Full Text Journal Articles by
Author Pankaj Gupta

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Hepatic artery pseudoaneurysm secondary to a cholangitic abscess and its spontaneous thrombosis.

Maninder Kaur, Harsimran Bhatia, Gaurav Muktesh, Pankaj Gupta,

Hepatic artery pseudoaneurysm (HAP) is mostly encountered secondary to trauma or iatrogenic causes. HAP associated with cholangitic liver abscess is a rare complication. We present a case of gallstone disease and choledocholithiasis who developed moderate cholangitis and a liver abscess. A small HAP was detected incidentally on a biphasic CT ... Read more >>

BMJ Case Rep (BMJ case reports)
[2021, 14(11):]

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Nonadherence in Hypertension: How to Develop and Implement Chemical Adherence Testing.

Dan Lane, Alexander Lawson, Angela Burns, Michel Azizi, Michel Burnier, Donald J L Jones, Benjamin Kably, Kamlesh Khunti, Reinhold Kreutz, Prashanth Patel, Alexandre Persu, Wilko Spiering, Stefan W Toennes, Maciej Tomaszewski, Bryan Williams, Pankaj Gupta, Indranil Dasgupta,

Nonadherence to antihypertensive medication is common, especially in those with apparent treatment-resistant hypertension (true treatment-resistant hypertension requires exclusion of nonadherence), and its routine detection is supported by clinical guidelines. Chemical adherence testing is a reliable and valid method to detect adherence, yet methods are unstandardized and are not ubiquitous. This ... Read more >>

Hypertension (Hypertension (Dallas, Tex. : 1979))
[2021, :HYPERTENSIONAHA12117596]

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Targeting Aberrant Expression of STAT3 and AP-1 Oncogenic Transcription Factors and HPV Oncoproteins in Cervical Cancer by Berberis aquifolium.

Tejveer Singh, Arun Chhokar, Kulbhushan Thakur, Nikita Aggarwal, Pragya Pragya, Joni Yadav, Tanya Tripathi, Mohit Jadli, Anjali Bhat, Pankaj Gupta, Anil Khurana, Alok Chandra Bharti,

Background: Present study examines phytochemical preparation that uses berberine's plant source B. aquifolium root for availability of similar anti-cervical cancer (CaCx) and anti-HPV activities to facilitate repurposing of the B. aquifolium based drug in the treatment of CaCx. Purpose: To evaluate therapeutic potential of different concentrations of ethanolic extract of ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2021, 12:757414]

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Ophthalmic presentations and long-term outcomes of subconjunctival and atypical orbital myocysticercosis.

Manpreet Singh, Manjula Sharma, Shweta Chaurasia, Aditi Mehta Grewal, Savleen Kaur, Manpreet Kaur, Deepti Yadav, Pankaj Gupta,

<h4>Purpose</h4>To study the clinical presentation, radiological features, diagnosis, and treatment response in subconjunctival and atypical orbital myocysticercosis.<h4>Methods</h4>Retrospective analysis of diagnosed subconjunctival and atypical (strabismus, diplopia, and blepharoptosis) orbital myocysticercosis was performed. A diagnostic criterion (2 of the 3) among clinical features, radiological findings, and treatment response was used in our ... Read more >>

Indian J Ophthalmol (Indian journal of ophthalmology)
[2021, 69(10):2782-2787]

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En bloc resection in giant bilobed splenic artery aneurysm.

Venu Bhargava Mulpuri, Jayanta Samanta, Pankaj Gupta, Vikas Gupta,

Giant splenic artery aneurysms are rare and associated with high morbidity and mortality. Early detection is the key to decreasing morbidity and mortality. We present a giant splenic artery aneurysm which was managed by en bloc resection of the spleen, distal pancreas. ... Read more >>

BMJ Case Rep (BMJ case reports)
[2021, 14(9):]

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Case-finding and genetic testing for familial hypercholesterolaemia in primary care.

Nadeem Qureshi, Ralph Kwame Akyea, Brittany Dutton, Steve E Humphries, Hasidah Abdul Hamid, Laura Condon, Stephen F Weng, Joe Kai, ,

<h4>Objective</h4>Familial hypercholesterolaemia (FH) is a common inherited disorder that remains mostly undetected in the general population. Through FH case-finding and direct access to genetic testing in primary care, this intervention study described the genetic and lipid profile of patients found at increased risk of FH and the outcomes in those ... Read more >>

Heart (Heart (British Cardiac Society))
[2021, :]

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Oesophageal Tuberculosis: A Systematic Review Focusing on Clinical Management.

Chhagan Lal Birda, Antriksh Kumar, Pankaj Gupta, Harjeet Singh, Vishal Sharma,

Oesophageal tuberculosis, an uncommon form of extrapulmonary tuberculosis, has been reported mainly as small case series and the literature is heterogeneous. A systematic review to characterize the clinical presentation, evaluation and management of oesophageal tuberculosis was performed. Electronic databases were searched with keywords: esophagus OR esophageal AND tuberculosis. We included ... Read more >>

Dysphagia (Dysphagia)
[2021, :]

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Using Computational Analysis of Behavior To Discover Developmental Change In Memory-Guided Attention Mechanisms In Childhood

Dima Amso, lakshmi govindarajan, Pankaj Gupta, Diego Placido, Heidi Baumgartner, Andrew Lynn, Kelley Gunther, Tarun Sharma, Vijay Veeraba, Kalpit Thakkar, Seung Chan Kim, Thomas Serre,

<p>We tested 4-9.5-year-old children on a naturalistic memory-guided attention visual search task. We measured fixation distribution during a search using wearable eye tracking, and simultaneously recorded depth video data for each participant and used computer vision algorithms to track them during navigation. We manipulated object placement and trial order such ... Read more >>

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Antinociceptive activity of standardized extract of Bacopa monnieri in different pain models of zebrafish.

Mahima Sharma, Pankaj Kumar Gupta, Pankaj Gupta, Debapriya Garabadu,

<h4>Ethnopharmacological relevance</h4>Bacopa monnieri L. (Scrophulariaceae) is commonly known as Brahmi and traditionally used as a neuroprotective herbal medicine. Recently, Bacopa monnieri exhibited significant therapeutic activity against animal model of neuropathic pain. However, the therapeutic potential of methanolic extract of Bacopa monnieri in experimental animal model is yet to establish.<h4>Aim of ... Read more >>

J Ethnopharmacol (Journal of ethnopharmacology)
[2022, 282:114546]

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Reply to: "Risk factors and screening intervals are crucial for evaluating the cost effectiveness of abbreviated MRI in HCC screening".

Pankaj Gupta, Vishal Sharma, Naveen Kalra,

J Hepatol (Journal of hepatology)
[2021, 75(5):1259-1260]

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Hypertension healthcare professional beliefs and behaviour regarding patient medication adherence: a survey conducted among European Society of Hypertension Centres of Excellence.

Michel Burnier, Aleksander Prejbisz, Thomas Weber, Michel Azizi, Vitoria Cunha, Jorie Versmissen, Pankaj Gupta, Jan Vaclavik, Andrzej Januszewicz, Alexandre Persu, Reinhold Kreutz, ,

<h4>Purpose</h4>Little is known on the beliefs, perceptions and practices of hypertension specialists in addressing non-adherence to therapy. Therefore, a survey was undertaken amongst healthcare professionals (HCPs) managing hypertension in the European Society of Hypertension (ESH) Centres of Excellence.<h4>Materials and methods</h4>Cross-sectional data were obtained between December 2020 and April 2021 using ... Read more >>

Blood Press (Blood pressure)
[2021, 30(5):282-290]

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Safe and appropriate use of diclofenac in chronic kidney disease: An Indian perspective.

Sharad Sheth, Sneha Thakur, Anup Thorat, Pankaj Gupta,

Pain is most common symptom associated with progressive disorder, chronic kidney disease (CKD), and is usually undertreated during the early stages of CKD. So, present review was conducted to evaluate the challenges for the management of pain in CKD patients and addresses the scope for considering Diclofenac as suitable alternative ... Read more >>

J Family Med Prim Care (Journal of family medicine and primary care)
[2021, 10(7):2450-2456]

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Impact of Different Patterns of Organ Failure on Mortality in Acute Necrotizing Pancreatitis.

Anupam K Singh, Jayanta Samanta, Jayendra Shukla, Chhagan Lal Birda, Jahnvi Dhar, Pankaj Gupta, Praveen Kumar-M, Vikas Gupta, Thakur Deen Yadav, Saroj K Sinha, Rakesh Kochhar,

<h4>Objectives</h4>Organ failure (OF) and infected necrosis (IN) are the most important predictors of mortality in necrotizing acute pancreatitis (AP). We studied the relationship between timing (onset and duration) and patterns of OF with mortality and the impact of IN on mortality.<h4>Methods</h4>Consecutive patients with necrotizing AP between January 2017 and February ... Read more >>

Pancreas (Pancreas)
[2021, 50(7):1030-1036]

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Long-term efficacy and safety of imiquimod 5% and fluorouracil 1% creams in medical monotherapy of complex eyelid basal cell carcinomas.

Manpreet Singh, Aditi Mehta Grewal, Himanshi Singh, Manjula Sharma, Manpreet Kaur, Pankaj Gupta, Zoramthara Zadeng,

<h4>Purpose</h4>To study the long-term efficacy and safety of local application of imiquimod 5% and fluorouracil 1% creams in complex eyelid basal cell carcinomas (BCCs).<h4>Methods</h4>A retrospective, non-comparative study in biopsy-proven, complex (involving canthi or >50% of eyelid length) eyelid BCC patients who were medically unfit for surgical procedures. All patients were ... Read more >>

Eur J Ophthalmol (European journal of ophthalmology)
[2021, :11206721211035614]

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Identification and functional characterisation of a rare MTTP variant underlying hereditary non-alcoholic fatty liver disease

Jane Grove, Peggy Cho Kiu Lo, Nick Shrine, Julian Barwell, Louise Wain, Martin Tobin, Andrew Salter, Neil Bennett, Catherine John, Ioanna Ntalla, Gabriela Jones, Christopher Neal, Mervyn Thomas, Helen Kuht, Pankaj Gupta, Vishwaraj Vemala, Allister Grant, Adeolu Adewoye, Kotacherry Shenoy, Leena Balakumaran, Edward Hollox, Nicholas R.F. Hannan, Guruprasad Aithal,

<h4>Background and aims</h4> Non-alcoholic fatty liver disease (NAFLD) is a complex trait that has a global prevalence estimated as 25%. We aimed to identify the genetic variant underlying a four-generation family with progressive NAFLD leading to cirrhosis, decompensation and development of hepatocellular carcinoma in the absence of common risk factors ... Read more >>

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Primary EUS-guided therapy of a giant visceral artery pseudoaneurysm: Expanding horizons (with video).

Jimil Shah, Jayanta Samanta, Gaurav Muktesh, Naveen Kumar, Pankaj Gupta, K Hemanth Kumar, Rakesh Kochhar,

Endosc Ultrasound (Endoscopic ultrasound)
[2021, 10(4):307-308]

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Adherence to prescribed medications in patients with heart failure: insights from liquid chromatography-tandem mass spectrometry-based urine analysis.

Joanne Simpson, Colette E Jackson, Caroline Haig, Pardeep S Jhund, Maciej Tomaszewski, Roy S Gardner, Yannis Tsorlalis, Mark C Petrie, John J V McMurray, Iain B Squire, Pankaj Gupta,

<h4>Aims</h4>None of the existing studies on adherence have directly measured levels of all medications (or their metabolites) in patients with heart failure (HF).<h4>Methods and results</h4>We used liquid chromatography-tandem mass spectrometry to measure the presence of prescribed drugs (diuretics, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, beta-blockers, and mineralocorticoid receptor antagonists) in the ... Read more >>

Eur Heart J Cardiovasc Pharmacother (European heart journal. Cardiovascular pharmacotherapy)
[2021, 7(4):296-301]

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'Rollover' abdominal paracentesis versus standard technique: protocol of a crossover randomized comparative trial.

Vishal Sharma, Daya Krishna Jha, Manish Rohilla, Chandan K Das, Harjeet Singh, Santhosh Irrinki, Aashima Arora, Subhas C Saha, Pankaj Gupta, Harshal S Mandavdhare, Usha Dutta, Aman Sharma,

The sensitivity of single abdominal paracentesis for diagnosis of peritoneal carcinomatosis in patients with malignant ascites is 40-70%. Tumor cells shed from the peritoneum settle preferentially in certain recesses of the peritoneum. We aim to compare the standard technique of abdominal paracentesis versus a rollover technique in a randomized crossover study ... Read more >>

Future Oncol (Future oncology (London, England))
[2021, 17(26):3425-3431]

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Hepatic tuberculosis: myriad of hues.

Arup Choudhury, Jayendra Shukla, Gaurav Mahajan, Day Krishna Jha, Pankaj Gupta, Vishal Sharma,

<h4>Introduction</h4>Gastrointestinal tuberculosis is an important form of extrapulmonary tuberculosis but liver involvement is uncommon. Hepatic tuberculosis can manifest in variable manners including as a space occupying lesion, diffuse infiltration by granulomas (granulomatous hepatitis) and as liver abscess. Hepatic tuberculosis is usually associated with lesions elsewhere but the diagnosis is often ... Read more >>

Germs (Germs)
[2021, 11(2):310-313]

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Image-guided percutaneous cholecystostomy: a comprehensive review.

Shayeri Roy Choudhury, Pankaj Gupta, Shikha Garg, Naveen Kalra, Mandeep Kang, Manavjit Singh Sandhu,

Acute cholecystitis (AC) is a common emergency condition with severity ranging from mild to severe. Gallstones and critical illnesses are the common predisposing factors. Mild AC is primarily managed with medical therapy and early cholecystectomy. Moderate and severe AC require individualized treatment with a preference for early cholecystectomy. However, cholecystectomy ... Read more >>

Ir J Med Sci (Irish journal of medical science)
[2021, :]

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Non-adherence to heart failure medications predicts clinical outcomes: assessment in a single spot urine sample by liquid chromatography-tandem mass spectrometry (results of a prospective multicentre study).

Pankaj Gupta, Adriaan A Voors, Prashanth Patel, Dan Lane, Stefan D Anker, John G F Cleland, Kenneth Dickstein, Gerasimos Filippatos, Chim C Lang, Dirk J van Veldhuisen, Marco Metra, Faiez Zannad, Nilesh J Samani, Don J L Jones, Iain B Squire, Leong L Ng,

<h4>Aims</h4>Liquid chromatography-mass spectrometry (LC-MS/MS) is an objective new technique to assess non-adherence to medications. We used this method to study the prevalence, predictors and outcomes of non-adherence in patients with heart failure with reduced left ventricular ejection fraction (HFrEF).<h4>Methods and results</h4>This study included 1296 patients with HFrEF from BIOSTAT-CHF, a ... Read more >>

Eur J Heart Fail (European journal of heart failure)
[2021, 23(7):1182-1190]

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Carbon Nanotube Microelectrode Set: Detection of Biomolecules to Heavy Metals.

Pankaj Gupta, Connor E Rahm, Benjamin Griesmer, Noe T Alvarez,

An ultrasensitive electrochemical microelectrode set (μ-ES), where all three electrodes are made of highly densified carbon nanotube fiber (HD-CNTf) cross sections (length ∼40 μm), embedded in an inert polymer matrix, and exposed open-ended CNTs at the interface, is presented here. Bare open ends of HD-CNTf rods were used as the ... Read more >>

Anal Chem (Analytical chemistry)
[2021, 93(20):7439-7448]

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The feasibility of the PAM intervention to support treatment-adherence in people with hypertension in primary care: a randomised clinical controlled trial.

Aikaterini Kassavou, Venus Mirzaei, Sonia Shpendi, James Brimicombe, Jagmohan Chauhan, Debi Bhattacharya, Felix Naughton, Wendy Hardeman, Helen Eborall, Miranda Van Emmenis, Anna De Simoni, Amrit Takhar, Pankaj Gupta, Prashanth Patel, Cecilia Mascolo, Andrew Toby Prevost, Stephen Morris, Simon Griffin, Richard J McManus, Jonathan Mant, Stephen Sutton,

The PAM intervention is a behavioural intervention to support adherence to anti-hypertensive medications and therefore to lower blood pressure. This feasibility trial recruited 101 nonadherent patients (54% male, mean age 65.8 years) with hypertension and high blood pressure from nine general practices in the UK. The trial had 15.5% uptake and ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):8897]

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Biochemical Urine Testing of Medication Adherence and Its Association With Clinical Markers in an Outpatient Population of Type 2 Diabetes Patients: Analysis in the DIAbetes and LifEstyle Cohort Twente (DIALECT).

Jelle M Beernink, Milou M Oosterwijk, Kamlesh Khunti, Pankaj Gupta, Prashanth Patel, Job F M van Boven, Hiddo J Lambers Heerspink, Stephan J L Bakker, Gerjan Navis, Roos M Nijboer, Gozewijn D Laverman,

<h4>Objective</h4>To assess adherence to the three main drug classes in real-world patients with type 2 diabetes using biochemical urine testing, and to determine the association of nonadherence with baseline demographics, treatment targets, and complications.<h4>Research design and methods</h4>Analyses were performed of baseline data on 457 patients in the DIAbetes and LifEstyle ... Read more >>

Diabetes Care (Diabetes care)
[2021, 44(6):1419-1425]

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Diverticular per oral endoscopic myotomy (DPOEM) for esophageal diverticular disease: a systematic review and meta-analysis.

Harshal S Mandavdhare, M Praveen Kumar, Dayakrishna Jha, Antriksh Kumar, Vishal Sharma, Pankaj Desai, Lada Shumkina, Pankaj Gupta, Harjeet Singh, Usha Dutta,

The traditional way to tackle Zenker's diverticulum (ZD) has been flexible endoscopic septum division (FESD). Recently, the concept of per oral endoscopic myotomy has been found useful for managing diverticular diseases of the esophagus and has been termed DPOEM. We performed a systematic review and meta-analysis to evaluate the efficacy ... Read more >>

Esophagus (Esophagus : official journal of the Japan Esophageal Society)
[2021, 18(3):436-450]

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