Full Text Journal Articles by
Author Pavla Pokorna

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Drug Disposition and Pharmacotherapy in Neonatal ECMO: From Fragmented Data to Integrated Knowledge.

Genny Raffaeli, Pavla Pokorna, Karel Allegaert, Fabio Mosca, Giacomo Cavallaro, Enno D Wildschut, Dick Tibboel,

Extracorporeal membrane oxygenation (ECMO) is a lifesaving support technology for potentially reversible neonatal cardiac and/or respiratory failure. As the survival and the overall outcome of patients rely on the treatment and reversal of the underlying disease, effective and preferentially evidence-based pharmacotherapy is crucial to target recovery. Currently limited data exist ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2019, 7:360]

Cited: 0 times

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Nomogram based on actual body weight for estimation of vancomycin maintenance dose in infants.

Pavla Pokorná, Martin Šíma, Olga Černá, Ondřej Slanař,

BACKGROUND:Vancomycin is the first-choice antibiotic for infants with β-lactam-resistant gram-positive bacterial infection. Despite long experience of prescribing of this drug optimal dosing is still challenging. This study aimed at investigating variables predicting vancomycin clearance in order to propose optimal maintenance dosing in infants treated for suspected or culture-proven sepsis. METHODS:Vancomycin ... Read more >>

Infect Dis (Lond) (Infectious diseases (London, England))
[2019, 51(5):334-339]

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Actual body weight-based vancomycin dosing in neonates.

Pavla Pokorná, Martin Šíma, Olga Černá, Karel Allegaert, Dick Tibboel, Ondřej Slanař,

This study aimed to explore vancomycin pharmacokinetics and its covariates in critically ill neonates and to propose an easy applicable dosing nomogram for initial treatment. Individual vancomycin pharmacokinetic parameters were calculated based on therapeutic drug monitoring data using a one-compartmental model. A linear regression model was used for examination of ... Read more >>

J Chemother (Journal of chemotherapy (Florence, Italy))
[2019, 31(6):307-312]

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Sufentanil pharmacokinetics in a full-term neonate treated with extracorporeal membrane oxygenation: a case report.

Pavla Pokorná, Martin Šíma, Václav Vobruba, Martina Bašková, Lenka Posch, Ondřej Slanař,

INTRODUCTION:Sufentanil is a potent analgesic drug used for pain management. A few studies describe the pharmacokinetics of sufentanil in neonates; however, no pharmacokinetic data about sufentanil during extracorporeal membrane oxygenation have been published yet. CASE REPORT:A 1-day-old neonate with moderate hypoxic-ischemic encephalopathy received veno-arterial extracorporeal membrane oxygenation support for refractory ... Read more >>

Perfusion (Perfusion)
[2019, 34(5):433-436]

Cited: 1 time

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Phenobarbital pharmacokinetics in neonates and infants during extracorporeal membrane oxygenation.

Pavla Pokorná, Martin Šíma, Václav Vobruba, Dick Tibboel, Ondřej Slanař,

INTRODUCTION:The disposition of drugs is potentially changed due to extracorporeal membrane oxygenation (ECMO) in neonates and infants. METHODS:The aim of the study was to evaluate the individual pharmacokinetics (PK) of phenobarbital and the effect of PK covariates in neonates and infants undergoing ECMO. Sixteen patients (7 neonates, 9 infants) treated ... Read more >>

Perfusion (Perfusion)
[2018, 33(1_suppl):80-86]

Cited: 1 time

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Severity of asphyxia is a covariate of phenobarbital clearance in newborns undergoing hypothermia.

Pavla Pokorná, Lenka Posch, Martin Šíma, Petr Klement, Ondrej Slanar, John van den Anker, Dick Tibboel, Karel Allegaert,

AIM:Phenobarbital (PB) pharmacokinetics (PK) in asphyxiated newborns show large variability, not only explained by hypothermia (HT). We evaluated potential relevant covariates of PK of PB in newborns treated with or without HT for hypoxic-ischemic encephalopathy (HIE). METHODS:Clearance (CL), distribution volume (Vd) and elimination half-life (t1/2) were calculated using one-compartment analysis. ... Read more >>

J. Matern. Fetal. Neonatal. Med. (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2019, 32(14):2302-2309]

Cited: 1 time

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The CLOSED trial; CLOnidine compared with midazolam for SEDation of paediatric patients in the intensive care unit: study protocol for a multicentre randomised controlled trial.

Antje Neubert, Manuel Alberto Baarslag, Monique van Dijk, Joost van Rosmalen, Joseph F Standing, Yucheng Sheng, Wolfgang Rascher, Deborah Roberts, Jackie Winslade, Louise Rawcliffe, Sara M Hanning, Tuuli Metsvaht, Viviana Giannuzzi, Peter Larsson, Pavla Pokorná, Alessandra Simonetti, Dick Tibboel, ,

INTRODUCTION:Sedation is an essential part of paediatric critical care. Midazolam, often in combination with opioids, is the current gold standard drug. However, as it is a far-from-ideal agent, clonidine is increasingly being used in children. This drug is prescribed off-label for this indication, as many drugs in paediatrics are. Therefore, ... Read more >>

BMJ Open (BMJ open)
[2017, 7(6):e016031]

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Valproic acid-induced hyperammonemic encephalopathy in a full-term neonate: a brief review and case report.

Pavla Pokorná, Karolina Hronová, Martin Šíma, Ondřej Slanař, Petr Klement, John N van den Anker, Dick Tibboel,

Eur. J. Clin. Pharmacol. (European journal of clinical pharmacology)
[2017, 73(5):647-649]

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Clinical recommendations for pain, sedation, withdrawal and delirium assessment in critically ill infants and children: an ESPNIC position statement for healthcare professionals.

Julia Harris, Anne-Sylvie Ramelet, Monique van Dijk, Pavla Pokorna, Joke Wielenga, Lyvonne Tume, Dick Tibboel, Erwin Ista,

BACKGROUND:This position statement provides clinical recommendations for the assessment of pain, level of sedation, iatrogenic withdrawal syndrome and delirium in critically ill infants and children. Admission to a neonatal or paediatric intensive care unit (NICU, PICU) exposes a child to a series of painful and stressful events. Accurate assessment of ... Read more >>

Intensive Care Med (Intensive care medicine)
[2016, 42(6):972-986]

Cited: 44 times

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Effects of high tidal volume mechanical ventilation on production of cytokines, iNOS, and MIP-1β proteins in pigs.

Václav Vobruba, Václav Vobruba, Václav Vobruba, Oxana V Klimenko, Jiri Kobr, Olga Cerna, Olga Cerna, Pavla Pokorna, Ivan Mikula, Jan Hridel, Olga Brantova, Pavel Martasek,

The aim of this study was to investigate longitudinal changes of the pulmonary inflammatory process as a result of mechanical stress due to mechanical ventilation. The concentrations of IL-8, TNF-α, MIP-1β, nitrites/nitrates, and inducible nitric oxide synthases (iNOS) were investigated indicate in bronchoalveolar lavage (BAL). Twenty-three piglets were divided into ... Read more >>

Exp. Lung Res. (Experimental lung research)
[2013, 39(1):1-8]

Cited: 6 times

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The impact of extracorporeal life support and hypothermia on drug disposition in critically ill infants and children.

Enno D Wildschut, Annewil van Saet, Pavla Pokorna, Maurice J Ahsman, John N Van den Anker, Dick Tibboel,

Extracorporeal membrane oxygenation (ECMO) support is an established lifesaving therapy for potentially reversible respiratory or cardiac failure. In 10% of all pediatric patients receiving ECMO, ECMO therapy is initiated during or after cardiopulmonary resuscitation. Therapeutic hypothermia is frequently used in children after cardiac arrest, despite the lack of randomized controlled ... Read more >>

Pediatr. Clin. North Am. (Pediatric clinics of North America)
[2012, 59(5):1183-1204]

Cited: 16 times

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Tolerability and outcomes of kinetically guided therapy with gentamicin in critically ill neonates during the first week of life: an open-label, prospective study.

Jirina Martínková, Pavla Pokorná, Jiri Záhora, Jaroslav Chládek, Václav Vobruba, Václav Vobruba, Václav Vobruba, Iva Selke-Krulichová, Jirina Chládková,

BACKGROUND: Aminoglycosides are bactericidal antibiotics used worldwide for the treatment of serious infections in critically ill patients, including neonates. Critically ill neonates constitute a unique challenge in dosing owing to the pathologic alterations that accompany severe illness and the rapidly changing conditions of these patients. OBJECTIVES: The main objective of ... Read more >>

Clin Ther (Clinical therapeutics)
[2010, 32(14):2400-2414]

Cited: 14 times

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Meropenem pharmacokinetics in the newborn.

John N van den Anker, Pavla Pokorna, Martina Kinzig-Schippers, Jirina Martinkova, Ronald de Groot, G L Drusano, Fritz Sorgel,

We studied meropenem in 23 pre-term (gestational age, 29 to 36 weeks) and 15 full-term (gestational age, 37 to 42 weeks) neonates. Meropenem doses of 10, 20, and 40 mg/kg were administered as single doses (30-min intravenous infusion) on a random basis. Blood was obtained for determining the meropenem concentration ... Read more >>

Antimicrob. Agents Chemother. (Antimicrobial agents and chemotherapy)
[2009, 53(9):3871-3879]

Cited: 33 times

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Enantiomeric determination of tramadol and O-desmethyltramadol in human plasma by fast liquid chromatographic technique coupled with mass spectrometric detection.

Lukás Chytil, Olga Matousková, Olga Cerná, Olga Cerná, Pavla Pokorná, Václav Vobruba, Václav Vobruba, Václav Vobruba, Frantisek Perlík, Ondrej Slanar,

A rapid and sensitive method using liquid chromatography-tandem mass spectrometry (LC-MS/MS) for enantiomeric determination of tramadol and its primary phase metabolite O-desmethyltramadol in human plasma has been developed. Tramadol hydrochloride-(13)C, d(3), was used as an isotopic labeled internal standard for quantification. The method involves a simple solid phase extraction. The ... Read more >>

J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (Journal of chromatography. B, Analytical technologies in the biomedical and life sciences)
[2010, 878(3-4):481-486]

Cited: 3 times

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Morphological and functional changes in p-glycoprotein during dexamethasone-induced hepatomegaly.

Stanislav Micuda, Leos Fuksa, Lucie Mundlova, Jan Osterreicher, Jaroslav Mokry, Jolana Cermanova, Eva Brcakova, Frantisek Staud, Pavla Pokorna, Jirina Martinkova,

1. The effect of dexamethasone on hepatic and renal P-glycoprotein (P-gp) expression, localization and activity was investigated in rats after 4 days oral administration of two dose regimens (1 or 25 mg/kg per day). Simultaneous increases in liver weight were evaluated by quantitative histological examination. 2. In the liver, dexamethasone ... Read more >>

Clin. Exp. Pharmacol. Physiol. (Clinical and experimental pharmacology & physiology)
[2007, 34(4):296-303]

Cited: 9 times

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