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Author Paxton V Dickson

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Critical analysis of lymph node examination in patients undergoing curative-intent resection for adrenocortical carcinoma.

Benjamin W Deschner, Zachary E Stiles, Olivia M DeLozier, Justin A Drake, Miriam Tsao, Evan S Glazer, Jeremiah L Deneve, Danny Yakoub, Paxton V Dickson,

BACKGROUND:Adrenocortical carcinoma (ACC) is a rare tumor and the role of lymph node dissection remains ill-defined. This study evaluates the effect of nodal examination on prognosis and survival in patients undergoing curative-intent resection of ACC. METHODS:The National Cancer Database (2004-2015) was queried for patients undergoing margin-negative resection for ACC. Patients ... Read more >>

J Surg Oncol (Journal of surgical oncology)
[2020, :]

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ASO Author Reflections: Conversion During Attempted Minimally Invasive Adrenalectomy for Adrenocortical Carcinoma: A Cautionary Tale.

Olivia M DeLozier, Paxton V Dickson,

Ann. Surg. Oncol. (Annals of surgical oncology)
[2020, :]

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Implications of Conversion during Attempted Minimally Invasive Adrenalectomy for Adrenocortical Carcinoma.

Olivia M Delozier, Zachary E Stiles, Benjamin W Deschner, Justin A Drake, Jeremiah L Deneve, Evan S Glazer, Miriam W Tsao, Danny Yakoub, Paxton V Dickson,

BACKGROUND:Although advocated by some, minimally invasive adrenalectomy (MIA) for adrenocortical carcinoma (ACC) is controversial. Moreover, the oncologic implications for patients requiring conversion to an open procedure during attempted MIA for ACC are not extensively reported. PATIENTS AND METHODS:The National Cancer Database was queried for patients undergoing resection for ACC. Overall ... Read more >>

Ann. Surg. Oncol. (Annals of surgical oncology)
[2020, :]

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Development and external validation of a prediction model for survival in patients with resected ampullary adenocarcinoma.

Alma L Moekotte, Stijn van Roessel, Giuseppe Malleo, Rushda Rajak, Brett L Ecker, Martina Fontana, Ho-Seong Han, Mohamed Rabie, Keith J Roberts, Khalid Khalil, Steven A White, Stuart Robinson, Asif Halimi, Laura Zarantonello, Giuseppe K Fusai, George Gradinariu, Adnan Alseidi, Morgan Bonds, Stephan Dreyer, Nigel B Jamieson, Nicholas Mowbray, Bilal Al-Sarireh, Vasileios K Mavroeidis, Zahir Soonawalla, Niccolò Napoli, Ugo Boggi, Tara S Kent, William E Fisher, Chung N Tang, Louisa Bolm, Michael G House, Mary E Dillhoff, Stephen W Behrman, Masafumi Nakamura, Chad G Ball, Adam C Berger, John D Christein, Amer H Zureikat, Ronald R Salem, Charles M Vollmer, Roberto Salvia, Marc G Besselink, Mohammed Abu Hilal, , Ra'ed Aljarrah, Courtney Barrows, Martha Navarro Cagigas, Eric C H Lai, Ulrich Wellner, John Aversa, Paxton V Dickson, Takao Ohtsuka, Elijah Dixon, Richard Zheng, Stacy Kowalski, Mollie Freedman-Weiss,

INTRODUCTION:Ampullary adenocarcinoma (AAC) is a rare malignancy with great morphological heterogeneity, which complicates the prediction of survival and, therefore, clinical decision-making. The aim of this study was to develop and externally validate a prediction model for survival after resection of AAC. MATERIALS AND METHODS:An international multicenter cohort study was conducted, ... Read more >>

Eur J Surg Oncol (European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology)
[2020, :]

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The utilization and impact of adjuvant therapy following neoadjuvant therapy and resection of pancreatic adenocarcinoma: does more really matter?

Justin A Drake, Zachary E Stiles, Stephen W Behrman, Evan S Glazer, Jeremiah L Deneve, Bradley G Somer, Noam A Vanderwalde, Paxton V Dickson,

BACKGROUND:Although neoadjuvant therapy is increasingly administered to patients with pancreatic ductal adenocarcinoma (PDAC), the impact of additional adjuvant therapy (AT) following resection is not well defined. METHODS:The National Cancer Database (NCDB) was queried for patients who received neoadjuvant therapy followed by R0 or R1 resection for PDAC. Factors influencing survival, ... Read more >>

HPB (Oxford) (HPB : the official journal of the International Hepato Pancreato Biliary Association)
[2020, :]

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Update on Pheochromocytoma and Paraganglioma from the SSO Endocrine/Head and Neck Disease-Site Work Group. Part 1 of 2: Advances in Pathogenesis and Diagnosis of Pheochromocytoma and Paraganglioma.

Dhaval Patel, John E Phay, Tina W F Yen, Paxton V Dickson, Tracy S Wang, Roberto Garcia, Anthony D Yang, Carmen C Solórzano, Lawrence T Kim,

This first part of a two-part review of pheochromocytoma and paragangliomas (PPGLs) addresses clinical presentation, diagnosis, management, treatment, and outcomes. In this first part, the epidemiology, prevalence, genetic etiology, clinical presentation, and biochemical and radiologic workup are discussed. In particular, recent advances in the genetics underlying PPGLs and the recommendation ... Read more >>

Ann. Surg. Oncol. (Annals of surgical oncology)
[2020, 27(5):1329-1337]

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Comprehensive tumor profiling reveals unique molecular differences between peritoneal metastases and primary colorectal adenocarcinoma.

Matthew K Stein, Forrest W Williard, Joanne Xiu, Miriam W Tsao, Michael G Martin, Benjamin W Deschner, Paxton V Dickson, Evan S Glazer, Danny Yakoub, David Shibata, Axel F Grothey, Philip A Philip, Jimmy J Hwang, Anthony F Shields, John L Marshall, W Michael Korn, Heinz-Josef Lenz, Jeremiah L Deneve,

BACKGROUND AND OBJECTIVES:Peritoneal metastases (PM) from primary colorectal cancer (pCRC) are associated with poor outcomes; however, molecular differences are not well defined. METHODS:We compared unpaired tumor profiles of patients with pCRC and PM from Caris Life Sciences. Testing included next-generation sequencing of 592 genes, microsatellite instability (MSI) and tumor mutational ... Read more >>

J Surg Oncol (Journal of surgical oncology)
[2020, 121(8):1320-1328]

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Restaging Patients with Rectal Cancer Following Neoadjuvant Chemoradiation: A Systematic Review.

Leah E Hendrick, Renee L Levesque, Nathan M Hinkle, Justin J Monroe, Evan S Glazer, Jeremiah L Deneve, Danny Yakoub, David Shibata, Paxton V Dickson,

BACKGROUND:In the USA, most patients with clinical stage II/III rectal cancer receive neoadjuvant chemoradiation (chemo/XRT) over 5-6 weeks followed by a 6-10-week break before proctectomy. As chemotherapy is delivered at radio-sensitizing doses, there is essentially a 3-month window during which potential systemic disease is untreated. Evidence regarding the utility of restaging ... Read more >>

World J Surg (World journal of surgery)
[2020, 44(3):973-979]

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Update on Pheochromocytoma and Paraganglioma from the SSO Endocrine and Head and Neck Disease Site Working Group, Part 2 of 2: Perioperative Management and Outcomes of Pheochromocytoma and Paraganglioma.

Dhaval Patel, John E Phay, Tina W F Yen, Paxton V Dickson, Tracy S Wang, Roberto Garcia, Anthony D Yang, Lawrence T Kim, Carmen C Solórzano,

This is the second part of a two-part review on pheochromocytoma and paragangliomas (PPGLs). In this part, perioperative management, including preoperative preparation, intraoperative, and postoperative interventions are reviewed. Current data on outcomes following resection are presented, including outcomes after cortical-sparing adrenalectomy for bilateral adrenal disease. In addition, pathological features of ... Read more >>

Ann. Surg. Oncol. (Annals of surgical oncology)
[2020, 27(5):1338-1347]

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Elevated Serum α-Fetoprotein is Associated with Abbreviated Survival for Patients with Fibrolamellar Hepatocellular Carcinoma Who Undergo a Curative Resection.

James D McDonald, Shreya Gupta, Mackenzie L Shindorf, Lauren A Gamble, Samantha M Ruff, Justin Drake, Theo Heller, Jim Y Wan, Paxton V Dickson, Evan S Glazer, Jeremy L Davis, Jeremiah L Deneve, Jonathan M Hernandez,

BACKGROUND:Fibrolamellar hepatocellular carcinoma (FLC) is a rare variant of hepatocellular carcinoma (HCC), with most clinical data stemming from single-institution series. The variability in the literature lends support for analysis using a large national dataset. In doing so, we sought to (1) define the characteristics and outcomes of patients with FLC; ... Read more >>

Ann. Surg. Oncol. (Annals of surgical oncology)
[2020, 27(6):1900-1905]

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The impact of race and socioeconomic status on the presentation, management and outcomes for gastric cancer patients: Analysis from a metropolitan area in the southeast United States.

Miriam W Tsao, Olivia M Delozier, Zachary E Stiles, Louis J Magnotti, Stephen W Behrman, Jeremiah L Deneve, Evan S Glazer, David Shibata, Danny Yakoub, Paxton V Dickson,

BACKGROUND:Socioeconomic disparities in gastric cancer have been associated with differences in care and inferior outcomes. We evaluated the presentation, treatment, and survival for patients with gastric cancer (GC) in a metropolitan setting with a large African American population. METHODS:Retrospective cohort analysis of patients with GC (2003-2018) across a multi-hospital system ... Read more >>

J Surg Oncol (Journal of surgical oncology)
[2020, 121(3):494-502]

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Outcomes Following Resection of Hepatocellular Carcinoma in the Absence of Cirrhosis.

Richard H Lewis, Evan S Glazer, David M Bittenbinder, Thomas O'Brien, Jeremiah L Deneve, David Shibata, Stephen W Behrman, Jason M Vanatta, Sanjaya K Satapathy, Paxton V Dickson,

BACKGROUND:Hepatocellular carcinoma (HCC) occasionally occurs in non-cirrhotic patients; however, outcomes for these patients are not extensively documented. METHODS:We performed an institutional review of patients without cirrhosis who underwent resection for HCC. Clinical data were evaluated to identify factors impacting recurrence-free survival (RFS) and overall survival (OS). RESULTS:Forty-two patients underwent hepatectomy ... Read more >>

J Gastrointest Cancer (Journal of gastrointestinal cancer)
[2019, 50(4):808-815]

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Rising BMI Is Associated with Increased Rate of Clinically Relevant Pancreatic Fistula after Distal Pancreatectomy for Pancreatic Adenocarcinoma.

Yixuan Zhou, Justin Drake, Jeremiah L Deneve, Stephen W Behrman, Paxton V Dickson, David Shibata, Evan S Glazer,

Clinically relevant pancreatic fistula (CR-POPF), after distal pancreatectomy (DP), remains a clinical challenge. Prior studies investigating the relationship between BMI and CR-POPF have yielded conflicting results. We hypothesized that BMI is associated with CR-POPF in patients having DP for pancreatic ductal adenocarcinoma (PDAC). Patients who underwent DP for PDAC at ... Read more >>

Am Surg (The American surgeon)
[2019, 85(12):1376-1380]

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Role of Adjuvant Multimodality Therapy After Curative-Intent Resection of Ampullary Carcinoma.

Brett L Ecker, Charles M Vollmer, Stephen W Behrman, Valentina Allegrini, John Aversa, Chad G Ball, Courtney E Barrows, Adam C Berger, Martha N Cagigas, John D Christein, Elijah Dixon, William E Fisher, Mollie Freedman-Weiss, Francisco Guzman-Pruneda, Robert H Hollis, Michael G House, Tara S Kent, Stacy J Kowalsky, Giuseppe Malleo, Ronald R Salem, Roberto Salvia, Carl R Schmidt, Thomas F Seykora, Richard Zheng, Amer H Zureikat, Paxton V Dickson,

Importance:Ampullary adenocarcinoma is a rare malignant neoplasm that arises within the duodenal ampullary complex. The role of adjuvant therapy (AT) in the treatment of ampullary adenocarcinoma has not been clearly defined. Objective:To determine if long-term survival after curative-intent resection of ampullary adenocarcinoma may be improved by selection of patients for ... Read more >>

JAMA Surg (JAMA surgery)
[2019, 154(8):706-714]

Cited: 1 time

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Resection and chemotherapy is the optimal treatment approach for patients with clinically node positive intrahepatic cholangiocarcinoma.

Sean P Martin, Justin Drake, Michael M Wach, Samantha M Ruff, Laurence P Diggs, Jim Y Wan, Meghan L Good, Dana A Dominguez, Reed I Ayabe, Evan S Glazer, Paxton V Dickson, Jeremy L Davis, Jeremiah L Deneve, Jonathan M Hernandez,

BACKGROUND:Clinically lymph node positive (cLNP) intrahepatic cholangiocarcinoma (ICC) carries a poor prognosis, without clear management guidelines for the practicing clinician. We sought to evaluate current practice patterns for cLNP ICC, including associations with survival. METHODS:The National Cancer Database was queried for patients with cLNP ICC, without extrahepatic metastases. RESULTS:We identified ... Read more >>

HPB (Oxford) (HPB : the official journal of the International Hepato Pancreato Biliary Association)
[2020, 22(1):129-135]

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Molecular Alterations Associated with DNA Repair in Pancreatic Adenocarcinoma Are Associated with Sites of Recurrence.

Margaret D Ferguson, Lei Dong, Jim Wan, Jeremiah L Deneve, Paxton V Dickson, Stephen W Behrman, David Shibata, Mike G Martin, Evan S Glazer,

BACKGROUND:Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies with a rising incidence. Mutational analysis of PDAC has provided valuable information but has not yet dramatically changed the therapeutic landscape due to the number of variations detected in any one individual. The pattern of molecular alterations-gene mutations, variations in ... Read more >>

J Gastrointest Cancer (Journal of gastrointestinal cancer)
[2019, 50(2):285-291]

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Laparoscopic Approach to Intrahepatic Cholangiocarcinoma is Associated with an Exacerbation of Inadequate Nodal Staging.

Sean P Martin, Justin Drake, Michael M Wach, Samantha Ruff, Laurence P Diggs, Jim Y Wan, Zachary J Brown, Reed I Ayabe, Evan S Glazer, Paxton V Dickson, Jeremy L Davis, Jeremiah L Deneve, Jonathan M Hernandez,

INTRODUCTION:Laparoscopic approach to liver resection is feasible and safe, though its utilization with intrahepatic cholangiocarcinoma (ICC) remains poorly documented. We sought to evaluate the use laparoscopy for ICC, and to examine adherence to oncologic standards. METHODS:The National Cancer Database was queried for patients who underwent resection for ICC. Patients were ... Read more >>

Ann. Surg. Oncol. (Annals of surgical oncology)
[2019, 26(6):1851-1857]

Cited: 1 time

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Desmoplastic Small Round Cell Tumor: Long-Term Complications After Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy.

Zachary E Stiles, Andrew J Murphy, Doralina L Anghelescu, Christina-Lin Brown, Andrew M Davidoff, Paxton V Dickson, Evan S Glazer, Michael W Bishop, Wayne L Furman, Alberto S Pappo, John T Lucas, Jeremiah L Deneve,

BACKGROUND:Desmoplastic small round cell tumor (DSRCT) is a rare intra-abdominal soft tissue sarcoma affecting adolescents and young adults. Cytoreduction, hyperthermic intraperitoneal chemotherapy (CRS/HIPEC), and adjuvant radiotherapy may improve local control. We review our experience with patients who undergo CRS/HIPEC and adjuvant radiotherapy for DSRCT. METHODS:A retrospective review was performed for ... Read more >>

Ann. Surg. Oncol. (Annals of surgical oncology)
[2020, 27(1):171-178]

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Long-Term Implications of Unplanned Conversion During Laparoscopic Liver Resection for Hepatocellular Carcinoma.

Zachary E Stiles, Evan S Glazer, Jeremiah L Deneve, David Shibata, Stephen W Behrman, Paxton V Dickson,

BACKGROUND:Laparoscopic liver resection (LLR) is increasingly utilized for patients with hepatocellular carcinoma (HCC). However, long-term outcomes for patients requiring conversion to an open procedure during LLR have not been examined. METHODS:Patients undergoing attempted LLR for HCC were identified within the National Cancer Database. Patients undergoing successful LLR were compared with ... Read more >>

Ann. Surg. Oncol. (Annals of surgical oncology)
[2019, 26(1):282-289]

Cited: 1 time

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Symptomatic Pancreatic Lipoma.

Benjamin Deschner, Jatin Gandhi, Jeremiah L Deneve, Paxton V Dickson, Ian Clark, Evan S Glazer,

J. Gastrointest. Surg. (Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract)
[2019, 23(9):1942-1943]

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Multifocal pheochromocytoma-paraganglioma in a 29-year-old woman with cyanotic congenital heart disease.

Susan M Wcislak, William S King, Benjamin R Waller, Natasha Goins, Paxton V Dickson,

BACKGROUND:Multifocal pheochromocytoma/paraganglioma presenting at an early age is commonly associated with a hereditary syndrome. CASE REPORT:A 29-year-old woman was referred for evaluation of multifocal pheochromocytoma/paraganglioma. Interestingly, her family history did not include pheochromocytoma/paraganglioma, and comprehensive genetic testing for the well-documented pheochromocytoma/paraganglioma susceptibility genes was negative. Of note, this patient had ... Read more >>

Surgery (Surgery)
[2019, 165(1):228-231]

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Anesthesia and Pain Management for Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Desmoplastic Small Round Cell Tumors in Children, Adolescents, and Young Adults.

Doralina L Anghelescu, Christina-Lin Brown, Andrew J Murphy, Andrew M Davidoff, Paxton V Dickson, Evan S Glazer, Zachary E Stiles, Michael W Bishop, Luke Douthitt, Jeremiah L Deneve,

BACKGROUND:Desmoplastic small round cell tumor (DSRCT) is a rare, aggressive sarcoma. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) may improve survival. METHODS:A retrospective review of anesthetic management and postoperative pain control strategies after CRS/HIPEC for DSRCT from 2013 to 2017 was performed. RESULTS:The review analyzed 10 CRS/HIPEC procedures performed ... Read more >>

Ann. Surg. Oncol. (Annals of surgical oncology)
[2019, 26(1):131-138]

Cited: 1 time

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Evaluation, Staging, and Surgical Management for Adrenocortical Carcinoma: An Update from the SSO Endocrine and Head and Neck Disease Site Working Group.

Paxton V Dickson, Lawrence Kim, Tina W F Yen, Anthony Yang, Elizabeth G Grubbs, Dhavel Patel, Carmen C Solórzano,

This is the first of a two-part review on adrenocortical carcinoma (ACC), a rare and aggressive malignancy that often presents at an advanced stage. Most patients present with symptoms related to cortisol and/or androgen excess. Appropriate biochemical evaluation and imaging is important in assessing the extent of disease, operative planning, ... Read more >>

Ann. Surg. Oncol. (Annals of surgical oncology)
[2018, 25(12):3460-3468]

Cited: 2 times

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Hypervascular lesions of the pancreas: Think before you act.

Susan M Wcislak, Zachary E Stiles, Jeremiah L Deneve, Evan S Glazer, Stephen W Behrman, Farees T Farooq, Paxton V Dickson,

BACKGROUND:The "classic" CT appearance of pancreatic neuroendocrine tumors (PNETs) is a solid, hypervascular lesion; however, non-PNET diagnoses may appear similar. In addition, some PNETs have a "non-classic" appearance. METHODS:Demographic, imaging, endoscopic ultrasound-fine needle aspiration (EUS/FNA) results, and pathology data were analyzed for patients who underwent pancreatectomy for suspected or confirmed ... Read more >>

Am. J. Surg. (American journal of surgery)
[2019, 218(2):362-367]

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Adjuvant and Neoadjuvant Therapy, Treatment for Advanced Disease, and Genetic Considerations for Adrenocortical Carcinoma: An Update from the SSO Endocrine and Head and Neck Disease Site Working Group.

Paxton V Dickson, Lawrence Kim, Tina W F Yen, Anthony Yang, Elizabeth G Grubbs, Dhavel Patel, Carmen C Solórzano,

This is the second of a two-part review on adrenocortical carcinoma (ACC) management. While margin-negative resection provides the only potential cure for ACC, recurrence rates remain high. Furthermore, many patients present with locally advanced, unresectable tumors and/or diffuse metastases. As a result, selecting patients for adjuvant therapy and understanding systemic ... Read more >>

Ann. Surg. Oncol. (Annals of surgical oncology)
[2018, 25(12):3453-3459]

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