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An Algorithm to Personalize Nerve Sparing in Men with Unilateral High-Risk Prostate Cancer.

Alberto Martini, Timo F W Soeterik, Hester Haverdings, Razvan George Rahota, Enrico Checcucci, Sabrina De Cillis, Thomas Hermanns, Christian Daniel Fankhauser, Luca Afferi, Marco Moschini, Agostino Mattei, Claudia Kesch, Isabel Heidegger, Felix Preisser, Fabio Zattoni, Alessandro Marquis, Giancarlo Marra, Paolo Gontero, Alberto Briganti, Francesco Montorsi, Francesco Porpiglia, Jean Paul Van Basten, Roderick C N Van den Bergh, Harm H E Van Melick, Guillaume Ploussard, Giorgio Gandaglia, Massimo Valerio,

<h4>Purpose</h4>Current guidelines do not provide strong recommendations on the preservation of the neurovascular bundles during RP in case of HR PCa and/or suspicious EPE. We aimed to evaluate when, in case of unilateral HR disease, contralateral NS should be considered or not.<h4>Methods</h4>Within a multi-institutional dataset we selected patients with unilateral ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000002205]

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Flexible Ureterorenoscopy under Spinal Anesthesia: Focus on Technique, Results, Complications, and Patients' Satisfaction from a Large Series.

Andrea Bosio, Eugenio Alessandria, Federico Vitiello, Eugenia Vercelli, Simone Agosti, Paolo Gontero,

<h4>Introduction</h4>Although spinal anesthesia (SA) may reduce postoperative morbidity, most urologists perform flexible ureterorenoscopy (fURS) under general anesthesia (GA). The objective of our study is to provide technical details, results, complications, and patients' satisfaction with fURS performed under exclusive SA.<h4>Methods</h4>We analyzed all consecutive fURS performed under SA to treat renal stones ... Read more >>

Urol Int (Urologia internationalis)
[2021, :1-6]

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European Association of Urology Guidelines on Non-muscle-invasive Bladder Cancer (Ta, T1, and Carcinoma in Situ).

Marko Babjuk, Maximilian Burger, Otakar Capoun, Daniel Cohen, Eva M Compérat, José L Dominguez Escrig, Paolo Gontero, Fredrik Liedberg, Alexandra Masson-Lecomte, A Hugh Mostafid, Joan Palou, Bas W G van Rhijn, Morgan Rouprêt, Shahrokh F Shariat, Thomas Seisen, Viktor Soukup, Richard J Sylvester,

<h4>Context</h4>The European Association of Urology (EAU) has released an updated version of the guidelines on non-muscle-invasive bladder cancer (NMIBC).<h4>Objective</h4>To present the 2021 EAU guidelines on NMIBC.<h4>Evidence acquisition</h4>A broad and comprehensive scoping exercise covering all areas of the NMIBC guidelines since the 2020 version was performed. Databases covered by the search ... Read more >>

Eur Urol (European urology)
[2021, :]

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Survival Outcomes After Immediate Radical Cystectomy Versus Conservative Management with Bacillus Calmette-Guérin Among T1 High-grade Micropapillary Bladder Cancer Patients: Results from a Multicentre Collaboration.

Chiara Lonati, Philipp Baumeister, Luca Afferi, Andrea Mari, Andrea Minervini, Wojciech Krajewski, Sosan Azizi, Kees Hendricksen, Alberto Martini, Andrea Necchi, Francesco Montorsi, Alberto Briganti, Renzo Colombo, Alessandro Tafuri, Alessandro Antonelli, Maria Angela Cerruto, Morgan Rouprêt, Alexandra Masson-Lecomte, Ekaterina Laukhtina, David D'Andrea, Shahrokh F Shariat, Francesco Soria, Giancarlo Marra, Paolo Gontero, Roberto Contieri, Rodolfo Hurle, Anne Sophie Valiquette, M Carmen Mir, Stefania Zamboni, Claudio Simeone, Tobias Klatte, Jeremy Yuen-Chun Teoh, Soichiro Yoshida, Yasuhisa Fujii, Roberto Carando, Gerald B Schulz, Livio Mordasini, Agostino Mattei, Marco Moschini, ,

<h4>Background</h4>Literature lacks clear evidence regarding the optimal treatment for non-muscle-invasive micropapillary bladder cancer (MPBC) due to its rarity and the presence of only small sample size and single-centre studies.<h4>Objective</h4>To assess cancer-specific mortality (CSM) and overall mortality (OM) between immediate radical cystectomy (RC) and conservative management among T1 high-grade (HG) MPBC.<h4>Design, ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Risk Stratification of Patients Candidate to Radical Prostatectomy Based on Clinical and Multiparametric Magnetic Resonance Imaging Parameters: Development and External Validation of Novel Risk Groups.

Elio Mazzone, Giorgio Gandaglia, Guillame Ploussard, Giancarlo Marra, Massimo Valerio, Riccardo Campi, Andrea Mari, Andrea Minervini, Sergio Serni, Marco Moschini, Alessandro Marquis, Jean Baptiste Beauval, Roderick van den Bergh, Razvan-George Rahota, Timo Soeterik, Mathieu Roumiguiè, Luca Afferi, Junlong Zhuang, Hongqian Tuo, Agostino Mattei, Paolo Gontero, Vito Cucchiara, Armando Stabile, Nicola Fossati, Francesco Montorsi, Alberto Briganti,

<h4>Background</h4>Despite the key importance of magnetic resonance imaging (MRI) parameters, risk classification systems for biochemical recurrence (BCR) in prostate cancer (PCa) patients treated with radical prostatectomy (RP) are still based on clinical variables alone.<h4>Objective</h4>We aimed at developing and validating a novel classification integrating clinical and radiological parameters.<h4>Design, setting, and participants</h4>A ... Read more >>

Eur Urol (European urology)
[2021, :]

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Penile injection of aedile silicone: A dangerous shortcut.

Omid Sedigh, Giuseppe Pizzuto, Maurizio Barale, Muhammad Dashti, Simone Mazzoli, Dorigo Righi, Ettore Dalmasso, Bruno Frea, Paolo Gontero,

<h4>Introduction</h4>The size of penis can cause concern in patients, even if the organ is clinically normal. Additionally, the cost of phosphodiesterase 5 inhibitors (iPDE5) and long waiting lists to access penile prosthesis placement can lead patients to resort to non-medical and potentially dangerous alternatives. One of these dangerous alternatives is ... Read more >>

Urologia (Urologia)
[2021, :3915603211040277]

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Reply to Eugenio Ventimiglia, Oliver Wiseman, and Olivier Traxer's Letter to the Editor re: Andrea Bosio, Eugenio Alessandria, Simone Agosti, et al. Pigtail Suture Stents Significantly Reduce Stent-related Symptoms Compared to Conventional Double J Stents: A Prospective Randomized Trial. Eur Urol Open Sci 2021;29:1-9.

Andrea Bosio, Eugenio Alessandria, Paolo Gontero,

Eur Urol Open Sci (European urology open science)
[2021, 31:47-48]

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Squamous Cell Carcinoma Developing in a Buccal Mucosa Graft after Urethroplasty: A Report of 2 Cases of Malignant Degeneration.

Catti Massimo, Nappo Gerocarni Simona, Tadini Barbara, Cerchia Elisa, Ferrero Luisa, Gambella Alessandro, Pacchioni Donatella, Elisabetta Teruzzi, Marco Falcone, Sedigh Omidreza, Gontero Paolo,

Buccal mucosa graft (BMG) was originally described in 1992 for the treatment of challenging cases of hypospadias (proximal or redo cases) and has gained increasingly popularity also when dealing with complicated urethral stenosis, as it is associated with a good outcome. The development of a malignancy in a BMG urethroplasty ... Read more >>

Case Rep Urol (Case reports in urology)
[2021, 2021:5569373]

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Low Levels of Urinary PSA Better Identify Prostate Cancer Patients.

Sergio Occhipinti, Giulio Mengozzi, Marco Oderda, Andrea Zitella, Luca Molinaro, Francesco Novelli, Mirella Giovarelli, Paolo Gontero,

Serum prostatic specific antigen (PSA) has proven to have limited accuracy in early diagnosis and in making clinical decisions about different therapies for prostate cancer (PCa). This is partially due to the fact that an increase in PSA in the blood is due to the compromised architecture of the prostate, ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(14):]

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A risk-group classification model in patients with bladder cancer under neoadjuvant cisplatin-based combination chemotherapy.

Matteo Ferro, Giuseppe Lucarelli, Ottavio de Cobelli, Pasquale Dolce, Daniela Terracciano, Gennaro Musi, Angelo Porreca, Gian Maria Busetto, Francesco Del Giudice, Francesco Soria, Paolo Gontero, Francesco Cantiello, Rocco Damiano, Fabio Crocerossa, Abdal Rahman Abu Farhan, Riccardo Autorino, Mihai Dorin Vartolomei, Michele Marchioni, Andrea Mari, Andrea Minervini, Nicola Longo, Giuseppe Celentano, Francesco Chiancone, Sisto Perdonà, Paola Del Prete, Pasquale Ditonno, Michele Battaglia, Stefania Zamboni, Alessandro Antonelli, Francesco Greco, Giorgio Ivan Russo, Rodolfo Hurle, Nicolae Crisan, Matteo Manfredi, Francesco Porpiglia, Dario Ribera, Pietro De Placido, Sergio Facchini, Luca Scafuri, Antonio Verde, Giuseppe Di Lorenzo, Vincenzo Cosimato, Angelo Luciano, Vincenzo Francesco Caputo, Felice Crocetto, Carlo Buonerba,

The objective of the current research was to explore the potential prognostic value of readily available clinical and pathologic variables in bladder cancer. The novel association found between cholesterol levels and prognosis may provide the rationale for exploring novel treatments. Patients included had histologically confirmed urothelial bladder cancer and were treated with ... Read more >>

Future Oncol (Future oncology (London, England))
[2021, :]

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Outcomes and Cost Evaluation Related to a Single-Use, Disposable Ureteric Stent Removal System: a Systematic Review of the Literature.

Thomas Hughes, Amelia Pietropaolo, Patrick Jones, Marco Oderda, Paolo Gontero, Bhaskar K Somani,

<h4>Purpose of review</h4>To present the latest evidence related to the outcomes and cost of single-use, disposable ureteric stent removal system (Isiris).<h4>Recent findings</h4>Our review suggests that compared to a reusable flexible cystoscope (re-FC), a disposable flexible cystoscope (d-FC) with built-in grasper (Isiris) significantly reduced procedural time and provided a cost benefit ... Read more >>

Curr Urol Rep (Current urology reports)
[2021, 22(8):41]

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100 years of Bacillus Calmette-Guérin immunotherapy: from cattle to COVID-19.

Niyati Lobo, Nathan A Brooks, Alexandre R Zlotta, Jeffrey D Cirillo, Stephen Boorjian, Peter C Black, Joshua J Meeks, Trinity J Bivalacqua, Paolo Gontero, Gary D Steinberg, David McConkey, Marko Babjuk, J Alfred Witjes, Ashish M Kamat,

Bacillus Calmette-Guérin (BCG) is the most widely used vaccine worldwide and has been used to prevent tuberculosis for a century. BCG also stimulates an anti-tumour immune response, which urologists have harnessed for the treatment of non-muscle-invasive bladder cancer. A growing body of evidence indicates that BCG offers protection against various ... Read more >>

Nat Rev Urol (Nature reviews. Urology)
[2021, :]

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Total phallic construction techniques in transgender men: an updated narrative review.

Marco Falcone, Mirko Preto, Gideon Blecher, Massimiliano Timpano, Paolo Gontero,

From 2012, the World Professional Association Transgender Health defined a structured therapeutic path and standards of care for transgender patients undergoing genital gender affirming surgery (GGAS). The main goal of GGAS in transgender males is to provide patients with an aesthetically appealing appearance of the neophallus that should allow standing ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2021, 10(6):2583-2595]

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Flexible fibre optic vs digital ureteroscopy and enhanced vs unenhanced imaging for diagnosis and treatment of upper tract urothelial carcinoma (UTUC): results from the Clinical Research Office of the Endourology Society (CROES)-UTUC registry.

Francesco Soria, M Pilar Laguna, Morgan Roupret, Patricio Garcia-Marchinena, Mariano Sebastián Gonzalez, Tomonori Habuchi, Erkan Erkan, Anthony Ng, Paolo Gontero, Jean de la Rosette,

<h4>Objectives</h4>To compare the oncological outcomes of patients with upper tract urothelial carcinoma (UTUC) undergoing kidney-sparing surgery (KSS) with fibre-optic (FO) vs digital (D) ureteroscopy (URS). To evaluate the oncological impact of image-enhancement technologies such as narrow-band imaging (NBI) and Image1-S in patients with UTUC.<h4>Patients and methods</h4>The Clinical Research Office of ... Read more >>

BJU Int (BJU international)
[2021, :]

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The role of lymph node dissection in salvage radical prostatectomy for patients with radiation recurrent prostate cancer.

Fahad Quhal, Pawel Rajwa, Keiichiro Mori, Ekaterina Laukhtina, Nico C Grossmann, Victor M Schuettfort, Frederik König, Abdulmajeed Aydh, Reza S Motlagh, Satoshi Katayama, Hadi Mostafai, Benjamin Pradere, Giancarlo Marra, Paolo Gontero, Romain Mathieu, Pierre I Karakiewicz, Alberto Briganti, Shahrokh F Shariat, Axel Heidenreich,

<h4>Purpose</h4>To examine the effect of lymph node dissection on the outcomes of patients who underwent salvage radical prostatectomy (SRP).<h4>Material and methods</h4>We retrospectively reviewed data from radiation-recurrent patients with prostate cancer (PCa) who underwent SRP from 2000-2016. None of the patients had clinical lymph node involvement before SRP. The effect of ... Read more >>

Prostate (The Prostate)
[2021, 81(11):765-771]

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Role of systemic immune-inflammation index in patients treated with salvage radical prostatectomy.

Pawel Rajwa, Victor M Schuettfort, Fahad Quhal, Keiichiro Mori, Satoshi Katayama, Ekaterina Laukhtina, Benjamin Pradere, Reza Sari Motlagh, Hadi Mostafaei, Nico C Grossmann, Andreas Aulitzky, Andrzej Paradysz, Pierre I Karakiewicz, Harun Fajkovic, Kristin Zimmermann, Axel Heidenreich, Paolo Gontero, Shahrokh F Shariat,

<h4>Purpose</h4>To examine the predictive and prognostic value of preoperative Systemic Immune-inflammation Index (SII) in patients with radio-recurrent prostate cancer (PCa) treated with salvage radical prostatectomy (SRP).<h4>Materials and methods</h4>This multicenter retrospective study included 214 patients with radio-recurrent PCa, treated with SRP between 2007 and 2015. SII was measured preoperatively (neutrophils × ... Read more >>

World J Urol (World journal of urology)
[2021, :]

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Three vs. Four Cycles of Neoadjuvant Chemotherapy for Localized Muscle Invasive Bladder Cancer Undergoing Radical Cystectomy: A Retrospective Multi-Institutional Analysis.

Matteo Ferro, Ottavio de Cobelli, Gennaro Musi, Giuseppe Lucarelli, Daniela Terracciano, Daniela Pacella, Tommaso Muto, Angelo Porreca, Gian Maria Busetto, Francesco Del Giudice, Francesco Soria, Paolo Gontero, Francesco Cantiello, Rocco Damiano, Fabio Crocerossa, Abdal Rahman Abu Farhan, Riccardo Autorino, Mihai Dorin Vartolomei, Matteo Muto, Michele Marchioni, Andrea Mari, Luca Scafuri, Andrea Minervini, Nicola Longo, Francesco Chiancone, Sisto Perdona, Pietro De Placido, Antonio Verde, Michele Catellani, Stefano Luzzago, Francesco Alessandro Mistretta, Pasquale Ditonno, Vincenzo Francesco Caputo, Michele Battaglia, Stefania Zamboni, Alessandro Antonelli, Francesco Greco, Giorgio Ivan Russo, Rodolfo Hurle, Nicolae Crisan, Matteo Manfredi, Francesco Porpiglia, Giuseppe Di Lorenzo, Felice Crocetto, Carlo Buonerba,

<h4>Background</h4>Three or four cycles of cisplatin-based chemotherapy is the standard neoadjuvant treatment prior to cystectomy in patients with muscle-invasive bladder cancer. Although NCCN guidelines recommend 4 cycles of cisplatin-gemcitabine, three cycles are also commonly administered in clinical practice. In this multicenter retrospective study, we assessed a large and homogenous cohort ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:651745]

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The IDENTIFY study: the investigation and detection of urological neoplasia in patients referred with suspected urinary tract cancer - a multicentre observational study.

Sinan Khadhouri, Kevin M Gallagher, Kenneth R MacKenzie, Taimur T Shah, Chuanyu Gao, Sacha Moore, Eleanor F Zimmermann, Eric Edison, Matthew Jefferies, Arjun Nambiar, Miles P Mannas, Taeweon Lee, Giancarlo Marra, Beatrice Lillaz, Juan Gómez Rivas, Jonathan Olivier, Mark A Assmus, Taha Uçar, Francesco Claps, Matteo Boltri, Tara Burnhope, Nkwam Nkwam, George Tanasescu, Nicholas E Boxall, Alison P Downey, Asim A Lal, Marta Antón-Juanilla, Holly Clarke, David H W Lau, Kathryn Gillams, Matthew Crockett, Matthew Nielsen, Yemisi Takwoingi, Naomi Chuchu, John O'Rourke, Graeme MacLennan, John S McGrath, Veeru Kasivisvanathan, ,

<h4>Objective</h4>To evaluate the contemporary prevalence of urinary tract cancer (bladder cancer, upper tract urothelial cancer [UTUC] and renal cancer) in patients referred to secondary care with haematuria, adjusted for established patient risk markers and geographical variation.<h4>Patients and methods</h4>This was an international multicentre prospective observational study. We included patients aged ≥16 years, ... Read more >>

BJU Int (BJU international)
[2021, :]

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UVENTA urethral stents: Are we taking a step forward? The first clinical series.

Omid Sedigh, Ettore Dalmasso, Maurizio Barale, Giuseppe Pizzuto, Simone Agosti, Claudio Dadone, Orazio Maugeri, Alessandro Giammo, Alberto Manassero, Paolo Gontero,

<h4>Objectives</h4>To describe first clinical results in term of safety, complications and short term efficacy of temporary placement of UVENTA urethral stent in the treatment of urethral and bladder neck strictures.<h4>Methods</h4>UVENTA urethral stent (Taewoong Medical) is a temporary self expandable covered metallic stent. Anti-migration system and different radial force distribution are ... Read more >>

Arch Esp Urol (Archivos espanoles de urologia)
[2021, 74(4):435-440]

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Pigtail Suture Stents Significantly Reduce Stent-related Symptoms Compared to Conventional Double J Stents: A Prospective Randomized Trial.

Andrea Bosio, Eugenio Alessandria, Simone Agosti, Federico Vitiello, Eugenia Vercelli, Alessandro Bisconti, Paolo Piana, Fabrizio Fop, Paolo Gontero,

<h4>Background</h4>Double J (DJ) ureteral stents are commonly inserted after ureteroscopy (URS) procedures for stone treatment. However, stent-related symptoms are still a major issue.<h4>Objective</h4>To determine whether a commercially available pigtail suture stent (PSS) can reduce stent-related symptoms compared to a conventional DJ stent after uncomplicated URS.<h4>Design setting and participants</h4>We designed a ... Read more >>

Eur Urol Open Sci (European urology open science)
[2021, 29:1-9]

Cited: 3 times

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Functional and Patient Reported Outcomes Following Total Glans Resurfacing.

Mirko Preto, Marco Falcone, Gideon Blecher, Marco Capece, Andrea Cocci, Massimiliano Timpano, Paolo Gontero,

<h4>Background</h4>Whilst there is a trend away from aggressive nonorgan sparing surgical treatments for malignant penile disease, a variety of penile preservation options exist but functional outcomes and patient reported outcomes (PROs) in this area are poorly reported to date.<h4>Aim</h4>The aim of this study is to report functional outcomes and PROs ... Read more >>

J Sex Med (The journal of sexual medicine)
[2021, 18(6):1099-1103]

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Neutrophil percentage-to-albumin ratio predicts mortality in bladder cancer patients treated with neoadjuvant chemotherapy followed by radical cystectomy.

Matteo Ferro, Dragoş-Florin Babă, Ottavio de Cobelli, Gennaro Musi, Giuseppe Lucarelli, Daniela Terracciano, Angelo Porreca, Gian Maria Busetto, Francesco Del Giudice, Francesco Soria, Paolo Gontero, Francesco Cantiello, Rocco Damiano, Papalia Rocco, Roberto Mario Scarpa, Abdal Rahman Abu Farhan, Riccardo Autorino, Antonio Brescia, Michele Marchioni, Andrea Mari, Andrea Minervini, Nicola Longo, Francesco Chiancone, Sisto Perdona', Biagio Barone, Pietro De Placido, Michele Catellani, Danilo Bottero, Pasquale Ditonno, Michele Battaglia, Stefania Zamboni, Alessandro Antonelli, Francesco Greco, Giorgio Ivan Russo, Salvatore Smelzo, Rodolfo Hurle, Nicolae Crisan, Matteo Manfredi, Francesco Porpiglia, Felice Crocetto, Carlo Buonerba, Alina Danilesco, Mihai Dorin Vartolomei,

<h4>Aim</h4>To investigate the prognostic role of neutrophil percentage-to-albumin ratio (NPAR) in muscle-invasive bladder cancer (MIBC) patients treated with neoadjuvant chemotherapy (NAC) and radical cystectomy (RC).<h4>Patients & methods</h4>213 patients were included.<h4>Inclusion criteria</h4>Nonmetastatic, MIBC (cT2-T4aN0M0), at least three cycles of NAC, undergone RC and with blood count within 30 days before NAC.<h4>Results</h4>Five-years overall survival ... Read more >>

Future Sci OA (Future science OA)
[2021, 7(7):FSO709]

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Long-term Outcomes of Focal Cryotherapy for Low- to Intermediate-risk Prostate Cancer: Results and Matched Pair Analysis with Active Surveillance.

Giancarlo Marra, Timo Soeterik, Davide Oreggia, Rafael Tourinho-Barbosa, Marco Moschini, Claudia Filippini, Harm H E van Melick, Roderick C N van den Bergh, Paolo Gontero, Nathalie Cathala, Petr Macek, Rafael Sanchez-Salas, Xavier Cathelineau,

<h4>Background</h4>To date, only one trial compared focal therapy and active surveillance (AS) for low-risk prostate cancer (PCa). In addition, long-term outcomes of focal cryotherapy (FC) are lacking.<h4>Objective</h4>Our aim was to evaluate long-term outcomes of FC and compare them with AS.<h4>Design, setting, and participants</h4>We included two prospective series of 121 (FC) ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Reply to Francesco Montorsi, Marco Bandini, and Andrea Necchi's Letter to the Editor re: Francesco Soria, Marco Moschini, David D'Andrea, et al. Comparative Effectiveness in Perioperative Outcomes of Robotic versus Open Radical Cystectomy: Results from a Multicenter Contemporary Retrospective Cohort Study. Eur Urol Focus 2020;6:1233-9.

Francesco Soria, David D'Andrea, Paolo Gontero, Shahrokh F Shariat,

Eur Urol Focus (European urology focus)
[2021, :]

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Surgical Outcomes of Glansectomy and Split Thickness Skin Graft Reconstruction for Localized Penile Cancer.

Marco Falcone, Marco Oderda, Giorgio Calleris, Federica Peretti, Paolo Gontero,

<h4>Introduction</h4>The management of localized penile cancer is based on organ-sparing approaches. Our aim is to report surgical outcomes of glansectomy (GS) and split thickness skin graft (STSG) reconstruction in a consecutive series of penile cancers.<h4>Patients and methods</h4>Patients with a localized penile cancer underwent GS and STSG reconstruction in tertiary referral ... Read more >>

Urology (Urology)
[2021, 152:195]

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