Full Text Journal Articles by
Author Patrick Meybohm

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Current concepts in the evaluation and management of preoperative anemia.

Vanessa Neef, Suma Choorapoikayil, Florian Piekarski, Tobias Schlesinger, Patrick Meybohm, Kai Zacharowski,

<h4>Purpose of review</h4>In the past years, patient blood management (PBM) has evolved to improve patient's care and safety. Anemia is one of the most common medical diseases in the world and is an independent risk factor for morbidity and mortality. Iron deficiency is the main cause for anemia and constitutes ... Read more >>

Curr Opin Anaesthesiol (Current opinion in anaesthesiology)
[2021, 34(3):352-356]

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Association of Intravenous Tranexamic Acid With Thromboembolic Events and Mortality: A Systematic Review, Meta-analysis, and Meta-regression.

Isabel Taeuber, Stephanie Weibel, Eva Herrmann, Vanessa Neef, Tobias Schlesinger, Peter Kranke, Leila Messroghli, Kai Zacharowski, Suma Choorapoikayil, Patrick Meybohm,

<h4>Importance</h4>Tranexamic acid (TXA) is an efficient antifibrinolytic agent; however, concerns remain about the potential adverse effects, particularly vascular occlusive events, that may be associated with its use.<h4>Objective</h4>To examine the association between intravenous TXA and total thromboembolic events (TEs) and mortality in patients of all ages and of any medical disciplines.<h4>Data ... Read more >>

JAMA Surg (JAMA surgery)
[2021, :e210884]

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Effects of an Animated Blood Clot Technology (Visual Clot) on the Decision-Making of Users Inexperienced in Viscoelastic Testing: Multicenter Trial.

Sadiq Said, Tadzio Raoul Roche, Julia Braun, Micheal Thomas Ganter, Patrick Meybohm, Johannes Herrmann, Kai Zacharowski, Florian Jürgen Raimann, Florian Piekarski, Eva Rivas, Eva Rivas, Manuel López-Baamonde, Manuel López-Baamonde, Donat R Spahn, Christoph Beat Nöthiger, David Werner Tscholl,

<h4>Background</h4>Viscoelastic test-guided coagulation management has become increasingly important in assessing hemostasis. We developed Visual Clot, an animated, 3D blood clot that illustrates raw rotational thromboelastometry (ROTEM) parameters in a user-centered and situation awareness-oriented method.<h4>Objective</h4>This study aimed to evaluate the applicability of Visual Clot by examining its effects on users that ... Read more >>

J Med Internet Res (Journal of medical Internet research)
[2021, 23(5):e27124]

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Death in hospital following ICU discharge: insights from the LUNG SAFE study.

Fabiana Madotto, Bairbre McNicholas, Emanuele Rezoagli, Tài Pham, John G Laffey, Giacomo Bellani, , ,

<h4>Background</h4>To determine the frequency of, and factors associated with, death in hospital following ICU discharge to the ward.<h4>Methods</h4>The Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE study was an international, multicenter, prospective cohort study of patients with severe respiratory failure, conducted across 459 ICUs from ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):144]

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The impact of frailty on survival in elderly intensive care patients with COVID-19: the COVIP study.

Christian Jung, Hans Flaatten, Jesper Fjølner, Raphael Romano Bruno, Bernhard Wernly, Antonio Artigas, Bernardo Bollen Pinto, Joerg C Schefold, Georg Wolff, Malte Kelm, Michael Beil, Sigal Sviri, Peter Vernon van Heerden, Wojciech Szczeklik, Miroslaw Czuczwar, Muhammed Elhadi, Michael Joannidis, Sandra Oeyen, Tilemachos Zafeiridis, Brian Marsh, Finn H Andersen, Rui Moreno, Maurizio Cecconi, Susannah Leaver, Ariane Boumendil, Dylan W De Lange, Bertrand Guidet, ,

<h4>Background</h4>The COVID-19 pandemic has led highly developed healthcare systems to the brink of collapse due to the large numbers of patients being admitted into hospitals. One of the potential prognostic indicators in patients with COVID-19 is frailty. The degree of frailty could be used to assist both the triage into ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):149]

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Removal of EpCAM-positive tumor cells from blood collected during major oncological surgery using the Catuvab device- a pilot study

Andreas Winter, Kai Zacharowski, Patrick Meybohm, Andreas Schnitzbauer, Peter Ruf, Claudia Kellermann, Horst Lindhofer,

<h4>Background: </h4> Intraoperative blood salvage (IBS) is regarded as an alternative to allogeneic blood transfusion excluding the risks associated with allogeneic blood. Currently, IBS is generally avoided in tumor surgeries due to concern for potential metastasis caused by residual tumor cells in the erythrocyte concentrate. <h4>Methods: </h4> The feasibility, efficacy ... Read more >>

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Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study.

Sonia O Labeau, Elsa Afonso, Julie Benbenishty, Bronagh Blackwood, Carole Boulanger, Stephen J Brett, Silvia Calvino-Gunther, Wendy Chaboyer, Fiona Coyer, Mieke Deschepper, Guy François, Patrick M Honore, Radmilo Jankovic, Ashish K Khanna, Mireia Llaurado-Serra, Frances Lin, Louise Rose, Francesca Rubulotta, Leif Saager, Ged Williams, Stijn I Blot, , ,

Intensive Care Med (Intensive care medicine)
[2021, 47(4):503-520]

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Mitochondria and Pharmacologic Cardiac Conditioning-At the Heart of Ischemic Injury.

Christopher Lotz, Johannes Herrmann, Quirin Notz, Patrick Meybohm, Franz Kehl,

Pharmacologic cardiac conditioning increases the intrinsic resistance against ischemia and reperfusion (I/R) injury. The cardiac conditioning response is mediated via complex signaling networks. These networks have been an intriguing research field for decades, largely advancing our knowledge on cardiac signaling beyond the conditioning response. The centerpieces of this system are ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(6):]

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Safety and preliminary efficacy of sequential multiple ascending doses of solnatide to treat pulmonary permeability edema in patients with moderate-to-severe ARDS - a randomized, placebo-controlled, double-blind trial

Benedikt Schmid, Markus Kredel, Roman Ullrich, Katharina Krenn, Rudolf Lucas, Klaus Markstaller, Bernhard Fischer, Peter Kranke, Patrick Meybohm, Bernhard Zwißler, Sandra Frank,

<h4>Background: </h4> Acute respiratory distress syndrome (ARDS) is a complex clinical diagnosis with various possible etiologies. One common feature, however, is pulmonary permeability edema, which leads to an increased alveolar diffusion pathway and, subsequently, impaired oxygenation and decarboxylation. A novel inhaled peptide agent (AP301, solnatide) was shown to markedly reduce ... Read more >>

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SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.

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<h4>Background</h4>Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling.<h4>Methods</h4>The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an ... Read more >>

Br J Surg (The British journal of surgery)
[2021, :]

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[Perioperative Anesthesiologic Management: Risk Assessment and Preoperative Improvement of Patient Conditions].

Elisabeth Ellinger, Patrick Meybohm, Daniel Röder,

With patient safety being anesthesiologists' top priority, the focus of preoperative assessment must be to reduce perioperative morbidity and mortality of each patient entrusted to us. Perioperative risk is multifactorial and depends on the extent of surgery and the preoperative condition of the patient.The three main causes of unexpected perioperative ... Read more >>

Anasthesiol Intensivmed Notfallmed Schmerzther (Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS)
[2021, 56(3):159-173]

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Frailty is associated with long-term outcome in patients with sepsis who are over 80 years old: results from an observational study in 241 European ICUs.

Lenneke E M Haas, Ariane Boumendil, Hans Flaatten, Bertrand Guidet, Mercedes Ibarz, Christian Jung, Rui Moreno, Alessandro Morandi, Finn H Andersen, Tilemachos Zafeiridis, Sten Walther, Sandra Oeyen, Susannah Leaver, Ximena Watson, Carole Boulanger, Wojciech Szczeklik, Joerg C Schefold, Maurizio Cecconi, Brian Marsh, Michael Joannidis, Yuriy Nalapko, Muhammed Elhadi, Jesper Fjølner, Antonio Artigas, Dylan W de Lange, ,

<h4>Background</h4>Sepsis is one of the most frequent reasons for acute intensive care unit (ICU) admission of very old patients and mortality rates are high. However, the impact of pre-existing physical and cognitive function on long-term outcome of ICU patients ≥ 80 years old (very old intensive care patients (VIPs)) with sepsis is unclear.<h4>Objective</h4>To ... Read more >>

Age Ageing (Age and ageing)
[2021, :]

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Feasibility and beneficial effects of an early goal directed therapy after cardiac arrest: evaluation by conductance method.

Ole Broch, Lars Hummitzsch, Jochen Renner, Patrick Meybohm, Martin Albrecht, Peter Rosenthal, Ann-Christine Rosenthal, Markus Steinfath, Berthold Bein, Matthias Gruenewald,

Although beneficial effects of an early goal directed therapy (EGDT) after cardiac arrest and successful return of spontaneous circulation (ROSC) have been described, clinical implementation in this period seems rather difficult. The aim of the present study was to investigate the feasibility and the impact of EGDT on myocardial damage ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):5326]

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Vitamin D deficiency in critically ill COVID-19 ARDS patients.

Quirin Notz, Johannes Herrmann, Tobias Schlesinger, Peter Kranke, Magdalena Sitter, Philipp Helmer, Jan Stumpner, Daniel Roeder, Karin Amrein, Christian Stoppe, Christopher Lotz, Patrick Meybohm,

<h4>Background & aims</h4>Vitamin D's pleiotropic effects include immune modulation, and its supplementation has been shown to prevent respiratory tract infections. The effectivity of vitamin D as a therapeutic intervention in critical illness remains less defined. The current study analyzed clinical and immunologic effects of vitamin D levels in patients suffering ... Read more >>

Clin Nutr (Clinical nutrition (Edinburgh, Scotland))
[2021, :]

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COVID-19 and the kidney: A retrospective analysis of 37 critically ill patients using machine learning

Anna Laura Herzog, Holger Jouanne-Diedrich, Christoph Wanner, Dirk Weismann, Tobias Schlesinger, Patrick Meybohm, Jan Stumpner,

<h4>Introduction: </h4> There is evidence that SARS-CoV2 has a particular affinity for kidney tissue and is often associated with kidney failure. <h4>Methods: </h4> We assessed whether proteinuria can be predictive of kidney failure, the development of chronic kidney disease, and mortality in 37 critically ill COVID-19 patients. We used machine ... Read more >>

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Managing CBRN Mass Casualty Incidents at Hospitals - Find a Simple Solution for a Complex Problem: a Pilot Study

Maximilian Kippnich, Nora Schorscher, Helmut Sattler, Uwe Kippnich, Patrick Meybohm, Thomas Wurmb,

<h4>Background: </h4> Chemical, Biological or Radio-nuclear (CBRN) incidents are a major challenge for emergency medical services and the involved hospitals. The challenge becomes even greater, if decontamination needs to be performed nearby or even within the hospital campus. To be prepared for such scenarios, the University Hospital Wuerzburg has developed ... Read more >>

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[Prehospital and In-hospital Concepts for Disaster Response and Preparedness].

Maximilian Kippnich, Patrick Meybohm, Thomas Wurmb,

Disaster medicine faces complex challenges and will play an increasing role in the future. Disaster medicine is dominated by a phased imbalance of available and required resources. Various factors, such as a possible hazard for the rescue forces, inaccessible terrain or even destroyed infrastructure increase the complexity enormously. For casualties, ... Read more >>

Anasthesiol Intensivmed Notfallmed Schmerzther (Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS)
[2021, 56(2):111-123]

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The association between intraoperative cell salvage and red blood cell transfusion in cardiac surgery - an observational study in a patient blood management centre.

Vanessa Neef, Linda Vo, Eva Herrmann, Chris Triphaus, Leonie Judd, Andreas Winter, Kai Zacharowski, Suma Choorapoikayil, Patrick Meybohm,

<h4>Introduction</h4>Cell salvage (CS) is an integral part of patient blood management (PBM) and aims to reduce allogeneic red blood cell (RBC) transfusion.<h4>Material and methods</h4>This observational study analysed patients scheduled for elective cardiac surgery requiring cardiopulmonary bypass (CPB) between November 2015 and October 2018. Patients were divided into a CS group (patients ... Read more >>

Anaesthesiol Intensive Ther (Anaesthesiology intensive therapy)
[2021, 53(1):1-9]

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Audit of international intraoperative hemotherapy and blood loss documentation on anesthetic records.

Florian Piekarski, George Zhong, Vanessa Neef, Jan Kloka, Florian Wunderer, Patrick Meybohm, Kai Zacharowski, Florian J Raimann,

<h4>Background</h4>Anesthetic records facilitate information transmission to the next healthcare professional and should contain all relevant information of perioperative care. While most anesthesia societies provide guidelines for record content, important topics like hemotherapy and hemostatic therapy are not well represented. We considered the quality of anesthetic records with regard to the ... Read more >>

Minerva Anestesiol (Minerva anestesiologica)
[2021, 87(3):312-318]

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[Placebo Effect - The Benefit of "Nothingness" in Pain Therapy].

Ann-Kristin Reinhold, Patrick Meybohm, Peter Kranke,

For a long time considered ineffective, placebos nowadays have an accepted role in studies as well as clinical practice. The identification of psychological as well as neurophysiological mechanisms helped to conceptualize and legitimize the placebo effect. Moreover, studies have even proven a therapeutic value. Consequently, the benefits of a thoughtfully ... Read more >>

Dtsch Med Wochenschr (Deutsche medizinische Wochenschrift (1946))
[2020, 145(25):1861-1866]

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Do Small Incisions Need Only Minimal Anesthesia?-Anesthetic Management in Laparoscopic and Robotic Surgery.

Sebastian Hottenrott, Tobias Schlesinger, Philipp Helmer, Patrick Meybohm, Ibrahim Alkatout, Peter Kranke,

Laparoscopic techniques have established themselves as a major part of modern surgery. Their implementation in every surgical discipline has played a vital part in the reduction of perioperative morbidity and mortality. Precise robotic surgery, as an evolution of this, is shaping the present and future operating theatre that an anesthetist ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(12):]

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COVID-19 Induced Acute Respiratory Distress Syndrome-A Multicenter Observational Study.

Johannes Herrmann, Elisabeth Hannah Adam, Quirin Notz, Philipp Helmer, Michael Sonntagbauer, Peter Ungemach-Papenberg, Andreas Sanns, York Zausig, Thorsten Steinfeldt, Iuliu Torje, Benedikt Schmid, Tobias Schlesinger, Caroline Rolfes, Christian Reyher, Markus Kredel, Jan Stumpner, Alexander Brack, Thomas Wurmb, Daniel Gill-Schuster, Peter Kranke, Dirk Weismann, Hartwig Klinker, Peter Heuschmann, Viktoria Rücker, Stefan Frantz, Georg Ertl, Ralf Michael Muellenbach, Haitham Mutlak, Patrick Meybohm, Kai Zacharowski, Christopher Lotz,

<b>Background:</b> Proportions of patients dying from the coronavirus disease-19 (COVID-19) vary between different countries. We report the characteristics; clinical course and outcome of patients requiring intensive care due to COVID-19 induced acute respiratory distress syndrome (ARDS). <b>Methods:</b> This is a retrospective, observational multicentre study in five German secondary or tertiary ... Read more >>

Front Med (Lausanne) (Frontiers in medicine)
[2020, 7:599533]

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Nulla Per Os (NPO) guidelines: time to revisit?

Sabine Friedrich, Patrick Meybohm, Peter Kranke,

<h4>Purpose of review</h4>Preoperative fasting guidelines are generalized to elective procedures and usually do not distinguish between the ambulatory and inpatient setting. Prevalence of aspiration is low while prolonged preoperative fasting is common clinical reality. Recently, changes in preoperative fasting guidelines have been widely discussed.<h4>Recent findings</h4>Rates of prolonged clear fluid fasting ... Read more >>

Curr Opin Anaesthesiol (Current opinion in anaesthesiology)
[2020, 33(6):740-745]

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Effects of inhaled nitric oxide in COVID-19-induced ARDS - Is it worthwhile?

Christopher Lotz, Ralf M Muellenbach, Patrick Meybohm, Haitham Mutlak, Philipp M Lepper, Caroline-Barbara Rolfes, Asghar Peivandi, Jan Stumpner, Markus Kredel, Peter Kranke, Iuliu Torje, Christian Reyher,

<h4>Background</h4>Changes in pulmonary hemodynamics and ventilation/perfusion were proposed as hallmarks of Coronavirus disease 2019 (COVID-19)-induced acute respiratory distress syndrome (ARDS). Inhaled nitric oxide (iNO) may overcome these issues and improve arterial oxygenation.<h4>Methods</h4>We retrospectively analyzed arterial oxygenation and pulmonary vasoreactivity in seven COVID-19 ARDS patients receiving 20 ppm iNO for 15-30 minutes.<h4>Results</h4>The inhalation ... Read more >>

Acta Anaesthesiol Scand (Acta anaesthesiologica Scandinavica)
[2021, 65(5):629-632]

Cited: 2 times

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Physicians' Perceptions of a Situation Awareness-Oriented Visualization Technology for Viscoelastic Blood Coagulation Management (Visual Clot): Mixed Methods Study.

Tadzio Raoul Roche, Sadiq Said, Julian Rössler, Malgorzata Gozdzik, Patrick Meybohm, Kai Zacharowski, Donat R Spahn, Christoph B Nöthiger, David W Tscholl,

<h4>Background</h4>Viscoelastic tests enable a time-efficient analysis of coagulation properties. An important limitation of viscoelastic tests is the complicated presentation of their results in the form of abstract graphs with a multitude of numbers. We developed Visual Clot to simplify the interpretation of presented clotting information. This visualization technology applies user-centered ... Read more >>

JMIR Serious Games (JMIR serious games)
[2020, 8(4):e19036]

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