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Author Paul LaBarre

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Automated Respiratory Rate Counter to Assess Children for Symptoms of Pneumonia: Protocol for Cross-Sectional Usability and Acceptability Studies in Ethiopia and Nepal.

Kevin Baker, Alice Maurel, Charlotte Ward, Dawit Getachew, Tedila Habte, Cindy McWhorter, Paul LaBarre, Jonas Karlström, Max Petzold, Karin Källander,

BACKGROUND:Manually counting a child's respiratory rate (RR) for 60 seconds using an acute respiratory infection timer is the World Health Organization (WHO) recommended method for detecting fast breathing as a sign of pneumonia. However, counting the RR is challenging and misclassification of an observed rate is common, often leading to ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2020, 9(3):e14405]

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Determining the Agreement Between an Automated Respiratory Rate Counter and a Reference Standard for Detecting Symptoms of Pneumonia in Children: Protocol for a Cross-Sectional Study in Ethiopia.

Charlotte Ward, Kevin Baker, Sarah Marks, Dawit Getachew, Tedila Habte, Cindy McWhorter, Paul Labarre, Jonathan Howard-Brand, Nathan P Miller, Hayalnesh Tarekegn, Solomie Jebessa Deribessa, Max Petzold, Karin Kallander,

BACKGROUND:Acute respiratory infections (ARIs), primarily pneumonia, are the leading infectious cause of under-5 mortality worldwide. Manually counting respiratory rate (RR) for 60 seconds using an ARI timer is commonly practiced by community health workers to detect fast breathing, an important sign of pneumonia. However, correctly counting breaths manually and classifying ... Read more >>

JMIR Res Protoc (JMIR research protocols)
[2020, 9(4):e16531]

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Usability and acceptability of an automated respiratory rate counter to assess childhood pneumonia in Nepal.

Karin Källander, Charlotte Ward, Helen Smith, Radheshyam Bhattarai, Ashish Kc, Deepak Timsina, Bikash Lamichhane, Alice Maurel, Parashu Ram Shrestha, Sushil Baral, Cindy McWhorter, Paul LaBarre, Monica Anna de Cola, Kevin Baker,

AIM:Pneumonia is the leading cause of child death after the neonatal period, resulting from late care seeking and inappropriate treatment. Diagnosis involves counting respiratory rate (RR); however, RR counting remains challenging for health workers and miscounting, and misclassification of RR is common. We evaluated the usability of a new automated ... Read more >>

Acta Paediatr. (Acta paediatrica (Oslo, Norway : 1992))
[2020, 109(6):1207-1220]

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Usability and acceptability of an automated respiratory rate counter to assess children for symptoms of pneumonia: A cross-sectional study in Ethiopia.

Charlotte Ward, Kevin Baker, Helen Smith, Alice Maurel, Dawit Getachew, Tedila Habte, Cindy McWhorter, Paul LaBarre, Jonas Karlstrom, Jim Black, Quique Bassat, Agazi Ameha, Abraham Tariku, Max Petzold, Karin Källander,

AIM:Manually counting respiratory rate (RR) is commonly practiced by community health workers to detect fast breathing, an important sign of childhood pneumonia. Correctly counting and classifying breaths manually is challenging, often leading to inappropriate treatment. This study aimed to determine the usability of a new automated RR counter (ChARM) by health ... Read more >>

Acta Paediatr. (Acta paediatrica (Oslo, Norway : 1992))
[2020, 109(6):1196-1206]

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Performance of a High-Sensitivity Rapid Diagnostic Test for Plasmodium falciparum Malaria in Asymptomatic Individuals from Uganda and Myanmar and Naive Human Challenge Infections.

Smita Das, Ihn Kyung Jang, Becky Barney, Roger Peck, John C Rek, Emmanuel Arinaitwe, Harriet Adrama, Maxwell Murphy, Mallika Imwong, Clare L Ling, Stephane Proux, Warat Haohankhunnatham, Melissa Rist, Annette M Seilie, Amelia Hanron, Glenda Daza, Ming Chang, Tomoka Nakamura, Michael Kalnoky, Paul Labarre, Sean C Murphy, James S McCarthy, Francois Nosten, Bryan Greenhouse, Sophie Allauzen, Gonzalo J Domingo,

Sensitive field-deployable diagnostic tests can assist malaria programs in achieving elimination. The performance of a new Alere™ Malaria Ag P.f Ultra Sensitive rapid diagnostic test (uRDT) was compared with the currently available SD Bioline Malaria Ag P.f RDT in blood specimens from asymptomatic individuals in Nagongera, Uganda, and in a ... Read more >>

Am. J. Trop. Med. Hyg. (The American journal of tropical medicine and hygiene)
[2017, 97(5):1540-1550]

Cited: 29 times

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A Field-Tailored Reverse Transcription Loop-Mediated Isothermal Assay for High Sensitivity Detection of Plasmodium falciparum Infections.

Sylvie Kemleu, Dylan Guelig, Carole Eboumbou Moukoko, Estelle Essangui, Steven Diesburg, Abas Mouliom, Bernard Melingui, Jeanne Manga, Christiane Donkeu, Annie Epote, Gaëtan Texier, Paul LaBarre, Robert Burton, Lawrence Ayong,

Highly sensitive and field deployable molecular diagnostic tools are critically needed for detecting submicroscopic, yet transmissible levels of malaria parasites prevalent in malaria endemic countries worldwide. A reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay was developed and evaluated in comparison with thick blood smear microscopy, an antigen-based rapid diagnostic test ... Read more >>

PLoS ONE (PloS one)
[2016, 11(11):e0165506]

Cited: 7 times

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Single-use, electricity-free amplification device for detection of HIV-1.

Kelly A Curtis, Donna L Rudolph, Daphne Morrison, Dylan Guelig, Steven Diesburg, David McAdams, Robert A Burton, Paul LaBarre, Michele Owen,

Early and accurate diagnosis of HIV is key for the reduction of transmission and initiation of patient care. The availability of a rapid nucleic acid test (NAT) for use at the point-of-care (POC) will fill a gap in HIV diagnostics, improving the diagnosis of acute infection and HIV in infants ... Read more >>

J. Virol. Methods (Journal of virological methods)
[2016, 237:132-137]

Cited: 4 times

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NINA-LAMP compared to microscopy, RDT, and nested PCR for the detection of imported malaria.

Abu Naser Mohon, Lydia Da-Yeong Lee, Abebe Genetu Bayih, Asongna Folefoc, Dylan Guelig, Robert A Burton, Paul LaBarre, Wilson Chan, Bonnie Meatherall, Dylan R Pillai,

Microscopy and field adaptable rapid diagnostic tests (RDTs) are not sensitive and specific in certain conditions such as poor training of microscopists, lack of electricity, or lower sensitivity in the detection of non-falciparum malaria. More sensitive point-of-care testing (POCT) would reduce delays in diagnosis and initiation of therapy. In the ... Read more >>

Diagn. Microbiol. Infect. Dis. (Diagnostic microbiology and infectious disease)
[2016, 85(2):149-153]

Cited: 10 times

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Molecular diagnostics in a teacup: Non-Instrumented Nucleic Acid Amplification (NINA) for rapid, low cost detection of Salmonella enterica.

Ryo Kubota, Paul Labarre, Bernhard H Weigl, Yong Li, Paul Haydock, Daniel M Jenkins,

We report on the use of a novel non-instrumented platform to enable a Loop Mediated isothermal Amplification (LAMP) based assay for Salmonella enterica. Heat energy is provided by addition of a small amount (<150 g) of boiling water, and the reaction temperature is regulated by storing latent energy at the ... Read more >>

Chin. Sci. Bull. (Chinese science bulletin = Kexue tongbao)
[2013, 58(10):1162-1168]

Cited: 9 times

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Evaluation of non-instrumented nucleic acid amplification by loop-mediated isothermal amplification (NINA-LAMP) for the diagnosis of malaria in Northwest Ethiopia.

Meslo Sema, Abebe Alemu, Abebe Genetu Bayih, Sisay Getie, Gebeyaw Getnet, Dylan Guelig, Robert Burton, Paul LaBarre, Dylan R Pillai,

Malaria is a major public health problem in sub-Saharan African countries including Ethiopia. Early and accurate diagnosis followed by prompt and effective treatment is among the various tools available for prevention, control and elimination of malaria. This study aimed to evaluate the performance of non-instrumented nucleic acid amplification loop-mediated isothermal ... Read more >>

Malar. J. (Malaria journal)
[2015, 14:44]

Cited: 27 times

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Assessment of the availability of technology for trauma care in Nepal.

Mihir Tejanshu Shah, Suraj Bhattarai, Norman Lamichhane, Arpita Joshi, Paul LaBarre, Manjul Joshipura, Charles Mock,

We sought to assess the availability of technology-related equipment for trauma care in Nepal and to identify factors leading to optimal availability as well as deficiencies. We also sought to identify potential solutions addressing the deficits in terms of health systems management and product development.Thirty-two items for large hospitals and ... Read more >>

Injury (Injury)
[2015, 46(9):1712-1719]

Cited: 5 times

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Assessment of the availability of technology for trauma care in India.

Mihir Tejanshu Shah, Manjul Joshipura, Jered Singleton, Paul LaBarre, Hem Desai, Eliza Sharma, Charles Mock,

We sought to assess the status of availability of technology for trauma care in a state in India and to identify factors contributing to both adequate levels of availability and to deficiencies. We also sought to identify potential solutions to deficiencies in terms of health system management and product development.Thirty-two ... Read more >>

World J Surg (World journal of surgery)
[2015, 39(2):363-372]

Cited: 9 times

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Challenges in optimizing the histidine rich protein 2-detecting rapid diagnostic test.

Robert Burton, Kathy Tietje, Kelly Ebels, Paul LaBarre,

Malar. J. (Malaria journal)
[2014, 13(Suppl 1):P20-P20]

Cited: 0 times

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Non-instrumented incubation of a recombinase polymerase amplification assay for the rapid and sensitive detection of proviral HIV-1 DNA.

Lorraine Lillis, Dara Lehman, Mitra C Singhal, Jason Cantera, Jered Singleton, Paul Labarre, Anthony Toyama, Olaf Piepenburg, Mathew Parker, Robert Wood, Julie Overbaugh, David S Boyle,

Sensitive diagnostic tests for infectious diseases often employ nucleic acid amplification technologies (NAATs). However, most NAAT assays, including many isothermal amplification methods, require power-dependent instrumentation for incubation. For use in low resource settings (LRS), diagnostics that do not require consistent electricity supply would be ideal. Recombinase polymerase amplification (RPA) is ... Read more >>

PLoS ONE (PloS one)
[2014, 9(9):e108189]

Cited: 35 times

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The essential role of infection-detection technologies for malaria elimination and eradication.

Kathleen Tietje, Kenneth Hawkins, Christine Clerk, Kelly Ebels, Sarah McGray, Chris Crudder, Lucy Okell, Paul LaBarre,

Recent emphasis on malaria elimination and eradication (E&E) goals is changing the way that experts evaluate malaria diagnostic tools and tactics. As prevalence declines, the focus of malaria management is pivoting toward low-density, subclinical infections and geographically and demographically concentrated reservoirs. These and other changes present challenges and opportunities for ... Read more >>

Trends Parasitol. (Trends in parasitology)
[2014, 30(5):259-266]

Cited: 26 times

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Prioritizing investments in innovations to protect women from the leading causes of maternal death.

Tara M Herrick, Claudia M Harner-Jay, Alice M Levisay, Patricia S Coffey, Michael J Free, Paul D LaBarre,

PATH, an international nonprofit organization, assessed nearly 40 technologies for their potential to reduce maternal mortality from postpartum hemorrhage and preeclampsia and eclampsia in low-resource settings. The evaluation used a new Excel-based prioritization tool covering 22 criteria developed by PATH, the Maternal and Neonatal Directed Assessment of Technology (MANDATE) model, ... Read more >>

BMC Pregnancy Childbirth (BMC pregnancy and childbirth)
[2014, 14:10]

Cited: 4 times

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Instrument-free exothermic heating with phase change temperature control for paper microfluidic devices.

Jered Singleton, Chris Zentner, Josh Buser, Paul Yager, Paul LaBarre, Bernhard H Weigl,

Many infectious diseases, as well as some cancers, that affect global health are most accurately diagnosed through nucleic acid amplification and detection. There is a great need to simplify nucleic acid-based assay systems for use in global health in low-resource settings as well as in settings that do not have ... Read more >>

Proc SPIE Int Soc Opt Eng (Proceedings of SPIE--the International Society for Optical Engineering)
[2013, 8615:86150R]

Cited: 5 times

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Non-Instrumented Nucleic Acid Amplification (NINA) for Rapid Detection of Ralstonia solanacearum Race 3 Biovar 2.

Ryo Kubota, Paul LaBarre, Jered Singleton, Andy Beddoe, Bernhard H Weigl, Anne M Alvarez, Daniel M Jenkins,

We report on the use of a non-instrumented device for the implementation of a loop-mediated amplification (LAMP) based assay for the select-agent bacterial-wilt pathogen Ralstonia solanacearum race 3 biovar 2. Heat energy is generated within the device by the exothermic hydration of calcium oxide, and the reaction temperature is regulated ... Read more >>

Biol Eng Trans (Biological engineering transactions)
[2011, 4(2):69-80]

Cited: 6 times

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Engineering global health.

Paul LaBarre,

IEEE Pulse (IEEE pulse)
[2011, 2(1):18-25]

Cited: 1 time

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Non-instrumented nucleic acid amplification (NINA): instrument-free molecular malaria diagnostics for low-resource settings.

Paul Labarre, Jay Gerlach, Jared Wilmoth, Andrew Beddoe, Jered Singleton, Bernhard Weigl,

We have achieved the first complete, non-instrumented nucleic acid amplification test (NAAT) using a calcium oxide heat source thermally linked to an engineered phase change material. These two components alone maintain a thermal profile suitable for the loop-mediated isothermal amplification assay. Starting with computational fluid dynamics analysis, we identified nominal ... Read more >>

Conf Proc IEEE Eng Med Biol Soc (Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference)
[2010, 2010:1097-1099]

Cited: 14 times

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Development of a microbicide-releasing diaphragm as an HIV prevention strategy.

Ian Major, Deborah Lowry, Karl Malcolm, David Woolfson, Jessica Cohen, Paul Labarre, Maggie Kilbourne-Brook, Gene Saxon, David Friend,

Contraceptive diaphragms offer a discreet method of pregnancy protection that women can use when needed with no side effects. Incorporating antiretroviral HIV microbicides into such devices may also provide protection against HIV infection. The paper gives a brief outline of the work being conducted by PATH, CONRAD and QUB on ... Read more >>

Conf Proc IEEE Eng Med Biol Soc (Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference)
[2010, 2010:1089-1092]

Cited: 2 times

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Diaphragm having a polymeric spring member with non-uniform bending characteristics

PAUL LABARRE, GLENN AUSTIN,

A contraceptive or non-contraceptive diaphragm has a rim surrounding a thin membrane, the membrane having a cervical dome extending downwardly from a posterior portion of the membrane. The rim has a spring member having non-uniform bending characteristics. The shape of the spring member can be contoured to provide a rim ... Read more >>

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