Full Text Journal Articles by
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Pre- and intraoperative thoracic spine localization techniques: a systematic review.

Michael J Strong, Julianne Santarosa, Timothy P Sullivan, Noojan Kazemi, Jacob R Joseph, Osama N Kashlan, Mark E Oppenlander, Nicholas J Szerlip, Paul Park, Clay M Elswick,

<h4>Objective</h4>In the era of modern medicine with an armamentarium full of state-of-the art technologies at our disposal, the incidence of wrong-level spinal surgery remains problematic. In particular, the thoracic spine presents a challenge for accurate localization due partly to body habitus, anatomical variations, and radiographic artifact from the ribs and ... Read more >>

J Neurosurg Spine (Journal of neurosurgery. Spine)
[2021, :1-8]

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Association of ≥ 12 months of delayed surgical treatment for cervical myelopathy with worsened postoperative outcomes: a multicenter analysis of the Quality Outcomes Database.

David T Asuzu, Jonathan J Yun, Mohammed Ali Alvi, Andrew K Chan, Cheerag D Upadhyaya, Domagoj Coric, Eric A Potts, Erica F Bisson, Jay D Turner, Jack J Knightly, Kai-Ming Fu, Kevin T Foley, Luis Tumialan, Mark Shaffrey, Mohamad Bydon, Praveen V Mummaneni, Paul Park, Scott Meyer, Anthony L Asher, Oren N Gottfried, Khoi D Than, Michael Y Wang, Avery L Buchholz,

<h4>Objective</h4>Degenerative cervical myelopathy (DCM) results in significant morbidity. The duration of symptoms prior to surgical intervention may be associated with postoperative surgical outcomes and functional recovery. The authors' objective was to investigate whether delayed surgical treatment for DCM is associated with worsened postoperative outcomes.<h4>Methods</h4>Data from 1036 patients across 14 surgical ... Read more >>

J Neurosurg Spine (Journal of neurosurgery. Spine)
[2021, :1-7]

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Two- and three-year outcomes of minimally invasive and hybrid correction of adult spinal deformity.

Andrew K Chan, Robert K Eastlack, Richard G Fessler, Khoi D Than, Dean Chou, Kai-Ming Fu, Paul Park, Michael Y Wang, Adam S Kanter, David O Okonkwo, Pierce D Nunley, Neel Anand, Juan S Uribe, Gregory M Mundis, Shay Bess, Christopher I Shaffrey, Vivian P Le, Praveen V Mummaneni, ,

<h4>Objective</h4>Previous studies have demonstrated the short-term radiographic and clinical benefits of circumferential minimally invasive surgery (cMIS) and hybrid (i.e., minimally invasive anterior or lateral interbody fusion with an open posterior approach) techniques to correct adult spinal deformity (ASD). However, it is not known if these benefits are maintained over longer ... Read more >>

J Neurosurg Spine (Journal of neurosurgery. Spine)
[2021, :1-14]

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EP300 selectively controls the enhancer landscape of MYCN-amplified neuroblastoma.

Adam D Durbin, Tingjian Wang, Virangika K Wimalasena, Mark W Zimmerman, Deyao Li, Neekesh V Dharia, Luca Mariani, Noha A M Shendy, Stephanie Nance, Anand G Patel, Ying Shao, Maya Mundada, Lily Maxham, Paul M C Park, Logan H Sigua, Ken Morita, Amy Saur Conway, Amanda L Robichaud, Antonio R Perez-Atayde, Melissa J Bikowitz, Taylor R Quinn, Olaf G Wiest, John Easton, Ernst Schonbrunn, Martha L Bulyk, Brian J Abraham, Kimberly Stegmaier, A Thomas Look, Jun Qi,

Gene expression is regulated by promoters and enhancers marked by histone H3-lysine-27 acetylation (H3K27ac), which is established by the paralogous histone acetyltransferases (HATs), EP300 and CBP. These enzymes display overlapping regulatory roles in untransformed cells, but less characterized roles in cancer cells. We demonstrate that the majority of high-risk pediatric ... Read more >>

Cancer Discov (Cancer discovery)
[2021, :]

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Commentary: A Novel Weave Tether Technique for Proximal Junctional Kyphosis Prevention in 71 Adult Spinal Deformity Patients: A Preliminary Case Series Assessing Early Complications and Efficacy.

Michael J Strong, Timothy J Yee, Whitney E Muhlestein, Yamaan S Saadeh, Paul Park,

Oper Neurosurg (Hagerstown) (Operative neurosurgery (Hagerstown, Md.))
[2021, 21(6):E469-E470]

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An updated management algorithm for incorporating minimally invasive techniques to treat thoracolumbar trauma.

Jacob K Greenberg, Stephen Shelby Burks, Christopher F Dibble, Saad Javeed, Vivek P Gupta, Alexander T Yahanda, Roberto J Perez-Roman, Vaidya Govindarajan, Andrew T Dailey, Sanjay Dhall, Daniel J Hoh, Daniel E Gelb, Adam S Kanter, Eric O Klineberg, Michael J Lee, Praveen V Mummaneni, Paul Park, Charles A Sansur, Khoi D Than, Jon J W Yoon, Michael Y Wang, Wilson Z Ray,

<h4>Objective</h4>Minimally invasive surgery (MIS) techniques can effectively stabilize and decompress many thoracolumbar injuries with decreased morbidity and tissue destruction compared with open approaches. Nonetheless, there is limited direction regarding the breadth and limitations of MIS techniques for thoracolumbar injuries. Consequently, the objectives of this study were to 1) identify the ... Read more >>

J Neurosurg Spine (Journal of neurosurgery. Spine)
[2021, :1-10]

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Classifying Patients Operated for Spondylolisthesis: A K-Means Clustering Analysis of Clinical Presentation Phenotypes.

Andrew K Chan, Thomas A Wozny, Erica F Bisson, Brenton H Pennicooke, Mohamad Bydon, Steven D Glassman, Kevin T Foley, Christopher I Shaffrey, Eric A Potts, Mark E Shaffrey, Domagoj Coric, John J Knightly, Paul Park, Michael Y Wang, Kai-Ming Fu, Jonathan R Slotkin, Anthony L Asher, Michael S Virk, Panagiotis Kerezoudis, Mohammed A Alvi, Jian Guan, Regis W Haid, Praveen V Mummaneni,

<h4>Background</h4>Trials of lumbar spondylolisthesis are difficult to compare because of the heterogeneity in the populations studied.<h4>Objective</h4>To define patterns of clinical presentation.<h4>Methods</h4>This is a study of the prospective Quality Outcomes Database spondylolisthesis registry, including patients who underwent single-segment surgery for grade 1 degenerative lumbar spondylolisthesis. Twenty-four-month patient-reported outcomes (PROs) were collected. ... Read more >>

Neurosurgery (Neurosurgery)
[2021, 89(6):1033-1041]

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Same Day Surgical Intervention Dramatically Minimizes Complication Occurrence and Optimizes Perioperative Outcomes for Central Cord Syndrome.

Cole Bortz, Michael Dinizo, Nicholas Kummer, Avery Brown, Haddy Alas, Katherine E Pierce, Muhammad B Janjua, Paul Park, Charles Wang, Pawel Jankowski, Aaron Hockley, Alex Soroceanu, Rafael De la Garza Ramos, Daniel M Sciubba, Anthony Frempong-Boadu, Dennis Vasquez-Montes, Bassel G Diebo, Michael C Gerling, Peter G Passias,

<h4>Study design</h4>This was a retrospective cohort study.<h4>Objective</h4>The aim of this study was to investigate associations between time to surgical intervention and outcomes for central cord syndrome (CCS) patients.<h4>Background</h4>As surgery is increasingly recommended for patients with neurological deterioration CCS, it is important to investigate the relationship between time to surgery and ... Read more >>

Clin Spine Surg (Clinical spine surgery)
[2021, 34(8):308-311]

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Preoperative HbA1c > 8% Is Associated With Poor Outcomes in Lumbar Spine Surgery: A Michigan Spine Surgery Improvement Collaborative Study.

Seokchun Lim, Hsueh-Han Yeh, Mohamed Macki, Tarek Mansour, Lonni Schultz, Edvin Telemi, Sameah Haider, David R Nerenz, Jason M Schwalb, Muwaffak Abdulhak, Paul Park, Ilyas Aleem, Richard Easton, Jad Khalil, Miguelangelo Perez-Cruet, Victor Chang,

<h4>Background</h4>Preoperative hemoglobin A1c (HbA1c) is a useful screening tool since a significant portion of diabetic patients in the United States are undiagnosed and the prevalence of diabetes continues to increase. However, there is a paucity of literature analyzing comprehensive association between HbA1c and postoperative outcome in lumbar spine surgery.<h4>Objective</h4>To assess ... Read more >>

Neurosurgery (Neurosurgery)
[2021, 89(5):819-826]

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Patient outcomes after circumferential minimally invasive surgery compared with those of open correction for adult spinal deformity: initial analysis of prospectively collected data.

Dean Chou, Virginie Lafage, Alvin Y Chan, Peter Passias, Gregory M Mundis, Robert K Eastlack, Kai-Ming Fu, Richard G Fessler, Munish C Gupta, Khoi D Than, Neel Anand, Juan S Uribe, Adam S Kanter, David O Okonkwo, Shay Bess, Christopher I Shaffrey, Han Jo Kim, Justin S Smith, Daniel M Sciubba, Paul Park, Praveen V Mummaneni, ,

<h4>Objective</h4>Circumferential minimally invasive spine surgery (cMIS) for adult scoliosis has become more advanced and powerful, but direct comparison with traditional open correction using prospectively collected data is limited. The authors performed a retrospective review of prospectively collected, multicenter adult spinal deformity data. The authors directly compared cMIS for adult scoliosis ... Read more >>

J Neurosurg Spine (Journal of neurosurgery. Spine)
[2021, :1-12]

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Does reduction of the Meyerding grade correlate with outcomes in patients undergoing decompression and fusion for grade I degenerative lumbar spondylolisthesis?

Andrew K Chan, Praveen V Mummaneni, John F Burke, Rory R Mayer, Erica F Bisson, Joshua Rivera, Brenton Pennicooke, Kai-Ming Fu, Paul Park, Mohamad Bydon, Steven D Glassman, Kevin T Foley, Christopher I Shaffrey, Eric A Potts, Mark E Shaffrey, Domagoj Coric, John J Knightly, Michael Y Wang, Jonathan R Slotkin, Anthony L Asher, Michael S Virk, Panagiotis Kerezoudis, Mohammed A Alvi, Jian Guan, Regis W Haid, Dean Chou,

<h4>Objective</h4>Reduction of Meyerding grade is often performed during fusion for spondylolisthesis. Although radiographic appearance may improve, correlation with patient-reported outcomes (PROs) is rarely reported. In this study, the authors' aim was to assess the impact of spondylolisthesis reduction on 24-month PRO measures after decompression and fusion surgery for Meyerding grade ... Read more >>

J Neurosurg Spine (Journal of neurosurgery. Spine)
[2021, :1-8]

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The role of postoperative antibiotic duration on surgical site infection after lumbar surgery.

Mohamed Macki, Travis Hamilton, Seokchun Lim, Tarek R Mansour, Edvin Telemi, Michael Bazydlo, Lonni Schultz, David R Nerenz, Paul Park, Victor Chang, Jason Schwalb, Muwaffak M Abdulhak,

<h4>Objective</h4>Despite a general consensus regarding the administration of preoperative antibiotics, poorly defined comparison groups and underpowered studies prevent clear guidelines for postoperative antibiotics. Utilizing a data set tailored specifically to spine surgery outcomes, in this clinical study the authors aimed to determine whether there is a role for postoperative antibiotics ... Read more >>

J Neurosurg Spine (Journal of neurosurgery. Spine)
[2021, :1-7]

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Femoral head to lower lumbar neural foramen distance as a novel radiographic parameter to predict postoperative stretch neuropraxia.

Alex S Ha, Meghan Cerpa, Justin Mathew, Paul Park, Joseph M Lombardi, Andrew J Luzzi, Nathan J Lee, Marc D Dyrszka, Zeeshan M Sardar, Ronald A Lehman, Lawrence G Lenke,

<h4>Objective</h4>Lumbosacral fractional curves in adult spinal deformity (ASD) patients often have sharp coronal curves resulting in significant pain and imbalance. Postoperative stretch neuropraxia after fractional curve correction can lead to discomfort and unsatisfactory outcomes. The goal of this study was to use radiographic measures to increase understanding of the relationship ... Read more >>

J Neurosurg Spine (Journal of neurosurgery. Spine)
[2021, :1-9]

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SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.

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<h4>Background</h4>Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling.<h4>Methods</h4>The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an ... Read more >>

Br J Surg (The British journal of surgery)
[2021, 108(9):1056-1063]

Cited: 18 times

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A narrative review of infection prevention techniques in adult and pediatric spinal deformity surgery.

Andrew N Sawires, Paul J Park, Lawrence G Lenke,

Spinal infections associated with pediatric and adult spinal deformity surgery are associated with postoperative morbidity and mortality along with elevated health-care costs. Prevention requires meticulous technique by the spine surgeon throughout the perioperative period. There is significant variability in the current practices of spinal deformity surgeons with regard to infection ... Read more >>

J Spine Surg (Journal of spine surgery (Hong Kong))
[2021, 7(3):413-421]

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Lateral mass screw placement in the atlas: description of a novel surgical technique, radiographic parameters, and review of the literature.

Bilal B Butt, Paul Gagnet, Joshua Piche, Rakesh Patel, Paul Park, Ilyas S Aleem,

<h4>Background</h4>Numerous techniques of C1 lateral mass screw placement have been described. We sought to delineate the radiographic angle of safety medially and laterally and describe a novel surgical technique of C1 lateral mass screw placement. We sought to (I) determine the angle of safety medially and laterally of the C1 ... Read more >>

J Spine Surg (Journal of spine surgery (Hong Kong))
[2021, 7(3):335-343]

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SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study.

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SARS-CoV-2 has been associated with an increased rate of venous thromboembolism in critically ill patients. Since surgical patients are already at higher risk of venous thromboembolism than general populations, this study aimed to determine if patients with peri-operative or prior SARS-CoV-2 were at further increased risk of venous thromboembolism. We ... Read more >>

Anaesthesia (Anaesthesia)
[2021, :]

Cited: 1 time

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Protection of Retinal Function by Nucleoside Reverse Transcriptase Inhibitors Following Retinal Ischemia/Reperfusion Injury.

William S Gange, James B Qiao, Paul J Park, James F McDonnell, Zhiqun Tan, Jay I Perlman, Ping Bu,

<b><i>Purpose:</i></b> Retinal ischemia/reperfusion (I/R) injury is a common cause of visual impairment and blindness for which there remain limited treatment options. Nucleoside reverse transcriptase inhibitors (NRTIs), such as zidovudine (AZT), have been shown to block the NLRP3 inflammasome and prevent retinal degeneration in a mouse model of age-related macular degeneration. ... Read more >>

J Ocul Pharmacol Ther (Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics)
[2021, 37(8):485-491]

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Age as a Risk Factor for Complications Following Anterior Cervical Discectomy and Fusion: Analysis From the Michigan Spine Surgery Improvement Collaborative (MSSIC).

Michael H Lawless, Doris Tong, Chad F Claus, Connor Hanson, Chenxi Li, Clifford M Houseman, Peter Bono, Boyd F Richards, Prashant S Kelkar, Muwaffak M Abdulhak, Victor Chang, Daniel A Carr, Paul Park, Teck M Soo,

<h4>Study design</h4>Retrospective analysis of prospectively collected registry data using multivariable analyses of imputed data.<h4>Objective</h4>We sought to demonstrate that age would not be associated with complications in patients undergoing anterior cervical discectomy and fusion (ACDF).<h4>Summary of background data</h4>Elderly patients (≥70 yrs) undergoing ACDF are considered a higher risk for complications. However, conclusive ... Read more >>

Spine (Phila Pa 1976) (Spine)
[2021, :]

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Effects of pre-operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study.

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We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave ... Read more >>

Anaesthesia (Anaesthesia)
[2021, 76(11):1454-1464]

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Low Back Pain

Anthony E. Chiodo, Suvarna N. Bhat, R. Van Harrison, Gregory D. Shumer, Ronald A. Wasserman, Paul Park, Rakesh D. Patel, April L. Proudlock, Karl T. Rew,

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A Matched Cohort Analysis of Drain Usage in Elective Anterior Cervical Discectomy and Fusion: A Michigan Spine Surgery Improvement Collaborative (MSSIC) Study.

Seokchun Lim, Michael Bazydlo, Mohamed Macki, Sameah Haider, Lonni Schultz, David Nerenz, Hassan Fadel, Jacob Pawloski, Hsueh-Han Yeh, Paul Park, Ilyas Aleem, Jad Khalil, Richard Easton, Jason Schwalb, Muwaffak Abdulhak, Victor Chang,

<h4>Study design</h4>This is a retrospective, cohort analysis of multi-institutional database.<h4>Objective</h4>This study was designed to analyze the impact of drain use following elective anterior cervical discectomy and fusion (ACDF) surgeries.<h4>Summary of background data</h4>After ACDF, a drain is often placed to prevent postoperative hematoma. However, there has been no high quality evidence ... Read more >>

Spine (Phila Pa 1976) (Spine)
[2021, :]

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Open reduction and internal fixation of metacarpal fractures using a thermoplastic splint as a surgical instrument.

Theodora Papavasiliou, Paul Dain Park, Ricardo Tejero, Niklaas Allain, Lauren Uppal,

Adequate positioning of the hand is a critical step in hand fracture operative repair that can impact both the clinical outcome and the efficiency of the operation. In this paper, we introduce the use of a thermoplastic splint with an added thumb stabilizing component as a means to increase the ... Read more >>

Arch Plast Surg (Archives of plastic surgery)
[2021, 48(4):384-388]

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Comparative photophysical properties of some widely used fluorescent proteins under two-photon excitation conditions.

Dhruba P Adhikari, Gabriel Biener, Michael R Stoneman, Dammar N Badu, Joel D Paprocki, Annie Eis, Paul S-H Park, Ionel Popa, Valerică Raicu,

Understanding the photophysical properties of fluorescent proteins (FPs), such as emission and absorption spectra, molecular brightness, photostability, and photo-switching, is critical to the development of criteria for their selection as tags for fluorescent-based biological applications. While two-photon excitation imaging techniques have steadily gained popularity - due to comparatively deeper penetration ... Read more >>

Spectrochim Acta A Mol Biomol Spectrosc (Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy)
[2021, 262:120133]

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Is There a Difference in Screw Accuracy, Robot Time Per Screw, Robot Abandonment, and Radiation Exposure Between the Mazor X and the Renaissance? A Propensity-Matched Analysis of 1179 Robot-Assisted Screws.

Nathan J Lee, Scott L Zuckerman, Ian A Buchanan, Venkat Boddapati, Justin Mathew, Gerard Marciano, Djani Robertson, Nikita Lakomkin, Paul J Park, Eric Leung, Joseph M Lombardi, Ronald A Lehman,

<h4>Study design</h4>Prospective single-cohort analysis.<h4>Objectives</h4>To compare the outcomes/complications of 2 robotic systems for spine surgery.<h4>Methods</h4>Adult patients (≥18-years-old) who underwent robot-assisted spine surgery from 2016-2019 were assessed. A propensity score matching (PSM) algorithm was used to match Mazor X to Renaissance cases. Preoperative CT scan for planning and an intraoperative O-arm for ... Read more >>

Global Spine J (Global spine journal)
[2021, :21925682211029867]

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