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Changes in Emergency Department Activity and the First COVID-19 Lockdown: A Cross-sectional Study.

Kate Honeyford, Charles Coughlan, Ruud G Nijman, Paul Expert, Gabriel Burcea, Ian Maconochie, Anne Kinderlerer, Graham S Cooke, Ceire E Costelloe,

<h4>Introduction</h4>Emergency department (ED) attendances fell across the UK after the 'lockdown' introduced on 23rd March 2020 to limit the spread of coronavirus disease 2019 (COVID-19). We hypothesised that reductions would vary by patient age and disease type. We examined pre- and in-lockdown ED attendances for two COVID-19 unrelated diagnoses: one ... Read more >>

West J Emerg Med (The western journal of emergency medicine)
[2021, 22(3):603-607]

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Electronic health record enabled track and trace in an urban hospital network: implications for infection prevention and control

Li Pi, Paul Expert, Jonathan Clarke, Elita Jauneikaite, Céire Costelloe,

<h4>ABSTRACT</h4> Healthcare-associated infections represent one of the most significant challenges for modern medicine as they can significantly impact patients’lives. Carbapenemase-producing Enterobacteriaceae (CPE) pose the greatest clinical threat, given the high levels of resistance to carbapenems, which are considered as agents of ‘last resort’ against life-threatening infections. Understanding patterns of CPE ... Read more >>

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A Complex Systems Perspective on Neuroimaging Studies of Behavior and Its Disorders.

Federico E Turkheimer, Fernando E Rosas, Ottavia Dipasquale, Daniel Martins, Erik D Fagerholm, Paul Expert, František Váša, Louis-David Lord, Robert Leech,

The study of complex systems deals with emergent behavior that arises as a result of nonlinear spatiotemporal interactions between a large number of components both within the system, as well as between the system and its environment. There is a strong case to be made that neural systems as well ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2021, :1073858421994784]

Cited: 1 time

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Modelling the Spread of Covid-19 on Malaysian Contact Networks for Practical Reopening Strategies in an Institutional Setting

Fatimah Abdul Razak, Paul Expert,

Reopening strategies are crucial to balance efforts of economic revitalization and bringing back a sense of normalcy while mitigating outbreaks and effectively flattening the infection curve. This paper proposes practical reopening, monitoring and testing strategies for institutions to reintroduce physical meetings based on SIR simulations run on a student friendship ... Read more >>

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Association between intrahospital transfer and hospital-acquired infection in the elderly: a retrospective case-control study in a UK hospital network.

Emanuela Estera Boncea, Paul Expert, Kate Honeyford, Anne Kinderlerer, Colin Mitchell, Graham S Cooke, Luca Mercuri, Céire E Costelloe,

<h4>Background</h4>Intrahospital transfers have become more common as hospital staff balance patient needs with bed availability. However, this may leave patients more vulnerable to potential pathogen transmission routes via increased exposure to contaminated surfaces and contacts with individuals.<h4>Objective</h4>This study aimed to quantify the association between the number of intrahospital transfers undergone ... Read more >>

BMJ Qual Saf (BMJ quality & safety)
[2021, 30(6):457-466]

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Quantifying the Alignment of Graph and Features in Deep Learning.

Yifan Qian, Paul Expert, Tom Rieu, Pietro Panzarasa, Mauricio Barahona,

We show that the classification performance of graph convolutional networks (GCNs) is related to the alignment between features, graph, and ground truth, which we quantify using a subspace alignment measure (SAM) corresponding to the Frobenius norm of the matrix of pairwise chordal distances between three subspaces associated with features, graph, ... Read more >>

IEEE Trans Neural Netw Learn Syst (IEEE transactions on neural networks and learning systems)
[2021, PP:]

Cited: 1 time

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Association between intrahospital transfers and hospital-acquired infection among elderly patients: A retrospective case-control study in one urban UK hospital trust

Estera Boncea, Paul Expert, Kate Honeyford, Anne Kinderlerer, Colin Mitchell, Graham Cooke, Luca Mercuri, Céire Costelloe,

<h4>Background</h4> Intrahospital transfers have become more common as hospital staff balance patient needs with bed availability. However, this may leave patients more vulnerable to potential pathogen transmission routes via increased exposure to contaminated surfaces and contacts with individuals. <h4>Objective</h4> This study aimed to quantify the association between the number of ... Read more >>

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Changes in Emergency Department attendances before and after COVID-19 lockdown implementation: a cross sectional study of one urban NHS Hospital Trust

Kate Honeyford, Charles Coughlan, Paul Expert, Gabriel Burcea, Ian Maconochie, Anne Kinderlerer, Graham Cooke, Ceire Costelloe,

<h4>Background: </h4> Emergency Department (ED) attendances have fallen across the UK since the "lockdown" introduced on 23rd March 2020 to limit the spread of coronavirus disease 2019 (COVID-19). We hypothesised that reductions would vary by patient age and disease type. We examined pre- and in-lockdown ED attendances for two COVID-19 ... Read more >>

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A Complex Systems Perspective on Neuroimaging Studies of Behaviour and Its Disorders

Paul Expert, Federico Turkheimer,

The study of complex systems deals with emergent behaviour that arises as a result of nonlinear spatio-temporal interactions between a large number of components both within the system, as well as between the system and its environment. There is a strong case to be made that neural systems as well ... Read more >>

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Using text mining to track outbreak trends in global surveillance of emerging diseases: ProMED-mail

Jingxian You, Paul Expert, Céire Costelloe,

<h4>ABSTRACT</h4> <h4>Objectives</h4> ProMED-mail (Program for Monitoring Emerging Disease, also abbreviated ProMED) is an international disease outbreak monitoring and early warning system. Every year, users contribute thousands of reports that include reference to infectious diseases and toxins, and these reports are then distributed to all subscribers of ProMED. However, the corpus ... Read more >>

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Topological gene expression networks recapitulate brain anatomy and function.

Alice Patania, Pierluigi Selvaggi, Mattia Veronese, Ottavia Dipasquale, Paul Expert, Giovanni Petri,

Understanding how gene expression translates to and affects human behavior is one of the ultimate goals of neuroscience. In this paper, we present a pipeline based on Mapper, a topological simplification tool, to analyze gene co-expression data. We first validate the method by reproducing key results from the literature on ... Read more >>

Netw Neurosci (Network neuroscience (Cambridge, Mass.))
[2019, 3(3):744-762]

Cited: 2 times

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Plastic Adaptation to Pathology in Psychiatry: Are Patients with Psychiatric Disorders Pathological Experts?

Ali Amad, Paul Expert, Louis-David Lord, Thomas Fovet, Pierre A Geoffroy,

Psychiatric disorders share the same pattern of longitudinal evolution and have courses that tend to be chronic and recurrent. These aspects of chronicity and longitudinal evolution are currently studied under the deficit-oriented neuroprogression framework. Interestingly, considering the plasticity of the brain, it is also necessary to emphasize the bidirectional nature ... Read more >>

Neuroscientist (The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry)
[2020, 26(3):208-223]

Cited: 0 times

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Editorial: Topological Neuroscience.

Paul Expert, Louis-David Lord, Morten L Kringelbach, Giovanni Petri,

Topology, in its many forms, describes relations. It has thus long been a central concept in neuroscience, capturing structural and functional aspects of the organization of the nervous system and their links to cognition. Recent advances in computational topology have extended the breadth and depth of topological descriptions. This Focus ... Read more >>

Netw Neurosci (Network neuroscience (Cambridge, Mass.))
[2019, 3(3):653-655]

Cited: 2 times

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Dynamical exploration of the repertoire of brain networks at rest is modulated by psilocybin.

Louis-David Lord, Paul Expert, Selen Atasoy, Leor Roseman, Kristina Rapuano, Renaud Lambiotte, David J Nutt, Gustavo Deco, Robin L Carhart-Harris, Morten L Kringelbach, Joana Cabral,

Growing evidence from the dynamical analysis of functional neuroimaging data suggests that brain function can be understood as the exploration of a repertoire of metastable connectivity patterns ('functional brain networks'), which potentially underlie different mental processes. The present study characterizes how the brain's dynamical exploration of resting-state networks is rapidly ... Read more >>

Neuroimage (NeuroImage)
[2019, 199:127-142]

Cited: 21 times

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Covariance statistics and network analysis of brain PET imaging studies.

Mattia Veronese, Lucia Moro, Marco Arcolin, Ottavia Dipasquale, Gaia Rizzo, Paul Expert, Wasim Khan, Patrick M Fisher, Claus Svarer, Alessandra Bertoldo, Oliver Howes, Federico E Turkheimer,

The analysis of structural and functional neuroimaging data using graph theory has increasingly become a popular approach for visualising and understanding anatomical and functional relationships between different cerebral areas. In this work we applied a network-based approach for brain PET studies using population-based covariance matrices, with the aim to explore ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):2496]

Cited: 8 times

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Altered ability to access a clinically relevant control network in patients remitted from major depressive disorder.

Caroline A Figueroa, Joana Cabral, Roel J T Mocking, Kristina M Rapuano, Tim J van Hartevelt, Gustavo Deco, Paul Expert, Aart H Schene, Morten L Kringelbach, Henricus G Ruhé,

Neurobiological models to explain vulnerability of major depressive disorder (MDD) are scarce and previous functional magnetic resonance imaging studies mostly examined "static" functional connectivity (FC). Knowing that FC constantly evolves over time, it becomes important to assess how FC dynamically differs in remitted-MDD patients vulnerable for new depressive episodes. Using ... Read more >>

Hum Brain Mapp (Human brain mapping)
[2019, 40(9):2771-2786]

Cited: 9 times

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Topological gene-expression networks recapitulate brain anatomy and function

Alice Patania, Pierluigi Selvaggi, Mattia Veronese, Ottavia Dipasquale, Paul Expert, Giovanni Petri,

Understanding how gene expression translates to and affects human behaviour is one of the ultimate aims of neuroscience. In this paper, we present a pipeline based on Mapper, a topological simplification tool, to produce and analyze genes co-expression data. We first validate the method by reproducing key results from the ... Read more >>

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Mesolimbic Dopamine Function Is Related to Salience Network Connectivity: An Integrative Positron Emission Tomography and Magnetic Resonance Study.

Robert A McCutcheon, Matthew M Nour, Tarik Dahoun, Sameer Jauhar, Fiona Pepper, Paul Expert, Mattia Veronese, Rick A Adams, Federico Turkheimer, Mitul A Mehta, Oliver D Howes,

<h4>Background</h4>A wide range of neuropsychiatric disorders, from schizophrenia to drug addiction, involve abnormalities in both the mesolimbic dopamine system and the cortical salience network. Both systems play a key role in the detection of behaviorally relevant environmental stimuli. Although anatomical overlap exists, the functional relationship between these systems remains unknown. ... Read more >>

Biol Psychiatry (Biological psychiatry)
[2019, 85(5):368-378]

Cited: 21 times

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The Plastic Adaptation to Pathology in Psychiatry. Are Patients with Psychiatric Disorders Pathological Experts?

Ali Amad, Paul Expert, Louis-David Lord, Thomas Fovet, Pierre Geoffroy,

Psychiatric disorders share the same pattern of longitudinal evolution and have courses that tend to be chronic and recurrent. These aspects of chronicity and longitudinal evolution of psychiatric disorders are currently studied under the neuroprogression framework. Interestingly, considering the plasticity of the brain, it is necessary to emphasize the bidirectional ... Read more >>

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A minimally invasive neurostimulation method for controlling abnormal synchronisation in the neuronal activity.

Malbor Asllani, Paul Expert, Timoteo Carletti,

Many collective phenomena in Nature emerge from the -partial- synchronisation of the units comprising a system. In the case of the brain, this self-organised process allows groups of neurons to fire in highly intricate partially synchronised patterns and eventually lead to high level cognitive outputs and control over the human ... Read more >>

PLoS Comput Biol (PLoS computational biology)
[2018, 14(7):e1006296]

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Altered trajectories in the dynamical repertoire of functional network states under psilocybin

Louis-David Lord, Paul Expert, Selen Atasoy, Leor Roseman, Kristina Rapuano, Renaud Lambiotte, David Nutt, Gustavo Deco, Robin Carhart-Harris, Morten Kringelbach, Joana Cabral,

Brain activity can be understood as the exploration of a dynamical landscape of activity configurations over both space and time. This dynamical landscape may be defined in terms of spontaneous transitions within a repertoire of discrete metastable states of functional connectivity (FC), which underlie different mental processes. However, it remains ... Read more >>

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Graph spectral characterization of the XY model on complex networks.

Paul Expert, Sarah de Nigris, Taro Takaguchi, Renaud Lambiotte,

There is recent evidence that the XY spin model on complex networks can display three different macroscopic states in response to the topology of the network underpinning the interactions of the spins. In this work we present a way to characterize the macroscopic states of the XY spin model based ... Read more >>

Phys Rev E (Physical review. E)
[2017, 96(1-1):012312]

Cited: 1 time

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Insights into Brain Architectures from the Homological Scaffolds of Functional Connectivity Networks.

Louis-David Lord, Paul Expert, Henrique M Fernandes, Giovanni Petri, Tim J Van Hartevelt, Francesco Vaccarino, Gustavo Deco, Federico Turkheimer, Morten L Kringelbach,

In recent years, the application of network analysis to neuroimaging data has provided useful insights about the brain's functional and structural organization in both health and disease. This has proven a significant paradigm shift from the study of individual brain regions in isolation. Graph-based models of the brain consist of ... Read more >>

Front Syst Neurosci (Frontiers in systems neuroscience)
[2016, 10:85]

Cited: 12 times

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MENGA: A New Comprehensive Tool for the Integration of Neuroimaging Data and the Allen Human Brain Transcriptome Atlas.

Gaia Rizzo, Mattia Veronese, Paul Expert, Federico E Turkheimer, Alessandra Bertoldo,

<h4>Introduction</h4>Brain-wide mRNA mappings offer a great potential for neuroscience research as they can provide information about system proteomics. In a previous work we have correlated mRNA maps with the binding patterns of radioligands targeting specific molecular systems and imaged with positron emission tomography (PET) in unrelated control groups. This approach ... Read more >>

PLoS One (PloS one)
[2016, 11(2):e0148744]

Cited: 17 times

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Generalised Sandpile Dynamics on Artificial and Real-World Directed Networks.

Nicky Zachariou, Paul Expert, Misako Takayasu, Kim Christensen,

The main finding of this paper is a novel avalanche-size exponent τ ≈ 1.87 when the generalised sandpile dynamics evolves on the real-world Japanese inter-firm network. The topology of this network is non-layered and directed, displaying the typical bow tie structure found in real-world directed networks, with cycles and triangles. ... Read more >>

PLoS One (PloS one)
[2015, 10(11):e0142685]

Cited: 1 time

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