disease caused by a germline mutation in the STK11 gene. It is characterized by mucocutaneous pigmentation, gastrointestinal hamartomatous polyps, and cancer predisposition. Aims We aimed to summarize the main clinical and genetic features of Chinese PJS patients and assessed the ... Read more >>

(BioMed Research International)
[2020, 2020:]

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Three-Dimensional Visualization for Extended Deep Inferior Epigastric Perforator Flaps.

HuaiRui Cui, MaoCao Ding, YiHua Mao, Peng Zhou, ChenYou Sun, MaoLin Tang, DaChuan Xu,

PURPOSE:The aim of the study was to provide an applied and digital anatomical basis of acquiring extended deep inferior epigastric perforator (DIEP) flaps for clinical use. METHODS:Five formalin-soaked specimens were received red latex injection and dissected by layers. The arteriography using the modified mixture of lead oxide-gelatin was performed on ... Read more >>

Ann Plast Surg (Annals of plastic surgery)
[2020, :]

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Clinical and Genetic Analyses of 38 Chinese Patients with Peutz-Jeghers Syndrome.

Bo-Da Wu, Yong-Jun Wang, Liang-Liang Fan, Hui Huang, Peng Zhou, Mei Yang, Xiao-Liu Shi,

Background:Peutz-Jeghers syndrome (PJS) is a rare autosomal dominant inherited disease caused by a germline mutation in the STK11 gene. It is characterized by mucocutaneous pigmentation, gastrointestinal hamartomatous polyps, and cancer predisposition. Aims:We aimed to summarize the main clinical and genetic features of Chinese PJS patients and assessed the genotype-phenotype correlations. ... Read more >>

Biomed Res Int (BioMed research international)
[2020, 2020:9159315]

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Treatment of fresh thoracolumbar vertebral burst fracture based on intraoperative CT scan

yuwei li, wei cui, Peng Zhou, Cheng Li, Wei Xiao, Yan Wen,

Abstract ObjectiveTo evaluate the value of intraoperative CT scanning in the treatment of fresh thoracolumbar burst fractures .MethodThe data of patients with thoracolumbar fractures from January 2008 to January 2015 were analyzed retrospectively,79 cases were treatment group which were treated with intraoperative CT scan and decompression mode was determined according ... Read more >>

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MicroRNA-127-3p regulates myoblast proliferation by targeting Sept7.

Jie Li, Gaofu Wang, Jing Jiang, Li Zhang, Peng Zhou, Hangxing Ren,

OBJECTIVE:MicroRNAs (miRNAs) are highly conserved, endogenous small RNAs that regulate gene expression at the post-transcriptional level. miR-127 plays an essential role in myogenic differentiation in vivo and in vitro. However, it is not clear whether miR-127-3p affects myogenic cell proliferation. METHODS:The detailed function of miR-127-3p in proliferative C2C12 cell lines ... Read more >>

Biotechnol. Lett. (Biotechnology letters)
[2020, :]

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Expression Profiling and Cell Type Classification Analysis in Periodontitis Reveal Dysregulation of Multiple lncRNAs in Plasma Cells.

Donglei Wu, Peng Zhou, Fengdi Cao, Zhengshen Lin, Defeng Liang, Xincai Zhou,

Objective:Periodontitis is a chronic inflammatory disease with a downregulated immune response. The mechanisms of the immune response, especially regarding immune-related long non-coding RNAs (lncRNAs), in periodontitis remain unclear. This study aimed to analyze the immune cell landscapes and immune-related transcriptome expression in periodontitis. Materials and Methods:The periodontitis-related microarray data set ... Read more >>

Front Genet (Frontiers in genetics)
[2020, 11:382]

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High Plasma Myeloperoxidase Is Associated with Plaque Erosion in Patients with ST-Segment Elevation Myocardial Infarction.

Yu Tan, Shujun Yang, Runzhen Chen, Zhaoxue Sheng, Peng Zhou, Chen Liu, Hanjun Zhao, Li Song, Jiannan Li, Jinying Zhou, Yi Chen, Hongbing Yan,

We aimed to investigate the association between plasma myeloperoxidase (MPO) and plaque erosion in patients presenting with ST-segment elevation myocardial infarction (STEMI). Two hundred and fifty-two patients with STEMI who underwent optical coherence tomography (OCT) evaluation of culprit lesion were prospectively enrolled. Of them, 92 and 80 patients were identified ... Read more >>

J Cardiovasc Transl Res (Journal of cardiovascular translational research)
[2020, :]

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Astragaloside IV acts through multi-scale mechanisms to effectively reduce diabetic nephropathy.

Enyu Wang, Liang Wang, Rui Ding, Mengting Zhai, Ruirui Ge, Peng Zhou, Tingting Wang, Haiyan Fang, Jinghui Wang, Jinling Huang,

Diabetic nephropathy (DN), a common complication of diabetes mellitus, is the main cause of end-stage nephropathy, and thus developing novel strategies for reversing DN remains urgent. Astragaloside IV (AS-IV), a glycoside extracted from the Astragalus membranaceus (Fisch.) Bunge, is a widely used Traditional Chinese Medicine (TCM) in China and presents ... Read more >>

Pharmacol. Res. (Pharmacological research)
[2020, 157:104831]

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Wearable Heterosynapses: Ultralow Power Wearable Heterosynapse with Photoelectric Synergistic Modulation (Adv. Sci. 8/2020).

Tian‐Yu Wang, Jia‐Lin Meng, Zhen‐Yu He, Lin Chen, Hao Zhu, Qing‐Qing Sun, Shi‐Jin Ding, Peng Zhou, David Wei Zhang,

In article number https://doi.org/10.1002/advs.201903480, Lin Chen, Qing‐Qing Sun, and co‐workers present a wearable 2D artificial heterosynapse for simulating multi‐terminal correlations in biology with two modulation modes–an electronic mode and a photoexcited mode. The artificial heterosynapse exhibits ultrafast speed and ultralow power consumption, providing a path for a neuromorphic computing system ... Read more >>

(Advanced Science)
[2020, 7(8):]

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Self-Paced Clustering Ensemble.

Peng Zhou, Liang Du, Xinwang Liu, Yi-Dong Shen, Mingyu Fan, Xuejun Li,

The clustering ensemble has emerged as an important extension of the classical clustering problem. It provides an elegant framework to integrate multiple weak base clusterings to generate a strong consensus result. Most existing clustering ensemble methods usually exploit all data to learn a consensus clustering result, which does not sufficiently ... Read more >>

IEEE Trans Neural Netw Learn Syst (IEEE transactions on neural networks and learning systems)
[2020, :]

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A stricter control of low-density lipoprotein is necessary for thrombosis reduction in "lower thrombosis risk" patients with atrial fibrillation: a multicenter retrospective cohort study.

Weizhuo Liu, Nanqing Xiong, Kun Xie, Bangwei Wu, Zhiyong Qi, Peng Zhou, Wen Gao, Liwen Bao, Xiufang Gao, Zhaohui Qiu, Hui Gong, Guibin He, Bin Cao, Haiming Shi, Xinping Luo, Jian Li,

Patients with atrial fibrillation (AF) are associated with increased thrombotic events. Our previous case-control study showed low-density lipoprotein cholesterol (LDL-C) was an independent predictor of ischemic stroke in AF patients. To investigate the risks of thrombosis in relation to LDL-C among AF patients at different stroke risks by long-time follow-up. ... Read more >>

J. Thromb. Thrombolysis (Journal of thrombosis and thrombolysis)
[2020, :]

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Optimization of multiplexed CRISPR/Cas9 system for highly efficient genome editing in Setaria viridis

Trevor Weiss, Chunfang Wang, Xiaojun Kang, Hui Zhao, Maria Elena Gamo, Colby Starker, Peter Crisp, Peng Zhou, Nathan Springer, Daniel Voytas, Feng Zhang,

Abstract In recent years, Setaria viridis has been developed as a model plant to better understand the C4 photosynthetic pathway in major crops. With the increasing availability of genomic resources for S. viridis research, highly efficient genome editing technologies are needed to create genetic variation resources for functional genomics. Here, ... Read more >>

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scSTATseq: Diminishing Technical Dropout Enables Core Transcriptome Recovery and Comprehensive Single-cell Trajectory Mapping

Zihan Zheng, Xiangyu Tang, Xin Qiu, Hao Xu, Haiyang Wu, Haili Yu, Xingzhao Wen, Zhou Peng, Fa Xu, Yiwen Zhou, Qingshan Ni, Jianzhi Zhou, Liyun Zou, Gang Chen, Ying Wan,

Abstract The advent of single-cell RNA sequencing has provided illuminating information on complex systems. However, large numbers of genes tend to be scarcely detected in common scRNAseq approaches due to technical dropout. Although bioinformatics approaches have been developed to approximate true expression profiles, assess the dropout events on single-cell transcriptomes ... Read more >>

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The Intrinsic Nature of Persulfate Activation and N-Doping in Carbocatalysis.

Wei Ren, Gang Nie, Peng Zhou, Hui Zhang, Xiaoguang Duan, Shaobin Wang,

Persulfates activation by carbon nanotubes (CNT) has been evidenced as nonradical systems for oxidation of organic pollutants. Peroxymonosulfate (PMS) and peroxydisulfate (PDS) possess discrepant atomic structures and redox potentials, while the nature of their distinct behaviors in carbocatalytic activation has not been investigated. Herein, we illustrated that the roles of ... Read more >>

Environ. Sci. Technol. (Environmental Science & Technology)
[2020, 54(10):6438-6447]

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ASK1-Mediated Phosphorylation Blocks HDAC6 Ubiquitination and Degradation to Drive the Disassembly of Photoreceptor Connecting Cilia.

Jie Ran, Min Liu, Jie Feng, Haixia Li, Huixian Ma, Ting Song, Yu Cao, Peng Zhou, Yuhan Wu, Yunfan Yang, Yang Yang, Fan Yu, Heng Guo, Liang Zhang, Songbo Xie, Dengwen Li, Jinmin Gao, Xiaomin Zhang, Xueliang Zhu, Jun Zhou,

Retinopathy of prematurity (ROP) is a leading cause of childhood blindness. However, the pathogenesis and molecular mechanisms underlying ROP remain elusive. Herein, using the oxygen-induced retinopathy (OIR) mouse model of ROP, we demonstrate that disassembly of photoreceptor connecting cilia is an early event in response to oxygen changes. Histone deacetylase ... Read more >>

Dev. Cell (Developmental cell)
[2020, 53(3):287-299.e5]

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Profilin 1 knockdown prevents ischemic brain damage by promoting M2 microglial polarization associated with the RhoA/ROCK pathway.

Ermei Lu, Qian Wang, Shengcun Li, Caiming Chen, Weibo Wu, Yang Xin Zi Xu, Peng Zhou, Wenzhan Tu, Xinfa Lou, Gaofeng Rao, Guanhu Yang, Songhe Jiang, Kecheng Zhou,

Microglial polarization to the anti-inflammatory M2 phenotype is essential in resolving neuroinflammation, making it a promising therapeutic strategy for stroke intervention. The actin cytoskeleton is known to be important for the physiological functions of microglia, including migration and phagocytosis. Profilin 1 (PFN1), an actin-binding protein, is involved in the dynamic ... Read more >>

J. Neurosci. Res. (Journal of neuroscience research)
[2020, 98(6):1198-1212]

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Room-temperature developed flexible biomemristor with ultralow switching voltage for array learning.

Tian-Yu Wang, Jia-Lin Meng, Zhen-Yu He, Lin Chen, Hao Zhu, Qing-Qing Sun, Shi-Jin Ding, Peng Zhou, David Wei Zhang,

As one of the emerging neuromorphic computing devices, memristors may break through the limitation of traditional computers with a von Neumann architecture. However, the development of flexible memristors is limited by the high-temperature fabrication process, large operating voltage and non-uniform distribution of resistance. The room-temperature process has attracted great attention ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(16):9116-9123]

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Synthetic NiO catalyst-assisted peroxymonosulfate for degradation of benzoic acid from aqueous solution.

Xiaowei Huo, Peng Zhou, Jing Zhang, Chenmo Wei, Yunxin Liu, Gucheng Zhang, Wenshu Li, Yongli Zhang,

A heterogeneous NiO catalyst was prepared by a precipitation process using nickel nitrate with oxalic acid and tested for heterogeneous oxidation of benzoic acid (BA) in the presence of peroxymonosulfate (PMS). It was found that the synthetic NiO is highly effective in heterogeneous activation of PMS to produce sulfate radicals ... Read more >>

Water Environ. Res. (Water environment research : a research publication of the Water Environment Federation)
[2020, :]

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