Full Text Journal Articles by
Author Paolo Bottau

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Hypersensitivity Reactions to Monoclonal Antibodies in Children.

Francesca Mori, Francesca Saretta, Annamaria Bianchi, Giuseppe Crisafulli, Silvia Caimmi, Lucia Liotti, Paolo Bottau, Fabrizio Franceschini, Claudia Paglialunga, Giampaolo Ricci, Angelica Santoro, Carlo Caffarelli,

Biologic drugs are widely used in pediatric medicine. Monoclonal antibodies (mAbs) in particular are a therapeutic option for rheumatic, autoinflammatory and oncologic diseases. Adverse drug reactions and hypersensitivity reactions (HSR) to mAbs may occur in children. Clinical presentation of HSRs to mAbs can be classified according to phenotypes in infusion-related ... Read more >>

Medicina (Kaunas) (Medicina (Kaunas, Lithuania))
[2020, 56(5):]

Cited: 0 times

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Component-Resolved Diagnosis in Food Allergies.

Elisabetta Calamelli, Lucia Liotti, Isadora Beghetti, Valentina Piccinno, Laura Serra, Paolo Bottau,

Component-resolved diagnostics (CRD) in food allergies is an approach utilized to characterize the molecular components of each allergen involved in a specific IgE (sIgE)-mediated response. In the clinical practice, CRD can improve diagnostic accuracy and assist the physician in many aspects of the allergy work-up. CRD allows for discriminatory co-sensitization ... Read more >>

Medicina (Kaunas) (Medicina (Kaunas, Lithuania))
[2019, 55(8):]

Cited: 2 times

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Drug-induced anaphylaxis in children.

Fabio Cardinale, Doriana Amato, Maria Felicia Mastrototaro, Carlo Caffarelli, Giuseppe Crisafulli, Fabrizio Franceschini, Lucia Liotti, Silvia Caimmi, Paolo Bottau, Francesca Saretta, Francesca Mori, Roberto Bernardini,

Anaphylaxis represents one of the most frequent medical emergencies in childhood. However, as compared to adults, drugs are less common triggers of anaphylaxis in children, with a frequency which is increasing  from infancy to adolescence. Deaths seldom occur, maybe because of the paucity of comorbidities in children.  Antibiotics and non-steroidal ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2019, 90(3-S):30-35]

Cited: 0 times

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Drug reaction with eosinophilia and systemic symptoms (DRESS) in children.

Francesca Mori, Carlo Caffarelli, Silvia Caimmi, Paolo Bottau, Lucia Liotti, Fabrizio Franceschini, Fabio Cardinale, Roberto Bernardini, Giuseppe Crisafulli, Francesca Saretta, Elio Novembre,

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) is a severe reaction to drugs. Incidence of DRESS in children is not well known and the mortality rate seems to be lower than 10%. Anticonvulsants are the main drugs involved both in adults and in children. The treatment of choice is ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2019, 90(3-S):66-79]

Cited: 0 times

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Chronic urticaria and drug hypersensitivity in children.

Carlo Mastrorilli, Roberto Bernardini, Lucia Liotti, Fabrizio Franceschini, Giuseppe Crisafulli, Silvia Caimmi, Paolo Bottau, Francesca Mori, Fabio Cardinale, Francesca Saretta, Giovanni Simeone, Marcello Bergamini, Carlo Caffarelli,

The cause of chronic urticaria remains often elusive. The association between chronic urticaria and intake of medications have been reported in children. However, the causative role of drugs has been rarely ascertained by onset of symptoms on drug provocation test. Chronic urticaria can be mediated by immunologic and nonimmunologic mechanisms. ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2019, 90(3-S):61-65]

Cited: 0 times

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Drug desensitization in allergic children.

Silvia Caimmi, Carlo Caffarelli, Francesca Saretta, Lucia Liotti, Giuseppe Crisafulli, Fabio Cardinale, Paolo Bottau, Francesca Mori, Fabrizio Franceschini, Roberto Bernardini, Gian Luigi Marseglia,

Drug allergy is an increasing problem worldwide, affecting all populations and races, children and adults, and for which diagnosis and treatment are not well standardized yet. Besides classical treatments, new drugs have been developed, especially for patients suffering from malignancies and chronic inflammatory diseases, that specifically target the cause of ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2019, 90(3-S):20-29]

Cited: 1 time

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Pediatric drug hypersensitivity: which diagnostic tests?

Francesca Saretta, Francesca Mori, Fabio Cardinale, Lucia Liotti, Fabrizio Franceschini, Giuseppe Crisafulli, Silvia Caimmi, Paolo Bottau, Roberto Bernardini, Carlo Caffarelli,

Along with the anamnesis and clinical evaluation, diagnostic tests are one of the mainstream key points in the evaluation and management of drug hypersensitivity reactions (DHR). A wide knowledge gap, both in diagnosis and management of pediatric DHR, must be filled.  Only a few published studies evaluated sensitivity and specificity ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2019, 90(3-S):94-107]

Cited: 1 time

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Clinical features, outcomes and treatment in children with drug induced Stevens-Johnson syndrome and toxic epidermal necrolysis.

Lucia Liotti, Silvia Caimmi, Paolo Bottau, Roberto Bernardini, Fabio Cardinale, Francesca Saretta, Francesca Mori, Giuseppe Crisafulli, Fabrizio Franceschini, Carlo Caffarelli,

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), which can be considered a late-onset allergic reaction, can cause serious long-term sequelae. SJS/TEN are considered a spectrum of life-threatening adverse drug reactions. They have the same clinical manifestations and the only difference is in the extent of epidermal detachment. These conditions ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2019, 90(3-S):52-60]

Cited: 1 time

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A practical management of children with antibiotic allergy.

Elisabetta Calamelli, Carlo Caffarelli, Fabrizio Franceschini, Francesca Saretta, Fabio Cardinale, Roberto Bernardini, Lucia Liotti, Francesca Mori, Giuseppe Crisafulli, Silvia Caimmi, Paolo Bottau,

About 10% of the parents reported that their children are allergic to one drug and the betalactam antibiotics are the most frequently suspected. Even if most of the adverse events following antibiotic prescriptions to children are considered allergic, after a full allergy work-up only a few of the suspected reactions ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2019, 90(3-S):11-19]

Cited: 0 times

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Mechanisms of hypersensitivity reactions induced by drugs.

Fabrizio Franceschini, Paolo Bottau, Silvia Caimmi, Fabio Cardinale, Giuseppe Crisafulli, Lucia Liotti, Francesca Saretta, Roberto Bernardini, Francesca Mori, Carlo Caffarelli,

Adverse drug reactions include drug hypersensitivity reactions (DHRs), which can be immunologically mediated or non-immunologically mediated. The high number of DHRs unconfirmed and/or self-reported is a frequent problem in daily clinical practice, with considerable impact on future prescription choices and patient health. It is important to distinguish between hypersensitivity and ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2019, 90(3-S):44-51]

Cited: 0 times

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Mild cutaneous reactions to drugs.

Giuseppe Crisafulli, Fabrizio Franceschini, Silvia Caimmi, Paolo Bottau, Lucia Liotti, Francesca Saretta, Roberto Bernardini, Fabio Cardinale, Francesca Mori, Carlo Caffarelli,

Adverse reactions to drugs are not frequent in childhood. Cutaneous reactions are the most frequent in this age group. Mild cutaneous reactions are immediate or delayed adverse reactions that do not seriously compromise the clinical condition of children. The patients usually early improve and recover the state of health. Although ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2019, 90(3-S):36-43]

Cited: 0 times

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Management of the child with allergy to non-antibiotic drugs.

Roberto Bernardini, Fabio Cardinale, Francesca Mori, Francesca Saretta, Lucia Liotti, Fabrizio Franceschini, Giuseppe Crisafulli, Silvia Caimmi, Paolo Bottau, Carlo Caffarelli,

Non-steroidal anti-inflammatory drugs, perioperative drugs, radio contrast media and chemotherapeutics drugs are, after the non-antibiotic drugs, the drugs most commonly responsible for allergic reactions in children. Management is different depending on the drug involved. ... Read more >>

Acta Biomed (Acta bio-medica : Atenei Parmensis)
[2019, 90(3-S):5-10]

Cited: 0 times

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SIAIP position paper: provocation challenge to antibiotics and non-steroidal anti-inflammatory drugs in children.

Carlo Caffarelli, Fabrizio Franceschini, Davide Caimmi, Francesca Mori, Lucia Diaferio, Dora Di Mauro, Carla Mastrorilli, Stefania Arasi, Simona Barni, Paolo Bottau, Silvia Caimmi, Fabio Cardinale, Pasquale Comberiati, Giuseppe Crisafulli, Lucia Liotti, Umberto Pelosi, Francesca Saretta, Gianluigi Marseglia, Marzia Duse, Francesco Paravati,

Drug hypersensitivity reactions (DHRs) in childhood are mainly caused by betalactam or non-betalactam antibiotics, and non-steroidal anti-inflammatory drugs (NSAIDs). Laboratory tests for identifying children who are allergic to drugs have low diagnostic accuracy and predictive value. The gold standard to diagnose DHR is represented by the drug provocation test (DPT), ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2018, 44(1):147]

Cited: 11 times

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Solid Food Introduction and the Development of Food Allergies.

Carlo Caffarelli, Dora Di Mauro, Carla Mastrorilli, Paolo Bottau, Francesca Cipriani, Giampaolo Ricci,

The rise of food allergy in childhood, particularly among developed countries, has a significant weight on public health and involves serious implications for patients' quality of life. Even if the mechanisms of food tolerance and the complex interactions between the immune system and environmental factors are still mainly unknown, pediatricians ... Read more >>

Nutrients (Nutrients)
[2018, 10(11):]

Cited: 6 times

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An oesophageal spring.

Elisabetta Calamelli, Tomasso Gargano, Sandra Brusa, Paolo Bottau, Mario Lima, Marcello Lanari,

Oesophageal foreign bodies (OFBs) are a relatively common emergency in young children. OFBs are complicated by significant morbidity and mortality because their ingestion often occurs without witnesses, leading to a delay in diagnosis and treatment. We report an occult OFB in an 11-month-old infant who initially presented without any specific ... Read more >>

J Int Med Res (The Journal of international medical research)
[2018, 46(7):2938-2943]

Cited: 0 times

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Evaluating children with suspected allergic reactions to vaccines for infectious diseases.

Fabrizio Franceschini, Paolo Bottau, Silvia Caimmi, Fabio Cardinale, Giuseppe Crisafulli, Lucia Liotti, Guido Pellegrini, Diego Peroni, Francesca Saretta, Carla Mastrorilli, Carlo Caffarelli,

BACKGROUND:Vaccines often contain potentially allergenic material in addition to pathogen-specific immunogens that may induce allergic reactions. Parents and physicians often suspect that adverse reactions to vaccines are allergic in etiology. The concern that some of the substances contained in vaccines may trigger an anaphylactic reaction may lead to a low ... Read more >>

Allergy Asthma Proc (Allergy and asthma proceedings)
[2018, 39(3):177-183]

Cited: 7 times

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Update on Interventions in Prevention and Treatment of Pediatric Asthma.

Elisabetta Calamelli, Paolo Bottau, Marcello Lanari,

BACKGROUND:Asthma represents a worldwide health problem with a strong morbidity and a major impact on the health care system. Multiple efforts have been made towards the development of new strategies for the prevention and treatment of this disorder. In the light of this the present review of the literature aimed ... Read more >>

Curr Med Chem (Current medicinal chemistry)
[2018, 25(16):1909-1919]

Cited: 1 time

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Immunological, Viral, Environmental, and Individual Factors Modulating Lung Immune Response to Respiratory Syncytial Virus.

Silvia Vandini, Paolo Bottau, Giacomo Faldella, Marcello Lanari,

Respiratory syncytial virus is a worldwide pathogen agent responsible for frequent respiratory tract infections that may become severe and potentially lethal in high risk infants and adults. Several studies have been performed to investigate the immune response that determines the clinical course of the infection. In the present paper, we ... Read more >>

Biomed Res Int (BioMed research international)
[2015, 2015:875723]

Cited: 4 times

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Recommendations on complementary feeding for healthy, full-term infants.

Patrizia Alvisi, Sandra Brusa, Stefano Alboresi, Sergio Amarri, Paolo Bottau, Giovanni Cavagni, Barbara Corradini, Linda Landi, Leonardo Loroni, Miris Marani, Irene M Osti, Carlotta Povesi-Dascola, Carlo Caffarelli, Luca Valeriani, Carlo Agostoni,

Weaning (or introduction of complementary feeding) is a special and important moment in the growth of a child, both for the family and the infant itself, and it can play a major role in the child's future health. Throughout the years, various weaning modes have come in succession, the latest ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2015, 41:36]

Cited: 22 times

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Maternal milk protects infants against bronchiolitis during the first year of life. Results from an Italian cohort of newborns.

Marcello Lanari, Federica Prinelli, Fulvio Adorni, Simona Di Santo, Giacomo Faldella, Michela Silvestri, Massimo Musicco, ,

OBJECTIVE: Bronchiolitis is one of the primary causes of hospitalization in infancy. We evaluated the effect of breastfeeding on the occurrence of hospitalization for bronchiolitis in the first year of life. METHODS: In a prospective cohort study, 1,814 newborns of =33 weeks of gestational age (wGA) were enrolled in 30 ... Read more >>

Early Hum. Dev. (Early human development)
[2013, 89 Suppl 1:S51-7]

Cited: 18 times

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The multicenter Italian birth cohort study on incidence and determinants of lower respiratory tract infection hospitalization in infants at 33 weeks GA or more: preliminary results.

Marcello Lanari, Fulvio Adorni, Michela Silvestri, Alessandra Coscia, Massimo Musicco, ,

BACKGROUND: Respiratory syncytial virus (RSV) causes respiratory infections during the first year of life. Very premature infants have more severe diseases and also 'late preterm infants' may be more susceptible to the infection. AIM OF THE STUDY: To evaluate in an Italian cohort the incidence and risk factors of severe ... Read more >>

Early Hum. Dev. (Early human development)
[2011, 87 Suppl 1:S43-6]

Cited: 11 times

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Cow's milk protein allergy in children: a practical guide.

Carlo Caffarelli, Francesco Baldi, Barbara Bendandi, Luigi Calzone, Miris Marani, Pamela Pasquinelli, ,

A joint study group on cow's milk allergy was convened by the Emilia-Romagna Working Group for Paediatric Allergy and by the Emilia-Romagna Working Group for Paediatric Gastroenterology to focus best practice for diagnosis, management and follow-up of cow's milk allergy in children and to offer a common approach for allergologists, ... Read more >>

Ital J Pediatr (Italian journal of pediatrics)
[2010, 36:5]

Cited: 27 times

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