Full Text Journal Articles by
Author Patrick Melchior

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Outcome of Stage IV Completely Necrotic Wilms Tumour and Local Stage III Treated According to the SIOP 2001 Protocol.

Raquel Dávila Fajardo, Rhoikos Furtwängler, Martine van Grotel, Harm van Tinteren, Claudia Pasqualini, Kathy Pritchard-Jones, Reem Al-Saadi, Beatriz de Camargo, Gema L Ramírez Villar, Norbert Graf, Xavier Muracciole, Patrick Melchior, Daniel Saunders, Christian Rübe, Marry M van den Heuvel-Eibrink, Geert O Janssens, Arnauld C Verschuur,

<h4>Objective</h4>Wilms tumour (WT) patients with a localised completely necrotic nephroblastoma after preoperative chemotherapy are a favourable outcome group. Since the introduction of the SIOP 2001 protocol, the SIOP- Renal Tumour Study Group (SIOP-RTSG) has omitted radiotherapy for such patients with low-risk, local stage III in an attempt to reduce treatment ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(5):]

Cited: 0 times

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Inter-clinician delineation variation for a new highly-conformal flank target volume in children with renal tumors: A SIOP-Renal Tumor Study Group international multicenter exercise.

Joeri Mul, Patrick Melchior, Enrica Seravalli, Daniel Saunders, Stephanie Bolle, Alison L Cameron, Kristin Gurtner, Semi Harrabi, Yasmin Lassen-Ramshad, Naomi Lavan, Henriette Magelssen, Henry Mandeville, Tom Boterberg, Petra S Kroon, Alexis N T J Kotte, Bianca A W Hoeben, Peter S N van Rossum, Martine van Grotel, Norbert Graf, Marry M van den Heuvel-Eibrink, Christian Rübe, Geert O Janssens,

<h4>Background and purpose</h4>Recently, the SIOP-RTSG developed a highly-conformal flank target volume definition for children with renal tumors. The aims of this study were to evaluate the inter-clinician delineation variation of this new target volume definition in an international multicenter setting and to explore the necessity of quality assurance.<h4>Materials and methods</h4>Six ... Read more >>

Clin Transl Radiat Oncol (Clinical and translational radiation oncology)
[2021, 28:39-47]

Cited: 1 time

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The SIOP-Renal Tumour Study Group consensus statement on flank target volume delineation for highly conformal radiotherapy.

Geert O Janssens, Patrick Melchior, Joeri Mul, Daniel Saunders, Stephanie Bolle, Alison L Cameron, Line Claude, Kristin Gurtner, Kees P van de Ven, Martine van Grotel, Semi Harrabi, Yasmin Lassen-Ramshad, Naomi Lavan, Henriette Magelssen, Xavier Muracciole, Tom Boterberg, Henry Mandeville, Jan Godzinski, Norbert Graf, Marry M van den Heuvel-Eibrink, Christian Rübe,

For decades, radiotherapy with two opposing photon beams has been the standard technique used to cover the flank target volume in paediatric patients with renal tumours. Nowadays, many institutes are implementing advanced radiotherapy techniques that spare healthy tissue. To decrease the radiotherapy dose to healthy structures while preserving oncological efficacy, ... Read more >>

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2020, 4(11):846-852]

Cited: 2 times

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Wilms tumor.

Luke Pater, Patrick Melchior, Christian Rübe, Benjamin T Cooper, Mary Fran McAleer, John A Kalapurakal, Arnold C Paulino,

The objectives for the treatment of Wilms tumor in both the Children's Oncology Group (COG) and the International Society of Paediatric Oncology (SIOP) have focused on improving cure rates and minimizing toxicity by limiting the use of radiation and doxorubicin. Although the timing of surgery is different in COG (upfront ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2021, 68 Suppl 2:e28257]

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Clinical and genetic risk factors define two risk groups of extracranial malignant rhabdoid tumours (eMRT/RTK).

Karolina Nemes, Susanne Bens, Denis Kachanov, Margarita Teleshova, Peter Hauser, Thorsten Simon, Stephan Tippelt, Wilhelm Woessmann, Olaf Beck, Christian Flotho, Lorenz Grigull, Pablo H Driever, Paul-Gerhardt Schlegel, Claudia Khurana, Kathrin Hering, Reinhard Kolb, Alfred Leipold, Floor Abbink, Maria J Gil-Da-Costa, Martin Benesch, Kornelius Kerl, Stephen Lowis, Carmen H Marques, Norbert Graf, Karsten Nysom, Christian Vokuhl, Patrick Melchior, Thomas Kröncke, Reinhard Schneppenheim, Uwe Kordes, Joachim Gerss, Reiner Siebert, Rhoikos Furtwängler, Michael C Frühwald,

<h4>Introduction</h4>Extracranial rhabdoid tumours are rare, highly aggressive malignancies primarily affecting young children. The EU-RHAB registry was initiated in 2009 to prospectively collect data of rhabdoid tumour patients treated according to the EU-RHAB therapeutic framework.<h4>Methods</h4>We evaluated 100 patients recruited within EU-RHAB (2009-2018). Tumours and matching blood samples were examined for SMARCB1 ... Read more >>

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2021, 142:112-122]

Cited: 1 time

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Local Stage Dependent Necessity of Radiation Therapy in Rhabdoid Tumors of the Kidney (RTK).

Patrick Melchior, Yvonne Dzierma, Christian Rübe, Norbert Graf, Leo Kager, Karin Dieckmann, Sabine Kroiss, Jochen Hubertus, Steven Warmann, Jens-Peter Schenk, Ivo Leuschner, Karolina Nemes, Clemens Magnus Meier, Christian Vokuhl, Michael Frühwald, Rhoikos Furtwängler,

<h4>Purpose</h4>Rhabdoid tumor of the kidney (RTK) is one of the most aggressive childhood renal tumors. Overall survival ranges from 22% to 47%. The indication for radiation therapy (RT) in usually very young patients is an ongoing discussion. Recent protocols recommend RT independent of local stage, the latter being a good ... Read more >>

Int J Radiat Oncol Biol Phys (International journal of radiation oncology, biology, physics)
[2020, 108(3):667-675]

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Outcome of patients with stage IV high-risk Wilms tumour treated according to the SIOP2001 protocol: A report of the SIOP Renal Tumour Study Group.

Claudia Pasqualini, Rhoikos Furtwängler, Harm van Tinteren, Roberto A P Teixeira, Tomas Acha, Lisa Howell, Gordan Vujanic, Jan Godzinski, Patrick Melchior, Anne M Smets, Aurore Coulomb-L'Hermine, Hervé Brisse, Kathy Pritchard-Jones, Christophe Bergeron, Beatriz de Camargo, Marry M van den Heuvel-Eibrink, Norbert Graf, Arnauld C Verschuur,

INTRODUCTION:High-risk (HR) metastatic (stage IV) Wilms tumours (WTs) have a particular poor outcome. METHODS:Here, we report the results of HR (diffuse anaplastic [DA] or blastemal type [BT]) stage IV WT treated patients according to the HR arm in the SIOP2001 prospective study. RESULTS:From January 2002 to August 2014, 3559 patients ... Read more >>

Eur J Cancer (European journal of cancer (Oxford, England : 1990))
[2020, 128:38-46]

Cited: 1 time

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Randomized phase-III-trial of concurrent chemoradiation for locally advanced head and neck cancer comparing dose reduced radiotherapy with paclitaxel/cisplatin to standard radiotherapy with fluorouracil/cisplatin: The PacCis-trial.

Rainer Fietkau, Markus Hecht, Benjamin Hofner, Dorota Lubgan, Heinrich Iro, Olaf Gefeller, Claus Rödel, Matthias G Hautmann, Oliver Kölbl, Attila Salay, Christian Rübe, Patrick Melchior, Peter Breinl, Waldemar Krings, Stephan Gripp, Barbara Wollenberg, Rainer Keerl, Ulrike Schreck, Birgit Siekmeyer, Gerhard G Grabenbauer, Panagiotis Balermpas, ,

<h4>Background and purpose</h4>This multicenter, phase 3 trial investigates whether the incorporation of concurrent paclitaxel and cisplatin together with a reduced total dose of radiotherapy is superior to standard fluorouracil-cisplatin based CRT.<h4>Materials and methods</h4>Patients with SCCHN, stage III-IVB, were randomized to receive paclitaxel/cisplatin (PacCis)-CRT (arm A; paclitaxel 20 mg/m<sup>2</sup> on days 2, ... Read more >>

Radiother Oncol (Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology)
[2020, 144:209-217]

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Therapy of isolated locoregional recurrent carcinoma of the breast.

Lena Gabriel, Marina Schmidt, Stephanie Juhasz-Böss, Patrick Melchior, Anika von Heesen, Gilda Schmidt, Nicole Kranzhöfer, Erich-Franz Solomayer, Ingolf Juhasz-Böss, Georg-Peter Breitbach,

<h4>Purpose</h4>There is widespread consent that isolated locoregional recurrence (ILRR) in breast cancer should be treated surgically. On searching literature and guidelines most studies include ipsilateral recurrence in breast tissue or on thoracic wall post-mastectomy, recurrence in scar tissue as well as in ipsilateral axillary lymph nodes. Some studies discuss metachronous contralateral ... Read more >>

Arch Gynecol Obstet (Archives of gynecology and obstetrics)
[2019, 300(2):365-376]

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High-dose treatment for malignant rhabdoid tumor of the kidney: No evidence for improved survival-The Gesellschaft für Pädiatrische Onkologie und Hämatologie (GPOH) experience.

Rhoikos Furtwängler, Leo Kager, Patrick Melchior, Christian Rübe, Martin Ebinger, Nasenien Nourkami-Tutdibi, Felix Niggli, Steven Warmann, Jochen Hubertus, Gabriele Amman, Ivo Leuschner, Christian Vokuhl, Norbert Graf, Michael C Frühwald,

<h4>Background</h4>Malignant rhabdoid tumor of the kidney (MRTK) is the most aggressive childhood renal tumor with overall survival (OS) rates ranging from 22% to 42%. Whether high-dose chemotherapy with autologous stem-cell transplantation (HDSCT) in an intensive first-line treatment offers additional benefit is an ongoing discussion.<h4>Methods</h4>A retrospective analysis of all 58 patients ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2018, 65(1):]

Cited: 2 times

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Comparative planning of flattening-filter-free and flat beam IMRT for hypopharynx cancer as a function of beam and segment number.

Yvonne Dzierma, Frank G Nuesken, Jochen Fleckenstein, Patrick Melchior, Norbert P Licht, Christian Rübe,

Although highly conformal dose distributions can be achieved by IMRT planning, this often requires a large number of segments or beams, resulting in increased treatment times. While flattening-filter-free beams offer a higher dose rate, even more segments may be required to create homogeneous target coverage. Therefore, it is worthwhile to ... Read more >>

PLoS One (PloS one)
[2014, 9(4):e94371]

Cited: 4 times

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The impact of individual in vivo repair of DNA double-strand breaks on oral mucositis in adjuvant radiotherapy of head-and-neck cancer.

Jochen Fleckenstein, Martin Kühne, Katharina Seegmüller, Sarah Derschang, Patrick Melchior, Stefan Gräber, Andreas Fricke, Claudia E Rübe, Christian Rübe,

<h4>Purpose</h4>To evaluate the impact of individual in vivo DNA double-strand break (DSB) repair capacity on the incidence of severe oral mucositis in patients with head-and-neck cancer undergoing adjuvant radiotherapy (RT) or radiochemotherapy (RCT).<h4>Patients and methods</h4>Thirty-one patients with resected head-and-neck cancer undergoing adjuvant RT or RCT were examined. Patients underwent RT ... Read more >>

Int J Radiat Oncol Biol Phys (International journal of radiation oncology, biology, physics)
[2011, 81(5):1465-1472]

Cited: 24 times

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