Full Text Journal Articles by
Author Peipei Wang

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Hypermetabolic Unicentric Castleman Disease of Kidney on FDG PET/CT.

Peipei Wang, Guozhu Hou, Fang Li, Xin Cheng,

<h4>Abstract</h4>A 62-year-old man presented with a huge lesion of left kidney on ultrasound in a health examination 1 month ago. The mass showed hypervascularity on enhanced CT and intense FDG uptake on FDG PET/CT in the lower pole of kidney, which suggested renal malignancy. The histopathological result after surgical resection ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2021, 46(6):510-511]

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Whole Genomic DNA Methylation Profiling of CpG Sites in Promoter Regions of Dorsal Root Ganglion in Diabetic Neuropathic Pain Mice.

Wen Chen, Ting Lan, Qingyu Sun, Yurui Zhang, Danmin Shen, Tingting Hu, Jing Liu, Yingzi Chong, Peipei Wang, Qian Li, Weihua Cui, Fei Yang,

DNA methylation and demethylation play an important role in neuropathic pain. In general, DNA methylation of CpG sites in the promoter region impedes gene expression, whereas DNA demethylation contributes to gene expression. Here, we evaluated the methylation status of CpG sites in genomic DNA promoter regions in dorsal root ganglions ... Read more >>

J Mol Neurosci (Journal of molecular neuroscience : MN)
[2021, :]

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Delivering an online course in emergency nursing education during the pandemic: What are the effects on students' learning?

Tao Lei, Xiaoxue Yu, Min Zou, Peipei Wang, Rong Hua Yuan,

<h4>Background</h4>Online learning emerged as an auxiliary approach in 2013 when MOOCs were imported and popularized in Chinese universities, particularly in the duration of pandemic outbreaks worldwide. World health organization (WHO) had recommended online education to keep social distance which still needs further evaluation. This study aimed to examine whether an ... Read more >>

Australas Emerg Care (Australasian emergency care)
[2021, :]

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Author Correction: Epitope-directed monoclonal antibody production using a mixed antigen cocktail facilitates antibody characterization and validation.

Oi Wah Liew, Samantha S M Ling, Shera Lilyanna, Yue Zhou, Peipei Wang, Jenny P C Chong, Yan Xia Ng, Angeline E S Lim, Eliot R Y Leong, Qifeng Lin, Teck Kwang Lim, Qingsong Lin, Enoch M W Ng, Tuck Wah Ng, A Mark Richards,

Commun Biol (Communications biology)
[2021, 4(1):531]

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Predictive models of genetic redundancy in Arabidopsis thaliana.

Siobhan A Cusack, Peipei Wang, Serena G Lotreck, Bethany M Moore, Fanrui Meng, Jeffrey K Conner, Patrick J Krysan, Melissa D Lehti-Shiu, Shin-Han Shiu,

Genetic redundancy refers to a situation where an individual with a loss-of-function mutation in one gene (single mutant) does not show an apparent phenotype until one or more paralogs are also knocked out (double/higher-order mutant). Previous studies have identified some characteristics common among redundant gene pairs, but a predictive model ... Read more >>

Mol Biol Evol (Molecular biology and evolution)
[2021, :]

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Low-level Chlorpyrifos Exposure Affects Synaptic Plasticity in Hippocampal Neurons

Wenjuan Zhou, Chen Zhang, Peipei Wang, Yuanying Deng, Hongmei Dai, Qiong Xi, Jing Tian, Mengwen Zhao, Guojiao Wu, Lingling Zhao,

Chlorpyrifos (CPF) is a widely used organophosphorus pesticide and exhibits environmental persistence and bioaccumulation. Increasing evidence has shown that exposure to CPF in early life might induce neurodevelopmental disorders in adulthood. Synaptic plasticity plays a crucial role in neurodevelopment. This study aimed to investigate the effect of CPF on synaptic ... Read more >>

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Multi-Mode Reconfigurable DNA-Based Chemical Reaction Circuits for Soft Matter Computing and Control.

Qian Tang, Wei Lai, Peipei Wang, Xiewei Xiong, Mingshu Xiao, Li Li, Chunhai Fan, Hao Pei,

Developing smart material system for performing different tasks in diverse environments remains challenging. Here, we show that by integrating stimuli-responsive soft materials with multi-mode reconfigurable DNA-based chemical reaction circuits (D-CRCs), it can control size change of microgels with multiple reaction pathways and adapt expansion behaviors to meet diverse environments. We ... Read more >>

Angew Chem Int Ed Engl (Angewandte Chemie (International ed. in English))
[2021, :]

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YBX1 is required for maintaining myeloid leukemia cell survival by regulating BCL2 stability in an m6A-dependent manner.

Mengdie Feng, Xueqin Xie, Guoqiang Han, Tiantian Zhang, Yashu Li, Yicun Li, Rong Yin, Qifan Wang, Tong Zhang, Peipei Wang, Jin Hu, Ying Cheng, Zhuying Gao, Jing Wang, Jiwei Chang, Manman Cui, Kexin Gao, Jihua Chai, Weidong Liu, Chengli Guo, Shaoguang Li, Lingbo Liu, Fuling Zhou, Jianjun Chen, Haojian Zhang,

RNA-binding proteins (RBPs) are critical regulators of transcription and translation that are often dysregulated in cancer. Although RBPs are increasingly appreciated as being important for normal hematopoiesis and for hematological malignancies as oncogenes or tumor suppressors, essential RBPs for leukemia maintenance and survival remain elusive. Here we show that YBX1 ... Read more >>

Blood (Blood)
[2021, :]

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Dimethyl fumarate prevents ferroptosis to attenuate acute kidney injury by acting on NRF2.

Yunwen Yang, Fangfang Cai, Ning Zhou, Suwen Liu, Peipei Wang, Shengnan Zhang, Yue Zhang, Aihua Zhang, Zhanjun Jia, Songming Huang,

Clin Transl Med (Clinical and translational medicine)
[2021, 11(4):e382]

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Lipocalin-type prostaglandin D synthase levels increase in patients with narcolepsy and idiopathic hypersomnia.

Peipei Wang, Qinghua Li, Xiaosong Dong, Haiyan An, Jing Li, Long Zhao, Han Yan, Kosuke Aritake, Zhili Huang, Kingman P Strohl, Yoshihiro Urade, Jun Zhang, Fang Han,

<h4>Study objectives</h4>Excessive daytime sleepiness (EDS) is a frequent cause for consultation and a defining symptom of narcolepsy and idiopathic hypersomnia (IH). The associated mechanisms remain unclear. Lipocalin-type prostaglandin D synthase (LPGDS) is a plausible sleep-inducing candidate. This study is to compare cerebral spinal fluid (CSF) and serum LPGDS levels in ... Read more >>

Sleep (Sleep)
[2021, 44(4):]

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Gut microbiota, key to unlocking the door of diabetic kidney disease.

Peipei Wang, Ting Wang, Xuejun Zheng, Wen Cui, Jin Shang, Zhanzheng Zhao,

This review discusses the influence of gut microbiota dysbiosis on diabetic kidney disease through metabolite profile changes and immune and inflammatory mechanisms. We also elaborate on the mechanism of dysbiosis in the onset and development of other kidney diseases. ... Read more >>

Nephrology (Carlton) (Nephrology (Carlton, Vic.))
[2021, :]

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Optimising the use of gene expression data to predict plant metabolic pathway memberships.

Peipei Wang, Bethany M Moore, Sahra Uygun, Melissa D Lehti-Shiu, Cornelius S Barry, Shin-Han Shiu,

Plant metabolites from diverse pathways are important for plant survival, human nutrition and medicine. The pathway memberships of most plant enzyme genes are unknown. While co-expression is useful for assigning genes to pathways, expression correlation may exist only under specific spatiotemporal and conditional contexts. Utilising > 600 tomato (Solanum lycopersicum) expression data ... Read more >>

New Phytol (The New phytologist)
[2021, :]

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Simultaneous imaging of mitochondrial viscosity and hydrogen peroxide in Alzheimer's disease by a single near-infrared fluorescent probe with a large Stokes shift.

Songjiao Li, Peipei Wang, Wenqi Feng, Yunhui Xiang, Kun Dou, Zhihong Liu,

It has been speculated that both the intracellular viscosity and H2O2 level in Alzheimer's disease (AD) brains are higher than that in healthy brains, but direct evidence from living beings is scarce. Herein, we report a NIR emissive fluorescent probe with a large Stokes shift for the associated detection of ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2020, 56(7):1050-1053]

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Conserved pleiotropy of an ancient plant homeobox gene uncovered by cis-regulatory dissection.

Anat Hendelman, Sophia Zebell, Daniel Rodriguez-Leal, Noah Dukler, Gina Robitaille, Xuelin Wu, Jamie Kostyun, Lior Tal, Peipei Wang, Madelaine E Bartlett, Yuval Eshed, Idan Efroni, Zachary B Lippman,

Divergence of gene function is a hallmark of evolution, but assessing functional divergence over deep time is not trivial. The few alleles available for cross-species studies often fail to expose the entire functional spectrum of genes, potentially obscuring deeply conserved pleiotropic roles. Here, we explore the functional divergence of WUSCHEL ... Read more >>

Cell (Cell)
[2021, 184(7):1724-1739.e16]

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3D augmented fundus images for identifying glaucoma via transferred convolutional neural networks.

Peipei Wang, Mingyuan Yuan, Yan He, Jiuai Sun,

<h4>Purpose</h4>Glaucoma is a chronic and irreversible retinopathy threatening the vision of millions of patients around the world. Its early diagnosis and treatment can help to prolong the period of sight deterioration from no visual impairment to blindness, whereas the screening and diagnosis of glaucoma in clinical remains challenging because some ... Read more >>

Int Ophthalmol (International ophthalmology)
[2021, :]

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Correction to: Forkhead box (FOX) G1 promotes hepatocellular carcinoma epithelial-Mesenchymal transition by activating Wnt signal through forming T-cell factor-4/Betacatenin/FOXG1 complex.

Xingrong Zheng, Jiaxin Lin, Hewei Wu, Zhishuo Mo, Yunwen Lian, Peipei Wang, Zhaoxia Hu, Zhiliang Gao, Liang Peng, Chan Xie,

J Exp Clin Cancer Res (Journal of experimental & clinical cancer research : CR)
[2021, 40(1):104]

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The effect of somatosensory alpha transcranial alternating current stimulation on pain empathy is trait empathy and gender dependent.

Peipei Wang, Minjia Zhu, Shaohua Mo, Xiaoli Li, Jing Wang,

<h4>Background</h4>Pain empathy enables a person to experience and understand other's pain state by observing others in pain condition. Such prosocial ability is deficient in many psychopathological disorders. Somatosensory alpha suppression is considered as neural correlates of pain empathy and is hypothesized as a target for enhancement of pain empathy. Researches ... Read more >>

CNS Neurosci Ther (CNS neuroscience & therapeutics)
[2021, :]

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Design, Synthesis, and Biological Evaluation of Orally Bioavailable CHK1 Inhibitors Active against Acute Myeloid Leukemia.

Tingting Jin, Peipei Wang, Xiubing Long, Kailong Jiang, Pinrao Song, Wenbiao Wu, Gaoya Xu, Yubo Zhou, Jia Li, Tao Liu,

Checkpoint kinase 1 (CHK1) is a central component in DNA damage response and has emerged as a target for antitumor therapeutics. Herein, we describe the design, synthesis, and biological evaluation of a novel series of potent diaminopyrimidine CHK1 inhibitors. The compounds exhibited moderate to potent CHK1 inhibition and could suppress ... Read more >>

ChemMedChem (ChemMedChem)
[2021, 16(9):1477-1487]

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Impact of short-read sequencing on the misassembly of a plant genome.

Peipei Wang, Fanrui Meng, Bethany M Moore, Shin-Han Shiu,

<h4>Background</h4>Availability of plant genome sequences has led to significant advances. However, with few exceptions, the great majority of existing genome assemblies are derived from short read sequencing technologies with highly uneven read coverages indicative of sequencing and assembly issues that could significantly impact any downstream analysis of plant genomes. In ... Read more >>

BMC Genomics (BMC genomics)
[2021, 22(1):99]

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Anti-aging function and molecular mechanism of Radix Astragali and Radix Astragali preparata via network pharmacology and PI3K/Akt signaling pathway.

Pin Gong, Danni Wang, Dandan Cui, Qian Yang, Peipei Wang, Wenjuan Yang, Fuxin Chen,

<h4>Background</h4>Radix Astragali (RA) consists of the dried root of Astragalus membranaceus Bunge and is one of the most frequently used dietetic Chinese herbs to treat inflammation and neurodegenerative disease among other conditions. Radix Astragali preparata (RAP) is a medicinal form of RA. RA and RAP have been used as anti-aging ... Read more >>

Phytomedicine (Phytomedicine : international journal of phytotherapy and phytopharmacology)
[2021, 84:153509]

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Prognostic Value of Positive Presurgical FDG PET/CT in the Evaluation of Tumor-Induced Osteomalacia.

Peipei Wang, Shu Zhang, Li Huo, Hongli Jing, Fang Li,

<h4>Methods</h4>Seventy-six patients who had surgically removed tumors that caused osteomalacia were included in this retrospective investigation. All patients underwent both 18F-FDG and 68Ga-DOTATATE PET/CT prior to surgery. The prognostic value of presurgical FDG PET/CT study was determined with 5-year follow-up.<h4>Results</h4>In the presurgical evaluation, 68Ga-DOTATATE detected lesions in all 76 patients. ... Read more >>

Clin Nucl Med (Clinical nuclear medicine)
[2021, 46(3):214-219]

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Corrigendum to "Hydrogen Gas Attenuates Hypoxic-Ischemic Brain Injury via Regulation of the MAPK/HO-1/PGC-1a Pathway in Neonatal Rats".

Peipei Wang, Mingyi Zhao, Zhiheng Chen, Guojiao Wu, Masayuki Fujino, Chen Zhang, Wenjuan Zhou, Mengwen Zhao, Shin-Ichi Hirano, Xiao-Kang Li, Lingling Zhao,

[This corrects the article DOI: 10.1155/2020/6978784.]. ... Read more >>

Oxid Med Cell Longev (Oxidative medicine and cellular longevity)
[2021, 2021:3539415]

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Neuron specific enolase promotes tumor metastasis by activating the Wnt/β-catenin pathway in small cell lung cancer.

Zhiqiang Zha, Dailing Li, Peiling Zhang, Peipei Wang, Xisheng Fang, Xia Liu, Chengyin Weng, Baoxiu Li, Yong Wu, Haibo Mao, Lina Wang, Lin Xu, Jiaming Dong, Mingmei Guan, Lin Lu, Guolong Liu,

Neuron-specific enolase (NSE) has been used as a specific biomarker for small cell lung cancer (SCLC) patients. Nevertheless, the biological function and mechanism of NSE in SCLC are still unclear. In this study, we clarified the role of NSE in the progression of SCLC and found that NSE expression was ... Read more >>

Transl Oncol (Translational oncology)
[2021, 14(4):101039]

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Personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer.

Zhenyu Ding, Qing Li, Rui Zhang, Li Xie, Yang Shu, Song Gao, Peipei Wang, Xiaoqing Su, Yun Qin, Yuelan Wang, Juemin Fang, Zhongzheng Zhu, Xuyang Xia, Guochao Wei, Hui Wang, Hong Qian, Xianling Guo, Zhibo Gao, Yu Wang, Yuquan Wei, Qing Xu, Heng Xu, Li Yang,

Neoantigens are considered to be ultimate target of tumor immunotherapy due to their high tumor specificity and immunogenicity. Dendritic cell (DCs) vaccines based on neoantigens have exciting effects in treatment of some malignant tumors and are a promising therapeutic modality. Lung cancer is a lethal disease with the highest morbidity ... Read more >>

Signal Transduct Target Ther (Signal transduction and targeted therapy)
[2021, 6(1):26]

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Functional Component Isolated from Phaseolus vulgaris Lectin Exerts In Vitro and In Vivo Anti-Tumor Activity Through Potentiation of Apoptosis and Immunomodulation.

Peipei Wang, Xiaohong Leng, Jiaqi Duan, Yue Zhu, Jue Wang, Zirui Yan, Shitong Min, Dapeng Wei, Xia Wang,

Phytohemagglutinin (PHA), the lectin purified from red kidney bean (Phaseolus vulgaris), is a well-known mitogen for human lymphocyte. Because it has obvious anti-proliferative and anti-tumor activity, PHA may serve as a potential antineoplastic drug in future cancer therapeutics. However, the literature is also replete with data on detrimental effects of ... Read more >>

Molecules (Molecules (Basel, Switzerland))
[2021, 26(2):]

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