Full Text Journal Articles by
Author Patricia R M Rocco

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Immunomodulators in anesthesia.

Fernanda F Cruz, Patricia R M Rocco, Paolo Pelosi,

<h4>Purpose of review</h4>Anesthetics are known to have immunomodulatory effects. These can be detrimental, inducing immunosuppression and facilitating the development of opportunistic infections, especially when used at high doses, for prolonged periods, or in patients with preexisting immune deficiency; or beneficial, modulating the inflammatory response, particularly in critical illness and systemic ... Read more >>

Curr Opin Anaesthesiol (Current opinion in anaesthesiology)
[2021, 34(3):357-363]

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Ten things you need to know about intensive care unit management of mechanically ventilated patients with COVID-19.

Chiara Robba, Denise Battaglini, Lorenzo Ball, Paolo Pelosi, Patricia R M Rocco,

<b>Introduction:</b> The ongoing pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has posed important challenges for clinicians and health-care systems worldwide.<b>Areas covered:</b> The aim of this manuscript is to provide brief guidance for intensive care unit management of mechanically ventilated patients with COVID-19 based on the literature and our ... Read more >>

Expert Rev Respir Med (Expert review of respiratory medicine)
[2021, :1-10]

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Healthy versus inflamed lung environments differentially effect MSCs.

Sara Rolandsson Enes, Thomas H Hampton, Jayita Barua, David H McKenna, Claudia C Dos Santos, Eyal Amiel, Alix Ashare, Kathleen D Liu, Anna D Krasnodembskaya, Karen English, Bruce A Stanton, Patricia R M Rocco, Michael A Matthay, Daniel J Weiss,

<h4>Background</h4>Despite increased interest in MSC-based cell therapies for the acute respiratory distress syndrome (ARDS), clinical investigations have not yet been successful and understanding of the potential <i>in vivo</i> mechanisms of MSC actions in ARDS remain limited. ARDS is driven by an acute severe innate immune dysregulation, often characterised by inflammation, ... Read more >>

Eur Respir J (The European respiratory journal)
[2021, :]

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Early effects of ventilatory rescue therapies on systemic and cerebral oxygenation in mechanically ventilated COVID-19 patients with acute respiratory distress syndrome: a prospective observational study.

Chiara Robba, Lorenzo Ball, Denise Battaglini, Danilo Cardim, Emanuela Moncalvo, Iole Brunetti, Matteo Bassetti, Daniele R Giacobbe, Antonio Vena, Nicolò Patroniti, Patricia R M Rocco, Basil F Matta, Paolo Pelosi, ,

<h4>Background</h4>In COVID-19 patients with acute respiratory distress syndrome (ARDS), the effectiveness of ventilatory rescue strategies remains uncertain, with controversial efficacy on systemic oxygenation and no data available regarding cerebral oxygenation and hemodynamics.<h4>Methods</h4>This is a prospective observational study conducted at San Martino Policlinico Hospital, Genoa, Italy. We included adult COVID-19 patients ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):111]

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Computed tomography assessment of PEEP-induced alveolar recruitment in patients with severe COVID-19 pneumonia.

Lorenzo Ball, Chiara Robba, Lorenzo Maiello, Jacob Herrmann, Sarah E Gerard, Yi Xin, Denise Battaglini, Iole Brunetti, Giuseppe Minetti, Sara Seitun, Antonio Vena, Daniele Roberto Giacobbe, Matteo Bassetti, Patricia R M Rocco, Maurizio Cereda, Lucio Castellan, Nicolò Patroniti, Paolo Pelosi, ,

<h4>Background</h4>There is a paucity of data concerning the optimal ventilator management in patients with COVID-19 pneumonia; particularly, the optimal levels of positive-end expiratory pressure (PEEP) are unknown. We aimed to investigate the effects of two levels of PEEP on alveolar recruitment in critically ill patients with severe COVID-19 pneumonia.<h4>Methods</h4>A single-center ... Read more >>

Crit Care (Critical care (London, England))
[2021, 25(1):81]

Cited: 1 time

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Impact of positive biphasic pressure during low and high inspiratory efforts in Pseudomonas aeruginosa-induced pneumonia.

Daniela G da Cruz, Raquel F de Magalhães, Gisele A Padilha, Mariana C da Silva, Cassia L Braga, Adriana R Silva, Cassiano F Gonçalves de Albuquerque, Vera L Capelozzi, Cynthia S Samary, Paolo Pelosi, Patricia R M Rocco, Pedro L Silva,

<h4>Background</h4>During pneumonia, normal alveolar areas coexist adjacently with consolidated areas, and high inspiratory efforts may predispose to lung damage. To date, no study has evaluated different degrees of effort during Biphasic positive airway pressure (BIVENT) on lung and diaphragm damage in experimental pneumonia, though largely used in clinical setting. We ... Read more >>

PLoS One (PloS one)
[2021, 16(2):e0246891]

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Early use of nitazoxanide in mild Covid-19 disease: randomised, placebo-controlled trial.

Patricia R M Rocco, Pedro L Silva, Fernanda F Cruz, Marco Antonio C M Junior, Paulo F G M M Tierno, Marcos A Moura, Luís Frederico G De Oliveira, Cristiano C Lima, Ezequiel A Dos Santos, Walter F Junior, Ana Paula S M Fernandes, Kleber G Franchini, Erick Magri, Nara F de Moraes, José Mário J Gonçalves, Melanie N Carbonieri, Ivonise S Dos Santos, Natália F Paes, Paula V M Maciel, Raissa P Rocha, Alex F de Carvalho, Pedro Augusto Alves, José Luiz P Modena, Artur T Cordeiro, Daniela B B Trivella, Rafael E Marques, Ronir R Luiz, Paolo Pelosi, Jose Roberto Lapa E Silva, ,

Nitazoxanide is widely available and exerts broad-spectrum antiviral activity <i>in vitro</i> However, there is no evidence of its impact on SARS-CoV-2 infection.In a multicenter, randomised, double-blind, placebo-controlled trial, adult patients presenting up to 3 days after onset of Covid-19 symptoms (dry cough, fever, and/or fatigue) were enrolled. After confirmation of SARS-CoV2 ... Read more >>

Eur Respir J (The European respiratory journal)
[2021, :]

Cited: 8 times

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Coagulative Disorders in Critically Ill COVID-19 Patients with Acute Distress Respiratory Syndrome: A Critical Review.

Chiara Robba, Denise Battaglini, Lorenzo Ball, Alberto Valbusa, Italo Porto, Roberta Della Bona, Giovanni La Malfa, Nicolò Patroniti, Iole Brunetti, Maurizio Loconte, Matteo Bassetti, Daniele R Giacobbe, Antonio Vena, Claudia Lucia M Silva, Patricia R M Rocco, Paolo Pelosi,

In critically ill patients with acute respiratory distress syndrome (ARDS) coronavirus disease 2019 (COVID-19), a high incidence of thromboembolic and hemorrhagic events is reported. COVID-19 may lead to impairment of the coagulation cascade, with an imbalance in platelet function and the regulatory mechanisms of coagulation and fibrinolysis. Clinical manifestations vary ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(1):]

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Time-Controlled Adaptive Ventilation Versus Volume-Controlled Ventilation in Experimental Pneumonia.

Raquel F de Magalhães, Daniela G Cruz, Mariana A Antunes, Marcos V de S Fernandes, Milena V Oliveira, Cassia L Braga, Joshua Satalin, Penny Andrews, Nader Habashi, Gary Nieman, Cassiano F Gonçalves de-Albuquerque, Adriana R Silva, Roseli V Ribeiro, Vera L Capelozzi, Fernanda F Cruz, Cynthia Dos S Samary, Patricia R M Rocco, Pedro L Silva,

<h4>Objectives</h4>We hypothesized that a time-controlled adaptive ventilation strategy would open and stabilize alveoli by controlling inspiratory and expiratory duration. Time-controlled adaptive ventilation was compared with volume-controlled ventilation at the same levels of mean airway pressure and positive end-release pressure (time-controlled adaptive ventilation)/positive end-expiratory pressure (volume-controlled ventilation) in a Pseudomonas aeruginosa-induced ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(1):140-150]

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Ischaemic stroke-induced distal organ damage: pathophysiology and new therapeutic strategies.

Chiara Robba, Denise Battaglini, Cynthia S Samary, Pedro L Silva, Lorenzo Ball, Patricia R M Rocco, Paolo Pelosi,

Acute ischaemic stroke is associated with a high risk of non-neurological complications, which include respiratory failure, cardiovascular dysfunction, kidney and liver injury, and altered immune and endocrine function. The aim of this manuscript is to provide an overview of the main forms of stroke-induced distal organ damage, providing new pathophysiological ... Read more >>

Intensive Care Med Exp (Intensive care medicine experimental)
[2020, 8(Suppl 1):23]

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Fluids in ARDS: more pros than cons.

Renata de S Mendes, Paolo Pelosi, Marcus J Schultz, Patricia R M Rocco, Pedro L Silva,

In acute respiratory distress syndrome (ARDS), increased pulmonary vascular permeability makes the lung vulnerable to edema. The use of conservative as compared to liberal fluid strategies may increase the number of ventilator-free days and survival, as well as reduce organ dysfunction. Monitoring the effects of fluid administration is of the ... Read more >>

Intensive Care Med Exp (Intensive care medicine experimental)
[2020, 8(Suppl 1):32]

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Comparative effects of neurally adjusted ventilatory assist and variable pressure support on lung and diaphragmatic function in a model of acute respiratory distress syndrome: A randomised animal study.

Martin Scharffenberg, Lillian Moraes, Andreas Güldner, Robert Huhle, Anja Braune, Ines Zeidler-Rentzsch, Michael Kasper, Christiane Kunert-Keil, Thea Koch, Paolo Pelosi, Patricia R M Rocco, Marcelo Gama de Abreu, Thomas Kiss,

<h4>Background</h4>Variable assisted mechanical ventilation has been shown to improve lung function and reduce lung injury. However, differences between extrinsic and intrinsic variability are unknown.<h4>Objective</h4>To investigate the effects of neurally adjusted ventilatory assist (NAVA, intrinsic variability), variable pressure support ventilation (Noisy PSV, extrinsic variability) and conventional pressure-controlled ventilation (PCV) on lung ... Read more >>

Eur J Anaesthesiol (European journal of anaesthesiology)
[2021, 38(1):32-40]

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Effects of higher PEEP and recruitment manoeuvres on mortality in patients with ARDS: a systematic review, meta-analysis, meta-regression and trial sequential analysis of randomized controlled trials.

Lorenzo Ball, Ary Serpa Neto, Valeria Trifiletti, Maura Mandelli, Iacopo Firpo, Chiara Robba, Marcelo Gama de Abreu, Marcus J Schultz, Nicolò Patroniti, Patricia R M Rocco, Paolo Pelosi, ,

<h4>Purpose</h4>In patients with acute respiratory distress syndrome (ARDS), lung recruitment could be maximised with the use of recruitment manoeuvres (RM) or applying a positive end-expiratory pressure (PEEP) higher than what is necessary to maintain minimal adequate oxygenation. We aimed to determine whether ventilation strategies using higher PEEP and/or RMs could ... Read more >>

Intensive Care Med Exp (Intensive care medicine experimental)
[2020, 8(Suppl 1):39]

Cited: 2 times

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Escalate and De-Escalate Therapies for Intracranial Pressure Control in Traumatic Brain Injury.

Denise Battaglini, Pasquale Anania, Patricia R M Rocco, Iole Brunetti, Alessandro Prior, Gianluigi Zona, Paolo Pelosi, Pietro Fiaschi,

Severe traumatic brain injury (TBI) is frequently associated with an elevation of intracranial pressure (ICP), followed by cerebral perfusion pressure (CPP) reduction. Invasive monitoring of ICP is recommended to guide a step-by-step "staircase approach" which aims to normalize ICP values and reduce the risks of secondary damage. However, if such ... Read more >>

Front Neurol (Frontiers in neurology)
[2020, 11:564751]

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Protective function of DJ-1/PARK7 in lipopolysaccharide and ventilator-induced acute lung injury.

Hajera Amatullah, Tatiana Maron-Gutierrez, Yuexin Shan, Sahil Gupta, James N Tsoporis, Amir K Varkouhi, Ana Paula Teixeira Monteiro, Xiaolin He, Jun Yin, John C Marshall, Patricia R M Rocco, Haibo Zhang, Wolfgang M Kuebler, Claudia C Dos Santos,

Oxidative stress is considered one of the early underlying contributors of acute lung injury (ALI) and ventilator-induced lung injury (VILI). DJ-1, also known as PARK7, has a well-established role as an antioxidant. We have previously shown maintaining oxidative balance via the ATF3-Nrf2 axis was important in protection from ALI. Here, ... Read more >>

Redox Biol (Redox biology)
[2021, 38:101796]

Cited: 1 time

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Differential effects of the cystic fibrosis lung inflammatory environment on mesenchymal stromal cells.

Soraia C Abreu, Thomas H Hampton, Evan Hoffman, Jacob Dearborn, Alix Ashare, Karatatiwant Singh Sidhu, Dwight E Matthews, David H McKenna, Eyal Amiel, Jayita Barua, Anna Krasnodembskaya, Karen English, Bernard Mahon, Claudia Dos Santos, Fernanda F Cruz, Daniel C Chambers, Kathleen D Liu, Michael A Matthay, Robert A Cramer, Bruce A Stanton, Patricia R M Rocco, Matthew J Wargo, Daniel J Weiss, Sara Rolandsson Enes,

Growing evidence demonstrates that human mesenchymal stromal cells (MSCs) modify their in vivo anti-inflammatory actions depending on the specific inflammatory environment encountered. Understanding this better is crucial to refine MSC-based cell therapies for lung and other diseases. Using acute exacerbations of cystic fibrosis (CF) lung disease as a model, the ... Read more >>

Am J Physiol Lung Cell Mol Physiol (American journal of physiology. Lung cellular and molecular physiology)
[2020, 319(6):L908-L925]

Cited: 0 times

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Iso-Oncotic Albumin Mitigates Brain and Kidney Injury in Experimental Focal Ischemic Stroke.

Renata de S Mendes, Gloria Martins, Milena V Oliveira, Nazareth N Rocha, Fernanda F Cruz, Mariana A Antunes, Soraia C Abreu, Adriana L Silva, Christina Takiya, Pedro M Pimentel-Coelho, Chiara Robba, Rosália Mendez-Otero, Paolo Pelosi, Patricia R M Rocco, Pedro L Silva,

<b>Background:</b> There is widespread debate regarding the use of albumin in ischemic stroke. We tested the hypothesis that an iso-oncotic solution of albumin (5%), administered earlier after acute ischemic stroke (3 h), could provide neuroprotection without causing kidney damage, compared to a hyper-oncotic albumin (20%) and saline. <b>Objective:</b> To compare ... Read more >>

Front Neurol (Frontiers in neurology)
[2020, 11:1001]

Cited: 0 times

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Response to letter to the editor: catastrophic antiphospholipid antibody syndrome and multiple organ dysfunctions in critically ill patients with COVID-19.

Chiara Robba, Denise Battaglini, Paolo Pelosi, Patricia R M Rocco,

Expert Rev Respir Med (Expert review of respiratory medicine)
[2020, 14(11):1073-1074]

Cited: 0 times

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Cell-Free Therapies: Novel Approaches for COVID-19.

Tatiana Maron-Gutierrez, Patricia R M Rocco,

Front Immunol (Frontiers in immunology)
[2020, 11:583017]

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Mesenchymal stromal cells protect against vascular damage and depression-like behavior in mice surviving cerebral malaria.

Maiara N Lima, Helena A Oliveira, Paula M Fagundes, Vanessa Estato, Adriano Y O Silva, Rodrigo J R X Freitas, Beatriz A B R Passos, Karina S Oliveira, Camila N Batista, Adriana L Vallochi, Patricia R M Rocco, Hugo C Castro-Faria-Neto, Tatiana Maron-Gutierrez,

<h4>Background</h4>Malaria is one of the most critical global infectious diseases. Severe systemic inflammatory diseases, such as cerebral malaria, lead to the development of cognitive and behavioral alterations, such as learning disabilities and loss of memory capacity, as well as increased anxiety and depression. The consequences are profound and usually contribute ... Read more >>

Stem Cell Res Ther (Stem cell research & therapy)
[2020, 11(1):367]

Cited: 1 time

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Impact of experimental obesity on diaphragm structure, function, and bioenergetics.

Gisele C Rodrigues, Nazareth N Rocha, Ligia de A Maia, Isabella Melo, Ana Carolina Simões, Mariana A Antunes, Flavia F Bloise, Juliana Woyames, Wagner S da Silva, Vera L Capelozzi, Glenn Paul Abela, Lorenzo Ball, Paolo Pelosi, Patricia R M Rocco, Pedro L Silva,

Obesity is associated with bioenergetic dysfunction of peripheral muscles; however, little is known regarding the impact of obesity on the diaphragm. We hypothesized that obesity would be associated with diaphragm dysfunction attributable to mitochondrial oxygen consumption and structural and ultrastructural changes. Wistar rat litters were culled to 3 pups to ... Read more >>

J Appl Physiol (1985) (Journal of applied physiology (Bethesda, Md. : 1985))
[2020, 129(5):1062-1074]

Cited: 1 time

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Emerging pharmacological therapies for ARDS: COVID-19 and beyond.

Shahd Horie, Bairbre McNicholas, Emanuele Rezoagli, Tài Pham, Ger Curley, Danny McAuley, Cecilia O'Kane, Alistair Nichol, Claudia Dos Santos, Patricia R M Rocco, Giacomo Bellani, John G Laffey,

ARDS, first described in 1967, is the commonest form of acute severe hypoxemic respiratory failure. Despite considerable advances in our knowledge regarding the pathophysiology of ARDS, insights into the biologic mechanisms of lung injury and repair, and advances in supportive care, particularly ventilatory management, there remains no effective pharmacological therapy ... Read more >>

Intensive Care Med (Intensive care medicine)
[2020, 46(12):2265-2283]

Cited: 3 times

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The authors reply.

Maria C Barbosa-Silva, Patricia R M Rocco, Tatiana Maron-Gutierrez,

Crit Care Med (Critical care medicine)
[2020, 48(7):e634-e635]

Cited: 0 times

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Elastic power but not driving power is the key promoter of ventilator-induced lung injury in experimental acute respiratory distress syndrome.

Patricia R M Rocco, Pedro L Silva, Cynthia S Samary, Muhammad K Hayat Syed, John J Marini,

<h4>Background</h4>We dissected total power into its primary components to resolve its relative contributions to tissue damage (VILI). We hypothesized that driving power or elastic (dynamic) power offers more precise VILI risk indicators than raw total power. The relative correlations of these three measures of power with VILI-induced histologic changes and ... Read more >>

Crit Care (Critical care (London, England))
[2020, 24(1):284]

Cited: 1 time

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Multiple organ dysfunction in SARS-CoV-2: MODS-CoV-2.

Chiara Robba, Denise Battaglini, Paolo Pelosi, Patricia R M Rocco,

Expert Rev Respir Med (Expert review of respiratory medicine)
[2020, 14(9):865-868]

Cited: 28 times

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