Full Text Journal Articles by
Author Paris Vail

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A Phase I Study of Ribociclib Plus Everolimus in Patients with Metastatic Pancreatic Adenocarcinoma Refractory to Chemotherapy.

Benjamin A Weinberg, Hongkun Wang, Agnieszka K Witkiewicz, John L Marshall, Aiwu R He, Paris Vail, Erik S Knudsen, Michael J Pishvaian,

Purpose: Metastatic pancreatic adenocarcinoma (mPC) has a poor prognosis. CDK4/6 is often deregulated in mPC due to CDKN2A loss, resulting in the loss of p16INK4a that inhibits CDK4/6. CDK4/6 inhibitor monotherapy is ineffective due to RAS-mediated activation of alternative pathways, including phosphatidylinositol 3-kinase-mammalian target of rapamycin (PI3K-mTOR). We conducted a ... Read more >>

J Pancreat Cancer (Journal of pancreatic cancer)
[2020, 6(1):45-54]

Cited: 0 times

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Targeting dual signalling pathways in concert with immune checkpoints for the treatment of pancreatic cancer.

Erik S Knudsen, Vishnu Kumarasamy, Sejin Chung, Amanda Ruiz, Paris Vail, Stephanie Tzetzo, Jin Wu, Ram Nambiar, Jared Sivinski, Shailender S Chauhan, Mukund Seshadri, Scott I Abrams, Jianmin Wang, Agnieszka K Witkiewicz,

OBJECTIVE:This study exploits the intersection between molecular-targeted therapies and immune-checkpoint inhibition to define new means to treat pancreatic cancer. DESIGN:Patient-derived cell lines and xenograft models were used to define the response to CDK4/6 and MEK inhibition in the tumour compartment. Impacts relative to immunotherapy were performed using subcutaneous and orthotopic ... Read more >>

Gut (Gut)
[2020, :]

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Targeting dual signaling pathways in concert with immune checkpoints for the treatment of pancreatic cancer

Erik Knudsen, Vishnu Kumarasamy, Sejin Chung, Paris Vail, Stephanie Tzetzo, Amanda Ruiz, Mukund Seshadri, Scott Abrams, Jianmin Wang, Agnieszka Witkiewicz,

ABSTRACT Pancreatic cancer harbors a poor prognosis due to the lack of effective systemic therapies. Here we interrogated means to target key effector pathways down-stream from KRAS. We found that combination treatment with MEK and CDK4/6 inhibitors was effective across a broad range of PDX models in delaying tumor progression. ... Read more >>

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Interrogating Mutant Allele Expression via Customized Reference Genomes to Define Influential Cancer Mutations.

Adam D Grant, Paris Vail, Megha Padi, Agnieszka K Witkiewicz, Erik S Knudsen,

Genetic alterations are essential for cancer initiation and progression. However, differentiating mutations that drive the tumor phenotype from mutations that do not affect tumor fitness remains a fundamental challenge in cancer biology. To better understand the impact of a given mutation within cancer, RNA-sequencing data was used to categorize mutations ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):12766]

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Cell cycle plasticity driven by MTOR signaling: integral resistance to CDK4/6 inhibition in patient-derived models of pancreatic cancer.

Erik S Knudsen, Vishnu Kumarasamy, Amanda Ruiz, Jared Sivinski, Sejin Chung, Adam Grant, Paris Vail, Shailender S Chauhan, Tun Jie, Taylor S Riall, Agnieszka K Witkiewicz,

Pancreatic ductal adenocarcinoma (PDAC), like many KRAS-driven tumors, preferentially loses CDKN2A that encodes an endogenous CDK4/6 inhibitor to bypass the RB-mediated cell cycle suppression. Analysis of a panel of patient-derived cell lines and matched xenografts indicated that many pancreatic cancers have intrinsic resistance to CDK4/6 inhibition that is not due ... Read more >>

Oncogene (Oncogene)
[2019, 38(18):3355-3370]

Cited: 5 times

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Coordinately Targeting Cell-Cycle Checkpoint Functions in Integrated Models of Pancreatic Cancer.

Sejin Chung, Paris Vail, Agnieszka K Witkiewicz, Erik S Knudsen,

PURPOSE:Cancer cells often have deficiencies in cell-cycle control mechanisms and could be dependent on specific cell-cycle checkpoints to maintain viability. Because of the documented role of KRAS in driving replication stress, we targeted the checkpoint governing DNA replication using CHK1 kinase inhibitors in pancreatic ductal adenocarcinoma (PDAC) models and examined ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2019, 25(7):2290-2304]

Cited: 6 times

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Interrogating Mutant Allele Expression via Customized Reference Genomes to Define Influential Cancer Mutations

Adam Grant, Paris Vail, Megha Padi, Agnieszka Witkiewicz, Erik Knudsen,

Abstract Genetic alterations are essential for cancer initiation and progression. However, differentiating mutations that drive the tumor phenotype from mutations that do not affect tumor fitness remains a fundamental challenge in cancer biology. To better understand the impact of a given mutation within cancer, RNA-sequencing data was used to categorize ... Read more >>

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Targeting the Vulnerability of RB Tumor Suppressor Loss in Triple-Negative Breast Cancer.

Agnieszka K Witkiewicz, Sejin Chung, Rachel Brough, Paris Vail, Jorge Franco, Christopher J Lord, Erik S Knudsen,

Approximately 30% of triple-negative breast cancers (TNBCs) exhibit functional loss of the RB tumor suppressor, suggesting a target for precision intervention. Here, we use drug screens to identify agents specifically antagonized by the retinoblastoma tumor suppressor (RB) using CDK4/6 inhibitors. A number of candidate RB-synthetic lethal small molecules were identified, ... Read more >>

Cell Rep (Cell reports)
[2018, 22(5):1185-1199]

Cited: 11 times

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Composite analysis of immunological and metabolic markers defines novel subtypes of triple negative breast cancer.

Thomas A Adams, Paris J Vail, Amanda Ruiz, Mehri Mollaee, Peter A McCue, Erik S Knudsen, Agnieszka K Witkiewicz,

Cancer biology is influenced by the tumor microenvironment, which impacts disease prognosis and therapeutic interventions. The inter-relationship of tumor-infiltrating lymphocytes, immune response regulators, and a glycolytic tumor environment was evaluated in a cohort of 183 largely consecutive patients with triple negative breast cancer diagnosis. High levels of tumor-infiltrating lymphocytes were ... Read more >>

Mod Pathol (Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc)
[2018, 31(2):288-298]

Cited: 8 times

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Biological specificity of CDK4/6 inhibitors: dose response relationship, in vivo signaling, and composite response signature.

Erik S Knudsen, Jack Hutcheson, Paris Vail, Agnieszka K Witkiewicz,

Recently developed potent and selective CDK4/6 inhibitors fall into two classes based on structure and toxicity profiles in clinical studies. One class, exemplified by palbociclib and ribociclib, exhibits neutropenia as a dose-limiting toxicity and requires discontinuous dosing. In contrast, the structurally distinct CDK4/6 inhibitor abemaciclib is dosed continuously, and has ... Read more >>

Oncotarget (Oncotarget)
[2017, 8(27):43678-43691]

Cited: 16 times

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Stratification of Pancreatic Ductal Adenocarcinoma: Combinatorial Genetic, Stromal, and Immunologic Markers.

Erik S Knudsen, Paris Vail, Uthra Balaji, Hoai Ngo, Ihab W Botros, Vladimir Makarov, Nadeem Riaz, Vinod Balachandran, Steven Leach, Debrah M Thompson, Timothy A Chan, Agnieszka K Witkiewicz,

Purpose: Pancreatic ductal adenocarcinoma (PDAC) is associated with an immunosuppressive milieu that supports immune system evasion and disease progression. Here, we interrogated genetic, stromal, and immunologic features of PDAC to delineate impact on prognosis and means to more effectively employ immunotherapy.Experimental Design: A cohort of 109 PDAC cases annotated for ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2017, 23(15):4429-4440]

Cited: 37 times

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Pancreatic cancer cell lines as patient-derived avatars: genetic characterisation and functional utility.

Erik S Knudsen, Uthra Balaji, Brian Mannakee, Paris Vail, Cody Eslinger, Christopher Moxom, John Mansour, Agnieszka K Witkiewicz,

Pancreatic ductal adenocarcinoma (PDAC) is a therapy recalcitrant disease with the worst survival rate of common solid tumours. Preclinical models that accurately reflect the genetic and biological diversity of PDAC will be important for delineating features of tumour biology and therapeutic vulnerabilities.27 primary PDAC tumours were employed for genetic analysis ... Read more >>

Gut (Gut)
[2018, 67(3):508-520]

Cited: 24 times

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Assessment of in silico protein sequence analysis in the clinical classification of variants in cancer risk genes.

Iain D Kerr, Hannah C Cox, Kelsey Moyes, Brent Evans, Brianna C Burdett, Aric van Kan, Heather McElroy, Paris J Vail, Krystal L Brown, Dechie B Sumampong, Nicholas J Monteferrante, Kennedy L Hardman, Aaron Theisen, Erin Mundt, Richard J Wenstrup, Julie M Eggington,

Missense variants represent a significant proportion of variants identified in clinical genetic testing. In the absence of strong clinical or functional evidence, the American College of Medical Genetics recommends that these findings be classified as variants of uncertain significance (VUS). VUSs may be reclassified to better inform patient care when ... Read more >>

(Journal of community genetics)
[2017, 8(2):87-95]

Cited: 5 times

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Proffered papers and posters presented at the Sixth International Symposium on Hereditary Breast and Ovarian Cancer—BRCA: Challenges and Opportunities : Presented by the Hereditary Breast and Ovarian Cancer Foundation in collaboration with the Program in Cancer Genetics, McGill University; Centre Mont-Royal, Montreal, QC; 10–13 May 2016

Lea M. Starita, Muhtadi Islam, Stanley Fields, Jeffrey D. Parvin, Jay Shendure, Jeroen Vierstraete, Andy Willaert, Kris Vleminckx, Petra Vermassen, Leen Pieters, Paul Coucke, Anne Vral, Kathleen Claes, Matthew Lebo, Kathleen-Rose Zakoor, Shana White, Kathy Chun, Marsha Speevak, John Waye, Elizabeth McCready, Jillian Parboosingh, Ryan Lamont, Harriet Feilotter, Ian Bosdet, Tracy Tucker, Sean Young, Aly Karsan, George Charames, Ronald Agatep, Elizabeth Spriggs, Caitlin Chisholm, Nasim Vasil, Hussein Daoud, Olga Jarinova, Robert Tomaszewski, Stacey Hume, Mohammad Akbari, Jordan Lerner-Ellis, Rosalind A. Eeles, Sarah Benafif, Christos Mikropoulos, Christina G. Selkirk, Sibel Saya, Elizabeth Bancroft, Tokhir Dadaev, Charles Brendler, Elizabeth Page, Daniel A. Leongamornlert, Natalie Taylor, The IMPACT study collaborators and Steering Committee, Sue Moss, Zsofia Kote-Jarai, Alexander Dias, Brian T. Helfand, Sharon Cantor, Nicholas Panzarino, Jennifer Calvo, Inga Plaskocinska, Hannah Shipman, James Drummond, Edward Thompson, Vanessa Buchanan, Barbara Newcombe, Charlotte Hodgkin, Study Group, Paul Pharoah, Gurdeep Sagoo, Stephen Abbs, Nick Hulbert-Williams, Robin Crawford, James Brenton, Marc Tischkowitz, Ravi Vermeulen, Marc van Beurden, Jacobien Kieffer, Eveline Bleiker, Heiddis B Valdimarsdottir, Leo Massuger, Marian J.E. Mourits, Katja Gaarenstroom, Eleonora B.L. van Dorst, Herman van der Putten, Neil Aaronson, Barbara Rivera, Massimo DiIorio, Javad Nadaf, Jessica Frankum, Suzanna Arcand, Silvie Giroux, Steven Narod, Francois Rousseau, Jacek Majewski, Guy Rouleau, Jacques Michaud, Mohammad R. Akbari, Cristopher J. Lord, Patricia Tonin, William D. Foulkes, Sari Lieberman, Ariela Tomer, Avraham Ben-Chetrit, Oded Olsha, Simon Levine, Rachel Beeri, Aviad Raz, Amnon Lahad, Ephrat Levy-Lahad, Tuya Pal, Courtney Lewis, Deborah Cragun, Devon Bonner, Lucia Camperlengo, Susan T. Vadaparampil, Yeh Chen Lee, Mathias Bressel, Peter Grant, Peter Russell, Charmaine Smith, Sandra Picken, Stephanie Camm, Belinda E. Kiely, Roger Milne, Sue-Ann McLachlan, Martha Hickey, Michael L. Friedlander, John L. Hopper, Kelly-Anne Phillips, Kelly Metcalfe, Andrea Eisen, David McCready, Tulin Cil, Frances Wright, Jordan Lerner-Ellis, Steven Narod, Marline Harmsen, Joanna IntHout, Marieke Arts-de Jong, Nicoline Hoogerbrugge, Leon Massuger, Rosella Hermens, Joanne de Hullu, Galen Joseph, Robin Lee, Antonis C. Antoniou, Andrew J. Lee, Alex P. Cunningham, Marc Tischkowitz, Jacques Simard, Paul D. Pharoah, Douglas F. Easton, D. Gareth Evans, Adam Brentnall, Helen Byers, Elaine Harkness, Paula Stavrinos, Anthony Howell, William Newman, Jack Cuzick, Anders Bojesen, Mads M. Aagaard, Annabeth H. Petersen, Paul A. James, Ella R. Thompson, Simone M. Rowley, Na Li, Simone McInerny, Lisa Devereux, Michelle W. Wong-Brown, Alison H. Trainer, Gillian Mitchell, Rodney J. Scott, Ian G. Campbell, Jill S. Dolinsky, Fergus J. Couch, David E. Goldgar, Steven N. Hart, Emily Halberg, Raymond Moore, Huong Meeks, Robert Huether, Holly LaDuca, Elizabeth C. Chao, Melissa C. Southey, Eric Joo, Ee Ming Wong, John L. Hopper, Dallas R. English, kConFab, David E. Goldgar, Roger L. Milne, James G. Dowty, Susan J. Ramus, Ed Dicks, Honglin Song, Jan Lubiński, Jacek Gronwald, Samantha Poblete, Qianqian Zhu, Shashi Lele, Lara Sucheston-Campbell, Kirsten B. Moysich, Kunle Odunsi, Paul D.P. Pharoah, Simon A. Gayther, Na Li, Ella Thompson, Simone Rowley, Lisa Devereux, Alison Trainer, Gillian Mitchell, Paul James, Ian Campbell, Meryam El Khachibi, Mohamed El Karroumi, Salaheddine Ayoubi, Ilham El Arrouchi, Amal Bouziyane, Sellama Nadifi, Rania Chehade, Rachael Pettapiece-Phillips, Leonardo Salmena, Max Kotlyar, Igor Jurisica, Steven A. Narod, Mohammad Akbari, Joanne Kotsopoulos, Aideen Campbell, Kienan Savage, Stuart McIntosh, Paul Harkin, Nur Yucer, Marie Holzapfel, Tilley Jenkins Vogel, Mae Zakhour, Bianca Barriga, Lindsay Lenaeus, Loren Ornelas, Anna Laury, Dhruv Sareen, Robert Barrett, Clive Svendsen, Beth Y. Karlan, Paula Silva Felicio, Matias Eliseo Melendez, Lidia Maria Rebolho Batista Arantes, Ligia Maria Kerr, Rebeca Silveira Grasel, Natalia Campacci, Cristovam Scapulatempo-Neto, Ana Carolina de Carvalho, Edenir Inêz Palmero, Thomas Bock, Joi Morris, Lawrence Brody, Alan Ashworth, Masami Arai, Shirou Yokoyama, Chie Watanabe, Tadashi Nomizu, Akihiro Sakurai, Masayoshi Sekine, Hiroyuki Nomura, Okawa Megumi, Junko Yotsumoto, Takayoshi Enomoto, Seigo Nakamura, Ava Kwong, John C.W. Ho, Chun H. Au, Fian B.F. Law, Dona N. Ho, Bui K. Ip, Anthony T.C. Wong, Rene M.Y. To, Gigi Choy, Vivian Y. Shin, Tsun L. Chan, Edmond S.K. Ma, James M. Ford, Annabeth Høgh Petersen, Mads M. Aagaard, Anders Bojesen, Karla R. Bowles, Brian Morris, Elisha Hughes, Dmitry Pruss, Priscilla H. Fernandes, Benjamin B. Roa, Alexander Gutin, Erin Mundt, Heather McElroy, Paris Vail, Lisa Esterling, Susan B. Olson, Susan Manley, Iain D. Kerr, Paola Nix, Lisa Esterling, Karla R. Bowles, Benjamin B. Roa, Susan Manley, M. Bryan Warf, Elizabeth Goossen, Jamie Willmott, Susana San Roman, Michelle Landon, Karla R. Bowles, Benjamin B. Roa, Tamar Safra, Lucia Borgato, Anat Wezman, Rivka Berger, Elsa Reich, Julia Smith, Franco M. Muggia, Gabriela Carvalho Fernandes, Rodrigo Depieri Michelli, Henrique Campos Galvão, André Escremim de Paula, Rui Pereira, Carlos Eduardo Andrade, Paula Silva Felicio, Cristiano Padua Souza, Rebeca Grasel, Cristina Silva Sabato, Danilo Vilela Viana, Cristovam Scapulatempo-Neto, Rui Manuel Reis, Edenir Inêz Palmero, Alyssa Smith, Cavin Wong, Claire Bascunana, Anita Hall, Yi Yi Zhang, Mohammad Akbari, George Chong, William Foulkes, George Zogopoulos, Stephen Lincoln, Shan Yang, Yuya Kobayashi, Scott Topper, Robert Nussbaum, Magdalena Ratajska, Magdalena Koczkowska, Monika Zuk, Adam Gorczynski, Wojciech Biernat, Janusz Limon, Bartosz Wasag, Rachel G. Liao, Steering Committee of the Challenge, Sigrid Tronsli Nergaard, Tone B.Aa. Vamre, Lovise O. Maehle, Monica Alvarado, Reina Haque, George E. Tiller, Syed A. Ahmed, David D. Stenehjem, Claire Telford, Sudhir K. Unni, Hillevi Bauer, Amy Sainski, Rishi Deka, Marisa Schauerhamer, Xiangyang Ye, Casey Tak, Junjie Ma, Lia Gutierrez§, James A. Kaye, Jerzy Tyczynski, Diana I. Brixner, Joseph E. Biskupiak, David D. Stenehjem, Jerzy Tyczynski, Sudhir K. Unni, Hillevi Bauer, Amy Sainski, Rishi Deka, Marisa Schauerhamer, Casey Tak, Junjie Ma, Lia Gutierrez, James A. Kaye, Claire Telford, Diana I. Brixner, Joseph E. Biskupiak, Nerina C. van der Merwe, Herculaas M.V.E. Combrink, Botma Visser, Jaco Oosthuizen, Pakiso J. Moeti, Ines Buccamazza, William D. Foulkes, Nerina C. van der Merwe, Jaco Oosthuizen, Herculaas M.V.E. Combrink, Pakiso J. Moeti, Caroline Nangota, Sheba Lothe, Vibeke Wethe Rognlien, Aleksandra Silye Hoven, Lise Bøe, Magnhild K. Fjeldvær, Teresia Wangensteen, Sarah Ariansen, Alexandra Gisbert, Adriana Lasa, David Fisas, Mónica Cornet, Consol López, Mercè Pintor, Nuria Calvo, Andrés Aguilar, Nuria Dueñas, Andrea Vethencourt, Anna Virgili, Maria Teresa Ramón y Cajal, Lea Velsher, Jessica Gu, Jill Furnival, Carmen Williams, Kisha Hope, Jeffrey Dungan, Shohreh Shahabi, Lee Shulman, Najaah Hussain, Ryan Noss, Marcellia Stephens, Kristy Nadolski, Colin O’Rourke, Joseph P. Crowe, Stephen R. Grobmyer, Charis Eng, Holly J. Pederson, Kokichi Sugano, Chikako Shimizu, Teruhiko Yoshida, Daisuke Aoki, Kenta Masuda, Kenjiro Kosaki, Kouji Tanakaya, Hiroshi Yagata, Mikiko Aoki, Shozo Ohsumi, Keika Kaneko, Shinji Kosugi, Tadashi Nomizu, Shinya Oda, Tomoki Koshou, Ingrid E. Fakkert, Eveline van der Veer, Elske Marije Abma, Joop D. Lefrandt, Bruce H.R. Wolffenbuttel, Jan C. Oosterwijk, Riemer H.J.A. Slart, Iris G. Westrik, Geertruida H. de Bock, Marian J.E. Mourits, Fiyinfolu Balogun, Franco Muggia, Missak Haigentz, Mark Persky, Alexander Maslov, Thomas Ow, Valerie Hastings, Jean Seely, Marie Lord, Alicia St. Hill, TracyLyn Tardiff, Kelly Anderson, Emilie Creede, Cathy Gilpin, Erika Smith, Alison Rusnak, Eva Tomiak, Gwyneth Hinds, Gareth Irwin, Lesley McFaul, Rachael Stewart, Lyndsey Morton, Kienan I. Savage, Patrick J. Morrison, Stuart A. McIntosh, Akira Yamauchi, Kumiko Ooseto, Yurina Maeshima, Ryouhei Katsuragi, Sachiko Takahara, Bobbie J. Rimel, Daniella Kamara, Jenny Lester, Ilana Cass, Christine Walsh, Andrew Li, Catherine Bresee, Beth Y. Karlan, Natalia Campacci, Rodrigo A.D. Michelli, Edmundo Mauad, André Lopes Carvalho, Matias E. Melendez, Raphael Haikel, Rui M. Reis, Benedito M. Rossi, Edenir I. Palmero, Jessica Taff, Tamar Safra, Deborah Axelrod, Tsivia Hochman, Julia Smith, Elsa Reich, Stephanie Blank, Bhavana Pothuri, Leslie Boyd, Judith Goldberg, John Curtin, Franco Muggia, Vishakha Tripathi, Anjana Kulkarni, Louise Izzat, Sarah Rose, Cecilia Compton, Ashutosh Kothari, Gautam Mehra, Andrew Tutt, Cherylin Reinholtz, Michelle Weston, Clare Firth, Angela Swampillai, Jian Farhardi, Eshika Haque, Reina Haque, George Tiller, Syed A. Ahmed, Jiaxiao Shi, Joanie Chung, Chantal Avila, Monica Alvarado, Olivier Charette, Gilles Bleau, Zaki El Haffaf, Johanne Richard, Kurosh Rahimi, Serge Nolet, Patricia Tonin, Anne-Marie Mes-Masson, Diane Provencher, Olivier Charette, Gilles Bleau, Zaki El Haffaf, Johanne Richard, Kurosh Rahimi, Serge Nolet, Patricia Tonin, Anne-Marie Mes-Masson, Diane Provencher, Jennifer Wiggins, Angela George, Zoe Kemp, Cathryn Moss, Kelly Kohut, Aimee Dane, Ros Eeles, Kelly Williams, Pagan Morris, Niki Lovick, Julie Mak, Pamela Munster, Wendy-Julie Madore, Etienne De Montigny, Fouzi Benboujja, Mikaël Leduc, Nicolas Godbout, Caroline Boudoux, Anne-Marie Mes-Masson, Kurosh Rahimi, Diane M. Provencher, Gerneiva Parkinson, Karen Wang, Carol Oladele, Marcella Nunez-Smith, Marieke Arts-deJong, Angela Maas, Suzette Elias-Smale, Liselore van Westerop, Leon Massuger, Maria Hopman, Nicoline Hoogerbrugge, Joanne deHullu, Lucinda Hossack, Paul James, Victoria Rasmussen, Mary-Anne Young, Laura Forrest, Mary Shanahan, Clare Hunt, Lyon Mascarenhas, Chris Michael-Lovatt, Susan Shanley, Marion Harris, Gillian Mitchell, Christine Garcia, Maria Martin, Liisa Lyon, Lue-Yen Tucker, Mary Anne Armstrong, Sally McBride-Allen, Ramey D Littell, Amy Alabaster, Tina Raine-Bennett, C. Bethan Powell, Karen Panabaker, Peter Ainsworth, Heather Shaddick, Jacob McGee, Justin Lorentz, Gabriella Ghanem, Stanley Liu, Danny Vesprini, Valeria Viassolo, Aurélie Ayme, Victor Chappuis, Jean-Marc Theler, Idris Guessous, Pierre O. Chappuis, Sarah Colonna, Wendy Kohlmann, Sandra Edwards, Amanda Gammon, Jennifer Saam, Camille Roundy, Carol Sweeney, Kim Herget, Saundra Buys, Bartha Maria Knoppers, Adrian Thorogood, Mark Phillips, Julie Hagan, Emmanuelle Lévesque, Bartha M. Knoppers, Marie-Christine Pouliot, Charles Joly-Beauparlant, Yvan Labrie, Jacques Simard, Arnaud Droit, Francine Durocher, Amanda J. Compadre, Melinda E. Simonson, Katy Gray, Kristin K. Zorn, Eman AlShehri, Suzanna L. Arcand, Kathleen Klein Oros, Anne-Marie Mes-Masson, Diane Provencher, Celia Greenwood, Patricia N. Tonin, Laurent Briollais, Wejdan M. Alenezi, Suzanna L. Arcand, Dunarel Badescu, Timothee Revil, Anne-Marie Mes-Masson, Diane Provencher, Ioannis Ragoussis, Patricia N. Tonin, Suzanna L. Arcand, Frédéric Ancot, Dunarel Badescu, Timothée Revil, Claire S. Leblond, Alexandre Dionne-Laporte, Anne-Marie Mes-Masson, Diane Provencher, Guy Rouleau, Ioannis Ragoussis, Patricia N. Tonin, Akira Hirasawa, Tomoko Akahane, Kenta Masuda, Tomomi Ninomiya, Wataru Yamagami, Hiroyuki Nomura, Fumio Kataoka, Kouji Banno, Nobuyuki Susumu, Daisuke Aoki, Jin Yong Patrick Park, Anita Hall, David Hedley, Ming Tsao, Steven Gallinger, George Zogopoulos, Arjen R. Mensenkamp, Michiel Simons, Aisha Sie, Hicham Ouchene, Monique van Asseldonk, Astrid Eijkelenboom, Alex Hoischen, Marcel Nelen, Nicoline Hoogerbrugge, Marjolijn J Ligtenberg, Mattias Van Heetvelde, Trees Lepez, Leen Pieters, Steve Lefever, Jo Van Dorpe, Kathleen Lambein, Marleen Praet, Ivo Van Den Berghe, Frauke Coppieters, Jo Vandesompele, Nadine Van Roy, Dieter Deforce, Anne Vral, Kim De Leeneer, Kathleen Claes, Nur Yucer, Marie Holzapfel, Mae Zakhour, Tilley Jenkins Vogel, David Rushton, Michael Nelson, Clive Svendsen, Beth Y. Karlan, Aurélie Ayme, Valeria Viassolo, Isabelle Gauchat-Bouchardy, Pierre O. Chappuis, Gillian Ellison, John Mills, Thomas Hedley Carr, Miika Ahdesmaki, Justin Jonson, Marisa Cunha, Sally Luke, Brian Dougherty, J. Carl Barrett, Jan Brouwer, Joost Kluiver, Rodrigo C. de Almeida, Rutger Modderman, Miente M. Terpstra, Klaas Kok, Sebo Withoff, Harry Hollema, Welmoed Reitsma, Geertruida H. de Bock, Marian J.E. Mourits, Anke van den Berg, Megan L. Marshall, Lisa R. Susswein, Laura M. Andolina, Kathleen S. Hruska, Rachel T. Klein, Laura Andolina, Megan Marshall, Lisa Susswein, Rachel Klein, Kathleen Hruska, Lídia Feliubadaló, Raúl Tonda, Mireia Gausachs, Jean-Rémi Trotta, Elisabeth Castellanos, Àlex Teulé, Eva Tornero, Bernat Gel, Marta Gut, Gabriel Capella, Ivo Gut, Eduard Serra, Joan Brunet, Sergi Beltran, Conxi Lázaro, Leora Witkowski, Catherine Goudie, Pilar Ramos, Anthony N. Karnezis, Talia Boshari, Michel Longy, James A. Knost, Emmanouil Saloustros, W. Glenn McCluggage, David Huntsman, Douglas A. Levine, William Hendricks, Jeffrey Trent, Martin Hasselblatt, William D. Foulkes, Abigail L. Savage, Georgia Chenevix-Trench, Jun Jun Li, kConFab, Simon S. McDade, Patrick J. Morrison, Stuart A. McIntosh, D. Paul Harkin, Kienan I. Savage, Lisa R. Susswein, Megan L. Marshall, Rachel Nusbaum, Lauren Yackowski, Karen Powell, Patricia D. Murphy, Kathleen S. Hruska, Rachel T. Klein, Stephen E. Lincoln, Andrea J. Desmond, Allison W. Kurian, Shan Yang, Yuya Kobayashi, Nadine M. Tung, James M. Ford, Lauren Bear, Shelley McCormick, Leif W. Ellisen, Shana J. Kim, Anna Zuchniak, Jan Lubinski, Susan Armel Randall, Andrea Eisen, Young-In Kim, Steven A. Narod, Joanne Kotsopoulos, Amanda Gammon, John Abernethy, Eric Rosenthal, Heidi Gorringe, Krystal Brown, John Kidd, Susan Manley, Judith Balmana, Joan Brunet, Sara Gutierrez-Enriquez, Eduard Serra, Sandra Bonache, L. Feliudabalo, Irene Esteban, Matilde Navarro, Neus Gadea, Elisabeth Castellanos, J. Del Valle, Elena Garcia-Arumi, Monica Salinas, Orland Diez, Conxi Lazaro, Roy Kessous, Ido Laskov, Jeremie Abitbol, Shannon Salvador, Susie Lau, Amber Yasmeen, Walter H. Gotlieb, Marjanka K. Schmidt, Frans Hogervorst, Sten Cornelissen, Lizet van der Kolk, Muriel Adank, Heli Nevanlinna, Stig Bojesen, Thilo Doerk, Douglas F. Easton, Tu Nguyen-Dumont, Alexis Roberge, Daniel J. Park, Miroslav K. Kapuscinski, Fleur Hammet, Maryam Mahmoodi, Helen Tsimiklis, Bernard J. Pope, Andrew Lonie, Khalid Mahmood, kConFab, ABCFS, John L. Hopper, Melissa C. Southey, , Justin Lorentz, Kelsey Kalbfleisch, Tracy Graham, Karen Ott, Talia Mancuso, Andrea Eisen, Ulrike Faust, Ilnaz Sepahi, Kristin Bosse, Martin Kehrer, Mechthilde Heilig, Kathrin Grundman-Hauser, Peter Bauer, Olaf Riess, Hoa Nguyen, Christopher Schroeder, Valentina Silvestri, Veronica Zelli, Virginia Valentini, Piera Rizzolo, Anna Sara Navazio, Giovanni Chillemi, Alessandra Viel, Antonio Russo, Maria Grazia Tibiletti, Domenico Palli, Laura Cortesi, Giuseppe Giannini, Paolo Radice, Marco Montagna, Laura Ottini, Olivia Moran, Zhou Chen, Katherine Vallis, Aletta Poll, Peter Ainsworth, Steven A. Narod, Joanne Kotsopoulos, Nicola Poplawski, Jacqueline Armstrong, Gemma Correnti, Vanessa Huntley, Alisha McLauchlan, Sally Russell, Debra Trott, Irene Catucci, Giovanna De Vecchi, Federica Zanardi, Simone Minardi, Mirko Riboni, Jacopo Azzollini, Bernard Peissel, Lidia Pezzani, Sara Volorio, Valeria Pensotti, Stefano Casola, Paolo Radice, Siranoush Manoukian, Paolo Peterlongo, Magdalena Ratajska, Magdalena Koczkowska, Maciej Stukan, Alina Kuzniacka, Katarzyna Klonowska, Piotr Kozlowski, Wojciech Biernat, Marcin Sniadecki, Jaroslaw Debniak, Dariusz Wydra, Miroslaw Dudziak, Janusz Limon, Bartosz Wasag, Petra Kleiblova, Jana Soukupova, Filip Lhota, Jan Hojny, Lenka Stolarova, Marketa Janatova, Petra Zemankova, Klara Zdarilova, Marianna Borecka, Ales Panczak, Kamila Vesela, Jaroslav Kotlas, Martina Zimovjanova, Michal Vocka, Zdenek Kleibl, Stavros Glentis, Antigone Dimas, Alexandros Dimopoulos, Kostas Rouskas, Florentia Fostira, Eirini Konstantopoulou, Drakoulis Yannoukakos, Ioannis Ragoussis, Katherine M. Tucker, Natalie Taylor, Emma Healey, Rachel Williams, Ian Campbell, Ella Thompson, Mary-Anne Young, Gillian Mitchell, Alison Trainer, Na Li, Simone Rowley, Paul James, Jinbo Chen, Xinglei Chai, Sining Chen, Susan Domchek, Timothy R. Rebbeck, Alicia Tone, Jeanna McCuaig, Carl Virtanen, Sarah Ferguson, Taymaa May, Stephane Laframboise, Raymond H. Kim, Jennifer Shuldiner, Gary Rodin, Terri Stuart-McEwan, Patricia Shaw, Amit Oza, Suzanne Kamel-Reid, Tracy Stockley, Marcus Bernardini, Setareh Moghadasi, Nizet Dijkstra, Wendy van Zelst-Stams, Jan Oosterwijk, Margreet Ausems, Rogier Oldenburg, Muriel Adank, Eveline Blom, Mariëlle Ruijs, Theo van Os, Carolien van Deurzen, John Martens, Carolien Schröder, Maaike Vreeswijk, Christi van Asperen, Ana Best, Margaret Tucker, Mark Greene, Hormuzd Katki, Jennifer Fulbright, Scott Michalski, Karen Vikstrom, Shan Yang, Steve Lincoln, Edward Esplin, Annie Tsz-Wai Chu, Desiree Man-Sik Tse, Ava Kwong, Kristina G. Flores, Laurie E. Steffen, Christopher J. McLouth, Belinda E. Vicuna, Amanda Gammon, Wendy Kohlmann, Lucretia Vigil, Zoneddy R. Dayao, Melanie E. Royce, Anita Y. Kinney, Natalia Teixeira, Simone Maistro, Maria del P.E. Diz, Marian J.E. Mourits, Maria A.K. Folgueira, Geertruida H. de Bock, Wendy S. Meschino, Joanne Honeyford, Tianhua Huang, Ingrid Ambus, Michael Misinai, Stephanie Robinson, Maria Muraca, Doreen Saint, Kjersti Jørgensen, Eli Marie Grindedal, Teresia Wangensteen, Trine Levin Bodd, Neal Clark, Lovise Mæhle, Adrià López, Lídia Feliubadaló, Hanan Ahmed, Esther Darder, Àngel Izquierdo, Ares Solanes, Eva Tornero, Àlex Teulé, Mireia Menéndez, Mònica Salinas, Àngela Velasco, Gabriel Capellá, Conxi Lázaro, Pilar Barretina§, Joan Brunet, Beth Souders, Michele Gabree, Jill Dolinsky, Rachel McFarland, Shuwei Li, David Hermel, Wendy McKinnon, Marc Greenblatt, Marie Wood, Emilie M. Creede, Erika Smith, Eva Tomiak, Adrià Lopez, Mònica Salinas, Silvia Iglesias, Angela Velasco, Esther Darder, Lidia Feliubadaló, Conxi Lázaro, Gabriel Capellà, Joan Brunet, Francsico Gil, Àlex Teulé, Kaylene Ready, Kathleen Berentsen, Elizabeth Denne, Gabriel Lazarin, Imran Haque, James Goldberg, Andrea D. Forman, Mary B. Daly, Deborah Casso, Claire Telford, Joe Clune, Susan A. Oliveria, Jasdeep Saggar, Jerzy E. Tyczynski, Magdalena Ratajska, Izabela Brozek, Magdalena Koczkowska, Alina Kuzniacka, Magdalena Krygier, Jaroslaw Debniak, Bartosz Wasag, Janusz Limon, Nora Johansen, Lars Mørkrid, Astrid Helene Liavaag, Trond Melbye Michelsen, Katherine Dempsey, Joseph Ensor, Angel Rodriguez, Jenny Chang, Tejal Patel, Heather Douglas, Ines Sumargo, Lea Velsher, Jocelyne Chiquette, Josée Rhéaume, Claire Brousseau, Karen Panabaker, Peter Ainsworth, C.M. (Meg) McLachlin, Eva Tomiak, Kelly Anderson, Bojana Djordjevic, Alexandra Grieb, Jennifer Scalia Wilbur, Jessica Laprise, Marcina Beaston, Robert Legare, Zaki El Haffaf, Nadine Dumas, Marie Claire Binet, Fanny Coron, Bouchra Labraki, Johanne Richard, Serge Nolet, Diane Provencher, Maude Lefebvre, Pavel Hamet, Gloria Huang, Ilian Tchakov, Philippe Huot-Marchand, Giovanni Scambia, Ettore Capoluongo, Begoña Graña, Zaida Garcia Casado, Andres Poveda, Sudeep Karve, Danielle Potter, David Lawrence, Jerzy E. Tyczynski, Eva Chalas,

A substantial proportion of women who undergo BRCA1/2 testing learn that they carry a variant of uncertain significance (vus), whose consequences for BRCA1/2 activity and therefore cancer risk are unknown. A path towards addressing this failure in cancer-risk assessment and prevention is to experimentally measure the functional consequences of all ... Read more >>

Curr Oncol (Current oncology (Toronto, Ont.))
[2016, 23(3):e284-e319]

Cited: 0 times

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Comparison of locus-specific databases for BRCA1 and BRCA2 variants reveals disparity in variant classification within and among databases.

Paris J Vail, Brian Morris, Aric van Kan, Brianna C Burdett, Kelsey Moyes, Aaron Theisen, Iain D Kerr, Richard J Wenstrup, Julie M Eggington,

Genetic variants of uncertain clinical significance (VUSs) are a common outcome of clinical genetic testing. Locus-specific variant databases (LSDBs) have been established for numerous disease-associated genes as a research tool for the interpretation of genetic sequence variants to facilitate variant interpretation via aggregated data. If LSDBs are to be used ... Read more >>

(Journal of community genetics)
[2015, 6(4):351-359]

Cited: 22 times

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Proffered papers and posters submitted to the Fifth International Symposium on Hereditary Breast and Ovarian Cancer, BRCA: Twenty Years of Advances

Eric Rosenthal, Kelsey Moyes, Christopher Arnell, Richard J. Wenstrup, Ankita Jhuraney, Aneliya Velkova, Bailey Kessing, Renato Carvalho, Phillip Wiley, Amanda Spurdle, Maaike P.G. Vreeswijk, Sandrine Caputo, Gael Millot, Ana Vega, Nicolas Coquelle, Alvaro Galli, Diana Eccles, Marinus J. Blok, Tuya Pal, Rob B. van der Luijt, Marta Santamariña Pena, Susan L. Neuhausen, Talia Donenberg, Eva Machackova, Simon Thomas, Maxime Vallée, Sean Tavtigian, J.N. Mark Glover, Marcelo Alex Carvalho, Lawrence Brody, Shyam Sharan, Alvaro N. Monteiro, Eliseos Mucaki, Natasha Caminsky, Alan Stuart, Coby Viner, Ben Shirley, Joan Knoll, Peter Ainsworth, Peter Rogan, Jude M. Mulligan, Laura A. Hill, Steve Deharo, Gareth Irwin, David Boyle, Katherine E. Keating, Olaide Y. Raji, Fionnuala A. McDyer, Eamonn O’Brien, Max Bylesjo, Manuel Salto–Tellez, Patrick G. Johnston, Fergus J. Couch, D. Paul Harkin, Richard D. Kennedy, Anders Bojesen, Annabeth Høgh Petersen, Mads Jørgensen, Henriette Nielsen, Marianne Waldstrøm, Karina Dahl Steffensen, Leora Witkowski, Jian Carrot–Zhang, Steffen Albrecht, Nancy Hamel, Eva Tomiak, David Grynspan, Emmanouil Saloustros, Catherine Gilpin, Rachel Silva–Smith, François Plourde, Barbara Rivera, Ester Castellsagué, Mona Wu, Somayyeh Fahiminiya, Avi Saskin, Madeleine Arseneault, Rouzan G. Karabakhtsian, Elizabeth A. Reilly, Frederick R. Ueland, Anna Margiolaki, Kitty Pavlakis, Sharon M. Castellino, Janez Lamovec, Lawrence M. Roth, Thomas M. Ulbright, Tracey A. Bender, Michel Longy, Andrew Berchuck, Marc Tischkowitz, Inga Nagel, Reiner Siebert, Vassilis Georgoulias, Colin J.R. Stewart, Jocelyne Arseneau, W. Glenn McCluggage, Blaise A. Clarke, Yasser Riazalhosseini, Martin Hasselblatt, Jacek Majewski, William D. Foulkes, Kienan I. Savage, Julia J. Gorski, Eliana M. Barros, Gareth W. Irwin, Simon S. McDade, Lorenzo Manti, Andrea Pellagatti, Natalia Lukashchuk, Dennis J. MCance, W. Glenn McCluggage, Giuseppe Schettino, Manuel Salto–Tellez, Jacqueline Boultwood, Derek J. Richard, D. Paul Harkin, Shailja Pathania, Sangeeta Bade, Karly Burke, Rachel Reed, Morwenna Le Guillou, Andrea Richardson, Jean Feunteun, Judy Garber, David Livingston, Maud Marques, Marie-Claude Beauchamp, Ido Laskov, Qiang Sun, Walter Gotlieb, Michael Witcher, Kelly Metcalfe, Parviz Ghadirian, Henry T. Lynch, Carrie Snyder, William D. Foulkes, Nadine Tung, Charmaine Kim–Sing, Olufunmilayo I. Olopade, Andrea Eisen, Barry Rosen, Shelly Gershman, Ping Sun, Steven Narod, Tamar Safra, Ori Rogowski, Franco Muggia, Heather L. Baltzer, Olivier Alonzo-Proulx, James G. Mainprize, Martin J. Yaffe, Kelly A. Metcalfe, Steve A. Narod, Ellen Warner, John L. Semple, Rosalind Eeles, Elena Castro, David Olmos, Ed Saunders, Daniel Leongamornlert, Malgorzata Tymrakiewicz, Liz Bancroft, Sibel Saya, Zsofia Kote–Jarai, Michelle Guy, Koveela Govindasami, Douglas F. Easton, Steve Ellis, Antonis C. Antoniou, EMBRACE collaborators, UKGPCS collaborators, Mohammad R. Akbari, C.J.D. Wallis, Ants Toi, John Trachtenberg, Ping Sun, Steven A. Narod, Robert K. Nam, Alyssa Smith, Robert Grant, Anita Hall, Najmeh Alirezaie, Claire Bascuñana, Spring Holter, Thomas Whelan, Iris Selander, Treasa McPherson, Atilla Omeroglu, Emmanouil Saloustros, Jacek Majewski, William Foulkes, Steven Gallinger, George Zogopoulos, Tuya Pal, Deborah Cragun, Devon Bonner, Mohammad Akbari, Steven Narod, Susan Vadaparampil, Janet R. Vos, Marian J.E. Mourits, Annemarie H. van der Hout, Jan C. Oosterwijk, Geertruida H. de Bock, Megan Myers, Peggy Conrad, Jonathan Terdiman, Sarah L. Sawyer, Jukka S. Moilanen, Roger A. Greenberg, Jeremy Schwartzentruber, University of Washington Centre for Mendelian Genomics, FORGE Canada Consortium, Jacek Majewski, Kym M. Boycott, A. Micheil Innes, David A. Dyment, Antonis C. Antoniou, Silvia Casadei, Tuomas Heikkinen, Katri Pylkäs, Kim De Leeneer, Florentia Fostira, Heli Nevanlinna, Zhi L. Teo, Clare Turnbull, Paolo Radice, Mary-Claire King, Melissa C. Southey, Robert Winqvist, William D. Foulkes, Marc Tischkowitz, Ella R. Thompson, Simone M. Rowley, Maria A. Doyle, Jason Ellul, Alison Trainer, Paul James, LifePool, Michelle Wong–Brown, Gillian Mitchell, Rodney J. Scott, Ian G. Campbell, James M. Ford, Allison W. Kurian, Yuya Kobayashi, Emily Hare, Meredith Mills, Kerry Kingham, Michele Cargill, Stephen Lincoln, Ian Campbell, Ella Thompson, Paul James, Gillian Mitchell, Alison Trainer, Paul A. James, Sarah Sawyer, Simone McInerny, Jonathan Beesley, Marion Harris, Kathleen Cunningham Foundation, AOCS, Geoffrey J. Lindeman, Georgia Chenevix–Trench, Gillian Mitchell, Christine Garcia, Liisa Lyon, Ramey D. Littell, C. Bethan Powell, Peter J. Ainsworth, Nancy Rodenhiser, Cara Reith, J. Alan Stuart, Peter Rogan, Heidi McCoy, Kelsey Moyes, Christopher Arnell, Michelle Landon, Eric Rosenthal, Dmitry Pruss, Richard J. Wenstrup, Karla R. Bowles, Brian Morris, Dmitry Pruss, Jack Ji, Nanda Singh, Benjamin B. Roa, Richard J. Wenstrup, Iain D. Kerr, Julie M. Eggington, Kelsey Moyes, Brianna C. Burdett, Aric Van Kan, Heather McElroy, Paris J. Vail, Dechie B. Sumampong, Nicholas J. Monteferrante, Kennedy L. Hardman, Aaron Theisen, Eric Rosenthal, Richard J. Wenstrup, Rakefet Chen–Shtoyerman, Noa Ben-Baruch, Tanir Allweis, Alon Ben Arie, Rachel Nissani, Zvi Appelman, Elizabeth J. van Rensburg, Michelle D. Sluiter, Cecilia M. Dorfling, Lenka Foretova, Marie Navratilova, Marek Svoboda, Eva Stahlova–Hrabincova, Petra Vasickova, Jana Hazova, Eva Machackova, Frederic Ancot, Suzanna L. Arcand, Serge Nolet, Anne-Marie Mes–Masson, Zaki El Haffaf, Diane M. Provencher, Patricia Tonin, Marcia Llacuachaqui, Julio Abugattas, Yasser Sullcahuaman Allende, Abelardo Arias Velásquez, Raul Velarde, Jose Cotrina, Milko Garcés, Mauricio Leon, Gabriela Calderon, Miguel de la Cruz, Robert Royer, Alejandra Ragone, Garrett Larson, Jeffrey N. Weitzel, Steven A. Narod, Talia Donenberg, Sophia George, Mohammad Akbari, Cheryl Alexis, Gillian Wharfe, Sook Yin, Hedda Dyer, Theodore Turnquest, Steven A. Narod, Judith Hurley, Nicholas T. Woods, Ankita Jhuraney, Rebekah Baskin, Tereza Vaclova, Edwin S. Iversen, Alvaro N.A. Monteiro, Ulrike Faust, Tanja Benkert, Mechthilde Heilig, Sonja Hertler, Marc Sturm, Kathrin Grundmann–Hauser, Huu Phuc Nguyen, Christopher Schroeder, Olaf Riess, Peter Bauer, Heidi Dreyfuss, Lindsay Dohany, Jennifer Fulbright, Ashley Reeves, Dana Zakalik, Christopher Schroeder, Ulrike Faust, Marc Sturm, Olaf Riess, Hoa Nguyen, Peter Bauer, Charles Strom, Chris Elzinga, Steven Rivera, Taraneh Angeloni, Sun Hee Rosenthal, Martin Siaw, Jamie Platt, Cory Braastadt, David Ross, Weimin Sun, Fian B.F. Law, Chun Hang Au, Dona N. Ho, Bui Kar Ip, Anthony T.C. Wong, Tsun Leung Chan, Edmond S.K. Ma, Ava Kwong, Iryna Vyarvelska, Svitlana Struk, Steven A. Narod, Jacek Gronwald, Joanne Kotsopoulos, Jan Lubinski, Henry T. Lynch, Christian Singer, Charis Eng, Susan L. Neuhausen, Beth Karlan, Charmaine Kim–Sing, Tomasz Huzarski, Jacek Gronwald, Jeanna McCuaig, Leigha Senter, Nadine Tung, Parviz Ghadirian, Andrea Eisen, Nora Johansen, Astrid Helene Liavaag, Ole-Erik Iversen, Anne Dørum, Trond Melbye Michelsen, Ian Campbell, Lisa Devereux, Gillian Mitchell, Paul James, Vicki Pridmore, Annelot Baert, Julie Depuydt, Bruce Poppe, Fransiska Malfait, Tom Van Maerken, Tim Van Damme, Kim De Leeneer, Kathleen Claes, Anne Vral, Adam H. Buchanan, Catherine Fine, Celette Sugg Skinner, Joellen M. Schildkraut, Nora Horick, P. Kelly Marcom, Corrine I. Voils, Vanessa Jacoby, Mindy Goldman, Julie Mak, Priscilla Hsue, Stephanie Lemp, Eric Vitttinghoff, Beth Crawford, Lee-May Chen, Dina Nikitina, Steven A. Narod, Joanne Kotsopoulos, Salha Bujassoum Al Bader, Hekmet Bugrein, Reena Alassam, Reem Al-Sulaiman, Hiroshi Yagata, Mikiko Yoshino, Hideko Yamauchi, Ceri Hirst, Stella Moss, Pieter De Richter, Sonya Guedaoura, Sylvie Pelletier, William D. Foulkes, Pavel Hamet, Jocelyne Chiquette, Nora Wong, Zaki El Haffaf, Jacques Simard, Michel Dorval, Gareth W. Irwin, Rachel A. Stewart, Lynsey A. Morton, Gwyneth Hinds, Lesley McFaul, Kienan I. Savage, Patrick J. Morrison, Stuart A. McIntosh, Geneviève Larouche, Jocelyne Chiquette, Jacques Simard, Michel Dorval, Jessica Taff, Julia Smith, Tsivia Hochman, Maria Alvear, Christine Marion, Yvonne Lin, Deborah Axelrod, Franco Muggia, Corissa Androich, Kathleen Bell, Lorrie Lynch, Louise Bordeleau, Kevin Zbuk, Charité Ricker, Heather MacDonald, Lynda Roman, Ira Shulman, Grace Wong, Neisha Opper, Darcy Spicer, Meera Joseph, Faiza Rab, Karen Panabaker, Jeff Nisker, Dominique St-Pierre, Ariane Santerre–Theil, Karine Bouchard, Catherine Gonthier, Anne-Marie Drolet, Claudia Côté, Josée Rhéaume, Jocelyne Chiquette, Michel Dorval, Ariane Santerre–Theil, Dominique St-Pierre, Karine Bouchard, Anne-Marie Drolet, Jocelyne Chiquette, Michel Dorval, Kelly Grover, Elisabeth Baugh, Lindsay Dohany, Heidi Dreyfuss, Jennifer Fulbright, Ashley Reeves, Dana Zakalik, Chieko Tamura, Keika Kaneko, Haruna Masuta, Yasushi Nakamura, Shozo Ohsumi, Edward S. Dove, Ma’n H. Zawati, Emmanuelle Lévesque, Jacques Simard, Bartha M. Knoppers, Jeff Nisker, Meera Joseph, Elise Karagueuzian, Alexandra Youngke, Bob Cook–Deegan, Kathleen Klein Oros, Suzanna Arcand, Patricia N. Tonin, Celia M.T. Greenwood, Filip Lhota, Viktor Stranecky, Petra Boudova, Jana Soukupova, Katerina Hodanova, Hana Hartmannova, Marketa Janatova, Petra Kleiblova, Petr Pohlreich, Stanislav Kmoch, Zdenek Kleibl, Alison H. Trainer, Ella Thompson, Maria Doyle, Sally Hunter, Simone Rowley, Paul A. James, Antonis Antoniou, K-Confab Breast Cancer Consortium, Nicholas Pachter, Julie McGaughran, Katherine Tucker, Jo Burke, Ian Campbell, Sophia H.L. George, Anca Milea, Ramlogan Sowamber, Danielle Toccalino, Patricia Shaw, Rachael Pettapiece–Phillips, Mohammad Akbari, Leonardo Salmena, Steven Narod, Joanne Kotsopoulos, Oreekha Amin, Amber Yasmeen, Marie-Claude Beauchamp, Paul Rbou Nader, Sanaa Iqbal, Walter H. Gotlieb, Gillian Ellison, Shuwen Huang, Hedley Carr, Andrew Wallace, Sanjeev Bashkar, John Mills, N.C. van der Merwe, H.M.V.E. Combrink, J. Oosthuizen, P.J. Moeti, B. Visser, N. Peter, I. Buccamazza, M. Schoeman, J.P. Apffelstaedt, W. Chen, W.D. Foulkes, Brooke E. Howitt, Emily E. Meserve, Suchanan Hanamorngruang, James R. Conner, Douglas Lin, Stephanie Schulte, Christopher P. Crum, Kelly Anderson, Bojana Djordjevic, Nancy Carson, Eva Tomiak, Zoe Andrei, Anita Hall, Abba Malina, Jerry Pelletier, Peter Metrakos, George Zogopoulos, Natalia Babkina, Sandra Orsulic, Xinmin Li, Beth Karlan, Ora Gordon, Stephen Lincoln, Allison Kurian, Kristen Shannon, Yuya Kobayashi, Michael Anderson, Geoffrey Nilsen, Kevin Jacobs, Meredith Mills, Andrew Schultz, Andrea Desmond, Martin Powers, Federico Monzon, James Ford, Leif Ellisen, Christine Rappaport–Fuerhauser, Andreas Weinhaeusel, Michael Seifert, Brigitte Marian, Christian F. Singer, Sarah D. Sawyer, Simone C. McInerny, Jonathan Beesley, Marion Harris, Geoffrey J. Lindeman, Martin B. Delatycki, Alison H. Trainer, Georgia Chenevix–Trench, Gillian Mitchell, Paul A. James, Jennifer Beebe–Dimmer, Ethan Lange, Kimberly Zuhlke, Kathleen Cooney, Kim De Leeneer, Tom Van Maerken, Ilse Coene, Brecht Crombez, Annelies De Jaegher, Bruce Poppe, Kathleen Claes, Steven Keiles, Jill Dollinsky, A.J. Stuenkel, Jennifer Thompson, Tricia Zion, Elizabeth Chao, Chaymaa Marouf, Amal Tazzite, Bréhima Diakité, Hassan Jouhadi, Abdellatif Benider, Sellama Nadifi, Danielle Hanna, Gordon Glendon, Julia Knight, Lothar Lilge, Louise Bordeleau, Susan Armel, Deborah Terespolsky, Seema Panchal, June Carroll, Irene Andrulis, Florentia Fostira, Paraskevi Apostolou, Myrto Papamentzelopoulou, Irene Konstanta, Athanasios Vratimos, George Fountzilas, Gerassimos Voutsinas, Irene Konstantopoulou, Drakoulis Yannoukakos, Pratibha Bhai, IC Verma, Saxena Renu, Katarzyna Klonowska, Magdalena Ratajska, Alina Kuzniacka, Izabela Brozek, Piotr Kozlowski, Janusz Limon, Magdalena Ratajska, Alina Kuzniacka, Magdalena Matusiak, Izabela Brozek, Maxim Pilyugin, Jaroslaw Debniak, Marcin Sniadecki, Dariusz Wydra, Irmgard Irminger–Finger, Janusz Limon, Fabienne Lesueur, Francesca Damiola, Maroulio Pertesi, Javier Oliver, Florence Le Calvez–Kelm, Erin L. Young, Terrell C. Roane, Gareth J. Williams, Breast Cancer Family Registry, John L. Hopper, Melissa C. Southey, Irene L. Andrulis, Esther M. John, David E. Goldgar, Sean V. Tavtigian, Karine Bédard, Suzanna L. Arcand, Najmeh Alirezaie, Jacek Majewski, Serge Nolet, Zaki El Haffaf, Diane M. Provencher, Anne-Marie Mes–Masson, Patricia N. Tonin, Lindsay Dohany, Heidi Dreyfuss, Jennifer Fulbright, Ashley Reeves, Dana Zakalik, Julie Dutil, Jamie K. Teer, Sean J. Yoder, Jaime L. Matta, Alvaro Monteiro, Suzanna L. Arcand, Mohammad R. Akbari, Anne-Marie Mes–Masson, Diane Provencher, Steven A. Narod, Patricia N. Tonin, Sarah D. Sawyer, Laura Forrest, Gillian Mitchell, Nina Hallowell, Paul A. James, Mary-Anne Young, Pnina Mor, Uzi Beller, Talia Eldar Geva, Gheona Altarescu, Julie Lapointe, Jacques Simard, Claire Julian–Reynier, Michel Dorval, Magan Trottier, Steven A. Narod, John Lunn, Talia Donenberg, Judith Hurley, DuVaughn Curling, Raleigh Butler, Jolyane Blouin–Bougie, Nabil Amara, Jalila Jbilou, Norrin Halilem, Jacques Simard, Réjean Landry, Vasily Giannakeas, Steven Narod, Andrea Eisen, Maegan Prummel, Wendy Meschino, Derek Muradali, Meaghan Horgan, June Carroll, Rene Shumak, Ellen Warner, Linda Rabeneck, Anna Chiarelli, Susan Randall Armel, Jeanna McCuaig, Nicole Gojska, Rochelle Demsky, Joan Murphy, Barry Rosen, Emanuele Mazzola, Jonathan Chipman, Su-Chun Cheng, Giovanni Parmigiani, Sarah McGarrigle, Emer Guinan, Juliette Hussey, Jacintha O’Sullivan, David Gallagher, Elizabeth Connolly, Emer M. Guinan, Sarah A. McGarrigle, Juliette Hussey, Laura A. Healy, David Gallagher, Elizabeth Connolly, Valerie Hastings, Marie Lord, Suzie Joanisse, Kelly Anderson, Emilie Creede, Cathy Gilpin, Erika Smith, Alison Rusnak, Eva Tomiak, Sivan Agranat, Hagit Barris, Inbal Kedar, Mordechai Shohat, Aaron Sulkes, Shulamith Rizel, Shlomit Perry, Rinat Yerushalmi, Gwyneth Hinds, Gareth Irwin, Lesley McFaul, Peter McGoldrick, Fiona Williams, Kienan Savage, Ian Harley, Shane McKee, Stuart A. McIntosh, Erika Smith, Nancy Carson, Kelly Anderson, Emilie Creede, Cathy Gilpin, Valerie Hastings, Alison Rusnak, Eva Tomiak, Sari Lieberman, Ariela Tomer, Aviad Raz, Avraham Ben-Chetrit, Oded Olsha, Amnon Lahad, Ephrat Levy–Lahad, Hitomi Kitagawa, Hiroshi Yagata, Atsushi Yoshida, Eriko Nakano, Mikiko Yoshino, Hideko Yamauchi, Anita Vabø, Eli Marie Grindedal, Lovise Maehle, Eldbjørg Hanslien, Heidi Medvik, Pål Møller, Valeria Viassolo, Aurélie Ayme, Véronique Membrez, Anne E. Murphy, Jean-Louis Blouin, Michela Rebsamen, Pierre Hutter, Pierre O. Chappuis, Norhashimah Hassan, Yoon Sook Yee, Nur Aishah Mohd Taib, Yip Cheng Har, Teo Soo Hwang, Julie Lecarpentier, Catherine Noguès, Emmanuelle Mouret–Fourme, Marion Gauthier–Villars, Valérie Bonadona, Jean-Pierre Fricker, Olivier Caron, Dominique Stoppa–Lyonnet, Pascaline Berthet, Laurence Faivre, Bruno Buecher, Isabelle Coupier, Catherine Dugast, Nadine Andrieu, Emilie Creede, Kelly Anderson, Erika Smith, Valerie Hastings, Cathy Gilpin, Eva Tomiak, Alison Rusnak, Maria Katapodi, Debra Duquette, Kara Milliron, Kari Mendelsohn–Victor, Beth Anderson, Sofia Merajver, Karen Panabaker, Nancy Rodenhiser, Peter Ainsworth, Joanie Leclerc, Karine Bouchard, Jocelyne Chiquette, Geneviève Larouche, Gord Glendon, Christine M. Maugard, Jacques Simard, Michel Dorval, Marie-Claire Binet, Maude Lefebvre, Fanny Coron, Nadine Dumas, Anna Szuto, Johanne Richard–Chesnay, Diane Provencher, Serge Nolet, Pavel Hamet, Zaki El Haffaf, Zaki El Haffaf, Marie-Claire Binet, Maude Lefebvre, Nadine Dumas, Anna Szuto, Fanny Coron, Johanne Richard–Chesnay, Diane Provencher, Serge Nolet, Pavel Hamet,

Objectives: It is estimated that 1%–2% of individuals of Ashkenazi Jewish (aj) ancestry carry one of three pathogenic founder mutations in BRCA1 and BRCA2. Targeted testing for these mutations (BRCA1 187delAG and 5385insC, and BRCA2 6174delT) is therefore recommended for all aj breast and ovarian cancer patients, regardless of age ... Read more >>

Curr Oncol (Current oncology (Toronto, Ont.))
[2014, 21(2):e358-e391]

Cited: 0 times

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