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Author Pedro Alves

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An Eleven-year-old Boy With Arthritis of the Hip Joint, and an 8-year-old Boy With Sacroiliitis.

Tânia Mendo, Susana Norte, Pedro Alves, Delfin Tavares, Margarida Pinto, Catarina Gouveia,

Pediatr Infect Dis J (The Pediatric infectious disease journal)
[2021, Publish Ahead of Print:]

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Early use of nitazoxanide in mild Covid-19 disease: randomised, placebo-controlled trial.

Patricia R M Rocco, Pedro L Silva, Fernanda F Cruz, Marco Antonio C M Junior, Paulo F G M M Tierno, Marcos A Moura, Luís Frederico G De Oliveira, Cristiano C Lima, Ezequiel A Dos Santos, Walter F Junior, Ana Paula S M Fernandes, Kleber G Franchini, Erick Magri, Nara F de Moraes, José Mário J Gonçalves, Melanie N Carbonieri, Ivonise S Dos Santos, Natália F Paes, Paula V M Maciel, Raissa P Rocha, Alex F de Carvalho, Pedro Augusto Alves, José Luiz P Modena, Artur T Cordeiro, Daniela B B Trivella, Rafael E Marques, Ronir R Luiz, Paolo Pelosi, Jose Roberto Lapa E Silva, ,

Nitazoxanide is widely available and exerts broad-spectrum antiviral activity <i>in vitro</i> However, there is no evidence of its impact on SARS-CoV-2 infection.In a multicenter, randomised, double-blind, placebo-controlled trial, adult patients presenting up to 3 days after onset of Covid-19 symptoms (dry cough, fever, and/or fatigue) were enrolled. After confirmation of SARS-CoV2 ... Read more >>

Eur Respir J (The European respiratory journal)
[2020, :]

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Identification of large genetic variations in the equine infectious anemia virus tat-gag genomic region.

Andreia Elisa Cursino, Maurício Teixeira Lima, Márcia Furlan Nogueira, Daniel Moura de Aguiar, Ana Paula Moreira Franco Luiz, Pedro Augusto Alves, João Pessoa Araujo Junior, Erna Geessien Kroon,

The aetiological agent of equine infectious anaemia (EIA) is the retrovirus equine infectious anemia virus (EIAV) that infects all members of the Equidae family. The EIA is widely disseminated in the Brazilian territory with a high seroprevalence in the Brazilian Pantanal and is mainly diagnosed using agar gel immunodiffusion (AGID). ... Read more >>

Transbound Emerg Dis (Transboundary and emerging diseases)
[2020, :]

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Social and racial inequalities in COVID-19 risk of hospitalisation and death across São Paulo state, Brazil

Sabrina Li, Rafael Pereira, Carlos Prete, Alexander Zarebski, Lucas Emanuel, Pedro JH Alves, Pedro Peixoto, Carlos KV Braga, Andreza de Souza Santos, William de Souza, Rogerio Barbosa, Lewis Buss, Alfredo Mendrone, Cesar de Almeida-Neto, Suzete Ferreira, Nanci Salles, Izabel Marcilio, Chieh-Hsi Wu, Nelson Gouveia, Vitor Nascimento, Ester Sabino, Nuno Faria, Jane Messina,

<h4>Summary</h4> <h4>Background</h4> Little evidence exists on the differential health effects of COVID-19 on disadvantaged population groups. Here we characterise the differential risk of hospitalisation and death in São Paulo state, Brazil and show how vulnerability to COVID-19 is shaped by socioeconomic inequalities. <h4>Methods</h4> We conducted a cross-sectional study using hospitalised ... Read more >>

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Early use of nitazoxanide in mild Covid-19 disease: randomized, placebo-controlled trial

Patricia Rocco, Pedro Silva, Fernanda Cruz, Marco Antonio Junior, Paulo Tierno, Marcos Moura, Luís Frederico De Oliveira, Cristiano Lima, Ezequiel Dos Santos, Walter Junior, Ana Paula Fernandes, Kleber Franchini, Erick Magri, Nara de Moraes, José Mário Gonçalves, Melanie Carbonieri, Ivonise Dos Santos, Natália Paes, Paula Maciel, Raissa Rocha, Alex de Carvalho, Pedro Augusto Alves, José Luiz Modena, Artur Cordeiro, Daniela Trivella, Rafael Marques, Ronir Luiz, Paolo Pelosi, Jose Roberto Lapa e Silva,

The antiparasitic drug nitazoxanide is widely available and exerts broad-spectrum antiviral activity in vitro . However, there is no evidence of its impact on SARS-CoV-2 infection. In a multicenter, randomized, double-blind, placebo-controlled trial, adult patients who presented up to 3 days after onset of Covid-19 symptoms (dry cough, fever, and/or ... Read more >>

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Anterior Knee Pain After Anterior Cruciate Ligament Reconstruction.

Fabiano da Silva Marques, Pedro Henrique Borges Barbosa, Pedro Rodrigues Alves, Sandro Zelada, Rodrigo Pereira da Silva Nunes, Marcio Régis de Souza, Márcio do Amaral Camargo Pedro, José Francisco Nunes, Wilson Mello Alves, Gustavo Constantino de Campos,

<h4>Background</h4>Anterior knee pain is a frequent condition after anterior cruciate ligament reconstruction (ACLR), but its origin remains uncertain. Studies have suggested that donor site morbidity in autologous bone-patellar tendon-bone reconstructions may contribute to patellofemoral pain, but this does not explain why hamstring tendon reconstructions may also present with anterior pain.<h4>Purpose</h4>To ... Read more >>

Orthop J Sports Med (Orthopaedic journal of sports medicine)
[2020, 8(10):2325967120961082]

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Neighbor danger: Yellow fever virus epizootics in urban and urban-rural transition areas of Minas Gerais state, during 2017-2018 yellow fever outbreaks in Brazil.

Lívia Sacchetto, Natalia Ingrid Oliveira Silva, Izabela Maurício de Rezende, Matheus Soares Arruda, Thais Alkifeles Costa, Érica Munhoz de Mello, Gabriela Fernanda Garcia Oliveira, Pedro Augusto Alves, Vítor Emídio de Mendonça, Rodolfo German Antonelli Vidal Stumpp, Alaine Izabela Alves Prado, Adriano Pereira Paglia, Fernando Araújo Perini, Maurício Lacerda Nogueira, Erna Geessien Kroon, Benoit de Thoisy, Giliane de Souza Trindade, Betânia Paiva Drumond,

<h4>Background</h4>From the end of 2016 until the beginning of 2019, Brazil faced a massive sylvatic yellow fever (YF) outbreak. The 2016-2019 YF epidemics affected densely populated areas, especially the Southeast region, causing thousands of deaths of humans and non-human primates (NHP).<h4>Methodology/principal findings</h4>We conducted a molecular investigation of yellow fever virus ... Read more >>

PLoS Negl Trop Dis (PLoS neglected tropical diseases)
[2020, 14(10):e0008658]

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Viola duet: A rare case of double sensitization to contact allergens in a professional musician.

Pedro B Alves, Ana Todo-Bom, Frederico S Regateiro,

Contact Dermatitis (Contact dermatitis)
[2020, 83(6):523-524]

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Growth, morphological, metabolic and photosynthetic responses of clones of eucalyptus to glyphosate

Wilson Roberto Cerveira Junior, Yanna Karoline Santos da Costa, Caio Antonio Carbonari, Stephen Oscar Duke, Pedro Luis da Costa Aguiar Alves, Leonardo Bianco de Carvalho,

We hypothesized that eucalyptus has clone-dependent responses to glyphosate, and such differential responses might be associated with morphological, metabolic and/or photosynthetic changes. Experiments were carried out under controlled conditions of temperature, photoperiod and nutrition, focusing on evaluating the response of Eucalyptus × urograndis clones (GG100 and I144) to increasing doses of glyphosate ... Read more >>

For Ecol Manage (Forest ecology and management)
[2020, 470-:Not Available]

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THE USE OF DENATURING SOLUTION AS COLLECTION AND TRANSPORT MEDIA TO IMPROVE SARS-COV-2 RNA DETECTION AND REDUCE INFECTION OF LABORATORY PERSONNEL

Alex Fiorini de Carvalho, Andreza Parreiras Gonçalves, Thaís Bárbara de Souza Silva, Hugo Itaru Sato, Larissa Vuitika, Flavia Fonseca Bagno, Sarah Aparecida Rodrigues Sérgio, Maria Marta Figueiredo, Raissa Prado Rocha, Ana Paula Salles Moura Fernandes, Pedro Augusto Alves, Santuza Maria Ribeiro Teixeira, Flavio Guimarães da Fonseca,

<h4>Background</h4> Since the emergence of the COVID-19, health officials have struggled to devise strategies to counteract the speed of the pandemic’s spread across the globe. It became imperative to implement accurate diagnostic tests for the detection of SARS-CoV-2 RNA on respiratory samples. In many places, however, besides the limited availability ... Read more >>

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High Tolerance of Trichogramma Pretiosum (Hymenoptera: Trichogrammatidae) to the Mixture of the Herbicides Nicosulfuron Plus Atrazine

Germano Leão Demolin Leite, João Marcos Batista Cordeiro, Leonardo David Tuffi Santos, Wagner de Souza Tavares, Alexandre Igor de Azevedo Pereira, Marcus Alvarenga Soares, Pedro Guilherme Lemes Alves, José Eduardo Serrão, José Cola Zanuncio,

<h4>Background: </h4> Maize, Zea mays (Poaceae), is one of the most important crops in the world, but defoliating caterpillars (Lepidoptera) and weeds can reduce the productivity of this plant. The control of weeds in the maize crop in Brazil is mainly accomplished with nicosulfuron- and atrazine-based herbicides, and of lepidopteran ... Read more >>

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Cognitive aging in migraine sufferers is associated with more subjective complaints but similar age-related decline: a 5-year longitudinal study.

Isabel Pavão Martins, Carolina Maruta, Pedro Nacimento Alves, Clara Loureiro, Joana Morgado, Joana Tavares, Raquel Gil-Gouveia,

OBJECTIVES AND BACKGROUND:The effect of headache on cognitive performance is controversial, due to conflicting results obtained from studies in clinical or population settings. We aimed to understand if migraine and other headaches modify the rates of decline on different cognitive measures, during a 5-year interval. DESIGN AND METHOD:A cohort of ... Read more >>

J Headache Pain (The journal of headache and pain)
[2020, 21(1):31]

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GO-DACT: a phase 3b randomised, double-blind, placebo-controlled trial of GOlimumab plus methotrexate (MTX) versus placebo plus MTX in improving DACTylitis in MTX-naive patients with psoriatic arthritis.

Elsa Vieira-Sousa, Pedro Alves, Ana M Rodrigues, Filipa Teixeira, Jose Tavares-Costa, Alexandra Bernardo, Sofia Pimenta, Fernando M Pimentel-Santos, João Lagoas Gomes, Renata Aguiar, Patrícia Pinto, Taciana Videira, Cristina Catita, Helena Santos, Joana Borges, Graça Sequeira, Célia Ribeiro, Lídia Teixeira, Pedro Ávila-Ribeiro, Fernando M Martins, Helena Canhão, Iain B McInnes, Ruy M Ribeiro, João Eurico Fonseca,

OBJECTIVES:To assess the efficacy of golimumab in combination with methotrexate (MTX) versus MTX monotherapy in psoriatic arthritis (PsA) dactylitis. METHODS:Multicentre, investigator-initiated, randomised, double-blind, placebo-controlled, parallel-design phase 3b trial in 11 Portuguese rheumatology centres. Patients with PsA along with active dactylitis and naive to MTX and biologic disease-modifying antirheumatic drugs (bDMARDs) ... Read more >>

Ann Rheum Dis (Annals of the rheumatic diseases)
[2020, 79(4):490-498]

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Osteoarticular infections in paediatric sickle cell disease: in the era of multidrugresistant bacteria.

Catarina Gouveia, Mariana Duarte, Susana Norte, Pedro Alves, Paula Kjöllerström, Maria Brito, Delfin Tavares,

Br J Haematol (British journal of haematology)
[2020, 189(4):e147-e150]

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Coumarin-grafted blue-emitting fluorescent alginate as a potentially valuable tool for biomedical applications.

Marco Araújo, Sílvia J Bidarra, Pedro M Alves, Jesús Valcarcel, José A Vázquez, Cristina C Barrias,

A novel blue-emitting fluorescent alginate derivative has been successfully synthesised in a simple two-reaction step procedure, using an aqueous conjugation strategy that involved carbodiimide coupling followed by an alkyne-azide "click" reaction. The modified alginate maintained the characteristic ability to form mechanically stable hydrogels by ionic crosslinking. The fluorescent properties of ... Read more >>

J Mater Chem B (Journal of materials chemistry. B)
[2020, 8(4):813-825]

Cited: 1 time

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Appropriateness of Radiology Test Requests by an Emergency Department: A Retrospective Study.

Rute Martins, Pedro Raimundo, Pedro Alves, Rodrigo Monteiro, Luís Duarte Silva, André Gomes, Graça Afonso,

INTRODUCTION:Imaging tests are essential for diagnosis in the emergency context and convey clinical information that is essential to assess the appropriateness of the tests and improve their interpretation. Therefore, we aimed to analyze the imaging tests requested by the Emergency Department in a district hospital. MATERIAL AND METHODS:We retrospectively analyzed computed tomography ... Read more >>

Acta Med Port (Acta medica portuguesa)
[2020, 33(1):7-14]

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Undetermined stroke genesis and hidden cardiomyopathies determined by cardiac magnetic resonance.

Ana Catarina Fonseca, João Pedro Marto, Daniela Pimenta, Tatiana Guimarães, Pedro N Alves, Nuno Inácio, Miguel Viana-Baptista, Teresa Pinho E Melo, Fausto J Pinto, José M Ferro, Ana G Almeida,

<h4>Objective</h4>To determine whether cardiac magnetic resonance imaging (CMR) could be useful in identifying previously undiagnosed cardiomyopathies in a cohort of patients with ischemic stroke who underwent standard etiologic investigation and to describe the type and frequency of these cardiomyopathies.<h4>Methods</h4>We performed a subanalysis of a previously collected prospective cohort of patients ... Read more >>

Neurology (Neurology)
[2020, 94(1):e107-e113]

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Yellow Fever Virus Genotyping Tool and Investigation of Suspected Adverse Events Following Yellow Fever Vaccination.

Izabela Maurício de Rezende, Pedro Augusto Alves, Matheus Soares Arruda, Andreza Parreiras Gonçalves, Gabriela Fernanda Garcia Oliveira, Leonardo Soares Pereira, Maria Rita Teixeira Dutra, Ana Carolina Campi-Azevedo, Valéria Valim, Renata Tourinho, Jaquelline Germano de Oliveira, Carlos Eduardo Calzavara, Rodrigo Fabiano do Carmo Said, Erna Geessien Kroon, Olindo Assis Martins-Filho, Andrea Teixeira-Carvalho, Betânia Paiva Drumond,

The yellow fever (YF) vaccine consists of an attenuated virus, and despite its relative safety, some adverse events following YF vaccination have been described. At the end of 2016, Brazil experienced the most massive sylvatic yellow fever outbreak over the last 70 years and an intense campaign of YF vaccination ... Read more >>

Vaccines (Basel) (Vaccines)
[2019, 7(4):]

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Protocol-based follow-up program for heart failure patients: Impact on prognosis and quality of life.

João R Agostinho, Inês Gonçalves, Joana Rigueira, Inês Aguiar-Ricardo, Afonso Nunes-Ferreira, Rafael Santos, Tatiana Guimarães, Pedro Alves, Nelson Cunha, Tiago Rodrigues, ŃZinga André, Mónica Pedro, Fátima Veiga, Fausto J Pinto, Dulce Brito, ,

INTRODUCTION:Heart failure is associated with high rates of readmission and mortality, and there is a need for measures to improve outcomes. This study aims to assess the impact of the implementation of a protocol-based follow-up program for heart failure patients on readmission and mortality rates and quality of life. METHODS:A ... Read more >>

Rev Port Cardiol (Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology)
[2019, 38(11):755-764]

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Automatic Focus Assessment on Dermoscopic Images Acquired with Smartphones.

José Alves, Dinis Moreira, Pedro Alves, Luís Rosado, Maria João M Vasconcelos,

Over recent years, there has been an increase in popularity of the acquisition of dermoscopic skin lesion images using mobile devices, more specifically using the smartphone camera. The demand for self-care and telemedicine solutions requires suitable methods to guide and evaluate the acquired images' quality in order to improve the ... Read more >>

Sensors (Basel) (Sensors (Basel, Switzerland))
[2019, 19(22):]

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Circulation of Chikungunya virus East-Central-South Africa genotype during an outbreak in 2016-17 in Piaui State, Northeast Brazil.

Felipe Daniel Cardoso, Izabela Mauricio de Rezende, Emanuela Lima Teixeira Barros, Lívia Sacchetto, Tereza Cristina de Carvalho Souza Garcês, Natalia Ingrid Oliveira Silva, Pedro Augusto Alves, Jefferson Oliveira Soares, Erna Geessien Kroon, Anna Carolina Toledo da Cunha Pereira, Betânia Paiva Drumond, Gustavo Portela Ferreira,

Chikungunya virus (CHIKV) is an arbovirus that emerged in the Americas in 2013. Infection with CHIKV is symptomatic in most of the cases and patients can develop chronic arthralgia that lasts from months to years in over 40% of the cases. The East-Central-South Africa (ECSA) genotype was introduced in Brazil ... Read more >>

Rev Inst Med Trop Sao Paulo (Revista do Instituto de Medicina Tropical de Sao Paulo)
[2019, 61:e57]

Cited: 1 time

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An improved neuroanatomical model of the default-mode network reconciles previous neuroimaging and neuropathological findings.

Pedro Nascimento Alves, Chris Foulon, Vyacheslav Karolis, Danilo Bzdok, Daniel S Margulies, Emmanuelle Volle, Michel Thiebaut de Schotten,

The brain is constituted of multiple networks of functionally correlated brain areas, out of which the default-mode network (DMN) is the largest. Most existing research into the DMN has taken a corticocentric approach. Despite its resemblance with the unitary model of the limbic system, the contribution of subcortical structures to ... Read more >>

Commun Biol (Communications biology)
[2019, 2:370]

Cited: 5 times

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Wild-Type Yellow Fever Virus RNA in Cerebrospinal Fluid of Child.

Paula E S Marinho, Pedro P M Alvarenga, Ana P C Crispim, Talitah M S Candiani, Alice M Alvarenga, Isabela M Bechler, Pedro A Alves, Fabio P Dornas, Danilo B de Oliveira, Aline A Bentes, Paulo P Christo, Erna G Kroon,

We report a 3-year-old child who was hospitalized because of severe manifestations of the central nervous system. The child died after 6 days of hospitalization. Analysis of postmortem cerebrospinal fluid showed the presence of yellow fever virus RNA. Nucleotide sequencing confirmed that the virus was wild-type yellow fever virus. ... Read more >>

Emerg Infect Dis (Emerging infectious diseases)
[2019, 25(8):1567-1570]

Cited: 2 times

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[Pyogenic sacroiliitis: Lessons learned from an atypical case series].

Joana Arcângelo, Susana Norte Ramos, Pedro Alves, Delfin Tavares, Catarina Gouveia,

<h4>Introduction</h4>Pyogenic sacroiliitis (PSI) is a rare condition that amounts to 1% to 2% of all joint infections in the paediatric age group. Its diagnosis is often difficult and delayed due to its nonspecific signs, symptoms and physical findings. Also, the identification of the causative microorganism is frequently challenging due to ... Read more >>

An Pediatr (Barc) (Anales de pediatria (Barcelona, Spain : 2003))
[2019, 91(1):42-46]

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Advanced MRI Patterns of Muscle Disease in Inherited and Acquired Myopathies: What the Radiologist Should Know.

António Proença Caetano, Pedro Alves,

Myopathies represent a heterogeneous group of skeletal muscle disorders characterized by morphological and functional changes in the muscle, such as replacement of muscle tissue by connective tissue, fatty infiltration, and/or inflammation. They can be classified as hereditary, acquired idiopathic, and secondary myopathies.Diagnosis of hereditary and acquired myopathies is challenging, with ... Read more >>

Semin Musculoskelet Radiol (Seminars in musculoskeletal radiology)
[2019, 23(3):e82-e106]

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