Full Text Journal Articles by
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Commentary: Conservative Management of Type II Odontoid Fractures in Older People: A Retrospective Observational Comparison of Osseous Union Versus Nonunion.

Paul M Arnold, Mark D Whiting,

Neurosurgery (Neurosurgery)
[2020, :]

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Clinical and Radiologic Outcomes of Thoracolumbar Fusions Using Intraoperative CT Guidance and Stereotactic Navigation in a Spinal Trauma Population: An Analysis of 58 Patients.

Joseph S Domino, Kyle A Smith, Paul M Arnold,

STUDY DESIGN:Retrospective review of prospectively collected single-institution database. OBJECTIVE:To analyze the clinical and radiographic outcomes of posterior thoracolumbar fusions using intraoperative computed tomography (CT)-guidance and stereotactic navigation in thoracolumbar spinal trauma. SUMMARY OF BACKGROUND DATA:Pedicle screw instrumentation is utilized for stabilization in thoracolumbar fusions. Suboptimal placement may lead to neurovascular ... Read more >>

Clin Spine Surg (Clinical spine surgery)
[2020, :]

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Metastatic Spine Disease: Should Patients With Short Life Expectancy Be Denied Surgical Care? An International Retrospective Cohort Study.

Nicolas Dea, Anne L Versteeg, Arjun Sahgal, Jorrit-Jan Verlaan, Raphaële Charest-Morin, Laurence D Rhines, Daniel M Sciubba, James M Schuster, Michael H Weber, Aron Lazary, Michael G Fehlings, Michelle J Clarke, Paul M Arnold, Stefano Boriani, Chetan Bettegowda, Ilya Laufer, Ziya L Gokaslan, Charles G Fisher,

BACKGROUND:Despite our inability to accurately predict survival in many cancer patients, a life expectancy of at least 3 mo is historically necessary to be considered for surgical treatment of spinal metastases. OBJECTIVE:To compare health-related quality of life (HRQOL) in patients surviving <3 mo after surgical treatment to patients surviving >3 mo to ... Read more >>

Neurosurgery (Neurosurgery)
[2020, 87(2):303-311]

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A Diagnostic Biomarker for Pediatric Generalized Anxiety Disorder Using the Error-Related Negativity.

Gregory L Hanna, Yanni Liu, Haley E Rough, Mihir Surapaneni, Barbara S Hanna, Paul D Arnold, William J Gehring,

The error-related negativity (ERN) is a negative deflection in the event-related potential following a mistake that is a putative biomarker of anxiety. The study assessed the ERN as a diagnostic biomarker using receiver operating characteristic (ROC) analyses in 96 cases with anxiety disorders (AD) and 96 matched healthy controls (HC) ... Read more >>

Child Psychiatry Hum Dev (Child psychiatry and human development)
[2020, :]

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Subcortical Brain Volume, Regional Cortical Thickness, and Cortical Surface Area Across Disorders: Findings From the ENIGMA ADHD, ASD, and OCD Working Groups.

Premika S W Boedhoe, Daan van Rooij, Martine Hoogman, Jos W R Twisk, Lianne Schmaal, Yoshinari Abe, Pino Alonso, Stephanie H Ameis, Anatoly Anikin, Alan Anticevic, Celso Arango, Paul D Arnold, Philip Asherson, Francesca Assogna, Guillaume Auzias, Tobias Banaschewski, Alexander Baranov, Marcelo C Batistuzzo, Sarah Baumeister, Ramona Baur-Streubel, Marlene Behrmann, Mark A Bellgrove, Francesco Benedetti, Jan C Beucke, Joseph Biederman, Irene Bollettini, Anushree Bose, Janita Bralten, Ivanei E Bramati, Daniel Brandeis, Silvia Brem, Brian P Brennan, Geraldo F Busatto, Sara Calderoni, Anna Calvo, Rosa Calvo, Francisco X Castellanos, Mara Cercignani, Tiffany M Chaim-Avancini, Kaylita C Chantiluke, Yuqi Cheng, Kang Ik K Cho, Anastasia Christakou, David Coghill, Annette Conzelmann, Ana I Cubillo, Anders M Dale, Sara Dallaspezia, Eileen Daly, Damiaan Denys, Christine Deruelle, Adriana Di Martino, Ilan Dinstein, Alysa E Doyle, Sarah Durston, Eric A Earl, Christine Ecker, Stefan Ehrlich, Benjamin A Ely, Jeffrey N Epstein, Thomas Ethofer, Damien A Fair, Andreas J Fallgatter, Stephen V Faraone, Jennifer Fedor, Xin Feng, Jamie D Feusner, Jackie Fitzgerald, Kate D Fitzgerald, Jean-Paul Fouche, Christine M Freitag, Egill A Fridgeirsson, Thomas Frodl, Matt C Gabel, Louise Gallagher, Tinatin Gogberashvili, Ilaria Gori, Patricia Gruner, Deniz A Gürsel, Shlomi Haar, Jan Haavik, Geoffrey B Hall, Neil A Harrison, Catharina A Hartman, Dirk J Heslenfeld, Yoshiyuki Hirano, Pieter J Hoekstra, Marcelo Q Hoexter, Sarah Hohmann, Marie F Høvik, Hao Hu, Chaim Huyser, Neda Jahanshad, Maria Jalbrzikowski, Anthony James, Joost Janssen, Fern Jaspers-Fayer, Terry L Jernigan, Dmitry Kapilushniy, Bernd Kardatzki, Georgii Karkashadze, Norbert Kathmann, Christian Kaufmann, Clare Kelly, Sabin Khadka, Joseph A King, Kathrin Koch, Gregor Kohls, Kerstin Konrad, Masaru Kuno, Jonna Kuntsi, Gerd Kvale, Jun Soo Kwon, Luisa Lázaro, Sara Lera-Miguel, Klaus-Peter Lesch, Liesbeth Hoekstra, Yanni Liu, Christine Lochner, Mario R Louza, Beatriz Luna, Astri J Lundervold, Charles B Malpas, Paulo Marques, Rachel Marsh, Ignacio Martínez-Zalacaín, David Mataix-Cols, Paulo Mattos, Hazel McCarthy, Jane McGrath, Mitul A Mehta, José M Menchón, Maarten Mennes, Mauricio Moller Martinho, Pedro S Moreira, Astrid Morer, Pedro Morgado, Filippo Muratori, Clodagh M Murphy, Declan G M Murphy, Akiko Nakagawa, Takashi Nakamae, Tomohiro Nakao, Leyla Namazova-Baranova, Janardhanan C Narayanaswamy, Rosa Nicolau, Joel T Nigg, Stephanie E Novotny, Erika L Nurmi, Eileen Oberwelland Weiss, Ruth L O'Gorman Tuura, Kirsten O'Hearn, Joseph O'Neill, Jaap Oosterlaan, Bob Oranje, Yannis Paloyelis, Mara Parellada, Paul Pauli, Chris Perriello, John Piacentini, Fabrizio Piras, Federica Piras, Kerstin J Plessen, Olga Puig, J Antoni Ramos-Quiroga, Y C Janardhan Reddy, Andreas Reif, Liesbeth Reneman, Alessandra Retico, Pedro G P Rosa, Katya Rubia, Oana Georgiana Rus, Yuki Sakai, Anouk Schrantee, Lena Schwarz, Lizanne J S Schweren, Jochen Seitz, Philip Shaw, Devon Shook, Tim J Silk, H Blair Simpson, Norbert Skokauskas, Juan Carlos Soliva Vila, Anastasia Solovieva, Noam Soreni, Carles Soriano-Mas, Gianfranco Spalletta, Emily R Stern, Michael C Stevens, S Evelyn Stewart, Gustavo Sudre, Philip R Szeszko, Leanne Tamm, Margot J Taylor, David F Tolin, Michela Tosetti, Fernanda Tovar-Moll, Aki Tsuchiyagaito, Theo G M van Erp, Guido A van Wingen, Alasdair Vance, Ganesan Venkatasubramanian, Oscar Vilarroya, Yolanda Vives-Gilabert, Georg G von Polier, Susanne Walitza, Gregory L Wallace, Zhen Wang, Thomas Wolfers, Yuliya N Yoncheva, Je-Yeon Yun, Marcus V Zanetti, Fengfeng Zhou, Georg C Ziegler, Kathrin C Zierhut, Marcel P Zwiers, , , , Paul M Thompson, Dan J Stein, Jan Buitelaar, Barbara Franke, Odile A van den Heuvel,

OBJECTIVE:Attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and obsessive-compulsive disorder (OCD) are common neurodevelopmental disorders that frequently co-occur. The authors sought to directly compare these disorders using structural brain imaging data from ENIGMA consortium data. METHODS:Structural T1-weighted whole-brain MRI data from healthy control subjects (N=5,827) and from patients ... Read more >>

Am J Psychiatry (The American journal of psychiatry)
[2020, :appiajp202019030331]

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Comparing rates of early pedicle screw loosening in posterolateral lumbar fusion with and without transforaminal lumbar interbody fusion.

David H Kim, Raymond W Hwang, Gyu-Ho Lee, Riya Joshi, Kevin C Baker, Paul Arnold, Rick Sasso, Daniel Park, Jeffrey Fischgrund,

BACKGROUND CONTEXT:Addition of interbody fusion via a transforaminal approach (TLIF) has become a popular surgical option for treatment of degenerative lumbar conditions. Although technically more complicated than posterolateral fusion surgery (PLF), it has been suggested that TLIF provides superior immediate stability and protects against early pedicle screw loosening. This theory ... Read more >>

Spine J (The spine journal : official journal of the North American Spine Society)
[2020, :]

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Reply to Dawes et al.

Abdullah Al Maruf, Mikayla Fan, Paul D Arnold, Daniel J Müller, Katherine Aitchison, Chad A Bousman,

Can J Psychiatry (Canadian journal of psychiatry. Revue canadienne de psychiatrie)
[2020, 65(8):586-587]

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Shared genetic etiology between obsessive-compulsive disorder, obsessive-compulsive symptoms in the population, and insulin signaling.

Janita Bralten, Joanna Widomska, Ward De Witte, Dongmei Yu, Carol A Mathews, Jeremiah M Scharf, Jan Buitelaar, Jennifer Crosbie, Russell Schachar, Paul Arnold, Mathieu Lemire, Christie L Burton, Barbara Franke, Geert Poelmans,

Obsessive-compulsive symptoms (OCS) in the population have been linked to obsessive-compulsive disorder (OCD) in genetic and epidemiological studies. Insulin signaling has been implicated in OCD. We extend previous work by assessing genetic overlap between OCD, population-based OCS, and central nervous system (CNS) and peripheral insulin signaling. We conducted genome-wide association ... Read more >>

Transl Psychiatry (Translational psychiatry)
[2020, 10(1):121]

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In memoriam: Glenda MacQueen (1965-2020).

Signe Lauren Bray, Valerie H Taylor, Paul Arnold,

J Psychiatry Neurosci (Journal of psychiatry & neuroscience : JPN)
[2020, 45(3):224]

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An overview of the first 5 years of the ENIGMA obsessive-compulsive disorder working group: The power of worldwide collaboration.

Odile A van den Heuvel, Premika S W Boedhoe, Sara Bertolin, Willem B Bruin, Clyde Francks, Iliyan Ivanov, Neda Jahanshad, Xiang-Zhen Kong, Jun Soo Kwon, Joseph O'Neill, Tomas Paus, Yash Patel, Fabrizio Piras, Lianne Schmaal, Carles Soriano-Mas, Gianfranco Spalletta, Guido A van Wingen, Je-Yeon Yun, Chris Vriend, H Blair Simpson, Daan van Rooij, Marcelo Q Hoexter, Martine Hoogman, Jan K Buitelaar, Paul Arnold, Jan C Beucke, Francesco Benedetti, Irene Bollettini, Anushree Bose, Brian P Brennan, Alessandro S De Nadai, Kate Fitzgerald, Patricia Gruner, Edna Grünblatt, Yoshiyuki Hirano, Chaim Huyser, Anthony James, Kathrin Koch, Gerd Kvale, Luisa Lazaro, Christine Lochner, Rachel Marsh, David Mataix-Cols, Pedro Morgado, Takashi Nakamae, Tomohiro Nakao, Janardhanan C Narayanaswamy, Erika Nurmi, Christopher Pittenger, Y C Janardhan Reddy, João R Sato, Noam Soreni, S Evelyn Stewart, Stephan F Taylor, David Tolin, Sophia I Thomopoulos, Dick J Veltman, Ganesan Venkatasubramanian, Susanne Walitza, Zhen Wang, Paul M Thompson, Dan J Stein, ,

Neuroimaging has played an important part in advancing our understanding of the neurobiology of obsessive-compulsive disorder (OCD). At the same time, neuroimaging studies of OCD have had notable limitations, including reliance on relatively small samples. International collaborative efforts to increase statistical power by combining samples from across sites have been ... Read more >>

Hum Brain Mapp (Human brain mapping)
[2020, :]

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Physiological responses of eastern hemlock (Tsuga canadensis) to light, adelgid infestation, and biological control: Implications for hemlock restoration

Chelcy Ford Miniat, Paul Arnold, Steven T Brantley, Cindi L Brown, Robert M Jetton, Albert E Mayfield III, James R Rhea, David R Zietlow,

The rapid loss of eastern hemlock (Tsuga canadensis) in the southern Appalachian Mountains due to hemlock woolly adelgid (Adelges tsugae, HWA) infestation has resulted in substantial changes to ecosystem structure and function. Several restoration strategies have been proposed, including silvicultural treatments that increase incident light in forest understories. We conducted ... Read more >>

For. Ecol. Manage. (Forest ecology and management)
[2020, 460:Not Available]

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Pharmacogenetic Testing Options Relevant to Psychiatry in Canada: Options de tests pharmacogénétiques pertinents en psychiatrie au Canada.

Abdullah Al Maruf, Mikayla Fan, Paul D Arnold, Daniel J Müller, Katherine J Aitchison, Chad A Bousman,

OBJECTIVE:To identify and assess pharmacogenetic testing options relevant to psychiatry in Canada. METHOD:Searches of published literature, websites, and Standard Council of Canada's Laboratory Directory were conducted to identify pharmacogenetic tests available in Canada. Identified tests were assessed on 8 key questions related to analytical validity, accessibility, test ordering, delivery of ... Read more >>

Can J Psychiatry (Canadian journal of psychiatry. Revue canadienne de psychiatrie)
[2020, 65(8):521-530]

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Serotonin system genes and hoarding with and without other obsessive-compulsive traits in a population-based, pediatric sample: A genetic association study.

Vanessa M Sinopoli, Lauren Erdman, Christie L Burton, Laura S Park, Annie Dupuis, Janet Shan, Tara Goodale, S-M Shaheen, Jennifer Crosbie, Russell J Schachar, Paul D Arnold,

BACKGROUND:Hoarding, originally only considered a symptom of obsessive-compulsive disorder (OCD), is now categorized as a separate disorder in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). We studied candidate serotonergic genes and the distinctness of hoarding in children and adolescents and hypothesized that unique gene ... Read more >>

Depress Anxiety (Depression and anxiety)
[2020, 37(8):760-770]

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Screening for Pediatric Obsessive-Compulsive Disorder Using the Obsessive-Compulsive Inventory-Child Version.

Haley E Rough, Barbara S Hanna, Carrie B Gillett, David R Rosenberg, William J Gehring, Paul D Arnold, Gregory L Hanna,

The study assessed the ability of the Obsessive-Compulsive Inventory-Child Version (OCI-CV) to detect pediatric obsessive-compulsive disorder (OCD) using receiver operating characteristic analyses. The sample consisted of 114 cases with current OCD, 340 cases with other psychiatric disorders (OPD), and 301 healthy controls (HC) ages 7 to 18 years. All 755 participants ... Read more >>

Child Psychiatry Hum Dev (Child psychiatry and human development)
[2020, :]

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Integration of Brain and Behavior Measures for Identification of Data-Driven Groups Cutting Across Children with ASD, ADHD, or OCD

Grace Jacobs, Aristotle Voineskos, Colin Hawco, Laura Stefanik, Natalie Forde, Erin Dickie, Meng-Chuan Lai, Peter Szatmari, Russell Schachar, Jennifer Crosbie, Paul Arnold, Anna Goldenberg, Lauren Erdman, Jason Lerch, Evdokia Anagnostou, Stephanie Ameis,

Abstract Autism spectrum disorder (ASD), obsessive-compulsive disorder (OCD) and attention-deficit/hyperactivity disorder (ADHD) are clinically and biologically heterogeneous neurodevelopmental disorders (NDDs). The objective of the present study was to integrate brain imaging and behavioral measures to identify new brain-behavior subgroups cutting across these disorders. A subset of the data from the ... Read more >>

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Anticoagulation and Spine Surgery.

Guilherme B F Porto, D O Jeffrey Wessell, Anthony Alvarado, Paul M Arnold, Avery L Buchholz,

Study Design:Literature review. Objective:Preoperative management of therapeutic anticoagulation in spine surgery is critical to minimize risk of thromboembolic events yet prevent postsurgical complications. Limited research is available, and most guidelines are based on drug half-lives. We aim to clarify current guidelines and available evidence for safe practice of spine surgery ... Read more >>

Global Spine J (Global spine journal)
[2020, 10(1 Suppl):53S-64S]

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Behavioral and Electrophysiological Correlates of Performance Monitoring and Development in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder.

Yanni Liu, Gregory L Hanna, Barbara S Hanna, Haley E Rough, Paul D Arnold, William J Gehring,

The pathophysiology of attention-deficit/hyperactivity disorder (ADHD) involves deficits in performance monitoring and adaptive adjustments. Yet, the developmental trajectory and underlying neural correlates of performance monitoring deficits in youth with ADHD remain poorly understood. To address the gap, this study recruited 77 children and adolescents with ADHD and 77 age- and ... Read more >>

Brain Sci (Brain sciences)
[2020, 10(2):]

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Brain structural covariance networks in obsessive-compulsive disorder: a graph analysis from the ENIGMA Consortium.

Je-Yeon Yun, Premika S W Boedhoe, Chris Vriend, Neda Jahanshad, Yoshinari Abe, Stephanie H Ameis, Alan Anticevic, Paul D Arnold, Marcelo C Batistuzzo, Francesco Benedetti, Jan C Beucke, Irene Bollettini, Anushree Bose, Silvia Brem, Anna Calvo, Yuqi Cheng, Kang Ik K Cho, Valentina Ciullo, Sara Dallaspezia, Damiaan Denys, Jamie D Feusner, Jean-Paul Fouche, Mònica Giménez, Patricia Gruner, Derrek P Hibar, Marcelo Q Hoexter, Hao Hu, Chaim Huyser, Keisuke Ikari, Norbert Kathmann, Christian Kaufmann, Kathrin Koch, Luisa Lazaro, Christine Lochner, Paulo Marques, Rachel Marsh, Ignacio Martínez-Zalacaín, David Mataix-Cols, José M Menchón, Luciano Minuzzi, Pedro Morgado, Pedro Moreira, Takashi Nakamae, Tomohiro Nakao, Janardhanan C Narayanaswamy, Erica L Nurmi, Joseph O'Neill, John Piacentini, Fabrizio Piras, Federica Piras, Y C Janardhan Reddy, Joao R Sato, H Blair Simpson, Noam Soreni, Carles Soriano-Mas, Gianfranco Spalletta, Michael C Stevens, Philip R Szeszko, David F Tolin, Ganesan Venkatasubramanian, Susanne Walitza, Zhen Wang, Guido A van Wingen, Jian Xu, Xiufeng Xu, Qing Zhao, , Paul M Thompson, Dan J Stein, Odile A van den Heuvel, Jun Soo Kwon,

Brain structural covariance networks reflect covariation in morphology of different brain areas and are thought to reflect common trajectories in brain development and maturation. Large-scale investigation of structural covariance networks in obsessive-compulsive disorder (OCD) may provide clues to the pathophysiology of this neurodevelopmental disorder. Using T1-weighted MRI scans acquired from ... Read more >>

Brain (Brain : a journal of neurology)
[2020, 143(2):684-700]

Cited: 1 time

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The functional connectivity profile of tics and obsessive-compulsive symptoms in Tourette Syndrome.

Tracy Bhikram, Paul Arnold, Adrian Crawley, Elia Abi-Jaoude, Paul Sandor,

Tourette Syndrome (TS) is characterized by the presence of tics and sensory phenomena, such as premonitory urges, and is often accompanied by significant obsessive-compulsive symptoms (OCS). The goal of this exploratory study was to determine the association between functional connectivity and the different symptom domains of TS, as little is ... Read more >>

J Psychiatr Res (Journal of psychiatric research)
[2020, 123:128-135]

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Examining the functional activity of different obsessive-compulsive symptom dimensions in Tourette syndrome.

Tracy Bhikram, Adrian Crawley, Paul Arnold, Elia Abi-Jaoude, Paul Sandor,

OBJECTIVES:Tourette syndrome (TS) is commonly comorbid with obsessive-compulsive disorder (OCD) and many phenomenological similarities exist between tics and obsessive-compulsive symptoms (OCS). Therefore, due to the clinical importance of comorbid OCD, the goal of this study was to investigate the neural substrates of OCS in TS using functional magnetic resonance imaging. ... Read more >>

Neuroimage Clin (NeuroImage. Clinical)
[2020, 26:102198]

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Minimizing Blood Loss in Spine Surgery.

Christopher Mikhail, Zach Pennington, Paul M Arnold, Darrel S Brodke, Jens R Chapman, Norman Chutkan, Michael D Daubs, John G DeVine, Michael G Fehlings, Daniel E Gelb, George M Ghobrial, James S Harrop, Christian Hoelscher, Fan Jiang, John J Knightly, Brian K Kwon, Thomas E Mroz, Ahmad Nassr, K Daniel Riew, Lali H Sekhon, Justin S Smith, Vincent C Traynelis, Jeffrey C Wang, Michael H Weber, Jefferson R Wilson, Christopher D Witiw, Daniel M Sciubba, Samuel K Cho,

Study Design:Broad narrative review. Objective:To review and summarize the current literature on guidelines, outcomes, techniques and indications surrounding multiple modalities of minimizing blood loss in spine surgery. Methods:A thorough review of peer-reviewed literature was performed on the guidelines, outcomes, techniques, and indications for multiple modalities of minimizing blood loss in ... Read more >>

Global Spine J (Global spine journal)
[2020, 10(1 Suppl):71S-83S]

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Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders.

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Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive ... Read more >>

Cell (Cell)
[2019, 179(7):1469-1482.e11]

Cited: 7 times

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Examining overlap and homogeneity in ASD, ADHD, and OCD: a data-driven, diagnosis-agnostic approach.

Azadeh Kushki, Evdokia Anagnostou, Christopher Hammill, Pierre Duez, Jessica Brian, Alana Iaboni, Russell Schachar, Jennifer Crosbie, Paul Arnold, Jason P Lerch,

The validity of diagnostic labels of autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and obsessive compulsive disorder (OCD) is an open question given the mounting evidence that these categories may not correspond to conditions with distinct etiologies, biologies, or phenotypes. The objective of this study was to determine the agreement ... Read more >>

Transl Psychiatry (Translational psychiatry)
[2019, 9(1):318]

Cited: 1 time

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Arm Pain Versus Neck Pain: A Novel Ratio as a Predictor of Post-Operative Clinical Outcomes in Cervical Radiculopathy Patients.

Peter G Passias, Saqib Hasan, Kris Radcliff, Robert Isaacs, Kristina Bianco, Cyrus M Jalai, Gregory W Poorman, Nancy J Worley, Samantha R Horn, Anthony Boniello, Peter L Zhou, Paul M Arnold, Patrick Hsieh, Alexander R Vaccaro, Michael C Gerling,

Background:Informed patient selection and counseling is key in improving surgical outcomes. Understanding the impact that certain baseline variables can have on postoperative outcomes is essential in optimizing treatment for certain symptoms, such as radiculopathy from cervical spine pathologies. The aim was to identify baseline characteristics that were related to improved ... Read more >>

Int J Spine Surg (International journal of spine surgery)
[2018, 12(5):629-637]

Cited: 1 time

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Genome-wide Association Study of Pediatric Obsessive-Compulsive Traits: Shared Genetic Risk between Traits and Disorder

Christie Burton, Mathieu Lemire, Bowei Xiao, Elizabeth Corfield, Lauren Erdman, Janita Bralten, Geert Poelmans, Dongmei Yu, S-M Shaheen, Tara Goodale, Noam Soreni, Gregory Hanna, Kate Fitzgerald, David Rosenberg, Gerry Nestadt, Andrew Paterson, Lisa Strug, Russell Schachar, Jennifer Crosbie, Paul Arnold, ,

Abstract Objective To identify genetic variants associated with obsessive-compulsive (OC) traits and test for sharing of genetic risks between OC traits and obsessive-compulsive disorder (OCD). Methods We conducted a genome-wide association analysis of OC traits using the Toronto Obsessive-Compulsive Scale (TOCS) in 5018 unrelated Caucasian children and adolescents from the ... Read more >>

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