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Stimuli-responsive polydopamine-based smart materials.

Peng Yang, Fang Zhu, Zhengbiao Zhang, Yiyun Cheng, Zhao Wang, Yiwen Li,

Stimuli responsiveness has long been a fascinating feature of smart material design. Polydopamine (PDA), a nature inspired polymeric pigment, exhibits excellent photo-responsive properties and has active surface functionality for loading various responsive motifs, making it a promising candidate for the construction of stimuli-responsive smart functional materials. PDA has long been ... Read more >>

Chem Soc Rev (Chemical Society reviews)
[2021, 50(14):8319-8343]

Cited: 2 times

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Cetuximab functionalization strategy for combining active targeting and antimigration capacities of a hybrid composite nanoplatform applied to deliver 5-fluorouracil: toward colorectal cancer treatment.

Ranran Chen, Yuanjian Huang, Lu Wang, Jiahui Zhou, Yuqian Tan, Chaofan Peng, Peng Yang, Wen Peng, Jie Li, Qiou Gu, Yuchen Sheng, Yan Wang, Guoqiang Shao, Qing Zhang, Yueming Sun,

Antibody-functionalized targeted nanocarriers to deliver chemotherapeutics have been widely explored. However, it remains highly desirable to understand and apply the antitumor potential of antibodies integrated in hybrid composite nanoplatforms. Herein, mesoporous silica nanoparticles, a supported lipid bilayer and cetuximab were integrated to fabricate a hybrid nanoplatform for effectively encapsulating and ... Read more >>

Biomater Sci (Biomaterials science)
[2021, 9(6):2279-2294]

Cited: 1 time

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Macrophage-stimulating activity of European eel (Anguilla anguilla) peptides in RAW264.7 cells mediated via NF-κB and MAPK signaling pathways.

Lijun Yao, Peng Yang, Wenqi Luo, Shuiming Li, Yan Wu, Nan Cai, Decheng Bi, Hui Li, Qingguo Han, Xu Xu,

European eel (Anguilla anguilla) is considered to be a vital commercial fish species. In this study, the effect and molecular mechanism of bioactive peptides from European eel on macrophage-stimulating activity in RAW264.7 cells were investigated. Eel peptide (EP) markedly induced NO and iNOS production and promoted TNF-α and IL-6 secretion ... Read more >>

Food Funct (Food & function)
[2020, 11(12):10968-10978]

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Amyloid-like protein aggregates combining antifouling with antibacterial activity.

Juanhua Tian, Yongchun Liu, Shuting Miao, Qingmin Yang, Xinyi Hu, Qian Han, Li Xue, Peng Yang,

Infections related to implanted medical devices have placed a heavy burden on public health and require feasible solutions. In this study, a simple approach is reported to fabricate an antifouling and antibacterial dual-functional coating. One-step aqueous supramolecular assembly of bovine serum albumin (BSA) is employed to immobilize ε-polylysine (ε-PL) and ... Read more >>

Biomater Sci (Biomaterials science)
[2020, 8(24):6903-6911]

Cited: 1 time

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Polyphenol scaffolds in tissue engineering.

Xueqian Zhang, Zhan Li, Peng Yang, Gaigai Duan, Xianhu Liu, Zhipeng Gu, Yiwen Li,

Polyphenols are a class of ubiquitous compounds distributed in nature, with fascinating inherent biocompatible, bioadhesive, antioxidant, and antibacterial properties. The unique polyphenolic structures based on catechol or pyrogallol moieties allow for strong non-covalent interactions (e.g., multiple hydrogen bonding, electrostatic, and cation-π interactions) as well as covalent interactions (e.g., Michael addition/Schiff-base ... Read more >>

Mater Horiz (Materials horizons)
[2021, 8(1):145-167]

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Organoids from Patient Biopsy Samples can Predict the Response of BC Patients to Neoadjuvant Chemotherapy

Dan Shu, Meiying Shen, Kang Li, Xiaojian Han, Han Li, Zhaofu Tan, Yu Wang, Yang Peng, Zhenrong Tang, Chi Qu, Aishun Jin, Shengchun Liu,

<h4>Background: </h4> Neoadjuvant chemotherapy (NAC) has been widely used to treat locally advanced and inflammatory breast cancer. The initial purpose of neoadjuvant chemotherapy in operable breast cancer is to reduce the tumor stage, achieve local control, and increase the conservative operation rate. Another significant advantage of using neoadjuvant chemotherapy is ... Read more >>

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Synthesis of pH-responsive cyclometalated iridium(III) complex and its application in the selective killing of cancerous cells.

Peng Yang, Shaoqing Zhang, Ke Wang, Honglan Qi,

Cyclometalated iridium(III) complexes are promising candidates as photosensitizers (PSs) in photodynamic therapy (PDT). The challenge in PDT is the selective killing of cancerous cells over the neighboring normal cells. In this work, a pH-responsive cyclometalated iridium(III) complex (probe 1) was designed and synthesized as an effective PS to selectively kill ... Read more >>

Dalton Trans (Dalton transactions (Cambridge, England : 2003))
[2021, 50(46):17338-17345]

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Mycoplasma ovipneumoniae induces caspase-8-dependent extrinsic apoptosis and p53- and ROS-dependent intrinsic apoptosis in murine alveolar macrophages.

Jing Chen, Yi Zhou, Erpeng Zhu, Peng Yang, Mei Li, Shuangxiang Zhang, Jun Yue, Ming Wen, Kaigong Wang, Zhentao Cheng,

<i>Mycoplasma ovipneumoniae (MO)</i> is a principle causative agent of chronic respiratory disease in ruminants, including sheep, goats, and deer, posing a great threat to the ruminant industry worldwide. However, the pathogenesis of <i>MO</i> infection still remains not well understood and needs further clarification. Here we report a time-dependent apoptosis in ... Read more >>

Virulence (Virulence)
[2021, 12(1):2703-2720]

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CircRAB3IP upregulates twist family BHLH transcription factor (TWIST1) to promote osteosarcoma progression by sponging miR-580-3p.

Guojun Tang, Linghua Liu, Zhihong Xiao, Shuo Wen, Liangyuan Chen, Peng Yang,

Circular RNAs (circ RNAs) have been found to play an important role in cancer development. However, the role of circRAB3IP in osteosarcoma (OS) is unclear.In the present study, We found that circRAB3IP was highly expressed in OS tissues and OS cells. High levels of circRAB3IP was correlated with advanced TNM ... Read more >>

Bioengineered (Bioengineered)
[2021, 12(1):3385-3397]

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Metagenomic and metabolomic profiling reveals the correlation between the microbiota and flavor compounds and nutrients in fermented sausages.

Peng Yang, Guixia Zhong, Juanchun Yang, Linyu Zhao, Ding Sun, Yaqin Tian, Ruren Li, Liangyan Rong,

Understanding the interrelationships between the differentially abundant microorganisms and metabolites of traditional "Fuet" fermented sausages (FSs) and inoculated fermented sausages (IFSs) can help us identify key species that are missing from commercial starter cultures to reproduce the flavor compounds and nutrients of traditional Fuet FSs. IFSs, inoculated with P. pentosaceus, ... Read more >>

Food Chem (Food chemistry)
[2021, :131645]

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Two-dimensional porphyrin covalent organic frameworks with tunable catalytic active sites for the oxygen reduction reaction.

Jie-Yu Yue, Yu-Tong Wang, Xin Wu, Peng Yang, Yu Ma, Xuan-He Liu, Bo Tang,

Four novel two-dimensional porphyrin COFs (M-TP-COF, M = H<sub>2</sub>, Co, Ni and Mn) with donor-acceptor dyads were fabricated and served as electrocatalysts for the oxygen reduction reaction (ORR). The ORR catalytic activity of M-TP-COF was tuned by changing the M atom in the center of the porphyrin backbone. The experimental ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2021, 57(94):12619-12622]

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Biopolymer-Based Membrane Adsorber for Removing Contaminants from Aqueous Solution: Progress and Prospects.

Facui Yang, Peng Yang,

The demand for energy-efficient water treatment as well as the limitation in adsorption of existing membranes has motivated the pursuit of membranes that can break the selectivity-permeability trade-off and provide high selective adsorption for chemicals of interest. The membrane adsorbers have received a lot of attention for removing contaminants from ... Read more >>

Macromol Rapid Commun (Macromolecular rapid communications)
[2021, :e2100669]

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Function and transcriptional regulation of TCTN1 in oral squamous cell carcinoma.

Guangliang Bai, Ning Wei, Fang Li, Peng Zhao, Zhen Meng, Bo Zou, Yujiao Liu, Kai Xu, Keyi Li, Chao Yao, Peng Yang,

Oral squamous cell carcinoma (OSCC) is one of the most common types of head and neck squamous cell carcinoma (HNSCC) with a poor survival rate. In the present study, the involvement of tectonic 1 (TCTN1) in OSCC was explored. The relevance between TCTN1 and HNSCC clinicopathological features was first analyzed and ... Read more >>

Oncol Rep (Oncology reports)
[2022, 47(2):]

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Physician-Modified Endograft With Triple Inner Branches for Extensive Aortic Arch Aneurysm.

Yu Zhang, Jiayu Shen, Peng Yang, Jia Hu,

<h4>Purpose</h4>The purpose of this case report was to demonstrate the feasibility of a physician-modified endograft (PMEG) with 3 inner branches for extensive aortic arch aneurysm.<h4>Case report</h4>A 69-year-old male presented with extensive aortic arch aneurysm involving all supra-aortic vessels. An Ankura thoracic stent graft was modified with 3 inner branches fashioned ... Read more >>

J Endovasc Ther (Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists)
[2021, :15266028211059439]

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Circ-ATAD1 is overexpressed in osteosarcoma (OS) and suppresses the maturation of miR-154-5p to increase cell invasion and migration.

Jihui Zhou, Li Xu, Peng Yang, Shibang Lin, Haizhou Huang,

Circ-ATAD1 plays an oncogenic role in gastric cancer. However, its roles in other cancers are unclear. We aimed to analyze the role of circ-ATAD1 in osteosarcoma (OS). The expression levels of circ-ATAD1, mature miR-154-5p, and premature miR-154-5p in paired OS and non-tumor tissues from 56 OS patients were determined using ... Read more >>

J Orthop Surg Res (Journal of orthopaedic surgery and research)
[2021, 16(1):699]

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Pediatric Extraspinal Subcutaneous Sacrococcygeal Myxopapillary Ependymoma: Case Report and Minireview.

Yufei Liu, Yang Peng, Xiaolu Wang, Zhaokun Guo, Chao Xiang, Weisong Wan, Xingfu Wang, Yuchang Hu,

<h4>Abstract</h4>A 9-year-old girl presented with a slow-growing and painless mass for 7 months in the soft tissue of the sacrococcygeal region. Magnetic resonance imaging revealed a well-circumscribed solid mass located in the subcutaneous soft tissue of the sacrococcygeal area, but not affecting bone structures. The mass was completely removed, and ... Read more >>

Am J Dermatopathol (The American Journal of dermatopathology)
[2021, 43(12):e273-e276]

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The Risk of QTc Prolongation in Non-Diabetic and Diabetic Patients Taking Tyrosine Kinase Inhibitors (TKIs)- A Patient Safety Project at a Private Oncology Practice.

Zhongju Lu, Ying Luu, Jack Ip, Imran Husain, Michael Lu, Chang-Kyung Kim, Peng Yang, David Chu, Richard Lin, Ira Cohen, Alan Kaell,

<b>Objective:</b> To assess the prevalence of QTc prolongation in both non-diabetic and diabetic patients on TKIs. Some TKIs have been reported to cause QTc prolongation, which is prevalent in diabetes. However, there is no Risk Evaluation and Mitigation Strategy using series ECG to monitor those patients. <b>Methods:</b> Patients taking TKIs, ... Read more >>

J Community Hosp Intern Med Perspect (Journal of community hospital internal medicine perspectives)
[2021, 11(6):799-807]

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Comprehensive genomic, immunological and clinical analysis of COVID-19 vaccine breakthrough infections: a prospective, comparative cohort study

Di Tian, Yang Song, Man Zhang, Yang Pan, Ziruo Ge, Yao Zhang, Xingxiang Ren, Jing Wen, Yanli Xu, Hong Guo, Peng Yang, Zhihai Chen, Wenbo Xu,

<h4>Objectives</h4> As the COVID-19 pandemic is still ongoing and SARS-CoV-2 variants are circulating worldwide, an increasing number of breakthrough infections have been detected despite the good efficacy of COVID-19 vaccines. <h4>Methods</h4> A prospective, comparative cohort study was conducted in Beijing Ditan Hospital to evaluate the clinical, immunological and genomic characteristics ... Read more >>

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Neoadjuvant camrelizumab plus chemotherapy in treating locally advanced esophageal squamous cell carcinoma patients: a pilot study.

Peng Yang, Xiao Zhou, Xuefeng Yang, Yuefeng Wang, Tao Sun, Shiying Feng, Xianyou Ma,

<h4>Background</h4>Camrelizumab (a PD-1 inhibitor) has been used as a potential therapy in unresectable advanced esophageal squamous cell carcinoma (ESCC) along with adjuvant treatment in locally advanced ESCC, exhibiting an acceptable efficacy and safety profile. This pilot study was designed to further investigate the clinical value and tolerance of neoadjuvant camrelizumab ... Read more >>

World J Surg Oncol (World journal of surgical oncology)
[2021, 19(1):333]

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Promoting ethylene production over a wide potential window on Cu crystallites induced and stabilized via current shock and charge delocalization.

Hao Sun, Ling Chen, Likun Xiong, Kun Feng, Yufeng Chen, Xiang Zhang, Xuzhou Yuan, Baiyu Yang, Zhao Deng, Yu Liu, Mark H Rümmeli, Jun Zhong, Yan Jiao, Yang Peng,

Electrochemical CO<sub>2</sub> reduction (CO<sub>2</sub>RR) in a product-orientated and energy-efficient manner relies on rational catalyst design guided by mechanistic understandings. In this study, the effect of conducting support on the CO<sub>2</sub>RR behaviors of semi-conductive metal-organic framework (MOF) - Cu<sub>3</sub>(HITP)<sub>2</sub> are carefully investigated. Compared to the stand-alone MOF, adding Ketjen Black greatly ... Read more >>

Nat Commun (Nature communications)
[2021, 12(1):6823]

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Polydopamine free radical scavengers.

Junfei Hu, Lei Yang, Peng Yang, Shaohua Jiang, Xianhu Liu, Yiwen Li,

Polydopamine (PDA) is the most typical kind of synthetic melanin, which possesses interesting properties such as antioxidation, photoprotection, metal chelation, and energy dissipation. Over the past few years, PDA has been successfully synthesized via polymerization methods and has demonstrated excellent free radical scavenging ability. The related applications have been rapidly ... Read more >>

Biomater Sci (Biomaterials science)
[2020, 8(18):4940-4950]

Cited: 5 times

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Identification and functional study of FOXC1 variants in Chinese families with glaucoma.

Xinyao Wang, Xiangyuan Liu, Yuying Li, Bo Yang, Xuejiao Sun, Peng Yang, Zilin Zhong, Jianjun Chen,

This study aimed to identify the disease-causing gene of three Chinese families with glaucoma. Whole exome sequencing was performed on the probands and detected three different variants (c.405C>A (p.Cys135Ter), c.851G>T (p.Ser284Ile), and c.392C>T (p.Ser131Leu)) in FOXC1 as a causative gene of glaucoma, and Sanger sequencing was performed for verification and ... Read more >>

Am J Med Genet A (American journal of medical genetics. Part A)
[2021, :]

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Growth asymmetry precedes differential auxin response during apical hook initiation in Arabidopsis.

Yang Peng, Dan Zhang, Yuping Qiu, Zhina Xiao, Yusi Ji, Wenyang Li, Yiji Xia, Yichuan Wang, Hongwei Guo,

The development of a hook-like structure at the apical part of the soil-emerging organs has fascinated botanists for centuries, but how it is initiated remains unclear. Here, we demonstrate with high-throughput infrared imaging and 2-D clinostat treatment that, when gravity-induced root bending is absent, apical hook formation still takes place. ... Read more >>

J Integr Plant Biol (Journal of integrative plant biology)
[2021, :]

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Ideal Cardiovascular Health Metrics Modify the Association Between Exposure to Chinese Famine in Fetal and Cardiovascular Disease: A Prospective Cohort Study.

Xiong Ding, Jinfeng Li, Ying Wu, Peng Yang, Dandan Zhao, Xiaojie Yuan, Shuohua Chen, Xiaoyan Luo, Yun Li, Shouling Wu,

<b>Background:</b> No study has explored the modification effect of ideal cardiovascular health metrics (ICVHMs) on the association between famine exposure and risk of cardiovascular disease (CVD) so far. We aim to examine the effect of ICVHMs on the association between exposure to famine early in life and the risk of ... Read more >>

Front Cardiovasc Med (Frontiers in cardiovascular medicine)
[2021, 8:751910]

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Changes in hip Joint Contact Stress During a Gait Cycle based on the Individualized Modeling Framework of"Gait-Musculoskeletal System-Finite Element"

Binglang Xiong, Peng Yang, Tianye Lin, Jinli Xu, Yong Xie, Yongliang Guo, Churong Liu, Qizhao Zhou, Qizhong Lai, Qiushi Wei, Wei He, Qingwen Zhang,

<h4>Objective: </h4> To construct a comprehensive simulation framework of "gait-musculoskeletal system(MS)-finite element(FE)" for analysis of hip joint dynamics characteristics and the changes in the contact stress in the hip throughout a gait cycle. <h4>Methods: </h4>: Two healthy volunteers (male and female) were recruited. The 3D gait trajectories during normal walking ... Read more >>

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