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Author Paolo Severino

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Prevalence and Clinical Implications of COVID-19 Myocarditis

Cristina Chimenti, Michele Magnocavallo, Federico Ballatore, Federico Bernardini, Maria Alfarano, Domenico Giovanni Della Rocca, Paolo Severino, Carlo Lavalle, Fedele Francesco, Andrea Frustaci,

Synopsis The clinical manifestations of COVID-19 are widely variable and may involve several districts. Although the clinical course is mostly characterized by respiratory involvement, up to 30% of hospitalized patients have evidence of myocardial injury due to acute coronary syndrome, cardiac arrhythmias, myocarditis, and cardiogenic shock. In particular, myocarditis is ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, :]

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Sodium-glucose cotransporter 2 inhibitors and heart failure: the best timing for the right patient.

Paolo Severino, Andrea D'Amato, Silvia Prosperi, Bettina Costi, Danilo Angotti, Lucia Ilaria Birtolo, Cristina Chimenti, Carlo Lavalle, Viviana Maestrini, Massimo Mancone, Francesco Fedele,

Sodium-glucose cotransporter 2 inhibitors (SGLT2i), initially born as anti-diabetic drugs, have shown many beneficial effects on the cardiovascular system, in particular against heart failure (HF). HF is a complex and multifaceted disease that requires a comprehensive approach. It should not be considered as a simplistic cardiac disease, but a systemic ... Read more >>

Heart Fail Rev (Heart failure reviews)
[2021, :]

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Dual pathway inhibition in atherothrombosis prevention: yes, now we can!

Francesco Summaria, Giuseppe Biondi-Zoccai, Enrico Romagnoli, Mamas A Mamas, Francesco Franchi, Paolo Severino, Carlo Lavalle, Francesco Versaci, Achille Gaspardone, Deepak L Bhatt,

Despite ongoing developments, prevention and treatment of atherothrombotic cardiovascular disease remains a common challenge. Antithrombotic options for cardiocerebrovascular disease prevention involves a choice between dual antiplatelet therapy (DAPT) and dual pathway inhibition (DPI), which includes an antiplatelet agent and a reduced dose anticoagulant agent. In selected patients at high risk ... Read more >>

Minerva Cardiol Angiol (Minerva cardiology and angiology)
[2021, :]

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Impact of COVID-19 Pandemic on Cardiac Electronic Device Management and Role of Remote Monitoring

Michele Magnocavallo, Giampaolo Vetta, Alessia Bernardini, Agostino Piro, Maria Chiara Mei, Martina Di Iorio, Marco Valerio Mariani, Domenico G. Della Rocca, Paolo Severino, Raffaele Quaglione, Giuseppe Giunta, Cristina Chimenti, Fabio Miraldi, Carmine Dario Vizza, Francesco Fedele, Carlo Lavalle,

Synopsis During the Coronavirus Disease 2019 (COVID-19) worldwide pandemic, patients with cardiac implantable electronic device (CIED) refused scheduled follow-up visits due to the risk of infection. In this scenario, different telemedicine strategies have been implemented to ensure continuity of care to CIED patients. Patients can be monitored through dedicated apps, ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2021, :]

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ECG evaluation in 11 949 Italian teenagers: results of screening in secondary school.

Massimo Mancone, Viviana Maestrini, Antonio Fusto, Francesco Adamo, Paola Scarparo, Alessandra D'Ambrosi, Alessandra Cinque, Maria Chiara Gatto, Nicolò Salvi, Gianluca Agnes, Mariateresa Pucci, Lucia Ilaria Birtolo, Laura Marruncheddu, Igino Genuini, Claudio De Lazzari, Paolo Severino, Giuseppe Giunta, Carlo Lavalle, Danilo Alunni Fegatelli, Annarita Vestri, Francesco Fedele, ,

<h4>Background</h4>There is lack of evidence regarding the screening role of ECG for sudden cardiac death (SCD) prevention.<h4>Objective</h4>To evaluate the prevalence of ECG abnormalities among teenagers according to sport participation and competitive status.<h4>Methods</h4>Eleven thousand nine hundred and forty-nine Italian pupils from 179 secondary schools (13-19 years) were consecutively enrolled. ECG abnormalities were ... Read more >>

J Cardiovasc Med (Hagerstown) (Journal of cardiovascular medicine (Hagerstown, Md.))
[2021, :]

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New evidence of direct oral anticoagulation therapy on cardiac valve calcifications, renal preservation and inflammatory modulation.

Luca Di Lullo, Carlo Lavalle, Michele Magnocavallo, Marco Valerio Mariani, Domenico Giovanni Della Rocca, Paolo Severino, Biagio Raffaele Di Iorio, Domenico Russo, Francesco Summaria, Giovanni Battista Forleo, Claudio Ronco, Massimo Mancone, Cristina Chimenti, Fabio Miraldi, Andrea Natale, Antonio Bellasi,

<h4>Background</h4>Rivaroxaban is a direct inhibitor of activated Factor X (FXa), an anti-inflammatory protein exerting a protective effect on the cardiac valve and vascular endothelium. We compare the effect of Warfarin and Rivaroxaban on inflammation biomarkers and their contribution to heart valve calcification progression and renal preservation in a population of ... Read more >>

Int J Cardiol (International journal of cardiology)
[2021, 345:90-97]

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Potential Role of eNOS Genetic Variants in Ischemic Heart Disease Susceptibility and Clinical Presentation.

Paolo Severino, Andrea D'Amato, Silvia Prosperi, Michele Magnocavallo, Marco Valerio Mariani, Lucrezia Netti, Lucia Ilaria Birtolo, Paolo De Orchi, Cristina Chimenti, Viviana Maestrini, Fabio Miraldi, Carlo Lavalle, Viviana Caputo, Raffaele Palmirotta, Massimo Mancone, Francesco Fedele,

<b>Background:</b> IHD is determined by an inadequate coronary blood supply to the myocardium, and endothelial dysfunction may represent one of the main pathophysiological mechanisms involved. Genetic predisposition to endothelial dysfunction has been associated with IHD and its clinical manifestation. However, studies are often confounding and inconclusive for several reasons, such ... Read more >>

J Cardiovasc Dev Dis (Journal of cardiovascular development and disease)
[2021, 8(9):]

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Effects of Metolazone Administration on Congestion, Diuretic Response and Renal Function in Patients with Advanced Heart Failure.

Alberto Palazzuoli, Gaetano Ruocco, Paolo Severino, Luigi Gennari, Filippo Pirrotta, Andrea Stefanini, Francesco Tramonte, Mauro Feola, Massimo Mancone, Francesco Fedele,

<h4>Background</h4>Advanced heart failure (HF) is a condition often requiring elevated doses of loop diuretics. Therefore, these patients often experience poor diuretic response. Both conditions have a detrimental impact on prognosis and hospitalization.<h4>Aims</h4>This retrospective, multicenter study evaluates the effect of the addition of oral metolazone on diuretic response (DR), clinical congestion, ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(18):]

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Cardiac involvement in consecutive unselected hospitalized COVID-19 population: In-hospital evaluation and one-year follow-up.

Viviana Maestrini, Lucia Ilaria Birtolo, Marco Francone, Gioacchino Galardo, Nicola Galea, Paolo Severino, Francesco Alessandri, Maria Chiara Colaiacomo, Giulia Cundari, Cristina Chimenti, Carlo Lavalle, Maria Ciardi, Paolo Palange, Alberto Deales, Gabriella d'Ettorre, Claudio M Mastroianni, Carlo Catalano, Franco Ruberto, Francesco Pugliese, Giulia d'Amati, Francesco Fedele, Massimo Mancone, ,

<h4>Background</h4>Cardiovascular disease (CVD) can occur in COVID-19 and has impact on clinical course. Data on CVD prevalence in hospitalized COVID-19 patients and sequelae in survivors is limited. Aim of this prospective study carried out on consecutive unselected COVID-19 population, was to assess: 1) CVD occurrence among hospitalized COVID-19 patients, 2) ... Read more >>

Int J Cardiol (International journal of cardiology)
[2021, 339:235-242]

Cited: 3 times

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Myocardial Tissue Characterization in Heart Failure with Preserved Ejection Fraction: From Histopathology and Cardiac Magnetic Resonance Findings to Therapeutic Targets.

Paolo Severino, Andrea D'Amato, Silvia Prosperi, Francesca Fanisio, Lucia Ilaria Birtolo, Bettina Costi, Lucrezia Netti, Cristina Chimenti, Carlo Lavalle, Viviana Maestrini, Massimo Mancone, Francesco Fedele,

Heart failure with preserved ejection fraction (HFpEF) is a complex clinical syndrome responsible for high mortality and morbidity rates. It has an ever growing social and economic impact and a deeper knowledge of molecular and pathophysiological basis is essential for the ideal management of HFpEF patients. The association between HFpEF ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(14):]

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HEART FAILURE HOSPITALIZATION RATE REDUCTION DURING COVID-19 PANDEMIC

Andrea D’Amato, Paolo Severino, Andrea Saglietto, Fabrizio D’Ascenzo, Claudia Marini, Marco Schiavone, Nicolò Ghionzoli, Filippo Pirrotta, Francesca Troiano, Margherita Cannillo, Marco Mennuni, Andrea Rognoni, Francesco Rametta, Alessandro Galluzzo, Gianluca Agnes, Fabio Infusino, Mariateresa Pucci, Carlo Lavalle, Luca Cacciotti, Paul Mather, Walter Grosso Marra, Fabrizio Ugo, Giovanni Forleo, Maurizio Viecca, Nuccia Morici, Giuseppe Patti, Gaetano Maria De Ferrari, Alberto Palazzuoli, Massimo Mancone, Francesco Fedele,

J Am Coll Cardiol (Journal of the American College of Cardiology)
[2021, 77(18):791-791]

Cited: 0 times

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Effect of combined renin angiotensin aldosterone inhibitors and diuretic treatment among patients hospitalized with SARS-CoV-2 Infection COVID-19

Alberto Palazzuoli, Kristen Tecson, Marco Vicenzi, Fabrizio D’Ascenzo, Gaetano Maria De Ferrari, Silvia Monticone, Gioel Secco, Guido Tavazzi, Giovanni Forleo, Paolo Severino, Francesco Fedele, Francesco De Rosa, Peter McCullough,

<h4>Background: </h4> Antecedent use of renin angiotensin aldosterone inhibitors (RAASi) appears crucial to prevent clinical deterioration and protect against cardiovascular and/or thrombotic complications of Coronavirus Disease (COVID-19), for indicated patients. Doubts have been raised about continuing treatment throughout infection, and nothing is known regarding its effect with concomitant medications. Hence, ... Read more >>

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Thromboembolic and Bleeding Risk in Atrial Fibrillation Patients with Chronic Kidney Disease: Role of Anticoagulation Therapy.

Michele Magnocavallo, Antonio Bellasi, Marco Valerio Mariani, Maria Fusaro, Maura Ravera, Ernesto Paoletti, Biagio Di Iorio, Vincenzo Barbera, Domenico Giovanni Della Rocca, Roberto Palumbo, Paolo Severino, Carlo Lavalle, Luca Di Lullo,

Atrial fibrillation (AF) and chronic kidney disease (CKD) are strictly related; several independent risk factors of AF are often frequent in CKD patients. AF prevalence is very common among these patients, ranging between 15% and 20% in advanced stages of CKD. Moreover, the results of several studies showed that AF ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 10(1):]

Cited: 2 times

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Impact of prior statin use on clinical outcomes in COVID-19 patients: data from tertiary referral hospitals during COVID-19 pandemic in Italy.

Gianfranco Mitacchione, Marco Schiavone, Antonio Curnis, Marcello Arca, Spinello Antinori, Alessio Gasperetti, Giosuè Mascioli, Paolo Severino, Federica Sabato, Maria M Caracciolo, Gianmarco Arabia, Laura D'Erasmo, Maurizio Viecca, Massimo Mancone, Massimo Galli, Giovanni B Forleo,

<h4>Background</h4>Epidemiological evidence suggests that anti-inflammatory and immunomodulatory properties of statins may reduce the risk of infections and infection-related complications.<h4>Objective</h4>We aimed to assess the impact of prior statin use on coronavirus disease (COVID-19) severity and mortality.<h4>Methods</h4>In this observational multicenter study, consecutive patients hospitalized for COVID-19 were enrolled. In-hospital mortality and severity ... Read more >>

J Clin Lipidol (Journal of clinical lipidology)
[2021, 15(1):68-78]

Cited: 17 times

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Left ventricular wall stress is associated with myocardial functional recovery in patients with severe aortic stenosis and systolic dysfunction undergoing transcatheter aortic valve replacement.

Fabio Infusino, Simone Calcagno, Sara Cimino, Mariateresa Pucci, Nicolò Salvi, Viviana Maestrini, Paolo Severino, Carlotta De Carlo, Riccardo Colantonio, Gennaro Sardella, Massimo Mancone, Francesco Fedele,

J Cardiovasc Med (Hagerstown) (Journal of cardiovascular medicine (Hagerstown, Md.))
[2021, 22(1):66-68]

Cited: 2 times

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Coronavirus disease 2019 in Rome: was it circulating before December?

Lucia Ilaria Birtolo, Viviana Maestrini, Paolo Severino, Cristina Chimenti, Gianluca Agnes, Marco Tocci, Maria Chiara Colaiacomo, Marco Francone, Massimo Mancone, Francesco Fedele,

J Cardiovasc Med (Hagerstown) (Journal of cardiovascular medicine (Hagerstown, Md.))
[2020, 21(10):835-836]

Cited: 1 time

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Ischemic Heart Disease Pathophysiology Paradigms Overview: From Plaque Activation to Microvascular Dysfunction.

Paolo Severino, Andrea D'Amato, Mariateresa Pucci, Fabio Infusino, Francesco Adamo, Lucia Ilaria Birtolo, Lucrezia Netti, Giulio Montefusco, Cristina Chimenti, Carlo Lavalle, Viviana Maestrini, Massimo Mancone, William M Chilian, Francesco Fedele,

Ischemic heart disease still represents a large burden on individuals and health care resources worldwide. By conventions, it is equated with atherosclerotic plaque due to flow-limiting obstruction in large-medium sized coronary arteries. However, clinical, angiographic and autoptic findings suggest a multifaceted pathophysiology for ischemic heart disease and just some cases ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(21):]

Cited: 20 times

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Reduction in heart failure hospitalization rate during coronavirus disease 19 pandemic outbreak.

Paolo Severino, Andrea D'Amato, Andrea Saglietto, Fabrizio D'Ascenzo, Claudia Marini, Marco Schiavone, Nicolò Ghionzoli, Filippo Pirrotta, Francesca Troiano, Margherita Cannillo, Marco Mennuni, Andrea Rognoni, Francesco Rametta, Alessandro Galluzzo, Gianluca Agnes, Fabio Infusino, Mariateresa Pucci, Carlo Lavalle, Luca Cacciotti, Paul J Mather, Walter Grosso Marra, Fabrizio Ugo, Giovanni Forleo, Maurizio Viecca, Nuccia Morici, Giuseppe Patti, Gaetano M De Ferrari, Alberto Palazzuoli, Massimo Mancone, Francesco Fedele,

<h4>Aims</h4>The recent coronavirus disease 19 (COVID-19) pandemic outbreak forced the adoption of restraint measures, which modified the hospital admission patterns for several diseases. The aim of the study is to investigate the rate of hospital admissions for heart failure (HF) during the early days of the COVID-19 outbreak in Italy, ... Read more >>

ESC Heart Fail (ESC heart failure)
[2020, :]

Cited: 10 times

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Management of cardiac implantable electronic device follow-up in COVID-19 pandemic: Lessons learned during Italian lockdown.

Agostino Piro, Michele Magnocavallo, Domenico Giovanni Della Rocca, Matteo Neccia, Giovanna Manzi, Marco Valerio Mariani, Martina Straito, Alessia Bernardini, Paolo Severino, Gino Iannucci, Giuseppe Giunta, Cristina Chimenti, Andrea Natale, Francesco Fedele, Carlo Lavalle,

<h4>Introduction</h4>Remote monitoring (RM) has significantly transformed the standard of care for patients with cardiac electronic implantable devices. It provides easy access to valuable information, such as arrhythmic events, acute decompensation manifestations and device-related issues, without the need of in-person visits.<h4>Methods</h4>Starting March 1st, 332 patients were introduced to an RM program ... Read more >>

J Cardiovasc Electrophysiol (Journal of cardiovascular electrophysiology)
[2020, 31(11):2814-2823]

Cited: 7 times

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Direct oral anticoagulants versus vitamin K antagonists in patients with atrial fibrillation and cancer a meta-analysis.

Marco Valerio Mariani, Michele Magnocavallo, Martina Straito, Agostino Piro, Paolo Severino, Gino Iannucci, Cristina Chimenti, Massimo Mancone, Domenico Giovanni Della Rocca, Giovanni Battista Forleo, Francesco Fedele, Carlo Lavalle,

<h4>Background</h4>Direct oral anticoagulants (DOACs) are recommended as first-line anticoagulants in patients with atrial fibrillation (AF). However, in patients with cancer and AF the efficacy and safety of DOACs are not well established.<h4>Objective</h4>We performed a meta-analysis comparing available data regarding the efficacy and safety of DOACs vs vitamin K antagonists (VKAs) ... Read more >>

J Thromb Thrombolysis (Journal of thrombosis and thrombolysis)
[2021, 51(2):419-429]

Cited: 4 times

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The role of cardiologists in the coronavirus disease 2019 pandemic.

Francesco Fedele, Fabio Infusino, Paolo Severino, Massimo Mancone,

Kardiol Pol (Kardiologia polska)
[2020, 78(7-8):808-809]

Cited: 2 times

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The Role of Ranolazine for the Treatment of Residual Angina beyond the Percutaneous Coronary Revascularization.

Simone Calcagno, Fabio Infusino, Nicolò Salvi, Temistocle Taccheri, Riccardo Colantonio, Emanuele Bruno, Lucia Ilaria Birtolo, Paolo Severino, Carlo Lavalle, Mariateresa Pucci, Gennaro Sardella, Massimo Mancone, Francesco Fedele,

INTRODUCTION:Despite a successful percutaneous coronary intervention (PCI), several studies reported that the recurrence of angina after revascularization, even complete, is a particularly frequent occurrence in the first year after PCI. METHODS:The aim was to evaluate the efficacy of treatment with ranolazine in addition to conventional anti-ischemic therapy in patients who ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(7):]

Cited: 3 times

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Diet Supplementation, Probiotics, and Nutraceuticals in SARS-CoV-2 Infection: A Scoping Review.

Fabio Infusino, Massimiliano Marazzato, Massimo Mancone, Francesco Fedele, Claudio Maria Mastroianni, Paolo Severino, Giancarlo Ceccarelli, Letizia Santinelli, Elena Cavarretta, Antonino G M Marullo, Fabio Miraldi, Roberto Carnevale, Cristina Nocella, Giuseppe Biondi-Zoccai, Cristiano Pagnini, Sonia Schiavon, Francesco Pugliese, Giacomo Frati, Gabriella d'Ettorre,

The severe acute respiratory syndrome coronavirus 2 (Sars-CoV-2) global pandemic is a devastating event that is causing thousands of victims every day around the world. One of the main reasons of the great impact of coronavirus disease 2019 (COVID-19) on society is its unexpected spread, which has not allowed an ... Read more >>

Nutrients (Nutrients)
[2020, 12(6):]

Cited: 47 times

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Susceptibility to ischaemic heart disease: Focusing on genetic variants for ATP-sensitive potassium channel beyond traditional risk factors.

Paolo Severino, Andrea D'Amato, Lucrezia Netti, Mariateresa Pucci, Marco V Mariani, Sara Cimino, Lucia I Birtolo, Fabio Infusino, Paolo De Orchi, Raffaele Palmirotta, Domenica Lovero, Franco Silvestris, Viviana Caputo, Antonio Pizzuti, Fabio Miraldi, Viviana Maestrini, Massimo Mancone, Francesco Fedele,

<h4>Aims</h4>Ischaemic heart disease is classically associated with coronary artery disease. Recent evidences showed the correlation between coronary microvascular dysfunction and ischaemic heart disease, even independently of coronary artery disease. Ion channels represent the final effectors of blood flow regulation mechanisms and their genetic variants, in particular of Kir6.2 subunit of ... Read more >>

Eur J Prev Cardiol (European journal of preventive cardiology)
[2020, :]

Cited: 4 times

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Susceptibility to ischaemic heart disease: Focusing on genetic variants for ATP-sensitive potassium channel beyond traditional risk factors.

Paolo Severino, Andrea D'Amato, Lucrezia Netti, Mariateresa Pucci, Marco V Mariani, Sara Cimino, Lucia I Birtolo, Fabio Infusino, Paolo De Orchi, Raffaele Palmirotta, Domenica Lovero, Franco Silvestris, Viviana Caputo, Antonio Pizzuti, Fabio Miraldi, Viviana Maestrini, Massimo Mancone, Francesco Fedele,

AIMS:Ischaemic heart disease is classically associated with coronary artery disease. Recent evidences showed the correlation between coronary microvascular dysfunction and ischaemic heart disease, even independently of coronary artery disease. Ion channels represent the final effectors of blood flow regulation mechanisms and their genetic variants, in particular of Kir6.2 subunit of ... Read more >>

Eur J Prev Cardiol (European journal of preventive cardiology)
[2020, :2047487320926780]

Cited: 6 times

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