Full Text Journal Articles by
Author Paul C Marker

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Impact of sex, androgens, and prostate size on C57BL/6J mouse urinary physiology: urethral histology.

Hannah Ruetten, Kyle A Wegner, Conner L Kennedy, Anne Turco, Helen L Zhang, Peiqing Wang, Jaskiran Sandhu, Simran Sandhu, Jacquelyn Morkrid, Zunyi Wang, Jill Macoska, Richard E Peterson, Dale E Bjorling, William A Ricke, Paul C Marker, Chad M Vezina,

The National Institutes of Health leveled new focus on sex as a biological variable with the goal of understanding sex-specific differences in health and physiology. We previously published a functional assessment of the impact of sex, androgens, and prostate size on C57BL/6J mouse urinary physiology (Ruetten H, Wegner KA, Zhang ... Read more >>

Am J Physiol Renal Physiol (American journal of physiology. Renal physiology)
[2020, 318(3):F617-F627]

Cited: 0 times

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Prostate epithelial-specific expression of activated PI3K drives stromal collagen production and accumulation.

Kyle A Wegner, Brett R Mueller, Christopher J Unterberger, Enrique J Avila, Hannah Ruetten, Anne E Turco, Steven R Oakes, Nicholas M Girardi, Richard B Halberg, Steven M Swanson, Paul C Marker, Chad M Vezina,

We genetically engineered expression of an activated form of P110 alpha, the catalytic subunit of PI3K, in mouse prostate epithelium to create a mouse model of direct PI3K activation (Pbsn-cre4Prb;PI3KGOF/+ ). We hypothesized that direct activation would cause rapid neoplasia and cancer progression. Pbsn-cre4Prb;PI3KGOF/+ mice developed widespread prostate intraepithelial hyperplasia, ... Read more >>

J Pathol (The Journal of pathology)
[2020, 250(2):231-242]

Cited: 1 time

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Insight and Resources From a Study of the "Impact of Sex, Androgens, and Prostate Size on C57BL/6J Mouse Urinary Physiology.

Hannah Ruetten, Kyle A Wegner, Helen L Zhang, Peiqing Wang, Jaskiran Sandhu, Simran Sandhu, Jacquelyn Morkrid, Brett Mueller, Zunyi Wang, Jill Macoska, Richard E Peterson, Dale E Bjorling, William A Ricke, Paul C Marker, Chad M Vezina,

The purpose of this symposium report is to summarize information from a session 3 oral presentation at the Society of Toxicologic Pathology Annual Symposium in Raleigh, North Carolina. Mice are genetically tractable and are likely to play an important role in elucidating environmental, genetic, and aging-related mechanisms of urinary dysfunction ... Read more >>

Toxicol Pathol (Toxicologic pathology)
[2019, 47(8):1038-1042]

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Impact of sex, androgens, and prostate size on C57BL/6J mouse urinary physiology: functional assessment.

Hannah Ruetten, Kyle A Wegner, Helen L Zhang, Peiqing Wang, Jaskiran Sandhu, Simran Sandhu, Brett Mueller, Zunyi Wang, Jill Macoska, Richard E Peterson, Dale E Bjorling, William A Ricke, Paul C Marker, Chad M Vezina,

Laboratory mice are used to identify causes of urinary dysfunction including prostate-related mechanisms of lower urinary tract symptoms. Effective use of mice for this purpose requires a clear understanding of molecular, cellular, anatomic, and endocrine contributions to voiding function. Whether the prostate influences baseline voiding function has not been specifically ... Read more >>

Am J Physiol Renal Physiol (American journal of physiology. Renal physiology)
[2019, 317(4):F996-F1009]

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Edar is a downstream target of beta-catenin and drives collagen accumulation in the mouse prostate.

Kyle A Wegner, Vatsal Mehta, Jeanette A Johansson, Brett R Mueller, Kimberly P Keil, Lisa L Abler, Paul C Marker, M Mark Taketo, Denis J Headon, Chad M Vezina,

Beta-catenin (CTNNB1) directs ectodermal appendage spacing by activating ectodysplasin A receptor (EDAR) transcription, but whether CTNNB1 acts by a similar mechanism in the prostate, an endoderm-derived tissue, is unclear. Here we examined the expression, function, and CTNNB1 dependence of the EDAR pathway during prostate development. In situ hybridization studies reveal ... Read more >>

Biol Open (Biology open)
[2019, 8(3):]

Cited: 0 times

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Prostatic collagen architecture in neutered and intact canines.

Hannah Ruetten, Kyle A Wegner, Michael F Romero, Michael W Wood, Paul C Marker, Douglas Strand, Sara A Colopy, Chad M Vezina,

BACKGROUND:Prostate stiffness and increased collagen content both associate with the presence of urinary symptoms in men but mechanisms responsible, including impact of age and androgens, are unknown. Dogs develop prostate-related urinary dysfunction similar to humans, but mechanisms are also unknown. Mice have been used to examine how prostatic collagen accumulation ... Read more >>

Prostate (The Prostate)
[2018, 78(11):839-848]

Cited: 3 times

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Multi-drug loaded micelles delivering chemotherapy and targeted therapies directed against HSP90 and the PI3K/AKT/mTOR pathway in prostate cancer.

Bao Le, Ginny L Powers, Yu Tong Tam, Nicholas Schumacher, Rita L Malinowski, Laura Steinke, Glen Kwon, Paul C Marker,

BACKGROUND:Advanced prostate cancers that are resistant to all current therapies create a need for new therapeutic strategies. One recent innovative approach to cancer therapy is the simultaneous use of multiple FDA-approved drugs to target multiple pathways. A challenge for this approach is caused by the different solubility requirements of each ... Read more >>

PLoS One (PloS one)
[2017, 12(3):e0174658]

Cited: 2 times

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Ornithine Decarboxylase Activity Is Required for Prostatic Budding in the Developing Mouse Prostate.

Melissa Gamat, Rita L Malinowski, Linnea J Parkhurst, Laura M Steinke, Paul C Marker,

The prostate is a male accessory sex gland that produces secretions in seminal fluid to facilitate fertilization. Prostate secretory function is dependent on androgens, although the mechanism by which androgens exert their effects is still unclear. Polyamines are small cationic molecules that play pivotal roles in DNA transcription, translation and ... Read more >>

PLoS One (PloS one)
[2015, 10(10):e0139522]

Cited: 1 time

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Beta-catenin is elevated in human benign prostatic hyperplasia specimens compared to histologically normal prostate tissue.

Tyler M Bauman, Chad M Vezina, Wei Huang, Paul C Marker, Richard E Peterson, William A Ricke,

Benign prostatic hyperplasia (BPH) is linked to lower urinary tract symptoms (LUTS) such as incomplete bladder emptying, urinary frequency and urgency. Mechanisms responsible for BPH are not fully known. Here, we tested whether beta-catenin (CTNNB1) immunostaining intensity and distribution differ in human glandular BPH tissue specimens compared to normal prostate ... Read more >>

Am J Clin Exp Urol (American journal of clinical and experimental urology)
[2014, 2(4):313-322]

Cited: 10 times

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Phosphodiesterase 4D inhibitors limit prostate cancer growth potential.

Ginny L Powers, Kimberly D P Hammer, Maribella Domenech, Katsiaryna Frantskevich, Rita L Malinowski, Wade Bushman, David J Beebe, Paul C Marker,

UNLABELLED:Phosphodiesterase 4D (PDE4D) has recently been implicated as a proliferation-promoting factor in prostate cancer and is overexpressed in human prostate carcinoma. However, the effects of PDE4D inhibition using pharmacologic inhibitors have not been examined in prostate cancer. These studies examined the effects of selective PDE4D inhibitors, NVP-ABE171 and cilomilast, as ... Read more >>

Mol Cancer Res (Molecular cancer research : MCR)
[2015, 13(1):149-160]

Cited: 18 times

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A novel method for somatic transgenesis of the mouse prostate using the Sleeping Beauty transposon system.

Kimberly D P Hammer, James D Alsop, Rita A Buresh-Stiemke, Katsiaryna Frantskevich, Rita L Malinowski, Laura S Roethe, Ginny L Powers, Paul C Marker,

In vivo ectopic gene expression is a common approach for prostate research through the use of transgenes in germline transgenic mice. For some other organs, somatic transgenesis with the Sleeping Beauty transposon system has allowed in vivo ectopic gene expression with higher throughput and lower cost than germline transgenic approaches.Mouse ... Read more >>

Prostate (The Prostate)
[2014, 74(7):781-791]

Cited: 0 times

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Recent advances in prostate development and links to prostatic diseases.

Ginny L Powers, Paul C Marker,

The prostate is a branched ductal-acinar gland that is part of the male reproductive tract. Prostate development depends upon the integration of steroid hormone signals, paracrine interactions between the stromal and epithelial tissue layers, and the actions of cell autonomous factors. Several genes and signaling pathways are known to be ... Read more >>

Wiley Interdiscip Rev Syst Biol Med (Wiley interdisciplinary reviews. Systems biology and medicine)
[2013, 5(2):243-256]

Cited: 7 times

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Distinct expression patterns of Sulf1 and Hs6st1 spatially regulate heparan sulfate sulfation during prostate development.

Rita A Buresh-Stiemke, Rita L Malinowski, Kimberly P Keil, Chad M Vezina, Arie Oosterhof, Toin H Van Kuppevelt, Paul C Marker,

Prostate morphogenesis initiates in the urogenital sinus (UGS) with epithelial bud development. Sulfatase-1 (SULF1) inhibits bud development by reducing extracellular heparan sulfate (HS) 6-O sulfation and impairing FGF10 signaling by means of the ERK1/2 mitogen activated kinases.We characterized the expression patterns of HS 6-O sulfation modifying enzymes in the developing ... Read more >>

Dev Dyn (Developmental dynamics : an official publication of the American Association of Anatomists)
[2012, 241(12):2005-2013]

Cited: 10 times

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Wnt inhibitory factor 1 (Wif1) is regulated by androgens and enhances androgen-dependent prostate development.

Kimberly P Keil, Vatsal Mehta, Amanda M Branam, Lisa L Abler, Rita A Buresh-Stiemke, Pinak S Joshi, Christopher T Schmitz, Paul C Marker, Chad M Vezina,

Fetal prostate development from urogenital sinus (UGS) epithelium requires androgen receptor (AR) activation in UGS mesenchyme (UGM). Despite growing awareness of sexually dimorphic gene expression in the UGS, we are still limited in our knowledge of androgen-responsive genes in UGM that initiate prostate ductal development. We found that WNT inhibitory ... Read more >>

Endocrinology (Endocrinology)
[2012, 153(12):6091-6103]

Cited: 27 times

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Testosterone and 17β-estradiol induce glandular prostatic growth, bladder outlet obstruction, and voiding dysfunction in male mice.

Tristan M Nicholson, Emily A Ricke, Paul C Marker, Joseph M Miano, Robert D Mayer, Barry G Timms, Frederick S vom Saal, Ronald W Wood, William A Ricke,

Benign prostatic hyperplasia (BPH) and bladder outlet obstruction (BOO) are common in older men and can contribute to lower urinary tract symptoms that significantly impact quality of life. Few existing models of BOO and BPH use physiological levels of hormones associated with disease progression in humans in a genetically manipulable ... Read more >>

Endocrinology (Endocrinology)
[2012, 153(11):5556-5565]

Cited: 53 times

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Sulfatase 1 is an inhibitor of ductal morphogenesis with sexually dimorphic expression in the urogenital sinus.

Rita A Buresh, Sheri L Kuslak, Melissa A Rusch, Chad M Vezina, Scott B Selleck, Paul C Marker,

The prostate gland develops from the urogenital sinus in response to circulating androgens. Androgens initiate and stimulate branching morphogenesis in the urogenital sinus via unknown mediators. Heparan sulfate proteoglycans are important extracellular molecules that sequester many growth factors in the extracellular matrix and facilitate signaling by some growth factors as ... Read more >>

Endocrinology (Endocrinology)
[2010, 151(7):3420-3431]

Cited: 10 times

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Identification of PDE4D as a proliferation promoting factor in prostate cancer using a Sleeping Beauty transposon-based somatic mutagenesis screen.

Eric P Rahrmann, Lara S Collier, Todd P Knutson, Meghan E Doyal, Sheri L Kuslak, Laura E Green, Rita L Malinowski, Laura Roethe, Keiko Akagi, Michelle Waknitz, Wei Huang, David A Largaespada, Paul C Marker,

Retroviral and transposon-based mutagenesis screens in mice have been useful for identifying candidate cancer genes for some tumor types. However, many of the organs that exhibit the highest cancer rates in humans, including the prostate, have not previously been amenable to these approaches. This study shows for the first time ... Read more >>

Cancer Res (Cancer research)
[2009, 69(10):4388-4397]

Cited: 55 times

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Does prostate cancer co-opt the developmental program?

Paul C Marker,

The hypothesis that cancer is a caricature of normal development and tissue renewal was originally based on descriptive studies of normal tissues and cancers. The concepts that arose from these studies were that both normal tissues and tumors are sustained by a self-renewing population of stem cells that initially gives ... Read more >>

Differentiation (Differentiation; research in biological diversity)
[2008, 76(6):736-744]

Cited: 10 times

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Prostate development and pathogenesis.

Axel A Thomson, Gerald R Cunha, Paul C Marker,

Differentiation (Differentiation; research in biological diversity)
[2008, 76(6):559-564]

Cited: 10 times

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Dominant negative Bmp5 mutation reveals key role of BMPs in skeletal response to mechanical stimulation.

Andrew M Ho, Paul C Marker, Hairong Peng, Andres J Quintero, David M Kingsley, Johnny Huard,

Over a hundred years ago, Wolff originally observed that bone growth and remodeling are exquisitely sensitive to mechanical forces acting on the skeleton. Clinical studies have noted that the size and the strength of bone increase with weight bearing and muscular activity and decrease with bed rest and disuse. Although ... Read more >>

BMC Dev Biol (BMC developmental biology)
[2008, 8:35]

Cited: 16 times

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Secreted frizzled related protein 1 is a paracrine modulator of epithelial branching morphogenesis, proliferation, and secretory gene expression in the prostate.

Margaret S Joesting, Thomas R Cheever, Katherine G Volzing, Terry P Yamaguchi, Vladimir Wolf, Dieter Naf, Jeffrey S Rubin, Paul C Marker,

Previous in vitro studies identified secreted frizzled related protein 1 (SFRP1) as a candidate pro-proliferative signal during prostatic development and cancer progression. This study determined the in vivo roles of SFRP1 in the prostate using expression studies in mice and by creating loss- and gain-of-function mouse genetic models. Expression studies ... Read more >>

Dev Biol (Developmental biology)
[2008, 317(1):161-173]

Cited: 33 times

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The mouse seminal vesicle shape mutation is allelic with Fgfr2.

Sheri L Kuslak, Joshua L Thielen, Paul C Marker,

The mouse seminal vesicle shape (svs) mutation is a spontaneous recessive mutation that causes branching morphogenesis defects in the prostate gland and seminal vesicles. Unlike many other mutations that reduce prostatic and/or seminal vesicle branching, the svs mutation dramatically reduces branching without reducing organ growth. Using a positional cloning approach, ... Read more >>

Development (Development (Cambridge, England))
[2007, 134(3):557-565]

Cited: 11 times

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Fibroblast growth factor receptor signaling through MEK-ERK is required for prostate bud induction.

Sheri L Kuslak, Paul C Marker,

The urogenital sinus (UGS) is specified as prostate in mice around embryonic day 15.5 as indicated by expression of the transcription factor Nkx3.1. Shortly thereafter, growth of epithelial buds into the UGS mesenchyme initiates prostatic morphogenesis. A comparison of male and female UGSs in vivo demonstrated sexually dimorphic expression of ... Read more >>

Differentiation (Differentiation; research in biological diversity)
[2007, 75(7):638-651]

Cited: 38 times

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Markers of prostate region-specific epithelial identity define anatomical locations in the mouse prostate that are molecularly similar to human prostate cancers.

Joshua L Thielen, Katherine G Volzing, Lara S Collier, Laura E Green, David A Largaespada, Paul C Marker,

Although the basic functions of the prostate gland are conserved among mammals, its morphology varies greatly among species. Comparative studies between mouse and human are important because mice are widely used to study prostate cancer, a disease that occurs in a region-restricted manner within the human prostate. An informatics-based approach ... Read more >>

Differentiation (Differentiation; research in biological diversity)
[2007, 75(1):49-61]

Cited: 15 times

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Integration of rapid signaling events with steroid hormone receptor action in breast and prostate cancer.

Carol A Lange, Daniel Gioeli, Stephen R Hammes, Paul C Marker,

Steroid hormone receptors (SRs) are ligand-activated transcription factors and sensors for growth factor-initiated signaling pathways in hormonally regulated tissues, such as the breast or prostate. Recent discoveries suggest that several protein kinases are rapidly activated in response to steroid hormone binding to cytoplasmic SRs. Induction of rapid signaling upon SR ... Read more >>

Annu. Rev. Physiol. (Annual review of physiology)
[2007, 69:171-199]

Cited: 50 times

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