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Children's dietary assessment and promotion: The Swiss situation.

Nicole Bender, Pedro Marques-Vidal, Pollyanna Patriota, Natalie Rangelov, Kaspar Staub, L Suzanne Suggs, Klazine van der Horst,

Int J Public Health (International journal of public health)
[2020, :]

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Risk factors of excessive daytime sleepiness in a prospective population-based cohort.

Mathieu Berger, Camila Hirotsu, Jose Haba-Rubio, Monica Betta, Giulio Bernardi, Francesca Siclari, Gerard Waeber, Peter Vollenweider, Pedro Marques-Vidal, Raphael Heinzer,

Although excessive daytime sleepiness is commonly evaluated in clinical and research settings using the Epworth Sleepiness Scale, few studies have assessed the factors associated with its incidence in the general population. We prospectively investigated the predictors of incident and persistent excessive daytime sleepiness in 2,751 subjects (46.1% men, mean age ... Read more >>

J Sleep Res (Journal of sleep research)
[2020, :e13069]

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Accelerometry Assessed Physical Activity of Older Adults Hospitalized with Acute Medical Illness - an Observational Study

Plamena Tasheva, Vanessa Kraege, Peter Vollenweider, Guillaume Roulet, Marie Méan, Pedro Marques-Vidal,

Abstract Background: In a hospital setting and among older patients, inactivity and bedrest are associated with a wide range of negative outcomes such as functional decline, increased risk of falls, longer hospitalization and institutionalization. Our aim was to assess the distribution, determinants and predictors of physical activity (PA) levels using ... Read more >>

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Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci.

Lisa de Las Fuentes, Yun Ju Sung, Raymond Noordam, Thomas Winkler, Mary F Feitosa, Karen Schwander, Amy R Bentley, Michael R Brown, Xiuqing Guo, Alisa Manning, Daniel I Chasman, Hugues Aschard, Traci M Bartz, Lawrence F Bielak, Archie Campbell, Ching-Yu Cheng, Rajkumar Dorajoo, Fernando P Hartwig, A R V R Horimoto, Changwei Li, Ruifang Li-Gao, Yongmei Liu, Jonathan Marten, Solomon K Musani, Ioanna Ntalla, Tuomo Rankinen, Melissa Richard, Xueling Sim, Albert V Smith, Salman M Tajuddin, Bamidele O Tayo, Dina Vojinovic, Helen R Warren, Deng Xuan, Maris Alver, Mathilde Boissel, Jin-Fang Chai, Xu Chen, Kaare Christensen, Jasmin Divers, Evangelos Evangelou, Chuan Gao, Giorgia Girotto, Sarah E Harris, Meian He, Fang-Chi Hsu, Brigitte Kühnel, Federica Laguzzi, Xiaoyin Li, Leo-Pekka Lyytikäinen, Ilja M Nolte, Alaitz Poveda, Rainer Rauramaa, Muhammad Riaz, Rico Rueedi, Xiao-Ou Shu, Harold Snieder, Tamar Sofer, Fumihiko Takeuchi, Niek Verweij, Erin B Ware, Stefan Weiss, Lisa R Yanek, Najaf Amin, Dan E Arking, Donna K Arnett, Sven Bergmann, Eric Boerwinkle, Jennifer A Brody, Ulrich Broeckel, Marco Brumat, Gregory Burke, Claudia P Cabrera, Mickaël Canouil, Miao Li Chee, Yii-Der Ida Chen, Massimiliano Cocca, John Connell, H Janaka de Silva, Paul S de Vries, Gudny Eiriksdottir, Jessica D Faul, Virginia Fisher, Terrence Forrester, Ervin F Fox, Yechiel Friedlander, He Gao, Bruna Gigante, Franco Giulianini, Chi Charles Gu, Dongfeng Gu, Tamara B Harris, Jiang He, Sami Heikkinen, Chew-Kiat Heng, Steven Hunt, M Arfan Ikram, Marguerite R Irvin, Mika Kähönen, Maryam Kavousi, Chiea Chuen Khor, Tuomas O Kilpeläinen, Woon-Puay Koh, Pirjo Komulainen, Aldi T Kraja, J E Krieger, Carl D Langefeld, Yize Li, Jingjing Liang, David C M Liewald, Ching-Ti Liu, Jianjun Liu, Kurt K Lohman, Reedik Mägi, Colin A McKenzie, Thomas Meitinger, Andres Metspalu, Yuri Milaneschi, Lili Milani, Dennis O Mook-Kanamori, Mike A Nalls, Christopher P Nelson, Jill M Norris, Jeff O'Connell, Adesola Ogunniyi, Sandosh Padmanabhan, Nicholette D Palmer, Nancy L Pedersen, Thomas Perls, Annette Peters, Astrid Petersmann, Patricia A Peyser, Ozren Polasek, David J Porteous, Leslie J Raffel, Treva K Rice, Jerome I Rotter, Igor Rudan, Oscar-Leonel Rueda-Ochoa, Charumathi Sabanayagam, Babatunde L Salako, Pamela J Schreiner, James M Shikany, Stephen S Sidney, Mario Sims, Colleen M Sitlani, Jennifer A Smith, John M Starr, Konstantin Strauch, Morris A Swertz, Alexander Teumer, Yih Chung Tham, André G Uitterlinden, Dhananjay Vaidya, M Yldau van der Ende, Melanie Waldenberger, Lihua Wang, Ya-Xing Wang, Wen-Bin Wei, David R Weir, Wanqing Wen, Jie Yao, Bing Yu, Caizheng Yu, Jian-Min Yuan, Wei Zhao, Alan B Zonderman, Diane M Becker, Donald W Bowden, Ian J Deary, Marcus Dörr, Tõnu Esko, Barry I Freedman, Philippe Froguel, Paolo Gasparini, Christian Gieger, Jost Bruno Jonas, Candace M Kammerer, Norihiro Kato, Timo A Lakka, Karin Leander, Terho Lehtimäki, , Patrik K E Magnusson, Pedro Marques-Vidal, Brenda W J H Penninx, Nilesh J Samani, Pim van der Harst, Lynne E Wagenknecht, Tangchun Wu, Wei Zheng, Xiaofeng Zhu, Claude Bouchard, Richard S Cooper, Adolfo Correa, Michele K Evans, Vilmundur Gudnason, Caroline Hayward, Bernardo L Horta, Tanika N Kelly, Stephen B Kritchevsky, Daniel Levy, Walter R Palmas, A C Pereira, Michael M Province, Bruce M Psaty, Paul M Ridker, Charles N Rotimi, E Shyong Tai, Rob M van Dam, Cornelia M van Duijn, Tien Yin Wong, Kenneth Rice, W James Gauderman, Alanna C Morrison, Kari E North, Sharon L R Kardia, Mark J Caulfield, Paul Elliott, Patricia B Munroe, Paul W Franks, Dabeeru C Rao, Myriam Fornage,

Educational attainment is widely used as a surrogate for socioeconomic status (SES). Low SES is a risk factor for hypertension and high blood pressure (BP). To identify novel BP loci, we performed multi-ancestry meta-analyses accounting for gene-educational attainment interactions using two variables, "Some College" (yes/no) and "Graduated College" (yes/no). Interactions ... Read more >>

Mol. Psychiatry (Molecular psychiatry)
[2020, :]

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Clinical determinants of the PR interval duration in Swiss middle-aged adults: The CoLaus/PsyCoLaus study.

Marylène Bay, Peter Vollenweider, Pedro Marques-Vidal, Federica Bocchi, Etienne Pruvot, Jürg Schläpfer,

BACKGROUND:Prolonged PR interval (PRi) is associated with adverse outcomes. However, PRi determinants are poorly known. We aimed to identify the clinical determinants of the PRi duration in the general population. HYPOTHESIS:Some clinical data are associated with prolonged PRi. METHODS:Cross-sectional study conducted between 2014 and 2017. Electrocardiogram-derived PRi duration was categorized ... Read more >>

Clin Cardiol (Clinical cardiology)
[2020, :]

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Comparison of lifestyle changes and pharmacological treatment on cardiovascular risk factors.

Pedro Marques-Vidal,

Heart (Heart (British Cardiac Society))
[2020, 106(11):852-862]

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Determinants of Metabolic Health Across Body Mass Index Categories in Central Europe: A Comparison Between Swiss and Czech Populations.

Sarka Kunzova, Andrea Maugeri, Jose Medina-Inojosa, Francisco Lopez-Jimenez, Manlio Vinciguerra, Pedro Marques-Vidal,

Comparisons among countries can help to identify opportunities for the reduction of inequalities in cardiometabolic health. The present cross-sectional analysis and meta-analysis aim to address to what extent obesity traits, socioeconomic, and behavioral factors determine poor metabolic health across body mass index (BMI) categories in two urban population-based samples from ... Read more >>

Front Public Health (Frontiers in public health)
[2020, 8:108]

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The haemochromatosis gene Hfe and Kupffer cells control LDL cholesterol homeostasis and impact on atherosclerosis development.

Egon Demetz, Piotr Tymoszuk, Richard Hilbe, Chiara Volani, David Haschka, Christiane Heim, Kristina Auer, Daniela Lener, Lucas B Zeiger, Christa Pfeifhofer-Obermair, Anna Boehm, Gerald J Obermair, Cornelia Ablinger, Stefan Coassin, Claudia Lamina, Juliane Kager, Verena Petzer, Malte Asshoff, Andrea Schroll, Manfred Nairz, Stefanie Dichtl, Markus Seifert, Laura von Raffay, Christine Fischer, Marina Barros-Pinkelnig, Natascha Brigo, Lara Valente de Souza, Sieghart Sopper, Jakob Hirsch, Michael Graber, Can Gollmann-Tepeköylü, Johannes Holfeld, Julia Halper, Sophie Macheiner, Johanna Gostner, Georg F Vogel, Raimund Pechlaner, Patrizia Moser, Medea Imboden, Pedro Marques-Vidal, Nicole M Probst-Hensch, Heike Meiselbach, Konstantin Strauch, Annette Peters, Bernhard Paulweber, Johann Willeit, Stefan Kiechl, Florian Kronenberg, Igor Theurl, Ivan Tancevski, Guenter Weiss,

AIMS:Imbalances of iron metabolism have been linked to the development of atherosclerosis. However, subjects with hereditary haemochromatosis have a lower prevalence of cardiovascular disease. The aim of our study was to understand the underlying mechanisms by combining data from genome-wide association study analyses in humans, CRISPR/Cas9 genome editing, and loss-of-function ... Read more >>

Eur. Heart J. (European heart journal)
[2020, :]

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Patterns of multimorbidity in medical inpatients: a multinational retrospective cohort study.

Carole Elodie Aubert, Jeffrey Lawrence Schnipper, Niklaus Fankhauser, Pedro Marques-Vidal, Jérôme Stirnemann, Andrew David Auerbach, Eyal Zimlichman, Sunil Kripalani, Eduard Eric Vasilevskis, Edmondo Robinson, Joshua Metlay, Grant Selmer Fletcher, Andreas Limacher, Jacques Donzé,

Multimorbidity is frequent and represents a significant burden for patients and healthcare systems. However, there are limited data on the most common combinations of comorbidities in multimorbid patients. We aimed to describe and quantify the most common combinations of comorbidities in multimorbid medical inpatients. We used a large retrospective cohort ... Read more >>

Intern Emerg Med (Internal and emergency medicine)
[2020, :]

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Primary prevention efforts are poorly developed in people at high cardiovascular risk: A report from the European Society of Cardiology EURObservational Research Programme EUROASPIRE V survey in 16 European countries.

Kornelia Kotseva, Guy De Backer, Dirk De Bacquer, Lars Rydén, Arno Hoes, Diederick Grobbee, Aldo Maggioni, Pedro Marques-Vidal, Catriona Jennings, Ana Abreu, Carlos Aguiar, Jolita Badariene, Jan Bruthans, Renata Cifkova, Kairat Davletov, Mirza Dilic, Maryna Dolzhenko, Dan Gaita, Nina Gotcheva, Hosam Hasan-Ali, Piotr Jankowski, Christos Lionis, Silvia Mancas, Davor Milićić, Erkin Mirrakhimov, Rafael Oganov, Nana Pogosova, Željko Reiner, Duško Vulić, David Wood,

BACKGROUND:European Action on Secondary and Primary Prevention by Intervention to Reduce Events (EUROASPIRE) V in primary care was carried out by the European Society of Cardiology EURObservational Research Programme in 2016-2018. The main objective was to determine whether the 2016 Joint European Societies' guidelines on cardiovascular disease prevention in people ... Read more >>

Eur J Prev Cardiol (European journal of preventive cardiology)
[2020, :2047487320908698]

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[Organizational Impacts and Clinical Challenges of the COVID-19 Pandemic on a Swiss Tertiary Internal Medicine Department].

Antoine Garnier, Julien Vaucher, Christophe Bianchi, Vanessa Kraege, Marie Méan, Julien Castioni, Pierre-Alexandre Bart, Valérie Champier, Philippe Eggimann, David Gachoud, Milica Jovanovic, Olivier Lamy, Pedro Marques-Vidal, Matteo Monti, Anne Perier, Sylvie Robert, Guillaume Roulet, Claudio Sartori, Gérard Waeber, Peter Vollenweider,

The rapid progression of COVID-19 is an organizational challenge for all hospitals. To secure the patient overflow, the Department internal medicine of the University Hospital of Lausanne increased nurse and medical workforces as well as bed capacity by 65 %, with extraordinary help from other departments. The implemented crisis management stood ... Read more >>

Rev Med Suisse (Revue medicale suisse)
[2020, 16(N° 691-2):869-874]

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Mean Oxygen Saturation during Sleep Is Related to Specific Brain Atrophy Pattern.

Nicola Andrea Marchi, Cristina Ramponi, Camila Hirotsu, José Haba-Rubio, Antoine Lutti, Martin Preisig, Pedro Marques-Vidal, Peter Vollenweider, Ferath Kherif, Raphael Heinzer, Bogdan Draganski,

OBJECTIVE:There is much controversy about the neurobiological mechanisms underlying the effects of sleep-disordered breathing on the brain. The aim of this study was to investigate the association between markers of sleep-related hypoxemia and brain anatomy. METHODS:We used data from a large-scale cohort from the general population (n = 775, 50.6% ... Read more >>

Ann. Neurol. (Annals of neurology)
[2020, 87(6):921-930]

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Ten-Year Trend in Polypharmacy in the Lausanne Population.

Nazanin Abolhassani, Peter Vollenweider, Gérard Waeber, Pedro Marques-Vidal,

BACKGROUND:Aging and associated morbidities place individuals at higher risk of polypharmacy and drug-drug interactions (DDIs). How polypharmacy and DDIs change with aging is important for public health management. OBJECTIVES:The aim of the study was to assess the 10-year trends in prevalence of polypharmacy and potential DDIs in a population-based sample. ... Read more >>

J Patient Saf (Journal of patient safety)
[2020, :]

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Comparison of Swiss and European risk algorithms for cardiovascular prevention in Switzerland.

Hadrien Beuret, Nadine Hausler, David Nanchen, Marie Méan, Pedro Marques-Vidal, Julien Vaucher,

BACKGROUND:In Switzerland, two distinct algorithms are recommended for cardiovascular prevention: (a) Arbeitsgruppe Lipide und Atherosklerose (AGLA); and (b) European Society of Cardiology (ESC). We validated and determined which algorithm better predicts incident atherosclerotic cardiovascular disease and assessed statin eligibility in Switzerland. DESIGN:A prospective population-based cohort. METHODS:We employed longitudinal data of ... Read more >>

Eur J Prev Cardiol (European journal of preventive cardiology)
[2020, :2047487320906305]

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Validation of Seven Type 2 Diabetes Mellitus Risk Scores in a Population-Based Cohort: The CoLaus Study.

Vanessa Kraege, Janko Fabecic, Pedro Marques-Vidal, Gérard Waeber, Marie Méan,

AIM:To assess the validity of seven type 2 diabetes mellitus (T2DM) risk scores in predicting the 10-year incidence of T2DM in a Swiss population-based study. METHODS:The prospective study included 5131 participants (55% women, age range 35 to 75 years) living in Lausanne, Switzerland. The baseline survey was conducted between 2003 ... Read more >>

J. Clin. Endocrinol. Metab. (The Journal of clinical endocrinology and metabolism)
[2020, 105(3):]

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Inter-hospital comparison of working time allocation among internal medicine residents using time-motion observations: an innovative benchmarking tool.

Simon Martin Frey, Marie Méan, Antoine Garnier, Julien Castioni, Nathalie Wenger, Michael Egloff, Pedro Marques-Vidal, Juerg-Hans Beer,

OBJECTIVES:The vast majority of residents' working time is spent away from patients. In hospital practice, many factors may influence the resident's working day structure.Using an innovative method, we aimed to compare working time allocation among internal medicine residents using time-motion observations. The first study goal was to describe how the ... Read more >>

BMJ Open (BMJ open)
[2020, 10(2):e033021]

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Added value of somato-sensory evoked potentials amplitude for prognostication after cardiac arrest.

Giuseppina Barbella, Jan Novy, Pedro Marques-Vidal, Mauro Oddo, Andrea O Rossetti,

AIMS:Bilateral absence of cortical somato-sensory evoked potentials (SSEPs) robustly predicts poor outcome after cardiac arrest (CA), but it is uncertain if SSEP amplitudes provide additional information. Here, we examined the prognostic value of cortical SSEP amplitude in comparison with other known outcome predictors. METHODS:We retrospectively determined SSEP amplitudes in a ... Read more >>

Resuscitation (Resuscitation)
[2020, 149:17-23]

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Converging patterns of aging-associated brain volume loss and tissue microstructure differences.

Marco Taubert, Elisabeth Roggenhofer, Lester Melie-Garcia, Sandrine Muller, Nico Lehmann, Martin Preisig, Peter Vollenweider, Pedro Marques-Vidal, Antoine Lutti, Ferath Kherif, Bogdan Draganski,

Given the worldwide increasing socioeconomic burden of aging-associated brain diseases, there is pressing need to gain in-depth knowledge about the neurobiology of brain anatomy changes across the life span. Advances in quantitative magnetic resonance imaging sensitive to brain's myelin, iron, and free water content allow for a detailed in vivo investigation ... Read more >>

Neurobiol. Aging (Neurobiology of aging)
[2020, 88:108-118]

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Prognostic role of EEG identical bursts in patients after cardiac arrest: Multimodal correlation.

Giuseppina Barbella, Jan Novy, Pedro Marques-Vidal, Mauro Oddo, Andrea O Rossetti,

AIMS:EEG burst-suppression (BS) heralds poor outcome after cardiac arrest (CA). Within this pattern, identical bursts (IB) have been suggested to be absolutely specific, in isolation. We assessed IB prevalence and their added predictive value for poor outcome in a multimodal prognostic approach. METHODS:We retrospectively analyzed a registry of comatose adults ... Read more >>

Resuscitation (Resuscitation)
[2020, 148:140-144]

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Pulse wave amplitude drops during sleep: clinical significance and characteristics in a general population sample.

Camila Hirotsu, Monica Betta, Giulio Bernardi, Pedro Marques-Vidal, Peter Vollenweider, Gérard Waeber, Vincent Pichot, Frederic Roche, Francesca Siclari, Jose Haba-Rubio, Raphael Heinzer,

STUDY OBJECTIVES:To explore the clinical significance of pulse wave amplitude (PWA)-drops during sleep as a biomarker for cardiometabolic disorders and describe their main characteristics in a general population sample. METHODS:Cross-sectional study of HypnoLaus cohort, in which 2162 individuals underwent clinical assessment and in-home full polysomnography. PWA-drops were derived from photoplethysmography ... Read more >>

Sleep (Sleep)
[2020, :]

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PneumoLaus: Prévalence de troubles respiratoires fonctionnels dans un échantillon de la population lausannoise.

Alexandra Lenoir, Jean-William Fitting, Pedro Marques-Vidal, Laurent P Nicod,

PneumoLaus: Prevalence of Lung Function Abnormalities in a Sample of the General Population of Lausanne Abstract. Reduced lung function predicts increased mortality. The prevalence of spirometric abnormalities depends on their definition, the references values used and the use or not of bronchodilation. In the PneumoLaus study, conducted between 2014 and ... Read more >>

Praxis (Bern 1994) (Praxis)
[2020, 109(1):13-17]

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Patterns of benzodiazepine prescription among older adults in Switzerland: a cross-sectional analysis of claims data.

Xhyljeta Luta, Christophe Bagnoud, Mark Lambiris, Anne Decollogny, Yves Eggli, Marie-Annick Le Pogam, Pedro Marques-Vidal, Joachim Marti,

OBJECTIVE:This study aimed to examine the prevalence and determinants of benzodiazepine prescription among older adults in Switzerland, and analyse association with hospitalisation and costs. DESIGN:Retrospective analysis of claims data. SETTING:The study was conducted in nine cantons in Switzerland. PARTICIPANTS:Older adults aged 65 years and older enrolled with a large Swiss ... Read more >>

BMJ Open (BMJ open)
[2020, 10(1):e031156]

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Best Definitions of Multimorbidity to Identify Patients With High Health Care Resource Utilization.

Carole E Aubert, Jeffrey L Schnipper, Marie Roumet, Pedro Marques-Vidal, Jérôme Stirnemann, Andrew D Auerbach, Eyal Zimlichman, Sunil Kripalani, Eduard E Vasilevskis, Edmondo Robinson, Grant S Fletcher, Drahomir Aujesky, Andreas Limacher, Jacques Donzé,

Objective:To compare different definitions of multimorbidity to identify patients with higher health care resource utilization. Patients and Methods:We used a multinational retrospective cohort including 147,806 medical inpatients discharged from 11 hospitals in 3 countries (United States, Switzerland, and Israel) between January 1, 2010, and December 31, 2011. We compared the ... Read more >>

Mayo Clin Proc Innov Qual Outcomes (Mayo Clinic proceedings. Innovations, quality & outcomes)
[2020, 4(1):40-49]

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CoLaus: l’alimentation, la grande oubliée dans la prévention des maladies cardiovasculaires.

Pedro Marques-Vidal, Gérard Waeber, Peter Vollenweider,

CoLaus: Diet, the Forgotten Key to Preventing Cardiovascular Diseases Abstract. Healthy eating is paramount for the prevention and management of cardiovascular diseases. Still, data from the CoLaus study show that dietary management of cardiovascular risk factors and cardiovascular disease is little implemented. Less than one fifth of participants with dyslipidemia ... Read more >>

Praxis (Bern 1994) (Praxis)
[2020, 109(1):31-34]

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Dietary measures among patients with coronary heart disease in Europe. ESC EORP Euroaspire V.

Pedro Marques-Vidal, Piotr Jankowski, Dirk De Bacquer, Kornelia Kotseva, ,

OBJECTIVE:Assess the dietary recommendations provided to patients hospitalized for a coronary heart disease (CHD) event. DESIGN:Cross-sectional, multicentre observational study (ESC EORP Euroaspire V). METHODS:8261 participants (25.8% women, 9.3% aged<50 years) from 27 countries, 6 to 24 months after hospitalization for a CHD event were included. Participants were asked if they had been ... Read more >>

Int. J. Cardiol. (International journal of cardiology)
[2020, 302:5-14]

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