Full Text Journal Articles by
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Hyperoxemia in postsurgical sepsis/septic shock patients is associated with reduced mortality.

Marta Martín-Fernández, María Heredia-Rodríguez, Irene González-Jiménez, Mario Lorenzo-López, Estefanía Gómez-Pesquera, Rodrigo Poves-Álvarez, F Javier Álvarez, Pablo Jorge-Monjas, Juan Beltrán-DeHeredia, Eduardo Gutiérrez-Abejón, Francisco Herrera-Gómez, Gabriella Guzzo, Esther Gómez-Sánchez, Álvaro Tamayo-Velasco, Rocío Aller, Paolo Pelosi, Jesús Villar, Eduardo Tamayo,

<h4>Background</h4>Despite growing interest in treatment strategies that limit oxygen exposure in ICU patients, no studies have compared conservative oxygen with standard oxygen in postsurgical patients with sepsis/septic shock, although there are indications that it may improve outcomes. It has been proven that high partial pressure of oxygen in arterial blood ... Read more >>

Crit Care (Critical care (London, England))
[2022, 26(1):4]

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Arterial and Venous Cerebral Blood Flow Velocities and Their Correlation in Healthy Volunteers and Traumatic Brain Injury Patients.

Danilo Cardim, Marek Czosnyka, Karthikka Chandrapatham, Rafael Badenes, Alessandro Bertuccio, Francesco Corradi, Joseph Donnelly, Paolo Pelosi, Peter J Hutchinson, Chiara Robba,

<h4>Background</h4>Few studies have explored the cerebral venous compartment or the correlation between venous and arterial cerebral blood flows. We aimed to correlate cerebral blood flow velocities in the arterial (middle cerebral artery) and venous (straight sinus) compartments in healthy volunteers and traumatic brain injury (TBI) patients. In addition, we determined ... Read more >>

J Neurosurg Anesthesiol (Journal of neurosurgical anesthesiology)
[2022, 34(1):e24-e33]

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Geo-economic variations in epidemiology, ventilation management and outcome of patients receiving intraoperative ventilation during general anesthesia- posthoc analysis of an observational study in 29 countries.

Liselotte Hol, Sunny G L H Nijbroek, Ary Serpa Neto, Sabrine N T Hemmes, Goran Hedenstierna, Michael Hiesmayr, Markus W Hollmann, Gary H Mills, Marcos F Vidal Melo, Christian Putensen, Werner Schmid, Paolo Severgnini, Hermann Wrigge, Marcelo Gama de Abreu, Paolo Pelosi, Marcus J Schultz, ,

<h4>Background</h4>The aim of this analysis is to determine geo-economic variations in epidemiology, ventilator settings and outcome in patients receiving general anesthesia for surgery.<h4>Methods</h4>Posthoc analysis of a worldwide study in 29 countries. Lower and upper middle-income countries (LMIC and UMIC), and high-income countries (HIC) were compared. The coprimary endpoint was the ... Read more >>

BMC Anesthesiol (BMC anesthesiology)
[2022, 22(1):15]

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The Use of Different Components of Brain Oxygenation for the Assessment of Cerebral Haemodynamics: A Prospective Observational Study on COVID-19 Patients.

Chiara Robba, Danilo Cardim, Lorenzo Ball, Denise Battaglini, Wojciech Dabrowski, Matteo Bassetti, Daniele Roberto Giacobbe, Marek Czosnyka, Rafael Badenes, Paolo Pelosi, Basil Matta, ,

<b>Introduction:</b> The role of near-infrared spectroscopy (NIRS) for the evaluation of cerebral haemodynamics is gaining increasing popularity because of its noninvasive nature. The aim of this study was to evaluate the role of the integral components of regional cerebral oxygenation (rSO<sub>2</sub>) measured by NIRS [i.e., arterial-oxyhemoglobin (O<sub>2</sub>Hbi) and venous-deoxyhemoglobin (HHbi)-components], ... Read more >>

Front Neurol (Frontiers in neurology)
[2021, 12:735469]

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Pituitary Dysfunction After Aneurysmal Subarachnoid Hemorrhage: A Prospective Cohort Study.

Chiara Robba, Raffaele Aspide, Marianna Pegoli, Ekaterina Kondratyeva, Paolo Gritti, Marco F Fustini, Denise Battaglini, Paolo Pelosi, Peter J Hutchinson, Adel Helmy, Carlo Bortolotti, Corrado Zenesini, Federico Bilotta,

<h4>Background</h4>The prevalence of pituitary dysfunction after aneurysmal subarachnoid hemorrhage (aSAH) remains incompletely elucidated. Furthermore, it is not clear whether these abnormalities impact patient outcomes. The aim of this study was to evaluate the prevalence of pituitary dysfunction after aSAH and its effect on outcomes.<h4>Methods</h4>We carried out a prospective, cohort study ... Read more >>

J Neurosurg Anesthesiol (Journal of neurosurgical anesthesiology)
[2022, 34(1):44-50]

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Cardiac point-of-care ultrasound in hospitalized coronavirus disease-2019 patients: findings and association with outcome.

Vered Gilad, Vincenzo De Marzo, Giulia Guglielmi, Roberta Della Bona, Stefano Giovinazzo, Fabio Pescetelli, Alberto Valbusa, Gian Paolo Bezante, Andrea De Maria, Nicolò Patroniti, Diego Ferone, Paolo Pelosi, Matteo Bassetti, Italo Porto, ,

J Cardiovasc Med (Hagerstown) (Journal of cardiovascular medicine (Hagerstown, Md.))
[2022, 23(1):e3-e7]

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Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies.

Luigi Pisani, Anna Geke Algera, Ary Serpa Neto, Luciano Azevedo, Tài Pham, Frederique Paulus, Marcelo Gama de Abreu, Paolo Pelosi, Arjen M Dondorp, Giacomo Bellani, John G Laffey, Marcus J Schultz, , , , ,

Geoeconomic variations in epidemiology, the practice of ventilation, and outcome in invasively ventilated intensive care unit (ICU) patients without acute respiratory distress syndrome (ARDS) remain unexplored. In this analysis we aim to address these gaps using individual patient data of four large observational studies. In this pooled analysis we harmonised ... Read more >>

Lancet Glob Health (The Lancet. Global health)
[2021, :]

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A more gradual positive end-expiratory pressure increase reduces lung damage and improves cardiac function in experimental acute respiratory distress syndrome.

Marcos V S Fernandes, Nazareth N Rocha, Nathane Santanna Felix, Gisele C Rodrigues, Luisa Helena Andrade Silva, Mariana S Coelho, Ana Carolina Fernandes Fonseca, Ana Carolina G M Teixeira, Vera Luiza Capelozzi, Paolo Pelosi, Pedro Leme Silva, John J Marini, Patricia Rieken Macedo Rocco,

Increases in positive end-expiratory pressure (PEEP) or recruitment maneuvers may increase stress in lung parenchyma, extracellular matrix, and lung vessels; however, adaptative responses may occur. We evaluated the effects of PEEP on lung damage and cardiac function when increased abruptly, gradually, or more gradually in experimental mild/moderate acute respiratory distress ... Read more >>

J Appl Physiol (1985) (Journal of applied physiology (Bethesda, Md. : 1985))
[2021, :]

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Ventilation practices in burn patients-an international prospective observational cohort study.

Marcus J Schultz, Janneke Horn, Markus W Hollmann, Benedikt Preckel, Gerie J Glas, Kirsten Colpaert, Manu Malbrain, Ary Serpa Neto, Karim Asehnoune, Marcello Gamma de Abreu, Ignacio Martin-Loeches, Paolo Pelosi, Folke Sjöberg, Jan M Binnekade, Berry Cleffken, Nicole P Juffermans, Paul Knape, Bert G Loef, David P Mackie, Perenlei Enkhbaatar, Nadia Depetris, Anders Perner, Eva Herrero, Lucia Cachafeiro, Marc Jeschke, Jeffrey Lipman, Matthieu Legrand, Johannes Horter, Athina Lavrentieva, Gerie Glas, Alex Kazemi, Anne Berit Guttormsen, Frederik Huss, Mark Kol, Helen Wong, Therese Starr, Luc De Crop, Wilson de Oliveira Filho, João Manoel Silva Junior, Cintia M C Grion, Marc G Jeschke, Marjorie Burnett, Frederik Mondrup, Francois Ravat, Mathieu Fontaine, Karim Asehoune, Renan Le Floch, Mathieu Jeanne, Morgane Bacus, Maïté Chaussard, Marcus Lehnhardt, Bassem Daniel Mikhail, Jochen Gille, Aidan Sharkey, Nicole Trommel, Auke C Reidinga, Nadine Vieleers, Anna Tilsley, Henning Onarheim, Maria Teresa Bouza, Alexander Agrifoglio, Filip Fredén, Tina Palmieri, Lynda E Painting, ,

<h4>Background</h4>It is unknown whether lung-protective ventilation is applied in burn patients and whether they benefit from it. This study aimed to determine ventilation practices in burn intensive care units (ICUs) and investigate the association between lung-protective ventilation and the number of ventilator-free days and alive at day 28 (VFD-28).<h4>Methods</h4>This is ... Read more >>

Burns Trauma (Burns & trauma)
[2021, 9:tkab034]

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Enterococcal bloodstream infections in critically ill patients with COVID-19: a case series.

Daniele Roberto Giacobbe, Laura Labate, Stefania Tutino, Federico Baldi, Chiara Russo, Chiara Robba, Lorenzo Ball, Silvia Dettori, Anna Marchese, Chiara Dentone, Laura Magnasco, Francesca Crea, Edward Willison, Federica Briano, Denise Battaglini, Nicolò Patroniti, Iole Brunetti, Paolo Pelosi, Matteo Bassetti,

<h4>Background</h4>An unexpected high prevalence of enterococcal bloodstream infection (BSI) has been observed in critically ill patients with COVID-19 in the intensive care unit (ICU).<h4>Materials and methods</h4>The primary objective was to describe the characteristics of ICU-acquired enterococcal BSI in critically ill patients with COVID-19. A secondary objective was to exploratorily assess ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):1779-1786]

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Comparative effects of dexmedetomidine and propofol on brain and lung damage in experimental acute ischemic stroke.

Giselle C Sousa, Marcos Vinicius Fernandes, Fernanda F Cruz, Mariana A Antunes, Carla M da Silva, Christina Takyia, Denise Battaglini, Cynthia S Samary, Chiara Robba, Paolo Pelosi, Patricia R M Rocco, Pedro L Silva,

Acute ischemic stroke is associated with pulmonary complications, and often dexmedetomidine and propofol are used to decrease cerebral metabolic rate. However, it is unknown the immunomodulatory actions of dexmedetomidine and propofol on brain and lungs during acute ischemic stroke. The effects of dexmedetomidine and propofol were compared on perilesional brain ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):23133]

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Current pharmacotherapy for methicillin-resistant Staphylococcus aureus (MRSA) pneumonia.

Matteo Bassetti, Laura Labate, Monica Melchio, Chiara Robba, Denise Battaglini, Lorenzo Ball, Paolo Pelosi, Daniele Roberto Giacobbe,

<h4>Introduction</h4>Currently, several antibiotics are active against methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) and can be used for the treatment of pneumonia. They show great variability in terms of antibiotic class, indication, pharmacodynamic/pharmacokinetic properties, type of available formulations, spectrum of activity against bacteria other than MRSA, and toxicity profile.<h4>Areas covered</h4>In this narrative review, ... Read more >>

Expert Opin Pharmacother (Expert opinion on pharmacotherapy)
[2021, :1-15]

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Reverse Chemical Ecology Suggests Putative Primate Pheromones.

Valeriia Zaremska, Isabella Maria Fischer, Giovanni Renzone, Simona Arena, Andrea Scaloni, Wolfgang Knoll, Paolo Pelosi,

Pheromonal communication is widespread among living organisms, but in apes and particularly in humans there is currently no strong evidence for such phenomenon. Among primates, lemurs use pheromones to communicate within members of the same species, whereas in some monkeys such capabilities seem to be lost. Chemical communication in humans ... Read more >>

Mol Biol Evol (Molecular biology and evolution)
[2021, :]

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Infection control in the intensive care unit: expert consensus statements for SARS-CoV-2 using a Delphi method.

Prashant Nasa, Elie Azoulay, Arunaloke Chakrabarti, Jigeeshu V Divatia, Ravi Jain, Camilla Rodrigues, Victor D Rosenthal, Waleed Alhazzani, Yaseen M Arabi, Jan Bakker, Matteo Bassetti, Jan De Waele, George Dimopoulos, Bin Du, Sharon Einav, Laura Evans, Simon Finfer, Claude Guérin, Naomi E Hammond, Samir Jaber, Ruth M Kleinpell, Younsuck Koh, Marin Kollef, Mitchell M Levy, Flavia R Machado, Jordi Mancebo, Ignacio Martin-Loeches, Mervyn Mer, Michael S Niederman, Paolo Pelosi, Anders Perner, John V Peter, Jason Phua, Lise Piquilloud, Mathias W Pletz, Andrew Rhodes, Marcus J Schultz, Mervyn Singer, Jéan-François Timsit, Balasubramanian Venkatesh, Jean-Louis Vincent, Tobias Welte, Sheila N Myatra,

During the current COVID-19 pandemic, health-care workers and uninfected patients in intensive care units (ICUs) are at risk of being infected with SARS-CoV-2 as a result of transmission from infected patients and health-care workers. In the absence of high-quality evidence on the transmission of SARS-CoV-2, clinical practice of infection control ... Read more >>

Lancet Infect Dis (The Lancet. Infectious diseases)
[2021, :]

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Mechanical Power Correlates With Lung Inflammation Assessed by Positron-Emission Tomography in Experimental Acute Lung Injury in Pigs.

Martin Scharffenberg, Jakob Wittenstein, Xi Ran, Yingying Zhang, Anja Braune, Raphael Theilen, Lorenzo Maiello, Giulia Benzi, Thomas Bluth, Thomas Kiss, Paolo Pelosi, Patricia R M Rocco, Marcus J Schultz, Jörg Kotzerke, Marcelo Gama de Abreu, Robert Huhle,

<b>Background:</b> Mechanical ventilation (MV) may initiate or worsen lung injury, so-called ventilator-induced lung injury (VILI). Although different mechanisms of VILI have been identified, research mainly focused on single ventilator parameters. The mechanical power (MP) summarizes the potentially damaging effects of different parameters in one single variable and has been shown ... Read more >>

Front Physiol (Frontiers in physiology)
[2021, 12:717266]

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Cerebral Autoregulation in Non-Brain Injured Patients: A Systematic Review.

Yaroslava Longhitano, Francesca Iannuzzi, Giulia Bonatti, Christian Zanza, Antonio Messina, Daniel Godoy, Wojciech Dabrowski, Li Xiuyun, Marek Czosnyka, Paolo Pelosi, Rafael Badenes, Chiara Robba,

Introduction: Cerebral autoregulation (CA) plays a fundamental role in the maintenance of adequate cerebral blood flow (CBF). CA monitoring, through direct and indirect techniques, may guide an appropriate therapeutic approach aimed at improving CBF and reducing neurological complications; so far, the role of CA has been investigated mainly in brain-injured ... Read more >>

Front Neurol (Frontiers in neurology)
[2021, 12:732176]

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Effect of patient-ventilator asynchrony on lung and diaphragmatic injury in experimental acute respiratory distress syndrome in a porcine model.

Jakob Wittenstein, Robert Huhle, Mark Leiderman, Marius Möbius, Anja Braune, Sebastian Tauer, Paul Herzog, Giulio Barana, Alessandra de Ferrari, Andrea Corona, Thomas Bluth, Thomas Kiss, Andreas Güldner, Marcus J Schultz, Patricia R M Rocco, Paolo Pelosi, Marcelo Gama de Abreu, Martin Scharffenberg,

Patient-ventilator asynchrony during mechanical ventilation may exacerbate lung and diaphragm injury in spontaneously breathing subjects. We investigated whether subject-ventilator asynchrony increases lung or diaphragmatic injury in a porcine model of acute respiratory distress syndrome (ARDS). ARDS was induced in adult female pigs by lung lavage and injurious ventilation before mechanical ... Read more >>

Br J Anaesth (British journal of anaesthesia)
[2021, :]

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Assessment of 28-Day In-Hospital Mortality in Mechanically Ventilated Patients With Coronavirus Disease 2019: An International Cohort Study.

Gianluigi Li Bassi, Jacky Y Suen, Nicole White, Heidi J Dalton, Jonathon Fanning, Amanda Corley, Sally Shrapnel, Samuel Hinton, Simon Forsyth, Rex Parsons, John G Laffey, Eddy Fan, Robert Bartlett, Daniel Brodie, Aidan Burrell, Davide Chiumello, Alyaa Elhazmi, Giacomo Grasselli, Carol Hodgson, Shingo Ichiba, Carlos Luna, Eva Marwali, Laura Merson, Srinivas Murthy, Alistair Nichol, Mauro Panigada, Paolo Pelosi, Antoni Torres, Pauline Yeung Ng, Mark Ogino, John F Fraser,

Factors associated with mortality in coronavirus disease 2019 patients on invasive mechanical ventilation are still not fully elucidated.<h4>Objectives</h4>To identify patient-level parameters, readily available at the bedside, associated with the risk of in-hospital mortality within 28 days from commencement of invasive mechanical ventilation or coronavirus disease 2019.<h4>Design setting and participants</h4>Prospective observational ... Read more >>

Crit Care Explor (Critical care explorations)
[2021, 3(11):e0567]

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Effects of Different Levels of Variability and Pressure Support Ventilation on Lung Function in Patients With Mild-Moderate Acute Respiratory Distress Syndrome.

Lorenzo Ball, Yuda Sutherasan, Martina Fiorito, Antonella Dall'Orto, Lorenzo Maiello, Maria Vargas, Chiara Robba, Iole Brunetti, Davide D'Antini, Pasquale Raimondo, Robert Huhle, Marcus J Schultz, Patricia R M Rocco, Marcelo Gama de Abreu, Paolo Pelosi,

<b>Background:</b> Variable pressure support ventilation (vPSV) is an assisted ventilation mode that varies the level of pressure support on a breath-by-breath basis to restore the physiological variability of breathing activity. We aimed to compare the effects of vPSV at different levels of variability and pressure support (Δ<i>P</i> <sub>S</sub>) in patients ... Read more >>

Front Physiol (Frontiers in physiology)
[2021, 12:725738]

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Level of Diffusion and Training of Lung Ultrasound during the COVID-19 Pandemic - A National Online Italian Survey (ITALUS) from the Lung Ultrasound Working Group of the Italian Society of Anesthesia, Analgesia, Resuscitation, and Intensive Care (SIAARTI).

Luigi Vetrugno, Francesco Mojoli, Enrico Boero, Paola Berchialla, Elena Giovanna Bignami, Daniele Orso, Andrea Cortegiani, Francesco Forfori, Francesco Corradi, Gianmaria Cammarota, Edoardo De Robertis, Silvia Mongodi, Davide Chiumello, Daniele Poole, Mariachiara Ippolito, Daniele Guerino Biasucci, Paolo Persona, Tiziana Bove, Lorenzo Ball, Paolo Pelosi, Paolo Navalesi, Massimo Antonelli, Antonio Corcione, Antonino Giarratano, Flavia Petrini,

<h4>Purpose</h4> The goal of this survey was to describe the use and diffusion of lung ultrasound (LUS), the level of training received before and during the COVID-19 pandemic, and the clinical impact LUS has had on COVID-19 cases in intensive care units (ICU) from February 2020 to May 2020.<h4>Materials and methods</h4> The ... Read more >>

Ultraschall Med (Ultraschall in der Medizin (Stuttgart, Germany : 1980))
[2021, :]

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Effects of Positive End-Expiratory Pressure on Lung Recruitment, Respiratory Mechanics, and Intracranial Pressure in Mechanically Ventilated Brain-Injured Patients.

Chiara Robba, Lorenzo Ball, Stefano Nogas, Denise Battaglini, Antonio Messina, Iole Brunetti, Giuseppe Minetti, Lucio Castellan, Patricia R M Rocco, Paolo Pelosi,

<b>Background:</b> The pathophysiological effects of positive end-expiratory pressure (PEEP) on respiratory mechanics, lung recruitment, and intracranial pressure (ICP) in acute brain-injured patients have not been completely elucidated. The primary aim of this study was to assess the effects of PEEP augmentation on respiratory mechanics, quantitative computed lung tomography (qCT) findings, ... Read more >>

Front Physiol (Frontiers in physiology)
[2021, 12:711273]

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The value of open-source clinical science in pandemic response: lessons from ISARIC.

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Lancet Infect Dis (The Lancet. Infectious diseases)
[2021, 21(12):1623-1624]

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Opioid-free Anesthesia: Comment.

Patrice Forget, Jan Mulier, Patricia Lavand'homme, Luc De Baerdemaeker, Paolo Pelosi, Hans D de Boer,

Anesthesiology (Anesthesiology)
[2021, 135(4):751-753]

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Early Administration of Bamlanivimab in Combination with Etesevimab Increases the Benefits of COVID-19 Treatment: Real-World Experience from the Liguria Region.

Antonio Vena, Giovanni Cenderello, Elisa Balletto, Laura Mezzogori, Alessandro Santagostino Barbone, Marco Berruti, Lorenzo Ball, Denise Battaglini, Alessandro Bonsignore, Chiara Dentone, Daniele Roberto Giacobbe, Tarek Kamal Eldin, Malgorzata Mikulska, Barbara Rebesco, Chiara Robba, Ambra Scintu, Andrea Stimamiglio, Lucia Taramasso, Paolo Pelosi, Stefania Artioli, Matteo Bassetti,

Monoclonal antibodies, such as bamlanivimab and etesevimab combination (BEC), have been proposed for patients with mild or moderate coronavirus disease 2019 (COVID-19). However, few studies have assessed the factors associated with the early administration of BEC or the impact of early BEC treatment on the clinical evolution of the patients. ... Read more >>

J Clin Med (Journal of clinical medicine)
[2021, 10(20):]

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Sex difference and intra-operative tidal volume: Insights from the LAS VEGAS study.

Sunny G Nijbroek, Liselotte Hol, Pien Swart, Sabrine N T Hemmes, Ary Serpa Neto, Jan M Binnekade, Goran Hedenstierna, Samir Jaber, Michael Hiesmayr, Markus W Hollmann, Gary H Mills, Marcos F Vidal Melo, Christian Putensen, Werner Schmid, Paolo Severgnini, Hermann Wrigge, Marcelo Gama de Abreu, Paolo Pelosi, Marcus J Schultz, ,

<h4>Background</h4>One key element of lung-protective ventilation is the use of a low tidal volume (VT). A sex difference in use of low tidal volume ventilation (LTVV) has been described in critically ill ICU patients.<h4>Objectives</h4>The aim of this study was to determine whether a sex difference in use of LTVV also ... Read more >>

Eur J Anaesthesiol (European journal of anaesthesiology)
[2021, 38(10):1034-1041]

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