Full Text Journal Articles by
Author Pasquale Comberiati

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Current Transition Management of Adolescents and Young Adults with Allergy and Asthma: A European Survey.

Ekaterina Khaleva, Marta Vazquez-Ortiz, Pasquale Comberiati, Audrey DunnGalvin, Helena Pite, Katharina Blumchen, Teresa Garriga-Baraut, Valerie Hox, Alexandra Santos, Claudia Gore, Rebecca Knibb, Cherry Alviani, Charlotte Mortz, Elizabeth Angier, Bettina Duca, Britt Jensen, Silvia Sanchez-Garcia, Hazel Gowland, Frans Timmermans, Oliver Pfaar, Graham Roberts,

Abstract Background: Transition from parent-delivered to self-management is a vulnerable time for adolescents and young adults (AYA) with allergy and asthma. There is currently no European guideline available for healthcare professionals (HCPs) on transition of these patients and local/national protocols are also mostly lacking. Methods: European HCPs working with AYA ... Read more >>

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Topical corticosteroids for pediatric atopic dermatitis: Thoughtful tips for practice.

Andrea Chiricozzi, Pasquale Comberiati, Enza D'Auria, GianVincenzo Zuccotti, Diego G Peroni,

Atopic dermatitis (AD) is one of the most common chronic inflammatory skin disease, affecting up to 25% of children. Topical corticosteroids (TCS) are currently used as first-line antiinflammatory treatment for AD, due to their overall therapeutic efficacy, and the availability of different potency classes and a wide array of formulations. ... Read more >>

Pharmacol. Res. (Pharmacological research)
[2020, 158:104878]

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Vitamin D supplementation in pregnancy does not prevent school-age asthma.

Pasquale Comberiati, Diego G Peroni,

Allergy (Allergy)
[2020, :]

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EAACI Allergen Immunotherapy User's Guide.

Montserrat Alvaro-Lozano, Cezmi A Akdis, Mubeccel Akdis, Cherry Alviani, Elisabeth Angier, Stefania Arasi, Lisa Arzt-Gradwohl, Domingo Barber, Raphaëlle Bazire, Ozlem Cavkaytar, Pasquale Comberiati, Stephanie Dramburg, Stephen R Durham, Aarif O Eifan, Leandra Forchert, Susanne Halken, Max Kirtland, Umut C Kucuksezer, Janice A Layhadi, Paolo Maria Matricardi, Antonella Muraro, Cevdet Ozdemir, Giovanni Battista Pajno, Oliver Pfaar, Ekaterina Potapova, Carmen Riggioni, Graham Roberts, Pablo Rodríguez Del Río, Mohamed H Shamji, Gunter J Sturm, Marta Vazquez-Ortiz,

Allergen immunotherapy is a cornerstone in the treatment of allergic children. The clinical efficiency relies on a well-defined immunologic mechanism promoting regulatory T cells and downplaying the immune response induced by allergens. Clinical indications have been well documented for respiratory allergy in the presence of rhinitis and/or allergic asthma, to ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2020, 31 Suppl 25:1-101]

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Microbiome Composition and Its Impact on the Development of Allergic Diseases.

Diego G Peroni, Giulia Nuzzi, Irene Trambusti, Maria Elisa Di Cicco, Pasquale Comberiati,

Allergic diseases, such as food allergy (FA), atopic dermatitis (AD), and asthma, are heterogeneous inflammatory immune-mediated disorders that currently constitute a public health issue in many developed countries worldwide. The significant increase in the prevalence of allergic diseases reported over the last few years has closely paralleled substantial environmental changes ... Read more >>

Front Immunol (Frontiers in Immunology)
[2020, 11:700]

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The role of atopy in asthma development and persistence.

Maria Di Cicco, Sofia D'Elios, Diego G Peroni, Pasquale Comberiati,

PURPOSE OF REVIEW:Asthma is the most common chronic disease in pediatric age. Childhood-onset asthma, as opposed to adult-onset asthma, is typically characterized by a personal and often a family history of atopy and related markers of type 2-mediated inflammation. However, the interplay between atopy and asthma development is more complex ... Read more >>

Curr Opin Allergy Clin Immunol (Current opinion in allergy and clinical immunology)
[2020, 20(2):131-137]

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The effectiveness of interventions to improve self-management for adolescents and young adults with allergic conditions: a systematic review.

Rebecca C Knibb, Cherry Alviani, Teresa Garriga-Baraut, Charlotte G Mortz, Marta Vazquez-Ortiz, Elizabeth Angier, Katerina Blumchen, Pasquale Comberiati, Bettina Duca, Audrey DunnGalvin, Claudia Gore, Valerie Hox, Britt Jensen, Helena Pite, Alexandra F Santos, Silvia Sanchez-Garcia, M Hazel Gowland, Frans Timmermans, Graham Roberts,

BACKGROUND:This systematic review aimed to review the literature on interventions for improving self-management and wellbeing in adolescents and young adults (11-25 years) with asthma and allergic conditions. METHODS:A systematic literature search was undertaken across eight databases. References were checked by two reviewers for inclusion. Study data were extracted and their ... Read more >>

Allergy (Allergy)
[2020, :]

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Understanding the challenges faced by adolescents and young adults with allergic conditions: a systematic review.

Marta Vazquez-Ortiz, Elizabeth Angier, Katharina Blumchen, Pasquale Comberiati, Bettina Duca, Audrey DunnGalvin, Claudia Gore, Valérie Hox, Britt Jensen, Helena Pite, Alexandra F Santos, Silvia Sanchez, Cherry Alviani, Teresa Garriga-Baraut, Rebecca Knibb, Charlotte G Mortz, M Hazel Gowland, Frans Timmermans, Graham Roberts,

BACKGROUND:Adolescence represents a vulnerable time for individuals with asthma and allergic conditions. They suffer an unexpected degree of morbidity. This systematic review aimed to understand the challenges faced by adolescents and young adults with these conditions. METHODS:A systematic literature search was undertaken across eight databases. References were checked by two ... Read more >>

Allergy (Allergy)
[2020, :]

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Lung mechanical properties distinguish children with asthma with normal and diminished lung function.

Pasquale Comberiati, Joseph D Spahn, Keith Paull, Anna Faino, Reuben Cherniack, Ronina A Covar,

BACKGROUND:Children with asthma, even those with severe persistent disease, can have forced expiratory volume in 1 second (FEV1 ) values ≥100% of predicted, while others have diminished FEV1 . OBJECTIVE:We sought to characterize the lung mechanical properties underlying these two asthma phenotypes and the mechanisms explaining the paradox of severe asthmatic ... Read more >>

Clin. Exp. Allergy (Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology)
[2020, 50(4):453-462]

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The need for clean air: The way air pollution and climate change affect allergic rhinitis and asthma.

Ibon Eguiluz-Gracia, Alexander G Mathioudakis, Sabine Bartel, Susanne J H Vijverberg, Elaine Fuertes, Pasquale Comberiati, Yutong Samuel Cai, Peter Valentin Tomazic, Zuzana Diamant, Jørgen Vestbo, Carmen Galan, Barbara Hoffmann,

Air pollution and climate change have a significant impact on human health and well-being and contribute to the onset and aggravation of allergic rhinitis and asthma among other chronic respiratory diseases. In Westernized countries, households have experienced a process of increasing insulation and individuals tend to spend most of their ... Read more >>

Allergy (Allergy)
[2020, :]

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Wet Cough and Nasal Symptoms in Children: Can We Do Better?

Fernando M de Benedictis, Ines Carloni, Pasquale Comberiati, Michael D Shields, Andrew Bush, Anne B Chang,

The causes of chronic cough in children are mainly dependent on the setting and age of the child. Protracted bacterial bronchitis is a frequent cause of morbidity in childhood, and antibiotic treatment is beneficial. Prompt recognition and early treatment is important both to prevent inappropriate use of asthma medications and ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2019, 7:459]

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Practical Approach to Children Presenting With Eosinophila And Hypereosinophilia.

Giorgio Costagliola, Serena Di Marco, Pasquale Comberiati, Sofia D'Elios, Nino Petashvili, Maria Elisa Di Cicco, Diego Peroni,

Eosinophilia is not a rare finding in clinical practice, and often poses problems in terms of etiologic research and differential diagnosis. Peripheral eosinophilia is defined by a blood eosinophil count > 500 cells/µL. It is classified into mild (500-1500 cells/µl), moderate (1500-5000 cells/µl) and severe for an eosinophil count > ... Read more >>

Curr Pediatr Rev (Current pediatric reviews)
[2019, :]

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Anaphylaxis in adolescents.

Pasquale Comberiati, Joseph Spahn, Diego G Peroni,

PURPOSE OF REVIEW:The frequency of hospitalization for anaphylaxis has increased over the last 20 years across Europe, Australia, and North America, particularly, for food and medication triggers. Adolescents show the highest risk for morbidity and fatality from food-induced anaphylaxis, yet there is little high-quality evidence addressing the reasons for this ... Read more >>

Curr Opin Allergy Clin Immunol (Current opinion in allergy and clinical immunology)
[2019, 19(5):425-431]

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Markers of microbial exposure lower the incidence of atopic dermatitis.

Liliane Chatenoud, Paola Bertuccio, Federica Turati, Carlotta Galeone, Luigi Naldi, Lucienne Chatenoud, Carlo La Vecchia, Jean-François Bach, ,

BACKGROUND:The hygiene hypothesis proposes that reduced exposure to infectious agents in early life would explain the increase of allergic and autoimmune diseases observed over the past decades in high-income countries. METHODS:We conducted a matched case-control study on incident atopic dermatitis (AD). Cases were 426 outpatient children with a first diagnosis ... Read more >>

Allergy (Allergy)
[2020, 75(1):104-115]

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Refractory Chronic Spontaneous Urticaria Treated With Omalizumab in an Adolescent With Common Variable Immunodeficiency.

Pasquale Comberiati, Giorgio Costagliola, Niccolò Carli, Annalisa Legitimo, Sofia D'Elios, Rita Consolini, Diego G Peroni,

Chronic spontaneous urtcaria (CSU) can represent the leading sign of a wide spectrum of systemic diseases, including primary immunodeficiencies. We describe the case of a young adult female with coexisting CSU and common variable immunodeficiency (CVID) successfully treated with omalizumab. The patient, with a history of recurrent respiratory infections during ... Read more >>

Front Immunol (Frontiers in immunology)
[2019, 10:1700]

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Prevention of Food Allergy: The Significance of Early Introduction.

Pasquale Comberiati, Giorgio Costagliola, Sofia D'Elios, Diego Peroni,

Over the last two decades, the prevalence of food allergies has registered a significant increase in Westernized societies, potentially due to changes in environmental exposure and lifestyle. The pathogenesis of food allergies is complex and includes genetic, epigenetic and environmental factors. New evidence has highlighted the role of the intestinal ... Read more >>

Medicina (Kaunas) (Medicina (Kaunas, Lithuania))
[2019, 55(7):]

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Proportion of Severe Asthma Patients Eligible for Mepolizumab Therapy by Age and Age of Onset of Asthma.

Pasquale Comberiati, Katherine McCormack, Jonathan Malka-Rais, Joseph D Spahn,

BACKGROUND:Mepolizumab is an anti-IL-5 antibody approved for the treatment of severe eosinophilic asthma. However, the prevalence of patients with severe asthma eligible for mepolizumab remains unknown, especially among children. OBJECTIVE:To determine, in a population of patients with severe asthma from a tertiary referral center, the proportion of patients with an ... Read more >>

J Allergy Clin Immunol Pract (The journal of allergy and clinical immunology. In practice)
[2019, 7(8):2689-2696.e2]

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Pearls and pitfalls of bathing in atopic dermatitis.

Pasquale Comberiati, Luca Pecoraro, Roberta Pigozzi, Diego Peroni, Giorgio Piacentini,

The latest guidelines of the American Academy of Dermatology suggest bathing as an advantageous nonpharmacologic intervention for regular skin care of patients with atopic dermatitis. Regular bathing with water can hydrate the skin, remove scale, crust, irritants, and allergens, enhance penetration of topical agents, and potentially reduce bacterial colonization. However, ... Read more >>

Allergy Asthma Proc (Allergy and asthma proceedings)
[2019, 40(3):204-206]

Cited: 1 time

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When cough drives you nuts.

Luca Pecoraro, Pasquale Comberiati, Alessandro Bodini, Matteo Chinello, Laura Tenero, Giorgio Piacentini,

Minerva Pediatr. (Minerva pediatrica)
[2019, :]

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Early molecular biomarkers predicting the evolution of allergic rhinitis and its comorbidities: A longitudinal multicenter study of a patient cohort.

Francesca Cipriani, Salvatore Tripodi, Valentina Panetta, Serena Perna, Ekaterina Potapova, Arianna Dondi, Roberto Bernardini, Carlo Caffarelli, Antonella Casani, Rosa Cervone, Loredana Chini, Pasquale Comberiati, Giovanna De Castro, Michele Miraglia Del Giudice, Iride Dello Iacono, Andrea Di Rienzo Businco, Marcella Gallucci, Arianna Giannetti, Carla Mastrorilli, Viviana Moschese, Simone Pelosi, Ifigenia Sfika, Elena Varin, Valeria Villella, Anna Maria Zicari, Giulia Brindisi, Giampaolo Ricci, Paolo Maria Matricardi, ,

BACKGROUND:Pollen-related seasonal allergic rhinoconjunctivitis (SAR) is a very frequent pediatric disease in Westernized countries. Risk factors and disease phenotypes have been thoroughly examined in several cross-sectional studies. By contrast, only a few studies have examined disease evolution in patient cohorts. We investigated predictive biomarkers of disease evolution in a large ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2019, 30(3):325-334]

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SIAIP position paper: provocation challenge to antibiotics and non-steroidal anti-inflammatory drugs in children.

Carlo Caffarelli, Fabrizio Franceschini, Davide Caimmi, Francesca Mori, Lucia Diaferio, Dora Di Mauro, Carla Mastrorilli, Stefania Arasi, Simona Barni, Paolo Bottau, Silvia Caimmi, Fabio Cardinale, Pasquale Comberiati, Giuseppe Crisafulli, Lucia Liotti, Umberto Pelosi, Francesca Saretta, Gianluigi Marseglia, Marzia Duse, Francesco Paravati,

Drug hypersensitivity reactions (DHRs) in childhood are mainly caused by betalactam or non-betalactam antibiotics, and non-steroidal anti-inflammatory drugs (NSAIDs). Laboratory tests for identifying children who are allergic to drugs have low diagnostic accuracy and predictive value. The gold standard to diagnose DHR is represented by the drug provocation test (DPT), ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2018, 44(1):147]

Cited: 9 times

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Bronchoprovocation Testing in Asthma: An Update.

Pasquale Comberiati, Rohit K Katial, Ronina A Covar,

Bronchial hyperresponsiveness (BHR) is defined as a heightened bronchoconstrictive response to airway stimuli. It complements the cardinal features in asthma, such as variable or reversible airflow limitation and airway inflammation. Although BHR is considered a pathophysiologic hallmark of asthma, it should be acknowledged that this property of the airway is ... Read more >>

Immunol Allergy Clin North Am (Immunology and Allergy Clinics of North America)
[2018, 38(4):545-571]

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Levels of Growth Factors and IgA in the Colostrum of Women from Burundi and Italy.

Daniel Munblit, Priya Abrol, Shreya Sheth, Li Yan Chow, Ekaterina Khaleva, Alan Asmanov, Silvana Lauriola, Ezio M Padovani, Pasquale Comberiati, Attilio L Boner, John O Warner, Robert J Boyle, Diego G Peroni,

Colostrum is produced in the first days postpartum. It is a known source of immune mediators for a newborn within the first week of life. Although it is still unclear if colostrum composition varies between populations, recent data suggest differences. Hepatocyte growth factor (HGF); transforming growth factor-β (TGF-β) 1, 2, ... Read more >>

Nutrients (Nutrients)
[2018, 10(9):]

Cited: 3 times

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Duration of topical therapy in the maintenance of atopic dermatitis remission in paediatric age.

Luca Pecoraro, Marta Florile, Michele Piazza, Pasquale Comberiati, Maria Clemente, Elisa Tadiotto, Angelo Pietrobelli, Giorgio Piacentini,

Topical Corticosteroids (TCS) are the first-choice treatment for atopic dermatitis (AD) flares. In literature there are clear advices about the potency, dosage and frequency of application of TCS, but there are no shared indications about duration of the treatment during a flare. The aim of the study is to demonstrate ... Read more >>

Minerva Pediatr. (Minerva pediatrica)
[2018, :]

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Impact of delivery mode on the colostrum microbiota composition.

Marco Toscano, Roberta De Grandi, Diego Giampietro Peroni, Enzo Grossi, Valentina Facchin, Pasquale Comberiati, Lorenzo Drago,

Breast milk is a rich nutrient with a temporally dynamic nature. In particular, numerous alterations in the nutritional, immunological and microbiological content occur during the transition from colostrum to mature milk. The objective of our study was to evaluate the potential impact of delivery mode on the microbiota of colostrum, ... Read more >>

BMC Microbiol. (BMC microbiology)
[2017, 17(1):205]

Cited: 15 times

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