Full Text Journal Articles by
Author Pankaj Desai

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Positive white nipple sign on esophageal varices: Not a just bystander; our experience

Ritesh Prajhapati, Mohit Sethia, Pankaj Desai, Mayank Kabrawala, Rajiv Mehta, Subhash Nandwani, Chintan Patel, Nisharg Patel,

Background and study aims  The goal of this study was to assess whether a white nipple sign on esophageal varices is of no prognostic significance or mandates more attention. Patients and methods  We retrospectively analyzed data from 2601 patients undergoing upper gastrointestinal endoscopy for variceal bleed from January 2008 to January 2020. Intraprocedural ... Read more >>

(Endoscopy International Open)
[2021, 9(11):E1837-E1840]

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A First-In-Class, Humanized Antibody Targeting Alternatively Spliced Tissue Factor: Preclinical Evaluation in an Orthotopic Model of Pancreatic Ductal Adenocarcinoma.

Clayton S Lewis, Aniruddha Karve, Kateryna Matiash, Timothy Stone, Jingxing Li, Jordon K Wang, Henri H Versteeg, Bruce J Aronow, Syed A Ahmad, Pankaj B Desai, Vladimir Y Bogdanov,

In 2021, pancreatic ductal adenocarcinoma (PDAC) is the 3<sup>rd</sup> leading cause of cancer deaths in the United States. This is largely due to a lack of symptoms and limited treatment options, which extend survival by only a few weeks. There is thus an urgent need to develop new therapies effective ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:691685]

Cited: 1 time

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Crush cytology: an expeditious diagnostic tool for gastrointestinal tract malignancy.

Pankaj Desai, Mayank Kabrawala, Chintan Patel, Priya Arora, Rajiv Mehta, Subhash Nandwani, Parika Kalra, Ritesh Prajapati, Nisharg Patel, Krishna Parekh,

<b>Background and study aims</b>  Crush cytology is a simple and rapid method used for diagnosis of central nervous system lesions. We have evaluated the diagnostic accuracy of crush cytology for gastrointestinal tract lesions. <b>Patients and methods</b>  This was a prospective, cross-sectional, single center study, conducted on the patients who had ... Read more >>

Endosc Int Open (Endoscopy international open)
[2021, 9(5):E735-E740]

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Diverticular per oral endoscopic myotomy (DPOEM) for esophageal diverticular disease: a systematic review and meta-analysis.

Harshal S Mandavdhare, M Praveen Kumar, Dayakrishna Jha, Antriksh Kumar, Vishal Sharma, Pankaj Desai, Lada Shumkina, Pankaj Gupta, Harjeet Singh, Usha Dutta,

The traditional way to tackle Zenker's diverticulum (ZD) has been flexible endoscopic septum division (FESD). Recently, the concept of per oral endoscopic myotomy has been found useful for managing diverticular diseases of the esophagus and has been termed DPOEM. We performed a systematic review and meta-analysis to evaluate the efficacy ... Read more >>

Esophagus (Esophagus : official journal of the Japan Esophageal Society)
[2021, 18(3):436-450]

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Reuse of Molecules for Glioblastoma Therapy.

Abigail Koehler, Aniruddha Karve, Pankaj Desai, Jack Arbiser, David R Plas, Xiaoyang Qi, Renee D Read, Atsuo T Sasaki, Vaibhavkumar S Gawali, Donatien K Toukam, Debanjan Bhattacharya, Laura Kallay, Daniel A Pomeranz Krummel, Soma Sengupta,

Glioblastoma multiforme (GBM) is a highly malignant primary brain tumor. The current standard of care for GBM is the Stupp protocol which includes surgical resection, followed by radiotherapy concomitant with the DNA alkylator temozolomide; however, survival under this treatment regimen is an abysmal 12-18 months. New and emerging treatments include ... Read more >>

Pharmaceuticals (Basel) (Pharmaceuticals (Basel, Switzerland))
[2021, 14(2):]

Cited: 1 time

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Phosphoinositide 3-Kinase (PI3K) Reactive Oxygen Species (ROS)-Activated Prodrug in Combination with Anthracycline Impairs PI3K Signaling, Increases DNA Damage Response and Reduces Breast Cancer Cell Growth.

Rosalin Mishra, Long Yuan, Hima Patel, Aniruddha S Karve, Haizhou Zhu, Aaron White, Samar Alanazi, Pankaj Desai, Edward J Merino, Joan T Garrett,

RIDR-PI-103 is a novel reactive oxygen species (ROS)-induced drug release prodrug with a self-cyclizing moiety linked to a pan-PI3K inhibitor (PI-103). Under high ROS, PI-103 is released in a controlled manner to inhibit PI3K. The efficacy and bioavailability of RIDR-PI-103 in breast cancer remains unexplored. Cell viability of RIDR-PI-103 was ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(4):]

Cited: 2 times

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Use of cyanoacrylate glue in gastric variceal bleed: a modified technique without using lipiodol.

Pankaj N Desai, Chintan N Patel, Mayank V Kabrawala, Rajiv M Mehta, Subhash K Nandwani, Ritesh Prajapati, Nisharg Patel, Mohit Sethia,

VideoGIE (VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy)
[2021, 6(4):155-158]

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Impact of prior treatment on feasibility and outcomes of Zenker's peroral endoscopic myotomy (Z-POEM).

Omid Sanaei, Yervant Ichkhanian, Oscar V Hernández Mondragón, Jose Nieto, Arunkumar Krishnan, Marcel Tantau, Alina Tantau, Pankaj N Desai, Gregory G Ginsberg, Monica Saumoy, Ameya Deshmukh, Mikhail Attaar, Jad Farha, Manol Jovani, Sarah S Al-Ghamdi, Michael Ujiki, Mouen A Khashab,

<h4>Background</h4>Zenker's peroral endoscopic myotomy (Z-POEM) is a novel procedure for the management of symptomatic Zenker's diverticulum. This study aims to report the technical feasibility and outcomes of Z-POEM in the management of Zenker's diverticulum after prior failed interventions.<h4>Methods</h4>Patients with persistent or recurrent symptoms after prior endoscopic and/or surgical intervention for ... Read more >>

Endoscopy (Endoscopy)
[2021, 53(7):722-726]

Cited: 1 time

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Phase 1 dose-finding study of metformin in combination with concurrent cisplatin and radiotherapy in patients with locally advanced head and neck squamous cell cancer.

Shuchi Gulati, Janki Desai, Sarah M Palackdharry, John C Morris, Zheng Zhu, Roman Jandarov, Muhammad K Riaz, Vinita Takiar, Michelle Mierzwa, J Silvio Gutkind, Alfredo Molinolo, Pankaj B Desai, Nooshin Hashemi Sadraei, Trisha M Wise-Draper,

BACKGROUND:The 5-year overall survival (OS) rate remains at 50% for patients with locally advanced head and neck squamous cell carcinoma (LAHNSCC), thereby underscoring the need for improved treatments. An antidiabetic agent, metformin, was found in retrospective studies to improve survival in patients with HNSCC. Therefore, the authors conducted a phase ... Read more >>

Cancer (Cancer)
[2020, 126(2):354-362]

Cited: 4 times

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Multicenter Evaluation of Clinical Efficacy and Safety of Per-oral Endoscopic Myotomy in Children.

Adrien Choné, Pietro Familiari, Burkhard von Rahden, Pankaj Desai, Haruhiro Inoue, Yuto Shimamura, Nikos Eleftheriadis, Kanefumi Yamashita, Mouen A Khashab, Hinorari Shiwaku, Stefan Seewald, Peter V Draganov, Lybil B Mendoza Alvarez, Stanislas Chaussade, Marcel Tantau, Mathew Abraham, Jeffrey Marks, Gabriel Arevalo, Eduardo Albéniz, Francois Mion, Sabine Roman, Jérôme Rivory, Rémi Dubois, Alain Lachaux, Nicolas Benech, Fabien Subtil, Thierry Ponchon, Maximilien Barret, Mathieu Pioche,

OBJECTIVES:Per-oral endoscopic myotomy (POEM) is a recommended treatment modality for achalasia, but there is little published data for its use in children. The objective of the present study was to evaluate whether POEM is clinically effective and safe for children. METHODS:International multicenter retrospective study conducted in 14 tertiary centers that ... Read more >>

J Pediatr Gastroenterol Nutr (Journal of pediatric gastroenterology and nutrition)
[2019, 69(5):523-527]

Cited: 3 times

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CBMT-05. GENETIC AND EPIGENETIC MECHANISMS REGULATING SCD INHIBITOR SENSITIVITY IN GLIOBLASTOMA

Nicole Oatman, Nupur Dasgupta, Biplab Dasgupta, Kwangmin Choi, Mruniya Gawali, Nishtha Gupta, Sreeja Parameswaran, Sean Lawler, Cameron Brennan, Jianqiang Wu, Larry Sallans, Pankaj Desai, Matthew Weirauch, Kakajan Komurov, Biplab Dasgupta,

Abstract A status-quo in targeted cancer therapy is that out of the thousands of somatic alterations found in a cancer cell, alterations only in driver genes determine therapeutic strategy. Despite unimpressive results of some driver-targeted therapies, and given that the majority of genomic alterations in cancer are not ‘drivers’, but ... Read more >>

Neuro Oncol (Neuro-oncology)
[2019, 21(Suppl 6):vi33-vi33]

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An international study on the use of peroral endoscopic myotomy in the management of Zenker's diverticulum.

Juliana Yang, Stephanie Novak, Michael Ujiki, Óscar Hernández, Pankaj Desai, Petros Benias, David Lee, Kenneth Chang, Bertrand Brieau, Maximilien Barret, Nikhil Kumta, Xianhui Zeng, Bing Hu, Konstantinos Delis, Mouen A Khashab,

<h4>Background and aims</h4>The novel use of peroral endoscopic myotomy (POEM) in the treatment of Zenker's diverticulum (ZD) was recently described in case reports. The aim of this study is to report a multicenter experience with the POEM technique in the management of ZD.<h4>Methods</h4>This is a multicenter international retrospective study involving ... Read more >>

Gastrointest Endosc (Gastrointestinal endoscopy)
[2020, 91(1):163-168]

Cited: 9 times

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Notch depth index alone and in combination with pi in prediction of preeclampsia at or before 32 weeks of pregnancy.

Pankaj Desai,

Pregnancy Hypertens (Pregnancy hypertension)
[2019, 16:11-15]

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Preliminary experience with single fecal microbiota transplant for treatment of recurrent overt hepatic encephalopathy-A case series.

Rajiv Mehta, Mayank Kabrawala, Subhash Nandwani, Parika Kalra, Chintan Patel, Pankaj Desai, Krishna Parekh,

Experimental studies demonstrated that fecal microbiota transplant (FMT) may reverse intestinal microbial dysbiosis. In this retrospective case series, we share our experience of treating recurrent overt hepatic encephalopathy (HE) with single FMT treatment. A total of 10 patients, age ranged from 25 to 65 years, were treated with single FMT through ... Read more >>

Indian J Gastroenterol (Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology)
[2018, 37(6):559-562]

Cited: 5 times

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Plasma and brain pharmacokinetics of letrozole and drug interaction studies with temozolomide in NOD-scid gamma mice and sprague dawley rats.

Priyanka Arora, Courtney Huff Adams, Gary Gudelsky, Biplab DasGupta, Pankaj B Desai,

<h4>Purpose</h4>The aromatase inhibitor, letrozole, is being investigated in experimental animal models as a novel treatment for high-grade gliomas (HGGs). To facilitate optimal dosing for such studies, we evaluated the plasma and brain pharmacokinetics (PK) of letrozole in NOD-scid gamma (NSG) mice, which are frequently employed for assessing efficacy against patient-derived ... Read more >>

Cancer Chemother Pharmacol (Cancer chemotherapy and pharmacology)
[2019, 83(1):81-89]

Cited: 3 times

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Peroral endoscopic myotomy is effective and safe in non-achalasia esophageal motility disorders: an international multicenter study.

Mouen A Khashab, Pietro Familiari, Peter V Draganov, Hanaa Dakour Aridi, Joo Young Cho, Michael Ujiki, Ricardo Rio Tinto, Hubert Louis, Pankaj N Desai, Vic Velanovich, Eduardo Albéniz, Amyn Haji, Jeffrey Marks, Guido Costamagna, Jacques Devière, Yaseen Perbtani, Mason Hedberg, Fermin Estremera, Luis A Martin Del Campo, Dennis Yang, Majidah Bukhari, Olaya Brewer, Omid Sanaei, Lea Fayad, Amol Agarwal, Vivek Kumbhari, Yen-I Chen,

<h4>Background and study aims </h4>The efficacy of per oral endoscopic myotomy (POEM) in non-achalasia esophageal motility disorders such as esophagogastric junction outflow obstruction (EGJOO), diffuse esophageal spasm (DES), and jackhammer esophagus (JE) has not been well demonstrated. The aim of this international multicenter study was to assess clinical outcomes of POEM ... Read more >>

Endosc Int Open (Endoscopy international open)
[2018, 6(8):E1031-E1036]

Cited: 12 times

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Acylhydrazones as Antifungal Agents Targeting the Synthesis of Fungal Sphingolipids.

Cristina Lazzarini, Krupanandan Haranahalli, Robert Rieger, Hari Krishna Ananthula, Pankaj B Desai, Alan Ashbaugh, Michael J Linke, Melanie T Cushion, Bela Ruzsicska, John Haley, Iwao Ojima, Maurizio Del Poeta,

The incidence of invasive fungal infections has risen dramatically in recent decades. Current antifungal drugs are either toxic, likely to interact with other drugs, have a narrow spectrum of activity, or induce fungal resistance. Hence, there is a great need for new antifungals, possibly with novel mechanisms of action. Previously ... Read more >>

Antimicrob Agents Chemother (Antimicrobial agents and chemotherapy)
[2018, 62(5):]

Cited: 19 times

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Erratum for Mor et al., "Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids".

Visesato Mor, Antonella Rella, Amir M Farnoud, Ashutosh Singh, Mansa Munshi, Arielle Bryan, Shamoon Naseem, James B Konopka, Iwao Ojima, Erika Bullesbach, Alan Ashbaugh, Michael J Linke, Melanie Cushion, Margaret Collins, Hari Krishna Ananthula, Larry Sallans, Pankaj B Desai, Nathan P Wiederhold, Annette W Fothergill, William R Kirkpatrick, Thomas Patterson, Lai Hong Wong, Sunita Sinha, Guri Giaever, Corey Nislow, Patrick Flaherty, Xuewen Pan, Gabriele Vargas Cesar, Patricia de Melo Tavares, Susana Frases, Kildare Miranda, Marcio L Rodrigues, Chiara Luberto, Leonardo Nimrichter, Maurizio Del Poeta,

mBio (mBio)
[2018, 9(2):]

Cited: 5 times

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Retraction notice to "Long-term outcomes of per-oral endoscopic myotomy in patients with achalasia with a minimum follow-up of 2 years: an international multicenter study": [YMGE 85 (2017) 927-933].

Saowanee Ngamruengphong, Haruhiro Inoue, Philip Wai-Yan Chiu, Hon Chi Yip, Amol Bapaye, Michael Ujiki, Lava Patel, Pankaj N Desai, Bu Hayee, Amyn Haji, Vivien Wai-Yin Wong, Silvana Perretta, Shivangi Dorwat, Mathieu Pioche, Sabine Roman, Jérôme Rivory, François Mion, Thierry Ponchon, Aurélien Garros, Jun Nakamura, Yoshitaka Hata, Valerio Balassone, Manabu Onimaru, Gulara Hajiyeva, Amr Ismail, Yen-I Chen, Majidah Bukhari, Yamile Haito-Chavez, Vivek Kumbhari, Roberta Maselli, Alessandro Repici, Mouen A Khashab,

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted due to overlapping/duplicate material. Data from some patients from this study have previously been published in other journals without cross-referencing. Twenty patients overlap with a paper by Kumbhari et al.<sup>1</sup> Thirty-five patients overlap ... Read more >>

Gastrointest Endosc (Gastrointestinal endoscopy)
[2018, 87(4):1164]

Cited: 0 times

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VIDEO PLENARY 2: VID-HPB-04: Four cases of distal common bile duct polyps causing abdominal pain, jaundice, cholangitis, and acute pancreatitis

Pankaj Desai,

We have come across four cases presented to us with a history of abdominal pain, jaundice, cholangitis, and acute pancreatitis. On investigating, we found that all had distal common bile duct (CBD) polyps or polypoidal lesions causing these symptoms. All were subjected to endoscopic ultrasound and then endoscopic retrograde cholangiopancreatography. ... Read more >>

(Endoscopic Ultrasound)
[2017, 6(Suppl 1):S37-S38]

Cited: 0 times

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P-THER-24: Endoscopic ultrasound-guided biliary drainage in an operated case of right extended hepatectomy with secondaries causing hilarious obstruction

Pankaj Desai,

A 55-year-old male patient presented with complaints of increasing jaundice with itching and low-grade fever. He had undergone right extended hepatectomy 6 months back for right lobe hepatocellular carcinoma. Investigations revealed a total count of 9200/cumm, a bilirubin level of 18.6 mg/dl, and serum glutamic-pyruvic transaminase of 72 IU/L. Ultrasonography ... Read more >>

(Endoscopic Ultrasound)
[2017, 6(Suppl 1):S34-S34]

Cited: 0 times

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P-THER-17: Are plastic stents good enough for walled-off necrosis drainage? A retrospective analysis of 162 patients over the last 7 years

Pankaj Desai,

Objectives: To retrospectively analyze 162 cases of walled-off necrosis (WON) treated with only plastic stents in a tertiary referral center in India. Methods and Results: A total of 162 patients of WON underwent endoscopic ultrasound (EUS)-guided drainage with a 19-gauge needle puncture, tract formation with 6 Fr cystotome, dilatation with ... Read more >>

(Endoscopic Ultrasound)
[2017, 6(Suppl 1):S31-S32]

Cited: 0 times

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VID-THER-05: Endoscopic ultrasound-guided drainage of a pancreatic abscess from duodenum

Pankaj Desai,

A 56-year-old male patient presented with complaints of severe abdominal pain in the right paraumbilical region and epigastrium with fever and vomiting for 5 days. He had a history of acute pancreatitis related to alcohol before 6 weeks and had been admitted to the hospital elsewhere for 12 days. Investigations ... Read more >>

(Endoscopic Ultrasound)
[2017, 6(Suppl 1):S40-S40]

Cited: 0 times

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P-HPB-10: A prospective comparative study of efficacy of endoscopic ultrasound-guided fine needle aspiration versus endoscopic retrograde cholangiopancreatography-guided brush cytology in attainment of histopathology of distal common bile duct masses

Pankaj Desai, Mayank Kabrawala,

Objectives: To study the efficacy of endoscopic ultrasound (EUS)-guided fine needle aspiration (FNA) for attaining tissue from distal CBD masses and comparing it to endoscopic retrograde cholangiopancreatography (ERCP)-guided brush cytology from mass. Methods: Fifty-six cases with distal bile duct mass with obstructive jaundice in the last 3 years were taken ... Read more >>

(Endoscopic Ultrasound)
[2017, 6(Suppl 1):S20-S20]

Cited: 0 times

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P-LUM-15: Retrospective analysis of endoscopic ultrasound-guided fine needle data from a tertiary referral center in western india

Pankaj Desai, Mayank Kabrawala,

Objectives: To analyze our data of endoscopic ultrasound (EUS)-guided fine needle aspiration (FNA) done over the last 3 years. Methods: All cases referred for EUS-guided FNA were studied retrospectively. FNA was performed with a 22-gauge needle in the mediastinum and stomach. A 25-gauge was used for FNA from the duodenum. ... Read more >>

(Endoscopic Ultrasound)
[2017, 6(Suppl 1):S15-S16]

Cited: 0 times

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