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Author Pauline Wimberger

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Diagnostic Benefit of the Detection of Mitotic Figures in Endometriotic Lesions.

Michelle Wetzk, Nannette Grübling, Almuth Forberger, Jörg Klengel, Jan Kuhlmann, Pauline Wimberger, Maren Goeckenjan,

<b>Objectives</b> Endometriosis is a chronic disease which is diagnosed by surgical intervention combined with a histological work-up. Current international and national recommendations do not require the histological determination of the proliferation rate. The diagnostic and clinical importance of the mitotic rate in endometriotic lesions still remains to be elucidated. <b>Methods</b> ... Read more >>

Geburtshilfe Frauenheilkd (Geburtshilfe und Frauenheilkunde)
[2022, 82(1):85-92]

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Total mesometrial resection (TMMR) for cervical cancer FIGO IB-IIA: first results from the multicentric TMMR register study.

Paul Buderath, Maciej Stukan, Wencke Ruhwedel, Deivis Strutas, Gabriele Feisel-Schwickardi, Pauline Wimberger, Rainer Kimmig,

<h4>Objective</h4>The surgical concept of total mesometrial resection (TMMR) and therapeutic lymphadenectomy (tLNE) for the treatment of early cervical cancer is based on the ontogenetic cancer field model. Unicentric data show excellent locoregional control rates without adjuvant chemoradiation. However, there are so far no prospective, multicentric data supporting the method.<h4>Methods</h4>The multicentric ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2022, 33(1):e9]

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European Society of Gynaecological Oncology quality indicators for the surgical treatment of endometrial carcinoma.

Nicole Concin, François Planchamp, Nadeem R Abu-Rustum, Beyhan Ataseven, David Cibula, Anna Fagotti, Christina Fotopoulou, Pawel Knapp, Christian Marth, Philippe Morice, Denis Querleu, Jalid Sehouli, Artem Stepanyan, Cagatay Taskiran, Ignace Vergote, Pauline Wimberger, Ignacio Zapardiel, Jan Persson,

<h4>Background</h4>Quality of surgical care as a crucial component of a comprehensive multi-disciplinary management improves outcomes in patients with endometrial carcinoma, notably helping to avoid suboptimal surgical treatment. Quality indicators (QIs) enable healthcare professionals to measure their clinical management with regard to ideal standards of care.<h4>Objective</h4>In order to complete its set ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2021, 31(12):1508-1529]

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Evaluation of circulating Dickkopf-1 as a prognostic biomarker in ovarian cancer patients.

Daniel Martin Klotz, Theresa Link, Maren Goeckenjan, Pauline Wimberger, Anna R Poetsch, Nikolai Jaschke, Lorenz C Hofbauer, Andy Göbel, Tilman D Rachner, Jan Dominik Kuhlmann,

<h4>Objectives</h4>Dickkopf-1 (DKK1) is a secreted protein, known for suppressing the differentiation and activity of bone-building osteoblasts by acting as an inhibitor of Wnt-signalling. Soluble DKK1 (sDKK1) has been proposed as prognostic biomarker for a wide range of malignancies, however, clinical relevance of sDKK1 as potential blood-based marker for ovarian cancer ... Read more >>

Clin Chem Lab Med (Clinical chemistry and laboratory medicine)
[2021, :]

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Bevacizumab Combined with Platinum-Taxane Chemotherapy as First-Line Treatment for Advanced Ovarian Cancer: Results of the NOGGO Non-Interventional Study (OTILIA) in 824 Patients.

Jalid Sehouli, Alexander Mustea, Guelten Oskay-Özcelik, Maren Keller, Rolf Richter, Oliver Tomé, Hannah Woopen, Ann-Katrin Sommer-Joos, Jacek P Grabowski, Robert Armbrust, Pauline Wimberger,

In the single-arm non-interventional OTILIA study, patients with newly diagnosed International Federation of Gynecology and Obstetrics (FIGO) stage IIIB-IV ovarian cancer received bevacizumab (15 mg/kg every 3 weeks for up to 15 months) and standard carboplatin-paclitaxel. The primary aim was to assess safety and progression-free survival (PFS). Subgroup analyses according ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(19):]

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Neurocognitive development of novelty and error monitoring in children and adolescents.

Kathleen Kang, Nina Alexander, Jan R Wessel, Pauline Wimberger, Katharina Nitzsche, Clemens Kirschbaum, Shu-Chen Li,

The abilities to monitor one's actions and novel information in the environment are crucial for behavioural and cognitive control. This study investigated the development of error and novelty monitoring and their electrophysiological correlates by using a combined flanker with novelty-oddball task in children (7-12 years) and adolescents (14-18 years). Potential moderating influences of prenatal ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):19844]

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A Randomized Phase II Study of Anti-CSF1 Monoclonal Antibody Lacnotuzumab (MCS110) Combined with Gemcitabine and Carboplatin in Advanced Triple-Negative Breast Cancer.

Sherko Kuemmel, Mario Campone, Delphine Loirat, Rafael Lopez Lopez, J Thaddeus Beck, Michelino De Laurentiis, Seock-Ah Im, Sung-Bae Kim, Ava Kwong, Guenther G Steger, Esther Zamora Adelantado, Francois P Duhoux, Richard Greil, Irene Kuter, Yen-Shen Lu, Ariadna Tibau, Mustafa Özgüroğlu, Christian W Scholz, Christian F Singer, Estela Vega, Pauline Wimberger, Claudio Zamagni, Xuan-Mai Couillebault, Liqiong Fan, Nelson Guerreiro, Jennifer Mataraza, Janna Sand-Dejmek, Arlene Chan,

<h4>Purpose</h4>This phase II study determined the efficacy of lacnotuzumab added to gemcitabine plus carboplatin (gem-carbo) in patients with advanced triple-negative breast cancer (TNBC).<h4>Patients and methods</h4>Female patients with advanced TNBC, with high levels of tumor-associated macrophages not amenable to curative treatment by surgery or radiotherapy were enrolled. Lacnotuzumab was dosed at ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2022, 28(1):106-115]

Cited: 3 times

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Pembrolizumab for Persistent, Recurrent, or Metastatic Cervical Cancer.

Nicoletta Colombo, Coraline Dubot, Domenica Lorusso, M Valeria Caceres, Kosei Hasegawa, Ronnie Shapira-Frommer, Krishnansu S Tewari, Pamela Salman, Edwin Hoyos Usta, Eduardo Yañez, Mahmut Gümüş, Mivael Olivera Hurtado de Mendoza, Vanessa Samouëlian, Vincent Castonguay, Alexander Arkhipov, Sarper Toker, Kan Li, Stephen M Keefe, Bradley J Monk, ,

<h4>Background</h4>Pembrolizumab has efficacy in programmed death ligand 1 (PD-L1)-positive metastatic or unresectable cervical cancer that has progressed during chemotherapy. We assessed the relative benefit of adding pembrolizumab to chemotherapy with or without bevacizumab.<h4>Methods</h4>In a double-blind, phase 3 trial, we randomly assigned patients with persistent, recurrent, or metastatic cervical cancer in ... Read more >>

N Engl J Med (The New England journal of medicine)
[2021, 385(20):1856-1867]

Cited: 1 time

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SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.

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<h4>Background</h4>Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling.<h4>Methods</h4>The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an ... Read more >>

Br J Surg (The British journal of surgery)
[2021, 108(9):1056-1063]

Cited: 19 times

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SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study.

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SARS-CoV-2 has been associated with an increased rate of venous thromboembolism in critically ill patients. Since surgical patients are already at higher risk of venous thromboembolism than general populations, this study aimed to determine if patients with peri-operative or prior SARS-CoV-2 were at further increased risk of venous thromboembolism. We ... Read more >>

Anaesthesia (Anaesthesia)
[2022, 77(1):28-39]

Cited: 2 times

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Diminished PLK2 Induces Cardiac Fibrosis and Promotes Atrial Fibrillation.

Stephan R Künzel, Maximilian Hoffmann, Silvio Weber, Karolina Künzel, Susanne Kämmerer, Mario Günscht, Erik Klapproth, Johanna S E Rausch, Mirna S Sadek, Tomasz Kolanowski, Stefanie Meyer-Roxlau, Christopher Piorkowski, Sems M Tugtekin, Stefan Rose-John, Xiaoke Yin, Manuel Mayr, Jan Dominik Kuhlmann, Pauline Wimberger, Konrad Grützmann, Natalie Herzog, Jan-Heiner Küpper, Molly O'Reilly, S Nashitha Kabir, Laura C Sommerfeld, Kaomei Guan, Ben Wielockx, Larissa Fabritz, Stanley Nattel, Ursula Ravens, Dobromir Dobrev, Michael Wagner, Ali El-Armouche,

[Figure: see text]. ... Read more >>

Circ Res (Circulation research)
[2021, 129(8):804-820]

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Prognostic effect of low-level HER2 expression in patients with clinically negative HER2 status.

Alexander Hein, Andreas D Hartkopf, Julius Emons, Michael P Lux, Bernhard Volz, Florin-Andrei Taran, Friedrich Overkamp, Peyman Hadji, Hans Tesch, Lothar Häberle, Johannes Ettl, Diana Lüftner, Lena A Wurmthaler, Markus Wallwiener, Volkmar Müller, Matthias W Beckmann, Erik Belleville, Pauline Wimberger, Carsten Hielscher, Christian M Kurbacher, Rachel Wuerstlein, Christoph Thomssen, Michael Untch, Peter A Fasching, Wolfgang Janni, Tanja N Fehm, Diethelm Wallwiener, Sara Y Brucker, Andreas Schneeweiss, Hans-Christian Kolberg,

<h4>Purpose</h4>Assessment of HER2 overexpression using immunohistochemistry (IHC) and/or in situ hybridisation (ISH) for the detection of HER2 amplifications is standard to identify patients for established HER2-directed treatments. Patients with lower HER2 expression levels have recently also become candidates for novel therapies targeting HER2. This study aimed to assess tumour and patient ... Read more >>

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2021, 155:1-12]

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Effects of pre-operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study.

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We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave ... Read more >>

Anaesthesia (Anaesthesia)
[2021, 76(11):1454-1464]

Cited: 3 times

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Dendritic cell-based immunotherapy (DCVAC/OvCa) combined with second-line chemotherapy in platinum-sensitive ovarian cancer (SOV02): A randomized, open-label, phase 2 trial.

David Cibula, Lukas Rob, Peter Mallmann, Pawel Knapp, Jaroslav Klat, Josef Chovanec, Lubos Minar, Bohuslav Melichar, Alexander Hein, Dariusz Kieszko, Marek Pluta, Jiri Spacek, Pavel Bartos, Pauline Wimberger, Radoslaw Madry, Janina Markowska, Joanna Streb, Petr Valha, Hariz Iskandar Bin Hassan, Ladislav Pecen, Lorenzo Galluzzi, Jitka Fucikova, Tereza Hrnciarova, Marek Hraska, Jirina Bartunkova, Radek Spisek,

<h4>Objective</h4>DCVAC/OvCa is an active cellular immunotherapy designed to stimulate an immune response against ovarian cancer. We explored the safety and efficacy of DCVAC/OvCa plus carboplatin and gemcitabine in platinum-sensitive ovarian cancer.<h4>Methods</h4>In this open-label, parallel-group, phase 2 trial (ClinicalTrials.gov number NCT02107950), patients with platinum-sensitive ovarian cancer relapsing after first-line chemotherapy were ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, 162(3):652-660]

Cited: 1 time

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Clinical and molecular characteristics of HER2-low-positive breast cancer: pooled analysis of individual patient data from four prospective, neoadjuvant clinical trials.

Carsten Denkert, Fenja Seither, Andreas Schneeweiss, Theresa Link, Jens-Uwe Blohmer, Marianne Just, Pauline Wimberger, Almuth Forberger, Hans Tesch, Christian Jackisch, Sabine Schmatloch, Mattea Reinisch, Erich F Solomayer, Wolfgang D Schmitt, Claus Hanusch, Peter A Fasching, Kristina Lübbe, Christine Solbach, Jens Huober, Kerstin Rhiem, Frederik Marmé, Toralf Reimer, Marcus Schmidt, Bruno V Sinn, Wolfgang Janni, Elmar Stickeler, Laura Michel, Oliver Stötzer, Eric Hahnen, Jenny Furlanetto, Sabine Seiler, Valentina Nekljudova, Michael Untch, Sibylle Loibl,

<h4>Background</h4>The development of anti-HER2 antibody-drug conjugates opens new therapeutic options for patients with breast cancer, including patients with low expression of HER2. To characterise this new breast cancer subtype, we have compared the clinical and molecular characteristics of HER2-low-positive and HER2-zero breast cancer, including response to neoadjuvant chemotherapy and prognosis.<h4>Methods</h4>In ... Read more >>

Lancet Oncol (The Lancet. Oncology)
[2021, 22(8):1151-1161]

Cited: 3 times

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The effect of fertility-sparing surgery on sexuality and global quality of life in women with malignant ovarian germ cell and sex cord stromal tumors: an analysis of the CORSETT database of the AGO study group.

Annette Hasenburg, Hellmut Plett, Bernhard Krämer, Elena Braicu, Bastian Czogalla, Michaela Bossart, Susanne Singer, Doris Mayr, Annette Staebler, Andreas du Bois, Stefan Kommoss, Theresa Link, Alexander Burges, Florian Heitz, Jacqueline Keul, Fabian Trillsch, Philipp Harter, Pauline Wimberger, Paul Buderath, Maximilian Klar,

<h4>Purpose</h4>Malignant ovarian germ cell (MOGCT) and sex cord stromal tumors (SCST) are ovarian neoplasms that affect disproportionally young women. Little is known about the impact of surgical and adjuvant management of these patient's sexual life. This study investigated the effect of fertility-sparing surgery on sexual activity and global quality of ... Read more >>

Arch Gynecol Obstet (Archives of gynecology and obstetrics)
[2021, 304(6):1541-1549]

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Evaluation of Integrated HPV DNA as Individualized Biomarkers for the Detection of Recurrent CIN2/3 during Post-Treatment Surveillance.

Heike Hoyer, Grit Mehlhorn, Cornelia Scheungraber, Ingke Hagemann, Christine Hirchenhain, Linn Woelber, Claudia Stolte, Monika Hampl, Sarah Scherbring, Agnieszka Denecke, Janina Bartels, Andreas D Ebert, Sabina Meneder, Annett Petzold, Tabitha Heller, Karsten R Heidtke, Elisabeth Schwarz, Frederik Stübs, Stefanie Schütze, Eva-Lena Stange, Anna Jaeger, Franca Martignoni, Ansgar Dellmann, Achim Rody, Peter Hillemanns, Tanja Fehm, Karl-Ulrich Petry, Gerd Böhmer, Barbara Schmalfeldt, Pauline Wimberger, Matthias W Beckmann, Ingo B Runnebaum, Matthias Dürst,

<h4>Purpose</h4>Post-treatment follow-up in women with cervical pre-cancers (CIN3) is mandatory due to relapse in up to 10% of patients. Standard follow-up based on hrHPV-DNA/cytology co-testing has high sensitivity but limited specificity. The aim of our prospective, multicenter, observational study was to test the hypothesis that an individualized viral-cellular-junction test (vcj-PCR) ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(13):]

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Clinical effectiveness of olaparib monotherapy in germline BRCA-mutated, HER2-negative metastatic breast cancer in a real-world setting: phase IIIb LUCY interim analysis.

Karen A Gelmon, Peter A Fasching, Fergus J Couch, Judith Balmaña, Suzette Delaloge, Intidhar Labidi-Galy, James Bennett, Susan McCutcheon, Graham Walker, Joyce O'Shaughnessy, ,

<h4>Background</h4>In the phase III OlympiAD trial, olaparib significantly increased progression-free survival (PFS) compared with chemotherapy of physician's choice in patients with germline BRCA-mutated (gBRCAm), human epidermal growth factor 2 (HER2)-negative metastatic breast cancer (mBC). The phase IIIb LUCY trial assessed the clinical effectiveness of olaparib in similar patients, in a ... Read more >>

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2021, 152:68-77]

Cited: 1 time

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Are two children at once better than one? Risk analysis of twin pregnancies and births after assisted reproduction.

Maren Goeckenjan, Daria Madej, Anna Klimova, Pauline Wimberger, Cahit Birdir, Katrin Glaß,

<h4>Objectives</h4>Pregnancies and births following assisted reproductive treatment (ART) are related to an increased risk for adverse perinatal outcomes. The aim of this retrospective cohort study at a University Hospital with a tertiary perinatal center was the combined risk analysis of singleton and twin pregnancies after ART in comparison to spontaneously ... Read more >>

Eur J Obstet Gynecol Reprod Biol (European journal of obstetrics, gynecology, and reproductive biology)
[2021, 264:76-82]

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Endometrial Cancer Lymphadenectomy Trial (ECLAT) (pelvic and para-aortic lymphadenectomy in patients with stage I or II endometrial cancer with high risk of recurrence; AGO-OP.6).

Günter Emons, Jae-Weon Kim, Karin Weide, Nikolaus de Gregorio, Pauline Wimberger, Fabian Trillsch, Boris Gabriel, Dominik Denschlag, Stefan Kommoss, Mustafa Aydogdu, Thomas Papathemelis, Martina Gropp-Meier, Mustafa-Zelal Muallem, Cristin Kühn, Andreas Müller, Matthias Frank, Michael Weigel, Holger Bronger, Björn Lampe, Jörn Rau, Carmen Schade-Brittinger, Philipp Harter,

<h4>Background</h4>The impact of comprehensive pelvic and para-aortic lymphadenectomy on survival in patients with stage I or II endometrial cancer with a high risk of recurrence is not reliably documented. The side effects of this procedure, including lymphedema and lymph cysts, are evident.<h4>Primary objective</h4>Evaluation of the effect of comprehensive pelvic and ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2021, 31(7):1075-1079]

Cited: 1 time

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Differential predictors of birth-related posttraumatic stress disorder symptoms in mothers and fathers - A longitudinal cohort study.

Victoria Kress, Tilmann von Soest, Marie Kopp, Pauline Wimberger, Susan Garthus-Niegel,

<h4>Background</h4>Evidence on risk factors of birth-related posttraumatic stress disorder (PTSD) symptoms in mothers is increasing, whereas fathers are less examined. This study aims to determine differential predictors of PTSD symptoms in mothers and fathers.<h4>Methods</h4>Data derive from the DREAM study, including 1,146 mothers and 828 fathers. We assessed mental health, work, ... Read more >>

J Affect Disord (Journal of affective disorders)
[2021, 292:121-130]

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Uterine serous carcinoma.

Giorgio Bogani, Isabelle Ray-Coquard, Nicole Concin, Natalie Y L Ngoi, Philippe Morice, Takayuki Enomoto, Kazuhiro Takehara, Hannelore Denys, Remi A Nout, Domenica Lorusso, Michelle M Vaughan, Marta Bini, Masashi Takano, Diane Provencher, Alice Indini, Satoru Sagae, Pauline Wimberger, Robert Póka, Yakir Segev, Se Ik Kim, Francisco J Candido Dos Reis, Salvatore Lopez, Andrea Mariani, Mario M Leitao, Francesco Raspagliesi, Pieluigi Benedetti Panici, Violante Di Donato, Ludovico Muzii, Nicoletta Colombo, Giovanni Scambia, Sandro Pignata, Bradley J Monk,

Serous endometrial cancer represents a relative rare entity accounting for about 10% of all diagnosed endometrial cancer, but it is responsible for 40% of endometrial cancer-related deaths. Patients with serous endometrial cancer are often diagnosed at earlier disease stage, but remain at higher risk of recurrence and poorer prognosis when ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2021, 162(1):226-234]

Cited: 1 time

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Primary platinum resistance and its prognostic impact in patients with recurrent ovarian cancer: an analysis of three prospective trials from the NOGGO study group.

Fabian Trillsch, Sven Mahner, Bastian Czogalla, Miriam Rottmann, Radoslav Chekerov, Elena Ioana Braicu, Gülten Oskay-Öczelik, Pauline Wimberger, Rolf Richter, Jalid Sehouli,

<h4>Objective</h4>Patients with platinum-resistant ovarian cancer (PROC) have a high need for reliable prognostic markers. Since significance of primary platinum resistance (PPR) versus secondary platinum resistance (SPR) was identified for patients receiving anti-angiogenic therapy, it has not been confirmed for chemotherapy only.<h4>Methods</h4>PROC patients from 3 prospective trials of the NOGGO study ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(3):e37]

Cited: 1 time

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Utilization of Interdisciplinary Tumor Boards for Sarcoma Care in Germany: Results from the PROSa Study.

Martin Eichler, Dimosthenis Andreou, Henriette Golcher, Leopold Hentschel, Stephan Richter, Peter Hohenberger, Bernd Kasper, Daniel Pink, Jens Jakob, Hany Ashmawy, Simone Hettmer, Armin Tuchscherer, Matthias Grube, Vitali Heidt, Christina Jentsch, Jessica Pablik, Eva Wardelmann, Karl-Friedrich Kreitner, Ulrich Kneser, Carolin Tonus, Pauline Wimberger, Olaf Schoffer, Peter Reichardt, Markus Wartenberg, Maria Eberlein-Gonska, Martin Bornhäuser, Jochen Schmitt, Markus K Schuler,

<h4>Background</h4>Data on institutional structures of sarcoma care in Germany are scarce. The utilization of an interdisciplinary tumor board (IDTB) is an essential part of modern cancer care. We investigated to which extent and when IDTB are used in sarcoma care. We hypothesized that IDTB before treatment initiation were used more ... Read more >>

Oncol Res Treat (Oncology research and treatment)
[2021, 44(6):301-312]

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The levels of soluble cMET ectodomain in the blood of patients with ovarian cancer are an independent prognostic biomarker.

Daniel Martin Klotz, Theresa Link, Maren Goeckenjan, Pauline Wimberger, Jan Dominik Kuhlmann,

The tyrosine kinase mesenchymal-epithelial transition (cMET) is typically overexpressed in up to 75% of patients with ovarian cancer, and cMET overexpression has been associated with poor prognosis. The proteolytic release of the soluble cMET (sMET) ectodomain by metalloproteases, a process called ectodomain shedding, reflects the malignant potential of tumour cells. ... Read more >>

Mol Oncol (Molecular oncology)
[2021, 15(9):2491-2503]

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