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Author Patricia Goggin

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Folding of the syncytiotrophoblast basal plasma membrane increases the surface area available for exchange in human placenta.

Stanimir A Tashev, Daisy Parsons, Cameron Hillman, Shelley Harris, Emma M Lofthouse, Patricia Goggin, David S Chatelet, Jane K Cleal, Neil Smyth, Helen Palaiologou, Anton Page, Rohan M Lewis,

<h4>Introduction</h4>The placental syncytiotrophoblast is the primary barrier between the mother and the fetus. To cross the placenta, nutrients and wastes must be transported across the apical microvillous and basal plasma membranes. While the syncytiotrophoblast basal plasma membrane is typically represented as relatively smooth, it has been shown to have invaginations ... Read more >>

Placenta (Placenta)
[2022, 117:57-63]

Cited: 0 times

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Whole genome sequencing in the diagnosis of primary ciliary dyskinesia.

Gabrielle Wheway, N Simon Thomas, Mary Carroll, Janice Coles, Regan Doherty, , Patricia Goggin, Ben Green, Amanda Harris, David Hunt, Claire L Jackson, Jenny Lord, Vito Mennella, James Thompson, Woolf T Walker, Jane S Lucas,

<h4>Background</h4>It is estimated that 1-13% of cases of bronchiectasis in adults globally are attributable to primary ciliary dyskinesia (PCD) but many adult patients with bronchiectasis have not been investigated for PCD. PCD is a disorder caused by mutations in genes required for motile cilium structure or function, resulting in impaired ... Read more >>

BMC Med Genomics (BMC medical genomics)
[2021, 14(1):234]

Cited: 0 times

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3D-Reconstructed Retinal Pigment Epithelial Cells Provide Insights into the Anatomy of the Outer Retina.

Eloise Keeling, David S Chatelet, Nicole Y T Tan, Farihah Khan, Rhys Richards, Thibana Thisainathan, Patricia Goggin, Anton Page, David A Tumbarello, Andrew J Lotery, J Arjuna Ratnayaka,

The retinal pigment epithelium (RPE) is located between the neuroretina and the choroid, and plays a critical role in vision. RPE cells internalise outer segments (OS) from overlying photoreceptors in the daily photoreceptor renewal. Changes to RPE structure are linked with age and retinopathy, which has been described in the ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(21):]

Cited: 2 times

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A Revised Protocol for Culture of Airway Epithelial Cells as a Diagnostic Tool for Primary Ciliary Dyskinesia.

Janice L Coles, James Thompson, Katie L Horton, Robert A Hirst, Paul Griffin, Gwyneth M Williams, Patricia Goggin, Regan Doherty, Peter M Lackie, Amanda Harris, Woolf T Walker, Christopher O'Callaghan, Claire Hogg, Jane S Lucas, Cornelia Blume, Claire L Jackson,

Air-liquid interface (ALI) culture of nasal epithelial cells is a valuable tool in the diagnosis and research of primary ciliary dyskinesia (PCD). Ex vivo samples often display secondary dyskinesia from cell damage during sampling, infection or inflammation confounding PCD diagnostic results. ALI culture enables regeneration of healthy cilia facilitating differentiation ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(11):]

Cited: 9 times

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Pericytes on placental capillaries in terminal villi preferentially cover endothelial junctions in regions furthest away from the trophoblast.

Shelley E Harris, Kate Sh Matthews, Eleni Palaiologou, Stanimir A Tashev, Emma M Lofthouse, Jennifer Pearson-Farr, Patricia Goggin, David S Chatelet, David A Johnston, Maaike Sa Jongen, Anton M Page, Jane K Cleal, Rohan M Lewis,

<h4>Introduction</h4>Pericytes are a common feature in the placental microvasculature but their roles are not well understood. Pericytes may provide physical or endocrine support for endothelium and in some tissues mediate vasoconstriction.<h4>Methods</h4>This study uses serial block-face scanning electron microscopy (SBFSEM) to generate three-dimensional (3D) reconstructions of placental pericytes of the terminal ... Read more >>

Placenta (Placenta)
[2021, 104:1-7]

Cited: 0 times

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Quantitative assessment of dentine mineralization and tubule occlusion by NovaMin and stannous fluoride using serial block face scanning electron microscopy.

Behrad Mahmoodi, Patricia Goggin, Christabel Fowler, Richard B Cook,

Dentine hypersensitivity (DH) is one of the most common dental conditions affecting most adults during their lifetime. Tubule occlusion is a widely accepted method for treating DH. Current in-vitro techniques such as focused ion beam, scanning electron microscopy (SEM), or hydraulic conductance that are used to determine tubule occlusion do ... Read more >>

J Biomed Mater Res B Appl Biomater (Journal of biomedical materials research. Part B, Applied biomaterials)
[2021, 109(5):717-722]

Cited: 0 times

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International consensus guideline for reporting transmission electron microscopy results in the diagnosis of primary ciliary dyskinesia (BEAT PCD TEM Criteria).

Amelia Shoemark, Mieke Boon, Christoph Brochhausen, Zuzanna Bukowy-Bieryllo, Maria M De Santi, Patricia Goggin, Paul Griffin, Richard G Hegele, Robert A Hirst, Margaret W Leigh, Alison Lupton, Karen MacKenney, Heymut Omran, Jean-Claude Pache, Andreia Pinto, Finn P Reinholt, Josep Schroeder, Panayotis Yiallouros, Estelle Escudier, ,

Primary ciliary dyskinesia (PCD) is a heterogeneous genetic condition. European and North American diagnostic guidelines recommend transmission electron microscopy (TEM) as one of a combination of tests to confirm a diagnosis. However, there is no definition of what constitutes a defect or consensus on reporting terminology. The aim of this ... Read more >>

Eur Respir J (The European respiratory journal)
[2020, 55(4):]

Cited: 15 times

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Serial block-face scanning electron microscopy reveals novel intercellular connections in human term placental microvasculature.

Eleni Palaiologou, Patricia Goggin, David S Chatelet, Rodolfo Ribeiro de Souza, Wendy Chiu, Brogan Ashley, Emma M Lofthouse, Bram G Sengers, Christopher Torrens, Anton M Page, Jane K Cleal, Rohan M Lewis,

The placental microvasculature is a conduit for fetal blood allowing solute exchange between the mother and the fetus. Serial block-face scanning electron microscopy (SBF SEM) allows ultrastructure to be viewed in three dimensions and provides a new perspective on placental anatomy. This study used SBF SEM to study endothelial cells ... Read more >>

J Anat (Journal of anatomy)
[2020, 237(2):241-249]

Cited: 4 times

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Clinical features and management of children with primary ciliary dyskinesia in England.

Bruna Rubbo, Sunayna Best, Robert Anthony Hirst, Amelia Shoemark, Patricia Goggin, Siobhan B Carr, Philip Chetcuti, Claire Hogg, Priti Kenia, Jane S Lucas, Eduardo Moya, Manjith Narayanan, Christopher O'Callaghan, Michael Williamson, Woolf Theodore Walker, ,

OBJECTIVE:In England, the National Health Service commissioned a National Management Service for children with primary ciliary dyskinesia (PCD). The aims of this study were to describe the health of children seen in this Service and compare lung function to children with cystic fibrosis (CF). DESIGN:Multi-centre service evaluation of the English ... Read more >>

Arch Dis Child (Archives of disease in childhood)
[2020, 105(8):724-729]

Cited: 6 times

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Clinical utility of NGS diagnosis and disease stratification in a multiethnic primary ciliary dyskinesia cohort.

Mahmoud R Fassad, Mitali P Patel, Amelia Shoemark, Thomas Cullup, Jane Hayward, Mellisa Dixon, Andrew V Rogers, Sarah Ollosson, Claire Jackson, Patricia Goggin, Robert A Hirst, Andrew Rutman, James Thompson, Lucy Jenkins, Paul Aurora, Eduardo Moya, Philip Chetcuti, Chris O'Callaghan, Deborah J Morris-Rosendahl, Christopher M Watson, Robert Wilson, Siobhan Carr, Woolf Walker, Andreia Pitno, Susana Lopes, Heba Morsy, Walaa Shoman, Luisa Pereira, Carolina Constant, Michael R Loebinger, Eddie M K Chung, Priti Kenia, Nisreen Rumman, Nader Fasseeh, Jane S Lucas, Claire Hogg, Hannah M Mitchison,

<h4>Background</h4>Primary ciliary dyskinesia (PCD), a genetically heterogeneous condition enriched in some consanguineous populations, results from recessive mutations affecting cilia biogenesis and motility. Currently, diagnosis requires multiple expert tests.<h4>Methods</h4>The diagnostic utility of multigene panel next-generation sequencing (NGS) was evaluated in 161 unrelated families from multiple population ancestries.<h4>Results</h4>Most (82%) families had affected ... Read more >>

J Med Genet (Journal of medical genetics)
[2020, 57(5):322-330]

Cited: 9 times

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Risk factors for situs defects and congenital heart disease in primary ciliary dyskinesia.

Sunayna Best, Amelia Shoemark, Bruna Rubbo, Mitali P Patel, Mahmoud R Fassad, Mellisa Dixon, Andrew V Rogers, Robert A Hirst, Andrew Rutman, Sarah Ollosson, Claire L Jackson, Patricia Goggin, Simon Thomas, Reuben Pengelly, Thomas Cullup, Eleni Pissaridou, Jane Hayward, Alexandros Onoufriadis, Christopher O'Callaghan, Michael R Loebinger, Robert Wilson, Eddie Mk Chung, Priti Kenia, Victoria L Doughty, Julene S Carvalho, Jane S Lucas, Hannah M Mitchison, Claire Hogg,

Primary ciliary dyskinesia (PCD) is associated with abnormal organ positioning (situs) and congenital heart disease (CHD). This study investigated genotype-phenotype associations in PCD to facilitate risk predictions for cardiac and laterality defects. This retrospective cohort study of 389 UK patients with PCD found 51% had abnormal situs and 25% had ... Read more >>

Thorax (Thorax)
[2019, 74(2):203-205]

Cited: 15 times

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High prevalence of CCDC103 p.His154Pro mutation causing primary ciliary dyskinesia disrupts protein oligomerisation and is associated with normal diagnostic investigations.

Amelia Shoemark, Eduardo Moya, Robert A Hirst, Mitali P Patel, Evelyn A Robson, Jane Hayward, Juliet Scully, Mahmoud R Fassad, William Lamb, Miriam Schmidts, Mellisa Dixon, Ramila S Patel-King, Andrew V Rogers, Andrew Rutman, Claire L Jackson, Patricia Goggin, Bruna Rubbo, Sarah Ollosson, Siobhán Carr, Woolf Walker, Beryl Adler, Michael R Loebinger, Robert Wilson, Andrew Bush, Hywel Williams, Christopher Boustred, Lucy Jenkins, Eamonn Sheridan, Eddie M K Chung, Christopher M Watson, Thomas Cullup, Jane S Lucas, Priti Kenia, Christopher O'Callaghan, Stephen M King, Claire Hogg, Hannah M Mitchison,

<h4>Rationale</h4>Primary ciliary dyskinesia is a genetically heterogeneous inherited condition characterised by progressive lung disease arising from abnormal cilia function. Approximately half of patients have situs inversus. The estimated prevalence of primary ciliary dyskinesia in the UK South Asian population is 1:2265. Early, accurate diagnosis is key to implementing appropriate management ... Read more >>

Thorax (Thorax)
[2018, 73(2):157-166]

Cited: 24 times

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Serial block-face scanning electron microscopy of erythrocytes protruding through the human placental syncytiotrophoblast.

Eleni Palaiologou, Patricia Goggin, David S Chatelet, Emma M Lofthouse, Christopher Torrens, Bram G Sengers, Jane K Cleal, Anton Page, Rohan M Lewis,

The syncytiotrophoblast forms a continuous barrier between the maternal and fetal circulations. Here we present a serial block-face scanning electron microscopy (SBFSEM) study, based on a single image stack, showing pooling of fetal blood underneath a region of stretched syncytiotrophoblast that has become detached from the basement membrane. Erythrocytes are ... Read more >>

J Anat (Journal of anatomy)
[2017, 231(4):634-637]

Cited: 1 time

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Diagnosis of primary ciliary dyskinesia: potential options for resource-limited countries.

Nisreen Rumman, Claire Jackson, Samuel Collins, Patricia Goggin, Janice Coles, Jane S Lucas,

Primary ciliary dyskinesia is a genetic disease of ciliary function leading to chronic upper and lower respiratory tract symptoms. The diagnosis is frequently overlooked because the symptoms are nonspecific and the knowledge about the disease in the primary care setting is poor. Additionally, none of the available tests is accurate ... Read more >>

Eur Respir Rev (European respiratory review : an official journal of the European Respiratory Society)
[2017, 26(143):]

Cited: 8 times

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Diagnostic Methods in Primary Ciliary Dyskinesia.

Jane S Lucas, Tamara Paff, Patricia Goggin, Eric Haarman,

Diagnosing primary ciliary dyskinesia is difficult. With no reference standard, a combination of tests is needed; most tests require expensive equipment and specialist scientists. We review the advances in diagnostic testing over the past hundred years, with emphasis on recent advances. We particularly focus on use of high-speed video analysis, ... Read more >>

Paediatr Respir Rev (Paediatric respiratory reviews)
[2016, 18:8-17]

Cited: 13 times

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Accuracy of diagnostic testing in primary ciliary dyskinesia.

Claire L Jackson, Laura Behan, Samuel A Collins, Patricia M Goggin, Elizabeth C Adam, Janice L Coles, Hazel J Evans, Amanda Harris, Peter Lackie, Samantha Packham, Anton Page, James Thompson, Woolf T Walker, Claudia Kuehni, Jane S Lucas,

Diagnosis of primary ciliary dyskinesia (PCD) lacks a "gold standard" test and is therefore based on combinations of tests including nasal nitric oxide (nNO), high-speed video microscopy analysis (HSVMA), genotyping and transmission electron microscopy (TEM). There are few published data on the accuracy of this approach.Using prospectively collected data from ... Read more >>

Eur Respir J (The European respiratory journal)
[2016, 47(3):837-848]

Cited: 35 times

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A case report of primary ciliary dyskinesia, laterality defects and developmental delay caused by the co-existence of a single gene and chromosome disorder.

Jillian P Casey, Patricia Goggin, Jennifer McDaid, Martin White, Sean Ennis, David R Betts, Jane S Lucas, Basil Elnazir, Sally Ann Lynch,

<h4>Background</h4>Primary ciliary dyskinesia (PCD) is a rare autosomal recessive disorder characterised by abnormal ciliary motion and impaired mucociliary clearance, leading to recurrent respiratory infections, sinusitis, otitis media and male infertility. Some patients also have laterality defects. We recently reported the identification of three disease-causing PCD genes in the Irish Traveller ... Read more >>

BMC Med Genet (BMC medical genetics)
[2015, 16:45]

Cited: 8 times

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Culture of primary ciliary dyskinesia epithelial cells at air-liquid interface can alter ciliary phenotype but remains a robust and informative diagnostic aid.

Robert A Hirst, Claire L Jackson, Janice L Coles, Gwyneth Williams, Andrew Rutman, Patricia M Goggin, Elizabeth C Adam, Anthony Page, Hazel J Evans, Peter M Lackie, Christopher O'Callaghan, Jane S Lucas,

<h4>Background</h4>The diagnosis of primary ciliary dyskinesia (PCD) requires the analysis of ciliary function and ultrastructure. Diagnosis can be complicated by secondary effects on cilia such as damage during sampling, local inflammation or recent infection. To differentiate primary from secondary abnormalities, re-analysis of cilia following culture and re-differentiation of epithelial cells ... Read more >>

PLoS One (PloS one)
[2014, 9(2):e89675]

Cited: 44 times

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Mutations in CCDC39 and CCDC40 are the major cause of primary ciliary dyskinesia with axonemal disorganization and absent inner dynein arms.

Dinu Antony, Anita Becker-Heck, Maimoona A Zariwala, Miriam Schmidts, Alexandros Onoufriadis, Mitra Forouhan, Robert Wilson, Theresa Taylor-Cox, Ann Dewar, Claire Jackson, Patricia Goggin, Niki T Loges, Heike Olbrich, Martine Jaspers, Mark Jorissen, Margaret W Leigh, Whitney E Wolf, M Leigh Anne Daniels, Peadar G Noone, Thomas W Ferkol, Scott D Sagel, Margaret Rosenfeld, Andrew Rutman, Abhijit Dixit, Christopher O'Callaghan, Jane S Lucas, Claire Hogg, Peter J Scambler, Richard D Emes, , Eddie M K Chung, Amelia Shoemark, Michael R Knowles, Heymut Omran, Hannah M Mitchison,

Primary ciliary dyskinesia (PCD) is a genetically heterogeneous disorder caused by cilia and sperm dysmotility. About 12% of cases show perturbed 9+2 microtubule cilia structure and inner dynein arm (IDA) loss, historically termed "radial spoke defect." We sequenced CCDC39 and CCDC40 in 54 "radial spoke defect" families, as these are ... Read more >>

Hum Mutat (Human mutation)
[2013, 34(3):462-472]

Cited: 87 times

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Ciliary beat pattern analysis below 37°C may increase risk of primary ciliary dyskinesia misdiagnosis.

Claire L Jackson, Patricia M Goggin, Jane S Lucas,

Chest (Chest)
[2012, 142(2):543-544]

Cited: 9 times

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Static respiratory cilia associated with mutations in Dnahc11/DNAH11: a mouse model of PCD.

Jane S Lucas, Elizabeth C Adam, Patricia M Goggin, Claire L Jackson, Nicola Powles-Glover, Saloni H Patel, James Humphreys, Martin D Fray, Emilie Falconnet, Jean-Louis Blouin, Michael T Cheeseman, Lucia Bartoloni, Dominic P Norris, Peter M Lackie,

Primary ciliary dyskinesia (PCD) is an inherited disorder causing significant upper and lower respiratory tract morbidity and impaired fertility. Half of PCD patients show abnormal situs. Human disease loci have been identified but a mouse model without additional deleterious defects is elusive. The inversus viscerum mouse, mutated at the outer ... Read more >>

Hum Mutat (Human mutation)
[2012, 33(3):495-503]

Cited: 42 times

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Generic microtiter plate assay for triaging clinical specimens prior to genotyping of human papillomavirus DNA via consensus PCR.

Véronique Legault, Ann Burchell, Patricia Goggin, Belinda Nicolau, Paul Brassard, Julie Guenoun, Pierre Forest, Marie-Hélène Mayrand, Eduardo Luis Franco, Francois Coutlée,

A generic human papillomavirus (HPV) probe assay was compared to the Linear Array to detect HPV DNA in 1,013 clinical specimens. The sensitivity, specificity, and negative predictive value of the assay were 99.5% (95% confidence interval [CI], 98.4% to 99.9%), 58.6% (95% CI, 53.9% to 63.1%), and 98.9% (95% CI, ... Read more >>

J Clin Microbiol (Journal of clinical microbiology)
[2011, 49(11):3977-3979]

Cited: 4 times

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Cost-effectiveness of high-risk human papillomavirus testing for cervical cancer screening in Québec, Canada.

Arthi Vijayaraghavan, Molly B Efrusy, Marie-Hélêne Mayrand, Christopher C Santas, Patricia Goggin,

<h4>Objectives</h4>Human papillomavirus (HPV) testing is not widely used for triage of equivocal Pap smears or primary screening in Québec, Canada. Our objective was to evaluate the cost-effectiveness of cervical cancer screening strategies utilizing HPV testing.<h4>Methods</h4>We used a lifetime Markov model to estimate costs, quality of life, and survival associated with ... Read more >>

Can J Public Health (Canadian journal of public health = Revue canadienne de sante publique)
[2010, 101(3):220-225]

Cited: 20 times

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Process of care failures in invasive cervical cancer: systematic review and meta-analysis.

Andrea R Spence, Patricia Goggin, Eduardo L Franco,

<h4>Objective</h4>As invasive cervical cancer is preventable when screening and treatment of pre-invasive lesions are timely and appropriate, several past studies attempted to enumerate the quality of preventive care invasive cervical cancer subjects received before diagnosis. Objectives of the present study were to review and to summarize the findings of these ... Read more >>

Prev Med (Preventive medicine)
[2007, 45(2-3):93-106]

Cited: 130 times

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Trends in cancer prevalence in Quebec.

Rabia Louchini, Michel Beaupré, Alain A Demers, Patricia Goggin, Clermont Bouchard,

Cancer prevalence is of prime interest in public health because of its use in estimating the disease's burden on the heath care system. This study's objective was to estimate five-year prevalence of tumours from 1989 to 1999 and ten-year prevalence of tumours from 1994 to 1999 in the Province of ... Read more >>

Chronic Dis Can (Chronic diseases in Canada)
[2006, 27(3):110-119]

Cited: 3 times

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