Full Text Journal Articles by
Author Pauline K Park

Advertisement

Find full text journal articles






Antibiotics versus Appendectomy for Acute Appendicitis - Longer-Term Outcomes.

, Giana H Davidson, David R Flum, Sarah E Monsell, Lillian S Kao, Emily C Voldal, Patrick J Heagerty, Erin Fannon, Danielle C Lavallee, Bonnie Bizzell, Sarah O Lawrence, Bryan A Comstock, Anusha Krishnadasan, Robert J Winchell, Wesley H Self, Callie M Thompson, Farhood Farjah, Pauline K Park, Hasan B Alam, Darin Saltzman, Gregory J Moran, Amy H Kaji, Daniel A DeUgarte, Matthew Salzberg, Lisa Ferrigno, Katherine A Mandell, Thea P Price, Nicole Siparsky, Jacob Glaser, Patricia Ayoung-Chee, William Chiang, Jesse Victory, Bruce Chung, Damien W Carter, Matthew E Kutcher, Alan Jones, Julie Holihan, Mike K Liang, Brett A Faine, Joseph Cuschieri, Heather L Evans, Jeffrey Johnson, Joe H Patton, Natasha Coleman, Katherine Fischkoff, F Thurston Drake, Sabrina E Sanchez, Charles Parsons, Stephen R Odom, Larry G Kessler, David A Talan,

N Engl J Med (The New England journal of medicine)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19.

, , , Ewan C Goligher, Charlotte A Bradbury, Bryan J McVerry, Patrick R Lawler, Jeffrey S Berger, Michelle N Gong, Marc Carrier, Harmony R Reynolds, Anand Kumar, Alexis F Turgeon, Lucy Z Kornblith, Susan R Kahn, John C Marshall, Keri S Kim, Brett L Houston, Lennie P G Derde, Mary Cushman, Tobias Tritschler, Derek C Angus, Lucas C Godoy, Zoe McQuilten, Bridget-Anne Kirwan, Michael E Farkouh, Maria M Brooks, Roger J Lewis, Lindsay R Berry, Elizabeth Lorenzi, Anthony C Gordon, Tania Ahuja, Farah Al-Beidh, Djillali Annane, Yaseen M Arabi, Diptesh Aryal, Lisa Baumann Kreuziger, Abi Beane, Zahra Bhimani, Shailesh Bihari, Henny H Billett, Lindsay Bond, Marc Bonten, Frank Brunkhorst, Meredith Buxton, Adrian Buzgau, Lana A Castellucci, Sweta Chekuri, Jen-Ting Chen, Allen C Cheng, Tamta Chkhikvadze, Benjamin Coiffard, Aira Contreras, Todd W Costantini, Sophie de Brouwer, Michelle A Detry, Abhijit Duggal, Vladimír Džavík, Mark B Effron, Heather F Eng, Jorge Escobedo, Lise J Estcourt, Brendan M Everett, Dean A Fergusson, Mark Fitzgerald, Robert A Fowler, Joshua D Froess, Zhuxuan Fu, Jean P Galanaud, Benjamin T Galen, Sheetal Gandotra, Timothy D Girard, Andrew L Goodman, Herman Goossens, Cameron Green, Yonatan Y Greenstein, Peter L Gross, Rashan Haniffa, Sheila M Hegde, Carolyn M Hendrickson, Alisa M Higgins, Alexander A Hindenburg, Aluko A Hope, James M Horowitz, Christopher M Horvat, David T Huang, Kristin Hudock, Beverley J Hunt, Mansoor Husain, Robert C Hyzy, Jeffrey R Jacobson, Devachandran Jayakumar, Norma M Keller, Akram Khan, Yuri Kim, Andrei Kindzelski, Andrew J King, M Margaret Knudson, Aaron E Kornblith, Matthew E Kutcher, Michael A Laffan, Francois Lamontagne, Grégoire Le Gal, Christine M Leeper, Eric S Leifer, George Lim, Felipe Gallego Lima, Kelsey Linstrum, Edward Litton, Jose Lopez-Sendon, Sylvain A Lother, Nicole Marten, Andréa Saud Marinez, Mary Martinez, Eduardo Mateos Garcia, Stavroula Mavromichalis, Daniel F McAuley, Emily G McDonald, Anna McGlothlin, Shay P McGuinness, Saskia Middeldorp, Stephanie K Montgomery, Paul R Mouncey, Srinivas Murthy, Girish B Nair, Rahul Nair, Alistair D Nichol, Jose C Nicolau, Brenda Nunez-Garcia, John J Park, Pauline K Park, Rachael L Parke, Jane C Parker, Sam Parnia, Jonathan D Paul, Mauricio Pompilio, John G Quigley, Robert S Rosenson, Natalia S Rost, Kathryn Rowan, Fernanda O Santos, Marlene Santos, Mayler O Santos, Lewis Satterwhite, Christina T Saunders, Jake Schreiber, Roger E G Schutgens, Christopher W Seymour, Deborah M Siegal, Delcio G Silva, Aneesh B Singhal, Arthur S Slutsky, Dayna Solvason, Simon J Stanworth, Anne M Turner, Wilma van Bentum-Puijk, Frank L van de Veerdonk, Sean van Diepen, Gloria Vazquez-Grande, Lana Wahid, Vanessa Wareham, R Jay Widmer, Jennifer G Wilson, Eugene Yuriditsky, Yongqi Zhong, Scott M Berry, Colin J McArthur, Matthew D Neal, Judith S Hochman, Steven A Webb, Ryan Zarychanski,

<h4>Background</h4>Thrombosis and inflammation may contribute to morbidity and mortality among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation would improve outcomes in critically ill patients with Covid-19.<h4>Methods</h4>In an open-label, adaptive, multiplatform, randomized clinical trial, critically ill patients with severe Covid-19 were randomly assigned to a pragmatically defined ... Read more >>

N Engl J Med (The New England journal of medicine)
[2021, 385(9):777-789]

Cited: 33 times

View full text PDF listing >>



Advertisement

Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19.

, , , Patrick R Lawler, Ewan C Goligher, Jeffrey S Berger, Matthew D Neal, Bryan J McVerry, Jose C Nicolau, Michelle N Gong, Marc Carrier, Robert S Rosenson, Harmony R Reynolds, Alexis F Turgeon, Jorge Escobedo, David T Huang, Charlotte A Bradbury, Brett L Houston, Lucy Z Kornblith, Anand Kumar, Susan R Kahn, Mary Cushman, Zoe McQuilten, Arthur S Slutsky, Keri S Kim, Anthony C Gordon, Bridget-Anne Kirwan, Maria M Brooks, Alisa M Higgins, Roger J Lewis, Elizabeth Lorenzi, Scott M Berry, Lindsay R Berry, Aaron W Aday, Farah Al-Beidh, Djillali Annane, Yaseen M Arabi, Diptesh Aryal, Lisa Baumann Kreuziger, Abi Beane, Zahra Bhimani, Shailesh Bihari, Henny H Billett, Lindsay Bond, Marc Bonten, Frank Brunkhorst, Meredith Buxton, Adrian Buzgau, Lana A Castellucci, Sweta Chekuri, Jen-Ting Chen, Allen C Cheng, Tamta Chkhikvadze, Benjamin Coiffard, Todd W Costantini, Sophie de Brouwer, Lennie P G Derde, Michelle A Detry, Abhijit Duggal, Vladimír Džavík, Mark B Effron, Lise J Estcourt, Brendan M Everett, Dean A Fergusson, Mark Fitzgerald, Robert A Fowler, Jean P Galanaud, Benjamin T Galen, Sheetal Gandotra, Sebastian García-Madrona, Timothy D Girard, Lucas C Godoy, Andrew L Goodman, Herman Goossens, Cameron Green, Yonatan Y Greenstein, Peter L Gross, Naomi M Hamburg, Rashan Haniffa, George Hanna, Nicholas Hanna, Sheila M Hegde, Carolyn M Hendrickson, R Duncan Hite, Alexander A Hindenburg, Aluko A Hope, James M Horowitz, Christopher M Horvat, Kristin Hudock, Beverley J Hunt, Mansoor Husain, Robert C Hyzy, Vivek N Iyer, Jeffrey R Jacobson, Devachandran Jayakumar, Norma M Keller, Akram Khan, Yuri Kim, Andrei L Kindzelski, Andrew J King, M Margaret Knudson, Aaron E Kornblith, Vidya Krishnan, Matthew E Kutcher, Michael A Laffan, Francois Lamontagne, Grégoire Le Gal, Christine M Leeper, Eric S Leifer, George Lim, Felipe Gallego Lima, Kelsey Linstrum, Edward Litton, Jose Lopez-Sendon, Jose L Lopez-Sendon Moreno, Sylvain A Lother, Saurabh Malhotra, Miguel Marcos, Andréa Saud Marinez, John C Marshall, Nicole Marten, Michael A Matthay, Daniel F McAuley, Emily G McDonald, Anna McGlothlin, Shay P McGuinness, Saskia Middeldorp, Stephanie K Montgomery, Steven C Moore, Raquel Morillo Guerrero, Paul R Mouncey, Srinivas Murthy, Girish B Nair, Rahul Nair, Alistair D Nichol, Brenda Nunez-Garcia, Ambarish Pandey, Pauline K Park, Rachael L Parke, Jane C Parker, Sam Parnia, Jonathan D Paul, Yessica S Pérez González, Mauricio Pompilio, Matthew E Prekker, John G Quigley, Natalia S Rost, Kathryn Rowan, Fernanda O Santos, Marlene Santos, Mayler Olombrada Santos, Lewis Satterwhite, Christina T Saunders, Roger E G Schutgens, Christopher W Seymour, Deborah M Siegal, Delcio G Silva, Manu Shankar-Hari, John P Sheehan, Aneesh B Singhal, Dayna Solvason, Simon J Stanworth, Tobias Tritschler, Anne M Turner, Wilma van Bentum-Puijk, Frank L van de Veerdonk, Sean van Diepen, Gloria Vazquez-Grande, Lana Wahid, Vanessa Wareham, Bryan J Wells, R Jay Widmer, Jennifer G Wilson, Eugene Yuriditsky, Fernando G Zampieri, Derek C Angus, Colin J McArthur, Steven A Webb, Michael E Farkouh, Judith S Hochman, Ryan Zarychanski,

<h4>Background</h4>Thrombosis and inflammation may contribute to the risk of death and complications among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation may improve outcomes in noncritically ill patients who are hospitalized with Covid-19.<h4>Methods</h4>In this open-label, adaptive, multiplatform, controlled trial, we randomly assigned patients who were hospitalized with ... Read more >>

N Engl J Med (The New England journal of medicine)
[2021, 385(9):790-802]

Cited: 32 times

View full text PDF listing >>



Variation in Early Management Practices in Moderate-to-Severe ARDS in the United States: The Severe ARDS: Generating Evidence Study.

Nida Qadir, Raquel R Bartz, Mary L Cooter, Catherine L Hough, Michael J Lanspa, Valerie M Banner-Goodspeed, Jen-Ting Chen, Shewit Giovanni, Dina Gomaa, Michael W Sjoding, Negin Hajizadeh, Jordan Komisarow, Abhijit Duggal, Ashish K Khanna, Rahul Kashyap, Akram Khan, Steven Y Chang, Joseph E Tonna, Harry L Anderson, Janice M Liebler, Jarrod M Mosier, Peter E Morris, Alissa Genthon, Irene K Louh, Mark Tidswell, R Scott Stephens, Annette M Esper, David J Dries, Anthony Martinez, Kraftin E Schreyer, William Bender, Anupama Tiwari, Pramod K Guru, Sinan Hanna, Michelle N Gong, Pauline K Park, , ,

<h4>Background</h4>Although specific interventions previously demonstrated benefit in patients with ARDS, use of these interventions is inconsistent, and patient mortality remains high. The impact of variability in center management practices on ARDS mortality rates remains unknown.<h4>Research question</h4>What is the impact of treatment variability on mortality in patients with moderate to severe ... Read more >>

Chest (Chest)
[2021, 160(4):1304-1315]

Cited: 3 times

View full text PDF listing >>



Tracheostomy for COVID-19 respiratory failure: timing, ventilatory characteristics, and outcomes.

Janice L Farlow, Pauline K Park, Michael W Sjoding, Stephen G Kay, Ross Blank, Kelly M Malloy, Laraine Washer, Lena M Napolitano, Venkatakrishna Rajajee, Michael J Brenner, Steven B Chinn, Jose De Cardenas,

<h4>Background</h4>Whereas data from the pre-pandemic era have demonstrated that tracheostomy can accelerate liberation from the ventilator, reduce need for sedation, and facilitate rehabilitation, concerns for healthcare worker safety have led to disagreement on tracheostomy placement in COVID-19 patients. Data on COVID-19 patients undergoing tracheostomy may inform best practices. Thus, we ... Read more >>

J Thorac Dis (Journal of thoracic disease)
[2021, 13(7):4137-4145]

Cited: 0 times

View full text PDF listing >>



Resonance Raman Spectroscopy Derived Tissue Hemoglobin Oxygen Saturation in Critically Ill and Injured Patients.

Mohamad H Tiba, Abdelrahman B Awad, Amanda Pennington, Christopher M Fung, Lena M Napolitano, Pauline K Park, David A Machado-Aranda, Kyle J Gunnerson, Padraic Romfh, Kevin R Ward,

<h4>Background</h4>In this study, we examined the ability of resonance Raman spectroscopy to measure tissue hemoglobin oxygenation (R-StO2) noninvasively in critically ill patients and compared its performance with conventional central venous hemoglobin oxygen saturation (ScvO2).<h4>Methods</h4>Critically ill patients (n = 138) with an indwelling central venous or pulmonary artery catheter in place were consented ... Read more >>

Shock (Shock (Augusta, Ga.))
[2021, 56(1):92-97]

Cited: 0 times

View full text PDF listing >>



Predicting Intensive Care Transfers and Other Unforeseen Events: Analytic Model Validation Study and Comparison to Existing Methods.

Brandon C Cummings, Sardar Ansari, Jonathan R Motyka, Guan Wang, Richard P Medlin, Steven L Kronick, Karandeep Singh, Pauline K Park, Lena M Napolitano, Robert P Dickson, Michael R Mathis, Michael W Sjoding, Andrew J Admon, Ross Blank, Jakob I McSparron, Kevin R Ward, Christopher E Gillies,

<h4>Background</h4>COVID-19 has led to an unprecedented strain on health care facilities across the United States. Accurately identifying patients at an increased risk of deterioration may help hospitals manage their resources while improving the quality of patient care. Here, we present the results of an analytical model, Predicting Intensive Care Transfers ... Read more >>

JMIR Med Inform (JMIR medical informatics)
[2021, 9(4):e25066]

Cited: 0 times

View full text PDF listing >>



Expert consensus statements for the management of COVID-19-related acute respiratory failure using a Delphi method.

Prashant Nasa, Elie Azoulay, Ashish K Khanna, Ravi Jain, Sachin Gupta, Yash Javeri, Deven Juneja, Pradeep Rangappa, Krishnaswamy Sundararajan, Waleed Alhazzani, Massimo Antonelli, Yaseen M Arabi, Jan Bakker, Laurent J Brochard, Adam M Deane, Bin Du, Sharon Einav, Andrés Esteban, Ognjen Gajic, Samuel M Galvagno, Claude Guérin, Samir Jaber, Gopi C Khilnani, Younsuck Koh, Jean-Baptiste Lascarrou, Flavia R Machado, Manu L N G Malbrain, Jordi Mancebo, Michael T McCurdy, Brendan A McGrath, Sangeeta Mehta, Armand Mekontso-Dessap, Mervyn Mer, Michael Nurok, Pauline K Park, Paolo Pelosi, John V Peter, Jason Phua, David V Pilcher, Lise Piquilloud, Peter Schellongowski, Marcus J Schultz, Manu Shankar-Hari, Suveer Singh, Massimiliano Sorbello, Ravindranath Tiruvoipati, Andrew A Udy, Tobias Welte, Sheila N Myatra,

<h4>Background</h4>Coronavirus disease 2019 (COVID-19) pandemic has caused unprecedented pressure on healthcare system globally. Lack of high-quality evidence on the respiratory management of COVID-19-related acute respiratory failure (C-ARF) has resulted in wide variation in clinical practice.<h4>Methods</h4>Using a Delphi process, an international panel of 39 experts developed clinical practice statements on the ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):106]

Cited: 9 times

View full text PDF listing >>



A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19.

, Jens D Lundgren, Birgit Grund, Christina E Barkauskas, Thomas L Holland, Robert L Gottlieb, Uriel Sandkovsky, Samuel M Brown, Kirk U Knowlton, Wesley H Self, D Clark Files, Mamta K Jain, Thomas Benfield, Michael E Bowdish, Bradley G Leshnower, Jason V Baker, Jens-Ulrik Jensen, Edward M Gardner, Adit A Ginde, Estelle S Harris, Isik S Johansen, Norman Markowitz, Michael A Matthay, Lars Østergaard, Christina C Chang, Victoria J Davey, Anna Goodman, Elizabeth S Higgs, Daniel D Murray, Thomas A Murray, Roger Paredes, Mahesh K B Parmar, Andrew N Phillips, Cavan Reilly, Shweta Sharma, Robin L Dewar, Marc Teitelbaum, Deborah Wentworth, Huyen Cao, Paul Klekotka, Abdel G Babiker, Annetine C Gelijns, Virginia L Kan, Mark N Polizzotto, B Taylor Thompson, H Clifford Lane, James D Neaton,

<h4>Background</h4>LY-CoV555, a neutralizing monoclonal antibody, has been associated with a decrease in viral load and the frequency of hospitalizations or emergency department visits among outpatients with coronavirus disease 2019 (Covid-19). Data are needed on the effect of this antibody in patients who are hospitalized with Covid-19.<h4>Methods</h4>In this platform trial of ... Read more >>

N Engl J Med (The New England journal of medicine)
[2021, 384(10):905-914]

Cited: 76 times

View full text PDF listing >>



Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients With COVID-19: A Randomized Clinical Trial.

Wesley H Self, Matthew W Semler, Lindsay M Leither, Jonathan D Casey, Derek C Angus, Roy G Brower, Steven Y Chang, Sean P Collins, John C Eppensteiner, Michael R Filbin, D Clark Files, Kevin W Gibbs, Adit A Ginde, Michelle N Gong, Frank E Harrell, Douglas L Hayden, Catherine L Hough, Nicholas J Johnson, Akram Khan, Christopher J Lindsell, Michael A Matthay, Marc Moss, Pauline K Park, Todd W Rice, Bryce R H Robinson, David A Schoenfeld, Nathan I Shapiro, Jay S Steingrub, Christine A Ulysse, Alexandra Weissman, Donald M Yealy, B Taylor Thompson, Samuel M Brown, , Jay Steingrub, Howard Smithline, Bogdan Tiru, Mark Tidswell, Lori Kozikowski, Sherell Thornton-Thompson, Leslie De Souza, Peter Hou, Rebecca Baron, Anthony Massaro, Imoigele Aisiku, Lauren Fredenburgh, Raghu Seethala, Lily Johnsky, Richard Riker, David Seder, Teresa May, Michael Baumann, Ashley Eldridge, Christine Lord, Nathan Shapiro, Daniel Talmor, Thomas O’Mara, Charlotte Kirk, Kelly Harrison, Lisa Kurt, Margaret Schermerhorn, Valerie Banner-Goodspeed, Katherine Boyle, Nicole Dubosh, Michael Filbin, Kathryn Hibbert, Blair Parry, Kendall Lavin-Parsons, Natalie Pulido, Brendan Lilley, Carl Lodenstein, Justin Margolin, Kelsey Brait, Alan Jones, James Galbraith, Rebekah Peacock, Utsav Nandi, Taylor Wachs, Michael Matthay, Kathleen Liu, Kirsten Kangelaris, Ralph Wang, Carolyn Calfee, Kimberly Yee, Gregory Hendey, Steven Chang, George Lim, Nida Qadir, Andrea Tam, Rebecca Beutler, Joseph Levitt, Jenny Wilson, Angela Rogers, Rosemary Vojnik, Jonasel Roque, Timothy Albertson, James Chenoweth, Jason Adams, Skyler Pearson, Maya Juarez, Eyad Almasri, Mohamed Fayed, Alyssa Hughes, Shelly Hillard, Ryan Huebinger, Henry Wang, Elizabeth Vidales, Bela Patel, Adit Ginde, Marc Moss, Amiran Baduashvili, Jeffrey McKeehan, Lani Finck, Carrie Higgins, Michelle Howell, Ivor Douglas, Jason Haukoos, Terra Hiller, Carolynn Lyle, Alicia Cupelo, Emily Caruso, Claudia Camacho, Stephanie Gravitz, James Finigan, Christine Griesmer, Pauline Park, Robert Hyzy, Kristine Nelson, Kelli McDonough, Norman Olbrich, Mark Williams, Raj Kapoor, Jean Nash, Meghan Willig, Henry Ford, Jayna Gardner-Gray, Mayur Ramesh, Montefiore Moses, Michelle Ng Gong, Michael Aboodi, Ayesha Asghar, Omowunmi Amosu, Madeline Torres, Savneet Kaur, Jen-Ting Chen, Aluko Hope, Brenda Lopez, Kathleen Rosales, Jee Young You, Jarrod Mosier, Cameron Hypes, Bhupinder Natt, Bryan Borg, Elizabeth Salvagio Campbell, R Duncan Hite, Kristin Hudock, Autumn Cresie, Faysal Alhasan, Jose Gomez-Arroyo, Abhijit Duggal, Omar Mehkri, Andrei Hastings, Debasis Sahoo, Francois Abi Fadel, Susan Gole, Valerie Shaner, Allison Wimer, Yvonne Meli, Alexander King, Thomas Terndrup, Matthew Exline, Sonal Pannu, Emily Robart, Sarah Karow, Catherine Hough, Bryce Robinson, Nicholas Johnson, Daniel Henning, Monica Campo, Stephanie Gundel, Sakshi Seghal, Sarah Katsandres, Sarah Dean, Akram Khan, Olivia Krol, Milad Jouzestani, Peter Huynh, Alexandra Weissman, Donald Yealy, Denise Scholl, Peter Adams, Bryan McVerry, David Huang, Derek Angus, Jordan Schooler, Steven Moore, Clark Files, Chadwick Miller, Kevin Gibbs, Mary LaRose, Lori Flores, Lauren Koehler, Caryn Morse, John Sanders, Caitlyn Langford, Kristen Nanney, Masiku MdalaGausi, Phyllis Yeboah, Peter Morris, Jamie Sturgill, Sherif Seif, Evan Cassity, Sanjay Dhar, Marjolein de Wit, Jessica Mason, Andrew Goodwin, Greg Hall, Abbey Grady, Amy Chamberlain, Samuel Brown, Joseph Bledsoe, Lindsay Leither, Ithan Peltan, Nathan Starr, Melissa Fergus, Valerie Aston, Quinn Montgomery, Rilee Smith, Mardee Merrill, Katie Brown, Brent Armbruster, Estelle Harris, Elizabeth Middleton, Robert Paine, Stacy Johnson, Macy Barrios, John Eppensteiner, Alexander Limkakeng, Lauren McGowan, Tedra Porter, Andrew Bouffler, J. Clancy Leahy, Bennet deBoisblanc, Matthew Lammi, Kyle Happel, Paula Lauto, Wesley Self, Jonathan Casey, Matthew Semler, Sean Collins, Frank Harrell, Christopher Lindsell, Todd Rice, William Stubblefield, Christopher Gray, Jakea Johnson, Megan Roth, Margaret Hays, Donna Torr, Arwa Zakaria, David Schoenfeld, Taylor Thompson, Douglas Hayden, Nancy Ringwood, Cathryn Oldmixon, Christine Ulysse, Richard Morse, Ariela Muzikansky, Laura Fitzgerald, Samuel Whitaker, Adrian Lagakos, Roy Brower, Lora Reineck, Neil Aggarwal, Karen Bienstock, Michelle Freemer, Myron Maclawiw, Gail Weinmann, Laurie Morrison, Mark Gillespie, Richard Kryscio, Daniel Brodie, Wojciech Zareba, Anne Rompalo, Michael Boeckh, Polly Parsons, Jason Christie, Jesse Hall, Nicholas Horton, Laurie Zoloth, Neal Dickert, Deborah Diercks,

<h4>Importance</h4>Data on the efficacy of hydroxychloroquine for the treatment of coronavirus disease 2019 (COVID-19) are needed.<h4>Objective</h4>To determine whether hydroxychloroquine is an efficacious treatment for adults hospitalized with COVID-19.<h4>Design, setting, and participants</h4>This was a multicenter, blinded, placebo-controlled randomized trial conducted at 34 hospitals in the US. Adults hospitalized with respiratory symptoms ... Read more >>

JAMA (JAMA)
[2020, 324(21):2165-2176]

Cited: 105 times

View full text PDF listing >>



Coronavirus Disease 2019 (COVID-19) Clinical Trial Oversight at a Major Academic Medical Center: Approach of Michigan Medicine.

Kayte Spector-Bagdady, Peter D R Higgins, Keith D Aaronson, Judy Birk, Kevin R Flaherty, Kevin S Gregg, Robert C Hyzy, Daniel R Kaul, Adam S Lauring, John C Magee, William J Meurer, Pauline K Park, Phillip Scott, Anna S Lok,

Clinicians, eager to offer the best care in the absence of guiding data, have provided patients with coronavirus disease 2019 (COVID-19) diverse clinical interventions. This usage has led to perceptions of efficacy of some interventions that, while receiving media coverage, lack robust evidence. Moving forward, randomized controlled clinical trials are ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, 71(16):2187-2190]

Cited: 7 times

View full text PDF listing >>



A Randomized Trial Comparing Antibiotics with Appendectomy for Appendicitis.

, David R Flum, Giana H Davidson, Sarah E Monsell, Nathan I Shapiro, Stephen R Odom, Sabrina E Sanchez, F Thurston Drake, Katherine Fischkoff, Jeffrey Johnson, Joe H Patton, Heather Evans, Joseph Cuschieri, Amber K Sabbatini, Brett A Faine, Dionne A Skeete, Mike K Liang, Vance Sohn, Karen McGrane, Matthew E Kutcher, Bruce Chung, Damien W Carter, Patricia Ayoung-Chee, William Chiang, Amy Rushing, Steven Steinberg, Careen S Foster, Shaina M Schaetzel, Thea P Price, Katherine A Mandell, Lisa Ferrigno, Matthew Salzberg, Daniel A DeUgarte, Amy H Kaji, Gregory J Moran, Darin Saltzman, Hasan B Alam, Pauline K Park, Lillian S Kao, Callie M Thompson, Wesley H Self, Julianna T Yu, Abigail Wiebusch, Robert J Winchell, Sunday Clark, Anusha Krishnadasan, Erin Fannon, Danielle C Lavallee, Bryan A Comstock, Bonnie Bizzell, Patrick J Heagerty, Larry G Kessler, David A Talan,

<h4>Background</h4>Antibiotic therapy has been proposed as an alternative to surgery for the treatment of appendicitis.<h4>Methods</h4>We conducted a pragmatic, nonblinded, noninferiority, randomized trial comparing antibiotic therapy (10-day course) with appendectomy in patients with appendicitis at 25 U.S. centers. The primary outcome was 30-day health status, as assessed with the European Quality ... Read more >>

N Engl J Med (The New England journal of medicine)
[2020, 383(20):1907-1919]

Cited: 26 times

View full text PDF listing >>



Rationale and Design of ORCHID: A Randomized Placebo-controlled Clinical Trial of Hydroxychloroquine for Adults Hospitalized with COVID-19.

Jonathan D Casey, Nicholas J Johnson, Matthew W Semler, Sean P Collins, Neil R Aggarwal, Roy G Brower, Steven Y Chang, John Eppensteiner, Michael Filbin, Kevin W Gibbs, Adit A Ginde, Michelle N Gong, Frank Harrell, Douglas L Hayden, Catherine L Hough, Akram Khan, Lindsay M Leither, Marc Moss, Cathryn F Oldmixon, Pauline K Park, Lora A Reineck, Nancy J Ringwood, Bryce R H Robinson, David A Schoenfeld, Nathan I Shapiro, Jay S Steingrub, Donna K Torr, Alexandra Weissman, Christopher J Lindsell, Todd W Rice, B Taylor Thompson, Samuel M Brown, Wesley H Self,

The ORCHID (Outcomes Related to COVID-19 treated with Hydroxychloroquine among In-patients with symptomatic Disease) trial is a multicenter, blinded, randomized trial of hydroxychloroquine versus placebo for the treatment of adults hospitalized with coronavirus disease (COVID-19). This document provides the rationale and background for the trial and highlights key design features. ... Read more >>

Ann Am Thorac Soc (Annals of the American Thoracic Society)
[2020, 17(9):1144-1153]

Cited: 6 times

View full text PDF listing >>



An Unusual Cause of Severe Hypoxemia and Acute Respiratory Distress Syndrome.

Jay Hammerling, Arielle Kanters, Benjamin Jacobs, Alfred Franzblau, Pauline K Park, Lena M Napolitano,

Chest (Chest)
[2020, 158(2):e71-e77]

Cited: 0 times

View full text PDF listing >>



Early High-Dose Vitamin D3 for Critically Ill, Vitamin D-Deficient Patients.

, Adit A Ginde, Roy G Brower, Jeffrey M Caterino, Lani Finck, Valerie M Banner-Goodspeed, Colin K Grissom, Douglas Hayden, Catherine L Hough, Robert C Hyzy, Akram Khan, Joseph E Levitt, Pauline K Park, Nancy Ringwood, Emanuel P Rivers, Wesley H Self, Nathan I Shapiro, B Taylor Thompson, Donald M Yealy, Daniel Talmor,

<h4>Background</h4>Vitamin D deficiency is a common, potentially reversible contributor to morbidity and mortality among critically ill patients. The potential benefits of vitamin D supplementation in acute critical illness require further study.<h4>Methods</h4>We conducted a randomized, double-blind, placebo-controlled, phase 3 trial of early vitamin D<sub>3</sub> supplementation in critically ill, vitamin D-deficient patients ... Read more >>

N Engl J Med (The New England journal of medicine)
[2019, 381(26):2529-2540]

Cited: 53 times

View full text PDF listing >>



The effect of timing of initiation of renal replacement therapy on mortality: A retrospective case-control study.

Milo Engoren, Michael D Maile, Michael Heung, James M Blum, Ross Blank, Lena M Napolitano, Pauline K Park, Krishnan Raghavendran, Elizabeth S Jewell, Craig Meldrum,

<h4>Purpose</h4>To determine if earlier initiation of renal replacement therapy (RRT) is associated with improved survival in patients with severe acute kidney injury.<h4>Methods</h4>We performed a retrospective case-control study of propensity-matched groups with multivariable logistic regression using Akaike Information Criteria to adjust for non-matched variables in a surgical ICU in a tertiary ... Read more >>

J Intensive Care Soc (Journal of the Intensive Care Society)
[2021, 22(1):8-16]

Cited: 0 times

View full text PDF listing >>



Immune checkpoint inhibition in sepsis: a Phase 1b randomized study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of nivolumab.

Richard S Hotchkiss, Elizabeth Colston, Sachin Yende, Elliott D Crouser, Greg S Martin, Timothy Albertson, Raquel R Bartz, Scott C Brakenridge, Matthew J Delano, Pauline K Park, Michael W Donnino, Mark Tidswell, Florian B Mayr, Derek C Angus, Craig M Coopersmith, Lyle L Moldawer, Ian M Catlett, Ihab G Girgis, June Ye, Dennis M Grasela,

PURPOSE:Sepsis-associated immunosuppression increases hospital-acquired infection and viral reactivation risk. A key underlying mechanism is programmed cell death protein-1 (PD-1)-mediated T-cell function impairment. This is one of the first clinical safety and pharmacokinetics (PK) assessments of the anti-PD-1 antibody nivolumab and its effect on immune biomarkers in sepsis. METHODS:Randomized, double-blind, parallel-group, ... Read more >>

Intensive Care Med (Intensive care medicine)
[2019, 45(10):1360-1371]

Cited: 27 times

View full text PDF listing >>



The authors reply.

Richard S Hotchkiss, Sachin Yende, Derek C Angus, Lyle L Moldawer, Elliott Crouser, Greg Martin, Craig M Coopersmith, Scott Brakenridge, Florian B Mayr, Pauline K Park,

Crit Care Med (Critical care medicine)
[2019, 47(9):e788-e789]

Cited: 0 times

View full text PDF listing >>



Immune Checkpoint Inhibition in Sepsis: A Phase 1b Randomized, Placebo-Controlled, Single Ascending Dose Study of Antiprogrammed Cell Death-Ligand 1 Antibody (BMS-936559).

Richard S Hotchkiss, Elizabeth Colston, Sachin Yende, Derek C Angus, Lyle L Moldawer, Elliott D Crouser, Greg S Martin, Craig M Coopersmith, Scott Brakenridge, Florian B Mayr, Pauline K Park, June Ye, Ian M Catlett, Ihab G Girgis, Dennis M Grasela,

<h4>Objectives</h4>To assess for the first time the safety and pharmacokinetics of an antiprogrammed cell death-ligand 1 immune checkpoint inhibitor (BMS-936559; Bristol-Myers Squibb, Princeton, NJ) and its effect on immune biomarkers in participants with sepsis-associated immunosuppression.<h4>Design</h4>Randomized, placebo-controlled, dose-escalation.<h4>Setting</h4>Seven U.S. hospital ICUs.<h4>Study population</h4>Twenty-four participants with sepsis, organ dysfunction (hypotension, acute respiratory failure, ... Read more >>

Crit Care Med (Critical care medicine)
[2019, 47(5):632-642]

Cited: 44 times

View full text PDF listing >>



Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome.

, Marc Moss, David T Huang, Roy G Brower, Niall D Ferguson, Adit A Ginde, M N Gong, Colin K Grissom, Stephanie Gundel, Douglas Hayden, R Duncan Hite, Peter C Hou, Catherine L Hough, Theodore J Iwashyna, Akram Khan, Kathleen D Liu, Daniel Talmor, B Taylor Thompson, Christine A Ulysse, Donald M Yealy, Derek C Angus,

<h4>Background</h4>The benefits of early continuous neuromuscular blockade in patients with acute respiratory distress syndrome (ARDS) who are receiving mechanical ventilation remain unclear.<h4>Methods</h4>We randomly assigned patients with moderate-to-severe ARDS (defined by a ratio of the partial pressure of arterial oxygen to the fraction of inspired oxygen of <150 mm Hg with ... Read more >>

N Engl J Med (The New England journal of medicine)
[2019, 380(21):1997-2008]

Cited: 153 times

View full text PDF listing >>



Utilization of Intensive Care Unit Nutrition Consultation Is Associated With Reduced Mortality.

Christopher J Tignanelli, Kyle H Sheetz, Ashley Petersen, Pauline K Park, Lena M Napolitano, Colin R Cooke, Jill R Cherry-Bukowiec,

<h4>Background</h4>The aim of this project was to investigate the prevalence of nutrition consultation (NC) in U.S. intensive care units (ICUs) and to examine its association with patient outcomes.<h4>Methods</h4>Data from the Healthcare Cost and Utilization Project's state inpatient databases was utilized from 2010 - 2014. A multilevel logistic regression model was ... Read more >>

JPEN J Parenter Enteral Nutr (JPEN. Journal of parenteral and enteral nutrition)
[2020, 44(2):213-219]

Cited: 0 times

View full text PDF listing >>



Prospective Assessment of the Feasibility of a Trial of Low-Tidal Volume Ventilation for Patients with Acute Respiratory Failure.

Michael J Lanspa, Michelle Ng Gong, David A Schoenfeld, Kathleen Tiffany Lee, Colin K Grissom, Peter C Hou, Ary Serpa-Neto, Samuel M Brown, Theodore J Iwashyna, Donald M Yealy, Catherine L Hough, Roy G Brower, Carolyn S Calfee, Robert C Hyzy, Michael A Matthay, Russell R Miller, Jay S Steingrub, B Taylor Thompson, Chadwick D Miller, Terry P Clemmer, Gregory W Hendey, David T Huang, Kusum S Mathews, Nida Qadir, Mark Tidswell, ,

<h4>Rationale</h4>Low-tidal volume ventilation (LTVV; 6 ml/kg) benefits patients with acute respiratory distress syndrome and may aid those with other causes of respiratory failure. Current early ventilation practices are poorly defined.<h4>Objectives</h4>We observed patients with acute respiratory failure to assess the feasibility of a pragmatic trial of LTVV and to guide experimental ... Read more >>

Ann Am Thorac Soc (Annals of the American Thoracic Society)
[2019, 16(3):356-362]

Cited: 12 times

View full text PDF listing >>



Computed Tomography Evidence of Psoas Muscle Atrophy Without Concomitant Tendon Wasting in Early Sepsis.

Carrie A Kubiak, Kavitha Ranganathan, Niki Matusko, Jon A Jacobson, Stewart C Wang, Pauline K Park, Benjamin L Levi,

<h4>Background</h4>Morphomic studies have demonstrated a correlation between sarcopenia and clinical outcomes in septic patients. However, tendon morphomics has not yet been studied in this context. The purpose of the present study was to evaluate tendon morphology in septic patients through analytic morphomics. We hypothesized that morphomic analyses would reveal concomitant ... Read more >>

J Surg Res (The Journal of surgical research)
[2019, 234:210-216]

Cited: 1 time

View full text PDF listing >>



Empirical systemic anticoagulation is associated with decreased venous thromboembolism in critically ill influenza A H1N1 acute respiratory distress syndrome patients.

Andrea T Obi, Christopher J Tignanelli, Benjamin N Jacobs, Shipra Arya, Pauline K Park, Thomas W Wakefield, Peter K Henke, Lena M Napolitano,

<h4>Background</h4>An association between increased venous thromboembolism (VTE) events and influenza A H1N1 (H1N1) was noted in the first 10 patients with severe acute respiratory distress syndrome (ARDS). An empirical systemic anticoagulation protocol (heparin intravenous infusion) was initiated when autopsy of patients with severe hypoxemia confirmed multiple primary pulmonary thrombi and ... Read more >>

J Vasc Surg Venous Lymphat Disord (Journal of vascular surgery. Venous and lymphatic disorders)
[2019, 7(3):317-324]

Cited: 73 times

View full text PDF listing >>



Indications and outcomes of extracorporeal life support in trauma patients.

Justyna Swol, Daniel Brodie, Lena Napolitano, Pauline K Park, Ravi Thiagarajan, Ryan P Barbaro, Roberto Lorusso, David McMullan, Nicholas Cavarocchi, Ali Ait Hssain, Peter Rycus, David Zonies, ,

<h4>Background</h4>The use of extracorporeal life support (ECLS) in the trauma population remains controversial and has been reported only in small cohort studies. Recent ECLS technical advances have increased its use as an advanced critical care option in trauma. Given the degree of resource utilization, costs, and expertise required to provide ... Read more >>

J Trauma Acute Care Surg (The journal of trauma and acute care surgery)
[2018, 84(6):831-837]

Cited: 7 times

View full text PDF listing >>



Advertisement


Disclaimer

1.9774 s