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Author Pasquale Comberiati

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Small-airway dysfunction in paediatric asthma.

Marcello Cottini, Carlo Lombardi, Alvise Berti, Pasquale Comberiati,

<h4>Purpose of review</h4>Asthma is a chronic inflammatory airway disorder that can involve the entire bronchial tree. Increasing evidence shows that ventilation heterogeneity and small airway dysfunction are relevant factors in the pathogenesis of asthma and represent a hallmark in adults with persistent asthma. Little is known about the contribution of ... Read more >>

Curr Opin Allergy Clin Immunol (Current opinion in allergy and clinical immunology)
[2021, 21(2):128-134]

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Risk factors for long covid in previously hospitalised children using the ISARIC Global follow-up protocol: A prospective cohort study

Ismail Osmanov, Ekaterina Spiridonova, Polina Bobkova, Aysylu Gamirova, Anastasia Shikhaleva, Margarita Andreeva, Oleg Blyuss, Yasmin El-Taravi, Audrey DunnGalvin, Pasquale Comberiati, Diego Peroni, Christian Apfelbacher, Jon Genuneit, Lyudmila Mazankova, Alexandra Miroshina, Evgeniya Chistyakova, Elmira Samitova, Svetlana Borzakova, Elena Bondarenko, Anatoliy Korsunskiy, Irina Konova, Sarah Wulf Hanson, Gail Carson, Louise Sigfrid, Janet Scott, Matthew Greenhawt, Elizabeth Whittaker, Elena Garralda, Olivia Swann, Danilo Buonsenso, Dasha Nicholls, Frances Simpson, Christina Jones, Malcolm Semple, John Warner, Theo Vos, Piero Olliaro, Daniel Munblit, ,

<h4>Background: </h4> The long-term sequelae of coronavirus disease 2019 (Covid-19) in children remain poorly characterised. This study aimed to assess long-term outcomes in children previously hospitalised with Covid-19 and associated risk factors. Methods This is a prospective cohort study of children (18 years old and younger) admitted with confirmed ... Read more >>

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Application of exhaled nitric oxide (FeNO) in pediatric asthma.

Maria Di Cicco, Diego Giampietro Peroni, Vincenzo Ragazzo, Pasquale Comberiati,

<h4>Purpose of review</h4>Fractional concentration of Nitric Oxide in the exhaled air (FeNO) is a moderately good biomarker of type-2 airway inflammation, and its measurement is feasible also in children. The available evidence is still not enough to support the routine use of FeNO to diagnose or manage asthma in every ... Read more >>

Curr Opin Allergy Clin Immunol (Current opinion in allergy and clinical immunology)
[2021, 21(2):151-158]

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Risk factors for long-term consequences of COVID-19 in hospitalised adults in Moscow using the ISARIC Global follow-up protocol: StopCOVID cohort study

Daniel Munblit, Polina Bobkova, Ekaterina Spiridonova, Anastasia Shikhaleva, Aysylu Gamirova, Oleg Blyuss, Nikita Nekliudov, Polina Bugaeva, Margarita Andreeva, Audrey DunnGalvin, Pasquale Comberiati, Christian Apfelbacher, Jon Genuneit, Sergey Avdeev, Valentina Kapustina, Alla Guekht, Victor Fomin, Andrey Svistunov, Peter Timashev, Thomas Drake, Sarah Wulf Hanson, Laura Merson, Peter Horby, Louise Sigfrid, Janet Scott, Malcolm Semple, John Warner, Theo Vos, Piero Olliaro, Petr Glybochko, Denis Butnaru, ,

<h4>ABSTRACT</h4> <h4>Background</h4> The long-term sequalae of COVID-19 remain poorly characterised. In this study, we aimed to assess long-standing symptoms (LS) (symptoms lasting from the time of discharge) in previously hospitalised patients with COVID-19 and assess associated risk factors. <h4>Methods</h4> This is a longitudinal cohort study of adults (≥18 years of ... Read more >>

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Could nutritional supplements act as therapeutic adjuvants in COVID-19?

Giorgio Costagliola, Erika Spada, Pasquale Comberiati, Diego G Peroni,

<h4>Background</h4>The role of the immune system and inflammatory response in the pathogenesis of the severe manifestations of coronavirus disease 2019 (COVID-19) is well known. Currently, different therapies active on the immune system are used for the management of COVID-19. The involvement of the immune system also opens the opportunity for ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2021, 47(1):32]

Cited: 3 times

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Media Influence on Anxiety, Health Utility, and Health Beliefs Early in the SARS-CoV-2 Pandemic-a Survey Study.

Matthew Greenhawt, Spencer Kimball, Audrey DunnGalvin, Elissa M Abrams, Marcus S Shaker, Giselle Mosnaim, Pasquale Comberiati, Nikita A Nekliudov, Oleg Blyuss, Martin Teufel, Daniel Munblit,

<h4>Background</h4>The psychological effects from the COVID-19 pandemic and response are poorly understood.<h4>Objective</h4>To understand the effects of the pandemic and response on anxiety and health utility in a nationally representative sample of US adults.<h4>Design</h4>A de-identified, cross-sectional survey was administered at the end of April 2020. Probability weights were assigned using estimates ... Read more >>

J Gen Intern Med (Journal of general internal medicine)
[2021, :]

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Reply to Russo et al.

Daniel Munblit, Nikita A Nekliudov, Polina Bugaeva, Oleg Blyuss, Peter Timashev, John O Warner, Pasquale Comberiati, Christian Apfelbacher, Mikhail E Politov, Andrey Yavorovskiy, Sergey Avdeev, Valentina A Kapustina, Victor Fomin, Andrey A Svistunov, Denis Butnaru, Petr Glybochko,

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

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Role of in vitro testing in food allergy.

Stefania Arasi, Simona Barni, Carla Mastrorilli, Pasquale Comberiati, Fernanda Chiera, Umberto Pelosi, Francesco Paravati, Davide Caimmi,

Oral food challenges remain the gold standard for the diagnosis of food allergy. Nevertheless, the allergy workup is based on the presence of a clinical history, which is evocative of an immune-allergic reaction, and the first assessment is usually the performance of skin prick tests. Based on these results, allergists ... Read more >>

Pediatr Allergy Immunol (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology)
[2020, 31 Suppl 26:36-38]

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StopCOVID cohort: An observational study of 3,480 patients admitted to the Sechenov University hospital network in Moscow city for suspected COVID-19 infection.

Daniel Munblit, Nikita A Nekliudov, Polina Bugaeva, Oleg Blyuss, Maria Kislova, Ekaterina Listovskaya, Aysylu Gamirova, Anastasia Shikhaleva, Vladimir Belyaev, Petr Timashev, John O Warner, Pasquale Comberiati, Christian Apfelbacher, Evgenii Bezrukov, Mikhail E Politov, Andrey Yavorovskiy, Ekaterina Bulanova, Natalya Tsareva, Sergey Avdeev, Valentina A Kapustina, Yuri I Pigolkin, Emmanuelle A Dankwa, Christiana Kartsonaki, Mark G Pritchard, Fomin Victor, Andrey A Svistunov, Denis Butnaru, Petr Glybochko,

<h4>Background</h4>The epidemiology, clinical course, and outcomes of COVID-19 patients in the Russian population are unknown. Information on the differences between laboratory-confirmed and clinically-diagnosed COVID-19 in real-life settings is lacking.<h4>Methods</h4>We extracted data from the medical records of adult patients who were consecutively admitted for suspected COVID-19 infection in Moscow, between April ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, :]

Cited: 4 times

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Current transition management of adolescents and young adults with allergy and asthma: a European survey.

Ekaterina Khaleva, Marta Vazquez-Ortiz, Pasquale Comberiati, Audrey DunnGalvin, Helena Pite, Katharina Blumchen, Teresa Garriga-Baraut, Valerie Hox, Alexandra F Santos, Claudia Gore, Rebecca C Knibb, Cherry Alviani, Charlotte G Mortz, Elizabeth Angier, Bettina Duca, Britt Jensen, Silvia Sanchez-Garcia, M Hazel Gowland, Frans Timmermans, Oliver Pfaar, Graham Roberts,

<h4>Background</h4>Transition from parent-delivered to self-management is a vulnerable time for adolescents and young adults (AYA) with allergy and asthma. There is currently no European guideline available for healthcare professionals (HCPs) on transition of these patients and local/national protocols are also mostly lacking.<h4>Methods</h4>European HCPs working with AYA with allergy and asthma ... Read more >>

Clin Transl Allergy (Clinical and translational allergy)
[2020, 10:40]

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Dietary Interventions and Nutritional Factors in the Prevention of Pediatric Asthma.

Irene Trambusti, Giulia Nuzzi, Giorgio Costagliola, Elvira Verduci, Enza D'Auria, Diego G Peroni, Pasquale Comberiati,

Asthma is the most frequent chronic disease in children, and its pathogenesis involves genetic, epigenetic, and environmental factors. The rapid rise in the prevalence of asthma registered over the last few decades has stressed the need to identify the environmental and modifiable factors associated with the development of the disease. ... Read more >>

Front Pediatr (Frontiers in pediatrics)
[2020, 8:480]

Cited: 1 time

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Excessive Media Consumption About COVID-19 is Associated With Increased State Anxiety: Outcomes of a Large Online Survey in Russia.

Nikita A Nekliudov, Oleg Blyuss, Ka Yan Cheung, Loukia Petrou, Jon Genuneit, Nikita Sushentsev, Anna Levadnaya, Pasquale Comberiati, John O Warner, Gareth Tudor-Williams, Martin Teufel, Matthew Greenhawt, Audrey DunnGalvin, Daniel Munblit,

<h4>Background</h4>The COVID-19 pandemic has potentially had a negative impact on the mental health and well-being of individuals and families. Anxiety levels and risk factors within particular populations are poorly described.<h4>Objective</h4>This study aims to evaluate confidence, understanding, trust, concerns, and levels of anxiety during the COVID-19 pandemic in the general population ... Read more >>

J Med Internet Res (Journal of medical Internet research)
[2020, 22(9):e20955]

Cited: 7 times

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Understanding the challenges faced by adolescents and young adults with allergic conditions: A systematic review.

Marta Vazquez-Ortiz, Elizabeth Angier, Katharina Blumchen, Pasquale Comberiati, Bettina Duca, Audrey DunnGalvin, Claudia Gore, Valérie Hox, Britt Jensen, Helena Pite, Alexandra F Santos, Silvia Sanchez, Cherry Alviani, Teresa Garriga-Baraut, Rebecca Knibb, Charlotte G Mortz, M Hazel Gowland, Frans Timmermans, Graham Roberts,

<h4>Background</h4>Adolescence represents a vulnerable time for individuals with asthma and allergic conditions. They suffer an unexpected degree of morbidity. This systematic review aimed to understand the challenges faced by adolescents and young adults with these conditions.<h4>Methods</h4>A systematic literature search was undertaken across eight databases. References were checked by two reviewers ... Read more >>

Allergy (Allergy)
[2020, 75(8):1850-1880]

Cited: 3 times

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Fractional exhaled nitric oxide response to oral corticosteroids in children with mild-to-moderate asthma: Influence of race.

Pasquale Comberiati, Diego Peroni, Jonathan Malka-Rais, Riccardo Morganti, Joseph D Spahn,

BACKGROUND:Fractional exhaled nitric oxide (FeNO) is a noninvasive biomarker of type 2 asthma that can predict response to inhaled corticosteroid therapy. Little is known regarding the magnitude of FeNO reduction after an oral corticosteroid (OCS) course, and less is known whether there are differential responses based on race in children ... Read more >>

Ann Allergy Asthma Immunol (Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology)
[2020, 125(4):440-446.e1]

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Go With Your Gut: The Shaping of T-Cell Response by Gut Microbiota in Allergic Asthma.

Alessandro Di Gangi, Maria Elisa Di Cicco, Pasquale Comberiati, Diego G Peroni,

Novel methods in immunological research and microbiome evaluation have dramatically changed several paradigms associated with the pathogenesis of allergic asthma (AAS). Ovalbumin and house dust mite-induced AAS in germ-free or specific pathogen-free mice are the two leading experimental platforms that significantly contribute to elucidate the relationship between AAS and gut ... Read more >>

Front Immunol (Frontiers in immunology)
[2020, 11:1485]

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The effectiveness of interventions to improve self-management for adolescents and young adults with allergic conditions: A systematic review.

Rebecca C Knibb, Cherry Alviani, Teresa Garriga-Baraut, Charlotte G Mortz, Marta Vazquez-Ortiz, Elizabeth Angier, Katerina Blumchen, Pasquale Comberiati, Bettina Duca, Audrey DunnGalvin, Claudia Gore, Valerie Hox, Britt Jensen, Helena Pite, Alexandra F Santos, Silvia Sanchez-Garcia, M Hazel Gowland, Frans Timmermans, Graham Roberts,

<h4>Background</h4>This systematic review aimed to review the literature on interventions for improving self-management and well-being in adolescents and young adults (11-25 years) with asthma and allergic conditions.<h4>Methods</h4>A systematic literature search was undertaken across eight databases. References were checked by two reviewers for inclusion. Study data were extracted, and their quality was ... Read more >>

Allergy (Allergy)
[2020, 75(8):1881-1898]

Cited: 1 time

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EAACI Guidelines on the effective transition of adolescents and young adults with allergy and asthma.

Graham Roberts, Marta Vazquez-Ortiz, Rebecca Knibb, Ekaterina Khaleva, Cherry Alviani, Elizabeth Angier, Katharina Blumchen, Pasquale Comberiati, Bettina Duca, Audrey DunnGalvin, Teresa Garriga-Baraut, Claudia Gore, M Hazel Gowland, Valérie Hox, Britt Jensen, Charlotte G Mortz, Oliver Pfaar, Helena Pite, Alexandra F Santos, Silvia Sanchez-Garcia, Frans Timmermans,

Adolescent and young adult (AYA) patients need additional support, while they experience the challenges associated with their age. They need specific training to learn the knowledge and skills required to confidently self-manage their allergies and/or asthma. Transitional care is a complex process, which should address the psychological, medical, educational and ... Read more >>

Allergy (Allergy)
[2020, 75(11):2734-2752]

Cited: 2 times

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Potential effects of E-cigarettes and vaping on pediatric asthma.

Maria Di Cicco, Margherita Sepich, Vincenzo Ragazzo, Diego G Peroni, Pasquale Comberiati,

Asthma is the most common chronic disease in childhood and exposure to tobacco smoke has been long recognized as a risk factor for its onset as well as for exacerbations and poor disease control. Since the early 2000s, electronic cigarettes have been marketed worldwide as a non-harmful electronic alternative to ... Read more >>

Minerva Pediatr (Minerva pediatrica)
[2020, 72(5):372-382]

Cited: 0 times

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Hyaluronic acid for the treatment of airway diseases in children: Little evidence for few indications.

Maria Di Cicco, Diego Peroni, Margherita Sepich, Maria Giulia Tozzi, Pasquale Comberiati, Renato Cutrera,

<h4>Background</h4>Hyaluronic acid (HA) is major physiological component of the extracellular matrix, which, in its high molecular weight form (HMW-HA) has anti-inflammatory properties. The diffusion of many different medical devices for inhalation therapy containing HA has led to an increase in their prescription, also in children. Here, we systematically review the ... Read more >>

Pediatr Pulmonol (Pediatric pulmonology)
[2020, 55(8):2156-2169]

Cited: 0 times

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Vitamin D supplementation in pregnancy does not prevent school-age asthma.

Pasquale Comberiati, Diego G Peroni,

Allergy (Allergy)
[2020, 75(8):2143-2144]

Cited: 0 times

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Current Transition Management of Adolescents and Young Adults with Allergy and Asthma: A European Survey.

Ekaterina Khaleva, Marta Vazquez-Ortiz, Pasquale Comberiati, Audrey DunnGalvin, Helena Pite, Katharina Blumchen, Teresa Garriga-Baraut, Valerie Hox, Alexandra Santos, Claudia Gore, Rebecca Knibb, Cherry Alviani, Charlotte Mortz, Elizabeth Angier, Bettina Duca, Britt Jensen, Silvia Sanchez-Garcia, Hazel Gowland, Frans Timmermans, Oliver Pfaar, Graham Roberts,

<h4>Background: </h4> Transition from parent-delivered to self-management is a vulnerable time for adolescents and young adults (AYA) with allergy and asthma. There is currently no European guideline available for healthcare professionals (HCPs) on transition of these patients and local/national protocols are also mostly lacking. <h4>Methods: </h4> European HCPs working with ... Read more >>

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Microbiome Composition and Its Impact on the Development of Allergic Diseases.

Diego G Peroni, Giulia Nuzzi, Irene Trambusti, Maria Elisa Di Cicco, Pasquale Comberiati,

Allergic diseases, such as food allergy (FA), atopic dermatitis (AD), and asthma, are heterogeneous inflammatory immune-mediated disorders that currently constitute a public health issue in many developed countries worldwide. The significant increase in the prevalence of allergic diseases reported over the last few years has closely paralleled substantial environmental changes ... Read more >>

Front Immunol (Frontiers in immunology)
[2020, 11:700]

Cited: 3 times

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Topical corticosteroids for pediatric atopic dermatitis: Thoughtful tips for practice.

Andrea Chiricozzi, Pasquale Comberiati, Enza D'Auria, GianVincenzo Zuccotti, Diego G Peroni,

Atopic dermatitis (AD) is one of the most common chronic inflammatory skin disease, affecting up to 25% of children. Topical corticosteroids (TCS) are currently used as first-line antiinflammatory treatment for AD, due to their overall therapeutic efficacy, and the availability of different potency classes and a wide array of formulations. ... Read more >>

Pharmacol Res (Pharmacological research)
[2020, 158:104878]

Cited: 1 time

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Multicentre Italian study of SARS-CoV-2 infection in children and adolescents, preliminary data as at 10 April 2020.

Silvia Garazzino, Carlotta Montagnani, Daniele Donà, Antonella Meini, Enrico Felici, Gianluca Vergine, Stefania Bernardi, Roberta Giacchero, Andrea Lo Vecchio, Paola Marchisio, Giangiacomo Nicolini, Luca Pierantoni, Ivana Rabbone, Giuseppe Banderali, Marco Denina, Elisabetta Venturini, Andrzej Krzysztofiak, Raffaele Badolato, Sonia Bianchini, Luisa Galli, Alberto Villani, Guido Castelli-Gattinara, , ,

Data on features of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in children and adolescents are scarce. We report preliminary results of an Italian multicentre study comprising 168 laboratory-confirmed paediatric cases (median: 2.3 years, range: 1 day-17.7 years, 55.9% males), of which 67.9% were hospitalised and 19.6% had comorbidities. Fever ... Read more >>

Euro Surveill (Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin)
[2020, 25(18):]

Cited: 48 times

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The role of atopy in asthma development and persistence.

Maria Di Cicco, Sofia D'Elios, Diego G Peroni, Pasquale Comberiati,

<h4>Purpose of review</h4>Asthma is the most common chronic disease in pediatric age. Childhood-onset asthma, as opposed to adult-onset asthma, is typically characterized by a personal and often a family history of atopy and related markers of type 2-mediated inflammation. However, the interplay between atopy and asthma development is more complex ... Read more >>

Curr Opin Allergy Clin Immunol (Current opinion in allergy and clinical immunology)
[2020, 20(2):131-137]

Cited: 2 times

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