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Targeting eosinophils in respiratory diseases: Biological axis, emerging therapeutics and treatment modalities.

Li-Yen Lee, Geena Suet Yin Hew, Meenu Mehta, Shakti D Shukla, Saurabh Satija, Navneet Khurana, Krishnan Anand, Harish Dureja, Sachin Kumar Singh, Vijay Mishra, Pankaj Kumar Singh, Monica Gulati, Parteek Prasher, Alaa A A Aljabali, Murtaza M Tambuwala, Lakshmi Thangavelu, Jithendra Panneerselvam, Gaurav Gupta, Flavia C Zacconi, Madhur Shastri, Niraj Kumar Jha, Dikaia Xenaki, Ronan MacLoughlin, Brian G Oliver, Dinesh Kumar Chellappan, Kamal Dua,

Eosinophils are bi-lobed, multi-functional innate immune cells with diverse cell surface receptors that regulate local immune and inflammatory responses. Several inflammatory and infectious diseases are triggered with their build up in the blood and tissues. The mobilization of eosinophils into the lungs is regulated by a cascade of processes guided ... Read more >>

Life Sci (Life sciences)
[2021, 267:118973]

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Analyzing FDA-approved drugs for compliance of pharmacokinetic principles: should there be a critical screening parameter in drug designing protocols?

Shelly Pathania, Pankaj Kumar Singh,

Expert Opin Drug Metab Toxicol (Expert opinion on drug metabolism & toxicology)
[2020, :1-4]

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Spontaneous external rupture of hydrocephalus after fontanelle closure: a case report and review of literature

Varidh Katiyar, Kanwaljeet Garg, Ramesh Doddamani, Pankaj Kumar Singh, Manmohan Singh, P. Sarat Chandra,

We report a 2-year-old child with congenital hydrocephalus who presented with a frontal meningocoele due to ventriculo-subgaleal fistula secondary to hydrocephalus (internal rupture), which gradually ruptured spontaneously through the skin. This case is unique given its association with occipital encephalocele and is only the second case to present with external ... Read more >>

Childs Nerv Syst (Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery)
[2020, :1-5]

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Bioprospecting of marine diatoms Thalassiosira, Skeletonema and Chaetoceros for lipids and other value-added products.

Raya Bhattacharjya, Thomas Kiran Marella, Archana Tiwari, Abhishek Saxena, Pankaj Kumar Singh, Bharti Mishra,

Diatoms are a major storehouse of valuable fucoxanthin and polyunsaturated fatty acids, with enormous nutraceuticals and biofuel potential. Three marine diatom species isolated from the southern coast of India has been screened and their results show that highest biomass concentration and fucoxanthin yield was obtained in Chaetoceros sp. as 0.217 g L<sup>-1</sup> ... Read more >>

Bioresour Technol (Bioresource technology)
[2020, 318:124073]

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Spontaneous external rupture of hydrocephalus after fontanelle closure: a case report and review of literature.

Varidh Katiyar, Kanwaljeet Garg, Ramesh Doddamani, Pankaj Kumar Singh, Manmohan Singh, P Sarat Chandra,

We report a 2-year-old child with congenital hydrocephalus who presented with a frontal meningocoele due to ventriculo-subgaleal fistula secondary to hydrocephalus (internal rupture), which gradually ruptured spontaneously through the skin. This case is unique given its association with occipital encephalocele and is only the second case to present with external ... Read more >>

Childs Nerv Syst (Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery)
[2020, :]

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Effectiveness of mouth self-examination for screening of oral premalignant/malignant diseases in tribal population of Dehradun district.

Amit Shah, Bharat Bhushan, Saifullah Akhtar, Pankaj Kumar Singh, Madhur Garg, Mayank Gupta,

<h4>Background</h4>Mouth self-examination (MSE) is shown as a speedy, economical, and effortless method of oral cancer detection. As previous studies were conducted in population with high literacy, the current survey was performed to explore the usefulness of MSE for finding the oral cancerous precancerous lesions in indigenous low literate population of ... Read more >>

J Family Med Prim Care (Journal of family medicine and primary care)
[2020, 9(8):4381-4385]

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Estimating global injuries morbidity and mortality: methods and data used in the Global Burden of Disease 2017 study.

Spencer L James, Chris D Castle, Zachary V Dingels, Jack T Fox, Erin B Hamilton, Zichen Liu, Nicholas L S Roberts, Dillon O Sylte, Gregory J Bertolacci, Matthew Cunningham, Nathaniel J Henry, Kate E LeGrand, Ahmed Abdelalim, Ibrahim Abdollahpour, Rizwan Suliankatchi Abdulkader, Aidin Abedi, Kedir Hussein Abegaz, Akine Eshete Abosetugn, Abdelrahman I Abushouk, Oladimeji M Adebayo, Jose C Adsuar, Shailesh M Advani, Marcela Agudelo-Botero, Tauseef Ahmad, Muktar Beshir Ahmed, Rushdia Ahmed, Miloud Taki Eddine Aichour, Fares Alahdab, Fahad Mashhour Alanezi, Niguse Meles Alema, Biresaw Wassihun Alemu, Suliman A Alghnam, Beriwan Abdulqadir Ali, Saqib Ali, Cyrus Alinia, Vahid Alipour, Syed Mohamed Aljunid, Amir Almasi-Hashiani, Nihad A Almasri, Khalid Altirkawi, Yasser Sami Abdeldayem Amer, Catalina Liliana Andrei, Alireza Ansari-Moghaddam, Carl Abelardo T Antonio, Davood Anvari, Seth Christopher Yaw Appiah, Jalal Arabloo, Morteza Arab-Zozani, Zohreh Arefi, Olatunde Aremu, Filippo Ariani, Amit Arora, Malke Asaad, Beatriz Paulina Ayala Quintanilla, Getinet Ayano, Martin Amogre Ayanore, Ghasem Azarian, Alaa Badawi, Ashish D Badiye, Atif Amin Baig, Mohan Bairwa, Ahad Bakhtiari, Arun Balachandran, Maciej Banach, Srikanta K Banerjee, Palash Chandra Banik, Amrit Banstola, Suzanne Lyn Barker-Collo, Till Winfried Bärnighausen, Akbar Barzegar, Mohsen Bayati, Shahrzad Bazargan-Hejazi, Neeraj Bedi, Masoud Behzadifar, Habte Belete, Derrick A Bennett, Isabela M Bensenor, Kidanemaryam Berhe, Akshaya Srikanth Bhagavathula, Pankaj Bhardwaj, Anusha Ganapati Bhat, Krittika Bhattacharyya, Zulfiqar A Bhutta, Sadia Bibi, Ali Bijani, Archith Boloor, Guilherme Borges, Rohan Borschmann, Antonio Maria Borzì, Soufiane Boufous, Dejana Braithwaite, Nikolay Ivanovich Briko, Traolach Brugha, Shyam S Budhathoki, Josip Car, Rosario Cárdenas, Félix Carvalho, João Mauricio Castaldelli-Maia, Carlos A Castañeda-Orjuela, Giulio Castelpietra, Ferrán Catalá-López, Ester Cerin, Joht S Chandan, Jens Robert Chapman, Vijay Kumar Chattu, Soosanna Kumary Chattu, Irini Chatziralli, Neha Chaudhary, Daniel Youngwhan Cho, Jee-Young J Choi, Mohiuddin Ahsanul Kabir Chowdhury, Devasahayam J Christopher, Dinh-Toi Chu, Flavia M Cicuttini, João M Coelho, Vera M Costa, Saad M A Dahlawi, Ahmad Daryani, Claudio Alberto Dávila-Cervantes, Diego De Leo, Feleke Mekonnen Demeke, Gebre Teklemariam Demoz, Desalegn Getnet Demsie, Kebede Deribe, Rupak Desai, Mostafa Dianati Nasab, Diana Dias da Silva, Zahra Sadat Dibaji Forooshani, Hoa Thi Do, Kerrie E Doyle, Tim Robert Driscoll, Eleonora Dubljanin, Bereket Duko Adema, Arielle Wilder Eagan, Demelash Abewa Elemineh, Shaimaa I El-Jaafary, Ziad El-Khatib, Christian Lycke Ellingsen, Maysaa El Sayed Zaki, Sharareh Eskandarieh, Oghenowede Eyawo, Pawan Sirwan Faris, Andre Faro, Farshad Farzadfar, Seyed-Mohammad Fereshtehnejad, Eduarda Fernandes, Pietro Ferrara, Florian Fischer, Morenike Oluwatoyin Folayan, Artem Alekseevich Fomenkov, Masoud Foroutan, Joel Msafiri Francis, Richard Charles Franklin, Takeshi Fukumoto, Biniyam Sahiledengle Geberemariyam, Hadush Gebremariam, Ketema Bizuwork Gebremedhin, Leake G Gebremeskel, Gebreamlak Gebremedhn Gebremeskel, Berhe Gebremichael, Getnet Azeze Gedefaw, Birhanu Geta, Agegnehu Bante Getenet, Mansour Ghafourifard, Farhad Ghamari, Reza Ghanei Gheshlagh, Asadollah Gholamian, Syed Amir Gilani, Tiffany K Gill, Amir Hossein Goudarzian, Alessandra C Goulart, Ayman Grada, Michal Grivna, Rafael Alves Guimarães, Yuming Guo, Gaurav Gupta, Juanita A Haagsma, Brian James Hall, Randah R Hamadeh, Samer Hamidi, Demelash Woldeyohannes Handiso, Josep Maria Haro, Amir Hasanzadeh, Shoaib Hassan, Soheil Hassanipour, Hadi Hassankhani, Hamid Yimam Hassen, Rasmus Havmoeller, Delia Hendrie, Fatemeh Heydarpour, Martha Híjar, Hung Chak Ho, Chi Linh Hoang, Michael K Hole, Ramesh Holla, Naznin Hossain, Mehdi Hosseinzadeh, Sorin Hostiuc, Guoqing Hu, Segun Emmanuel Ibitoye, Olayinka Stephen Ilesanmi, Leeberk Raja Inbaraj, Seyed Sina Naghibi Irvani, M Mofizul Islam, Sheikh Mohammed Shariful Islam, Rebecca Q Ivers, Mohammad Ali Jahani, Mihajlo Jakovljevic, Farzad Jalilian, Sudha Jayaraman, Achala Upendra Jayatilleke, Ravi Prakash Jha, Yetunde O John-Akinola, Jost B Jonas, Kelly M Jones, Nitin Joseph, Farahnaz Joukar, Jacek Jerzy Jozwiak, Suresh Banayya Jungari, Mikk Jürisson, Ali Kabir, Amaha Kahsay, Leila R Kalankesh, Rohollah Kalhor, Teshome Abegaz Kamil, Tanuj Kanchan, Neeti Kapoor, Manoochehr Karami, Amir Kasaeian, Hagazi Gebremedhin Kassaye, Taras Kavetskyy, Gbenga A Kayode, Peter Njenga Keiyoro, Abraham Getachew Kelbore, Yousef Saleh Khader, Morteza Abdullatif Khafaie, Nauman Khalid, Ibrahim A Khalil, Rovshan Khalilov, Maseer Khan, Ejaz Ahmad Khan, Junaid Khan, Tripti Khanna, Salman Khazaei, Habibolah Khazaie, Roba Khundkar, Daniel N Kiirithio, Young-Eun Kim, Yun Jin Kim, Daniel Kim, Sezer Kisa, Adnan Kisa, Hamidreza Komaki, Shivakumar K M Kondlahalli, Ali Koolivand, Vladimir Andreevich Korshunov, Ai Koyanagi, Moritz U G Kraemer, Kewal Krishan, Barthelemy Kuate Defo, Burcu Kucuk Bicer, Nuworza Kugbey, Nithin Kumar, Manasi Kumar, Vivek Kumar, Narinder Kumar, Girikumar Kumaresh, Faris Hasan Lami, Van C Lansingh, Savita Lasrado, Arman Latifi, Paolo Lauriola, Carlo La Vecchia, Janet L Leasher, Shaun Wen Huey Lee, Shanshan Li, Xuefeng Liu, Alan D Lopez, Paulo A Lotufo, Ronan A Lyons, Daiane Borges Machado, Mohammed Madadin, Muhammed Magdy Abd El Razek, Narayan Bahadur Mahotra, Marek Majdan, Azeem Majeed, Venkatesh Maled, Deborah Carvalho Malta, Navid Manafi, Amir Manafi, Ana-Laura Manda, Narayana Manjunatha, Fariborz Mansour-Ghanaei, Mohammad Ali Mansournia, Joemer C Maravilla, Amanda J Mason-Jones, Seyedeh Zahra Masoumi, Benjamin Ballard Massenburg, Pallab K Maulik, Man Mohan Mehndiratta, Zeleke Aschalew Melketsedik, Peter T N Memiah, Walter Mendoza, Ritesh G Menezes, Melkamu Merid Mengesha, Tuomo J Meretoja, Atte Meretoja, Hayimro Edemealem Merie, Tomislav Mestrovic, Bartosz Miazgowski, Tomasz Miazgowski, Ted R Miller, G K Mini, Andreea Mirica, Erkin M Mirrakhimov, Mehdi Mirzaei-Alavijeh, Prasanna Mithra, Babak Moazen, Masoud Moghadaszadeh, Efat Mohamadi, Yousef Mohammad, Aso Mohammad Darwesh, Abdollah Mohammadian-Hafshejani, Reza Mohammadpourhodki, Shafiu Mohammed, Jemal Abdu Mohammed, Farnam Mohebi, Mohammad A Mohseni Bandpei, Mariam Molokhia, Lorenzo Monasta, Yoshan Moodley, Masoud Moradi, Ghobad Moradi, Maziar Moradi-Lakeh, Rahmatollah Moradzadeh, Lidia Morawska, Ilais Moreno Velásquez, Shane Douglas Morrison, Tilahun Belete Mossie, Atalay Goshu Muluneh, Kamarul Imran Musa, Ghulam Mustafa, Mehdi Naderi, Ahamarshan Jayaraman Nagarajan, Gurudatta Naik, Mukhammad David Naimzada, Farid Najafi, Vinay Nangia, Bruno Ramos Nascimento, Morteza Naserbakht, Vinod Nayak, Javad Nazari, Duduzile Edith Ndwandwe, Ionut Negoi, Josephine W Ngunjiri, Trang Huyen Nguyen, Cuong Tat Nguyen, Diep Ngoc Nguyen, Huong Lan Thi Nguyen, Rajan Nikbakhsh, Dina Nur Anggraini Ningrum, Chukwudi A Nnaji, Richard Ofori-Asenso, Felix Akpojene Ogbo, Onome Bright Oghenetega, In-Hwan Oh, Andrew T Olagunju, Tinuke O Olagunju, Ahmed Omar Bali, Obinna E Onwujekwe, Heather M Orpana, Erika Ota, Nikita Otstavnov, Stanislav S Otstavnov, Mahesh P A, Jagadish Rao Padubidri, Smita Pakhale, Keyvan Pakshir, Songhomitra Panda-Jonas, Eun-Kee Park, Sangram Kishor Patel, Ashish Pathak, Sanghamitra Pati, Kebreab Paulos, Amy E Peden, Veincent Christian Filipino Pepito, Jeevan Pereira, Michael R Phillips, Roman V Polibin, Suzanne Polinder, Farshad Pourmalek, Akram Pourshams, Hossein Poustchi, Swayam Prakash, Dimas Ria Angga Pribadi, Parul Puri, Zahiruddin Quazi Syed, Navid Rabiee, Mohammad Rabiee, Amir Radfar, Anwar Rafay, Ata Rafiee, Alireza Rafiei, Fakher Rahim, Siavash Rahimi, Muhammad Aziz Rahman, Ali Rajabpour-Sanati, Fatemeh Rajati, Ivo Rakovac, Sowmya J Rao, Vahid Rashedi, Prateek Rastogi, Priya Rathi, Salman Rawaf, Lal Rawal, Reza Rawassizadeh, Vishnu Renjith, Serge Resnikoff, Aziz Rezapour, Ana Isabel Ribeiro, Jennifer Rickard, Carlos Miguel Rios González, Leonardo Roever, Luca Ronfani, Gholamreza Roshandel, Basema Saddik, Hamid Safarpour, Mahdi Safdarian, S Mohammad Sajadi, Payman Salamati, Marwa R Rashad Salem, Hosni Salem, Inbal Salz, Abdallah M Samy, Juan Sanabria, Lidia Sanchez Riera, Milena M Santric Milicevic, Abdur Razzaque Sarker, Arash Sarveazad, Brijesh Sathian, Monika Sawhney, Mehdi Sayyah, David C Schwebel, Soraya Seedat, Subramanian Senthilkumaran, Seyedmojtaba Seyedmousavi, Feng Sha, Faramarz Shaahmadi, Saeed Shahabi, Masood Ali Shaikh, Mehran Shams-Beyranvand, Aziz Sheikh, Mika Shigematsu, Jae Il Shin, Rahman Shiri, Soraya Siabani, Inga Dora Sigfusdottir, Jasvinder A Singh, Pankaj Kumar Singh, Dhirendra Narain Sinha, Amin Soheili, Joan B Soriano, Muluken Bekele Sorrie, Ireneous N Soyiri, Mark A Stokes, Mu'awiyyah Babale Sufiyan, Bryan L Sykes, Rafael Tabarés-Seisdedos, Karen M Tabb, Biruk Wogayehu Taddele, Yonatal Mesfin Tefera, Arash Tehrani-Banihashemi, Gebretsadkan Hintsa Tekulu, Ayenew Kassie Tesema Tesema, Berhe Etsay Tesfay, Rekha Thapar, Mariya Vladimirovna Titova, Kenean Getaneh Tlaye, Hamid Reza Tohidinik, Roman Topor-Madry, Khanh Bao Tran, Bach Xuan Tran, Jaya Prasad Tripathy, Alexander C Tsai, Aristidis Tsatsakis, Lorainne Tudor Car, Irfan Ullah, Saif Ullah, Bhaskaran Unnikrishnan, Era Upadhyay, Olalekan A Uthman, Pascual R Valdez, Tommi Juhani Vasankari, Yousef Veisani, Narayanaswamy Venketasubramanian, Francesco S Violante, Vasily Vlassov, Yasir Waheed, Yuan-Pang Wang, Taweewat Wiangkham, Haileab Fekadu Wolde, Dawit Habte Woldeyes, Temesgen Gebeyehu Wondmeneh, Adam Belay Wondmieneh, Ai-Min Wu, Grant M A Wyper, Rajaram Yadav, Ali Yadollahpour, Yuichiro Yano, Sanni Yaya, Vahid Yazdi-Feyzabadi, Pengpeng Ye, Paul Yip, Engida Yisma, Naohiro Yonemoto, Seok-Jun Yoon, Yoosik Youm, Mustafa Z Younis, Zabihollah Yousefi, Chuanhua Yu, Yong Yu, Telma Zahirian Moghadam, Zoubida Zaidi, Sojib Bin Zaman, Mohammad Zamani, Hamed Zandian, Fatemeh Zarei, Zhi-Jiang Zhang, Yunquan Zhang, Arash Ziapour, Sanjay Zodpey, Rakhi Dandona, Samath Dhamminda Dharmaratne, Simon I Hay, Ali H Mokdad, David M Pigott, Robert C Reiner, Theo Vos,

<h4>Background</h4>While there is a long history of measuring death and disability from injuries, modern research methods must account for the wide spectrum of disability that can occur in an injury, and must provide estimates with sufficient demographic, geographical and temporal detail to be useful for policy makers. The Global Burden ... Read more >>

Inj Prev (Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention)
[2020, 26(Supp 1):i125-i153]

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A Novel Redox Modulator Induces a GPX4-Mediated Cell Death That Is Dependent on Iron and Reactive Oxygen Species.

Shuai Hu, Mario Sechi, Pankaj Kumar Singh, Lipeng Dai, Sean McCann, Duxin Sun, Mats Ljungman, Nouri Neamati,

Redox modulators have been developed as an attractive approach to treat cancer. Herein, we report the synthesis, identification, and biological evaluation of a quinazolinedione reactive oxygen species (ROS) inducer, QD394, with significant cytotoxicity in pancreatic cancer cells. QD394 shows a transcriptomic profile remarkably similar to napabucasin, a cancer stemness inhibitor. ... Read more >>

J Med Chem (Journal of medicinal chemistry)
[2020, 63(17):9838-9855]

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Effector Biology of Biotrophic Plant Fungal Pathogens: Current Advances and Future Prospects.

Rajdeep Jaswal, Kanti Kiran, Sivasubramanian Rajarammohan, Himanshu Dubey, Pankaj Kumar Singh, Yogesh Sharma, Rupesh Deshmukh, Humira Sonah, Naveen Gupta, T R Sharma,

The interaction of fungal pathogens with their host requires a novel invading mechanism and the presence of various virulence-associated components responsible for promoting the infection. The small secretory proteins, explicitly known as effector proteins, are one of the prime mechanisms of host manipulation utilized by the pathogen to disarm the ... Read more >>

Microbiol Res (Microbiological research)
[2020, 241:126567]

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Inductively coupled plasma nanosilica based growth method for enhanced biomass production in marine diatom algae.

Abhishek Saxena, Kunal Prakash, Sakshi Phogat, Pankaj Kumar Singh, Archana Tiwari,

This work reports a novel solution-based method to trigger the growth of diatoms for enhanced biomass production, which can efficiently stimulate their applications in nutraceuticals, aquaculture and wastewater remediation. The optimization for the growth of three marine diatoms species was performed using inductively coupled plasma (ICP) synthesized nanosilica which can ... Read more >>

Bioresour Technol (Bioresource technology)
[2020, 314:123747]

Cited: 1 time

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Author Correction: Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017.

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An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Nat Med (Nature medicine)
[2020, 26(8):1308]

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Stereotactic guided ablation for subependymal giant cell astrocytomas: does it change the surgical indications?

Ramesh Sharanappa Doddamani, Rajesh Meena, Dattaraj Sawarkar, Pankaj Kumar Singh, P Sarat Chandra,

Childs Nerv Syst (Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery)
[2020, :]

Cited: 0 times

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Addressing selectivity issues of aldose reductase 2 inhibitors for the management of diabetic complications.

Manoj Kumar, Shalki Choudhary, Pankaj Kumar Singh, Om Silakari,

Aldose Reductase 2 (ALR2), the rate-limiting enzyme of the polyol pathway, plays an important role in detoxification of some toxic aldehydes. Under hyperglycemia, this enzyme overactivates and causes diabetic complications (DC). Therefore, ALR2 inhibition has been established as a potential approach to manage these complications. Several ALR2 inhibitors have been ... Read more >>

Future Med Chem (Future medicinal chemistry)
[2020, 12(14):1327-1358]

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Development of a Raltegravir-based Photoaffinity-Labeled Probe for Human Immunodeficiency Virus-1 Integrase Capture.

Nicolino Pala, Francesca Esposito, Enzo Tramontano, Pankaj Kumar Singh, Vanna Sanna, Mauro Carcelli, Lisa D Haigh, Sandro Satta, Mario Sechi,

Photoaffinity labeling (PAL) is one of the upcoming and powerful tools in the field of molecular recognition. It includes the determination of dynamic parameters, such as the identification and localization of the target protein and the site of drug binding. In this study, a photoaffinity-labeled probe for full-length human immunodeficiency ... Read more >>

ACS Med Chem Lett (ACS medicinal chemistry letters)
[2020, 11(10):1986-1992]

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Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017.

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A double burden of malnutrition occurs when individuals, household members or communities experience both undernutrition and overweight. Here, we show geospatial estimates of overweight and wasting prevalence among children under 5 years of age in 105 low- and middle-income countries (LMICs) from 2000 to 2017 and aggregate these to policy-relevant ... Read more >>

Nat Med (Nature medicine)
[2020, 26(5):750-759]

Cited: 1 time

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Structural investigation on the selective COX-2 inhibitors mediated cardiotoxicity: A review.

Mohit Arora, Shalki Choudhary, Pankaj Kumar Singh, Bharti Sapra, Om Silakari,

Initially, the selective COX-2 inhibitors were developed as safer alternatives to the conventional NSAIDs, but later on, most of them were withdrawn from the market due to the risk of heart attack and stroke. Celecoxib, the first selective COX-2 inhibitor, was approved by the Food and Drug Administration (FDA) in ... Read more >>

Life Sci (Life sciences)
[2020, 251:117631]

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Inhibition of Human Immunodeficiency Virus-1 Integrase by β-Diketo Acid Coated Gold Nanoparticles.

Vanna Sanna, Mohamed Fathy Youssef, Nicolino Pala, Dominga Rogolino, Mauro Carcelli, Pankaj Kumar Singh, Tino Sanchez, Nouri Neamati, Mario Sechi,

Gold nanoparticles (GNPs) have been proposed as carriers for drugs to improve their intrinsic therapeutic activities and to overcome pharmacokinetic problems. In this study, novel nanosystems constituted by a model β-diketo acid (DKA) grafted to the surface of GNPs were designed and synthesized following the "multivalent high-affinity" binding strategy. These ... Read more >>

ACS Med Chem Lett (ACS medicinal chemistry letters)
[2020, 11(5):857-861]

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In Reply to Letter to the Editor Regarding "Proposal of a New Safety Margin for Placement of C2 Pedicle Screws on Computed Tomography Angiography".

Mohit Agrawal, Pankaj Kumar Singh,

World Neurosurg (World neurosurgery)
[2020, 135:410]

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The burden of unintentional drowning: global, regional and national estimates of mortality from the Global Burden of Disease 2017 Study.

Richard Charles Franklin, Amy E Peden, Erin B Hamilton, Catherine Bisignano, Chris D Castle, Zachary V Dingels, Simon I Hay, Zichen Liu, Ali H Mokdad, Nicholas L S Roberts, Dillon O Sylte, Theo Vos, Gdiom Gebreheat Abady, Akine Eshete Abosetugn, Rushdia Ahmed, Fares Alahdab, Catalina Liliana Andrei, Carl Abelardo T Antonio, Jalal Arabloo, Aseb Arba Kinfe Arba, Ashish D Badiye, Shankar M Bakkannavar, Maciej Banach, Palash Chandra Banik, Amrit Banstola, Suzanne Lyn Barker-Collo, Akbar Barzegar, Mohsen Bayati, Pankaj Bhardwaj, Soumyadeep Bhaumik, Zulfiqar A Bhutta, Ali Bijani, Archith Boloor, Félix Carvalho, Mohiuddin Ahsanul Kabir Chowdhury, Dinh-Toi Chu, Samantha M Colquhoun, Henok Dagne, Baye Dagnew, Lalit Dandona, Rakhi Dandona, Ahmad Daryani, Samath Dhamminda Dharmaratne, Zahra Sadat Dibaji Forooshani, Hoa Thi Do, Tim Robert Driscoll, Arielle Wilder Eagan, Ziad El-Khatib, Eduarda Fernandes, Irina Filip, Florian Fischer, Berhe Gebremichael, Gaurav Gupta, Juanita A Haagsma, Shoaib Hassan, Delia Hendrie, Chi Linh Hoang, Michael K Hole, Ramesh Holla, Sorin Hostiuc, Mowafa Househ, Olayinka Stephen Ilesanmi, Leeberk Raja Inbaraj, Seyed Sina Naghibi Irvani, M Mofizul Islam, Rebecca Q Ivers, Achala Upendra Jayatilleke, Farahnaz Joukar, Rohollah Kalhor, Tanuj Kanchan, Neeti Kapoor, Amir Kasaeian, Maseer Khan, Ejaz Ahmad Khan, Jagdish Khubchandani, Kewal Krishan, G Anil Kumar, Paolo Lauriola, Alan D Lopez, Mohammed Madadin, Marek Majdan, Venkatesh Maled, Navid Manafi, Ali Manafi, Martin McKee, Hagazi Gebre Meles, Ritesh G Menezes, Tuomo J Meretoja, Ted R Miller, Prasanna Mithra, Abdollah Mohammadian-Hafshejani, Reza Mohammadpourhodki, Farnam Mohebi, Mariam Molokhia, Ghulam Mustafa, Ionut Negoi, Cuong Tat Nguyen, Huong Lan Thi Nguyen, Andrew T Olagunju, Tinuke O Olagunju, Jagadish Rao Padubidri, Keyvan Pakshir, Ashish Pathak, Suzanne Polinder, Dimas Ria Angga Pribadi, Navid Rabiee, Amir Radfar, Saleem Muhammad Rana, Jennifer Rickard, Saeed Safari, Payman Salamati, Abdallah M Samy, Abdur Razzaque Sarker, David C Schwebel, Subramanian Senthilkumaran, Faramarz Shaahmadi, Masood Ali Shaikh, Jae Il Shin, Pankaj Kumar Singh, Amin Soheili, Mark A Stokes, Hafiz Ansar Rasul Suleria, Ingan Ukur Tarigan, Mohamad-Hani Temsah, Berhe Etsay Tesfay, Pascual R Valdez, Yousef Veisani, Pengpeng Ye, Naohiro Yonemoto, Chuanhua Yu, Hasan Yusefzadeh, Sojib Bin Zaman, Zhi-Jiang Zhang, Spencer L James,

<h4>Background</h4>Drowning is a leading cause of injury-related mortality globally. Unintentional drowning (International Classification of Diseases (ICD) 10 codes W65-74 and ICD9 E910) is one of the 30 mutually exclusive and collectively exhaustive causes of injury-related mortality in the Global Burden of Disease (GBD) study. This study's objective is to describe ... Read more >>

Inj Prev (Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention)
[2020, 26(Supp 1):i83-i95]

Cited: 3 times

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Search for non-acidic ALR2 inhibitors: Evaluation of flavones as targeted agents for the management of diabetic complications.

Bhawna Vyas, Shalki Choudhary, Pankaj Kumar Singh, Manoj Kumar, Himanshu Verma, Manjinder Singh, Ashok Kumar Malik, Om Silakari,

Diabetic complications (DC) follow multiple pathophysiological pathways and one of the key pathways is the polyol pathway which involves the metabolism of glucose via aldose reductase (ALR2) and sorbitol dehydrogenase (SDH). ALR2 inhibitors such as epalrestat has already been established as promising candidates for the management of DC. On the ... Read more >>

Bioorg Chem (Bioorganic chemistry)
[2020, 96:103570]

Cited: 1 time

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Pharmacophore-based designing of putative ROS-1 targeting agents for NSCLC.

Disha Pathak, Shalki Choudhary, Pankaj Kumar Singh, Manjinder Singh, Navriti Chadha, Om Silakari,

Non-small cell lung cancer (NSCLC) is a fatal non-immunogenic malignancy, and proto-oncogene receptor tyrosine kinase (ROS-1) is one of its clinically relevant biomarkers. In this context, herein, we report a series of benzimidazol-2-amine derivatives which were synthesized on the basis of the pharmacophore of ROS-1 and evaluated for anti-proliferative activity. ... Read more >>

Mol Divers (Molecular diversity)
[2020, :]

Cited: 1 time

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Medicinal Potential of Heterocyclic Compounds from Diverse Natural Sources for the Management of Cancer.

Manjinder Singh, Pratibha Sharma, Pankaj Kumar Singh, Thakur Gurjeet Singh, Balraj Saini,

Natural products form a significant portion of medicinal agents that are currently used for the management of cancer. All these natural products have unique structures along with diverse action mechanisms with the capacity to interact with different therapeutic targets of several complex disorders. Although plants contribute as a major source ... Read more >>

Mini Rev Med Chem (Mini reviews in medicinal chemistry)
[2020, 20(11):942-957]

Cited: 0 times

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Correlation Study of Apolipoprotein'a' with Diabetic Retinopathy in Patients of Type 2 Diabetes Mellitus with Retinopathy.

Pankaj Kumar Singh, Ravi Tandon,

J Assoc Physicians India (The Journal of the Association of Physicians of India)
[2020, 68(1):49]

Cited: 0 times

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Letter to Editor. Giant intracranial aneurysms of the posterior circulation.

Satish Kumar Verma, Pankaj Kumar Singh,

J Neurosurg (Journal of neurosurgery)
[2019, :1-2]

Cited: 0 times

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The Superior Anticancer Effect of Reactive Oxygen Species-Responsive Paclitaxel Nanoparticles is Mediated Through Autophagic Cell Death.

Na Yu, Jun Li, Pankaj Kumar Singh, Dan Ding, Weihao Sun, Qiyun Tang, Huae Xu,

Paclitaxel (Ptx) is a first-line chemotherapeutic drug for advanced gastric cancer. However, the poor solubility of Ptx still limits its clinical application. Here, we designed a methoxy poly(ethylene glycol)/poly(epsilon-caprolactone) (DSPE-PEG<sub>2000</sub>-TK-Ptx) nanoparticle loaded with "ROS sensitive" groups-thioketal (TK) to improve Ptx release in high ROS areas in cells. We evaluated the ... Read more >>

J Biomed Nanotechnol (Journal of biomedical nanotechnology)
[2019, 15(11):2251-2261]

Cited: 1 time

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