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Cell-free DNA comparative analysis of genomic landscape of first-line hormone-receptor positive metastatic breast cancer from US and China

Xiao-Ran Liu, Davis Andrew, Feng Xie, Xinyu Gui, Yifei Chen, Qiang Zhang, Lorenzo Gerratana, Youbin Zhang, Ami Shah, Amir Behdad, Firas Wehbe, Yong Huang, Jianjun Yu, Pan Du, Shidong Jia, Huiping Li, Massimo Cristofanilli,

<h4>Purpose: </h4> Comparison of mutation landscape across ethnics using the identical detecting platform is important. We explored the differential genomic landscape of patients with hormone-receptor positive (HR+), HER2-negative MBC of first line recurrence or Stage IV at diagnosis from the United States (US) and China (CN). <h4>Methods: </h4> Twenty-seven US ... Read more >>

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Urinary Molecular Pathology for Patients with Newly Diagnosed Urothelial Bladder Cancer.

Ruiyun Zhang, Jingyu Zang, Feng Xie, Yue Zhang, Yiqiu Wang, Ying Jing, Yi Zhang, Zhaoxiong Chen, Akezhouli Shahatiaili, Mei-Chun Cai, Zhixin Zhao, Pan Du, Shidong Jia, Guanglei Zhuang, Haige Chen,

<h4>Purpose</h4>Next-generation sequencing (NGS)-based profiling of both urinary tumor DNA (utDNA) and circulating tumor DNA (ctDNA) shows promise for noninvasive detection and surveillance of urothelial bladder cancer (UBC). However, the analytic performance of these assays remains undefined in the real-world setting. Here, we sought to evaluate the concordance between tumor DNA ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001878]

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Correction: A Virus-infected, Reprogrammed Somatic Cell-derived Tumor Cell (VIReST) Vaccination Regime can Prevent Initiation and Progression of Pancreatic Cancer.

Shuangshuang Lu, Zhe Zhang, Pan Du, Louisa S Chard, Wenli Yan, Margueritte El Khouri, Zhizhong Wang, Zhongxian Zhang, Yongchao Chu, Dongling Gao, Qinxian Zhang, Lirong Zhang, Ai Nagano, Jun Wang, Claude Chelala, Jing Liu, Jiekai Chen, Pentao Liu, Yunshu Dong, Shengdian Wang, Xiaozhu Li, Jianzeng Dong, Nick R Lemoine, Duanqing Pei, Yaohe Wang,

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2021, 27(9):2663]

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Combined Cell-free DNA and RNA Profiling of the Androgen Receptor: Clinical Utility of a Novel Multianalyte Liquid Biopsy Assay for Metastatic Prostate Cancer.

Heidi Fettke, Edmond M Kwan, Maria M Docanto, Patricia Bukczynska, Nicole Ng, Lisa-Jane K Graham, Kate Mahon, Christine Hauser, Winston Tan, Xiao Hong Wang, Zhixin Zhao, Tiantian Zheng, Kemin Zhou, Pan Du, Jianjun Yu, Yong Huang, Shidong Jia, Manish Kohli, Lisa G Horvath, Arun A Azad,

<h4>Background</h4>The androgen receptor (AR) remains a critical driver in metastatic castration-resistant prostate cancer (mCRPC). Profiling AR aberrations in both circulating DNA and RNA may identify key predictive and/or prognostic biomarkers in the context of contemporary systemic therapy.<h4>Objective</h4>To profile AR aberrations in circulating nucleic acids and correlate with clinical outcomes.<h4>Design, setting, ... Read more >>

Eur Urol (European urology)
[2020, 78(2):173-180]

Cited: 2 times

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VGCN-BERT: Augmenting BERT with Graph Embedding for Text Classification

Zhibin Lu, Pan Du, Jian-Yun Nie,

Much progress has been made recently on text classification with methods based on neural networks. In particular, models using attention mechanism such as BERT have shown to have the capability of capturing the contextual information within a sentence or document. However, their ability of capturing the global information about the ... Read more >>

(Advances in Information Retrieval42nd European Conference on IR Research, ECIR 2020, Lisbon, Portugal, April 14–17, 2020, Proceedings, Part I)
[2020, 12035:369-382]

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Clinical and genomic insights into circulating tumor DNA-based alterations across the spectrum of metastatic hormone-sensitive and castrate-resistant prostate cancer.

Manish Kohli, Winston Tan, Tiantian Zheng, Amy Wang, Carlos Montesinos, Calven Wong, Pan Du, Shidong Jia, Siddhartha Yadav, Lisa G Horvath, Kate L Mahon, Edmond M Kwan, Heidi Fettke, Jianjun Yu, Arun A Azad,

<h4>Background</h4>Metastatic prostate cancer is a clonally heterogeneous disease state characterized by progressive somatic perturbations. The aim of this study was to identify cell free DNA- (cfDNA-) based alterations and their associations with outcomes in progressive metastatic prostate cancer.<h4>Methods</h4>In this longitudinal prospective cohort study plasma cfDNA/circulating tumor DNA (ctDNA) was analyzed ... Read more >>

EBioMedicine (EBioMedicine)
[2020, 54:102728]

Cited: 3 times

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A Virus-Infected, Reprogrammed Somatic Cell-Derived Tumor Cell (VIReST) Vaccination Regime Can Prevent Initiation and Progression of Pancreatic Cancer.

Shuangshuang Lu, Zhe Zhang, Pan Du, Louisa S Chard, Wenli Yan, Margueritte El Khouri, Zhizhong Wang, Zhongxian Zhang, Yongchao Chu, Dongling Gao, Qinxian Zhang, Lirong Zhang, Ai Nagano, Jun Wang, Claude Chelala, Jing Liu, Jiekai Chen, Pentao Liu, Yunshu Dong, Shengdian Wang, Xiaozhu Li, Jianzeng Dong, Nick R Lemoine, Duanqing Pei, Yaohe Wang,

<h4>Purpose</h4>Pancreatic cancer remains one of the most lethal cancers, and late detection renders most tumors refractory to conventional therapies. Development of cancer prophylaxis may be the most realistic option for improving mortality associated with this disease. Here, we develop a novel individualized prophylactic and therapeutic vaccination regimen using induced pluripotent ... Read more >>

Clin Cancer Res (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2020, 26(2):465-476]

Cited: 4 times

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Different tillage induces regulation in 2-acetyl-1-pyrroline biosynthesis in direct-seeded fragrant rice.

Pan Du, Haowen Luo, Jing He, Ting Mao, Bin Du, Lian Hu,

<h4>Background</h4>Land preparation is an important component of fragrant rice production. However, the effect of tillage on fragrant rice production is unclear, especially regarding the biosynthesis of 2-acetyl-1-pyrroline (2-AP), which is the main compound of the unique aroma of fragrant rice. This study aimed to explore 2-AP biosynthesis in fragrant rice ... Read more >>

BMC Plant Biol (BMC plant biology)
[2019, 19(1):308]

Cited: 3 times

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One-Step Integrated Surface Modification To Build a Stable Interface on High-Voltage Cathode for Lithium-Ion Batteries.

Rui Zhao, Li Li, Tinghua Xu, Dandan Wang, Du Pan, Guanjie He, Huiling Zhao, Ying Bai,

As one of the most promising cathode materials for next-generation energy storage applications, spinel LiNi<sub>0.5</sub>Mn<sub>1.5</sub>O<sub>4</sub> (LNMO) has been highlighted due to many advantages. However, it is still hindered by poor electrochemical stability derived from the bulk/interface structure degradation and side reactions under high working voltage. In this work, fast ion ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2019, 11(17):16233-16242]

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A novel approach for describing and classifying the unevenness of the bottom layer of paddy fields

Runmao Zhao, Pan Du, Jing He, Lian Hu, Xiwen Luo, Ting Mao, Lingmao Tang, Hao Zhou,

In recent years, increasing attention has been paid to the unevenness of farmlands since uneven land could reduce the working quality and service life of agricultural machinery. Due to the special constitution of paddy fields, the prevalent road profilers, such as laser range finders or 3D cameras, are unable to ... Read more >>

(Computers and electronics in agriculture.)
[2019, 162:552-560]

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Roll angle estimation using low cost MEMS sensors for paddy field machine

Lian Hu, Pan Du, Jing He, Xiwen Luo, Lingmao Tang, Weiwei Yang, Zhigang Zhang, Runmao Zhao, Hao Zhou,

The agricultural machinery implements in paddy field are required to measure the roll angle dynamically. In order to reduce the effects of external acceleration on roll estimation thus improving dynamic measurement precision with low cost, this paper proposed an algorithm, the external acceleration roll angle Kalman filter (EARAKF), which estimated ... Read more >>

(Computers and electronics in agriculture.)
[2019, 158:183-188]

Cited: 2 times

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Integrated Surface Functionalization of Li-Rich Cathode Materials for Li-Ion Batteries.

Dandan Wang, Tinghua Xu, Yaping Li, Du Pan, Xia Lu, Yong-Sheng Hu, Sheng Dai, Ying Bai,

As candidates for high-energy density cathodes, lithium-rich (Li-rich) layered materials have attracted wide interest for next-generation Li-ion batteries. In this work, surface functionalization of a typical Li-rich material Li<sub>1.2</sub>Mn<sub>0.56</sub>Ni<sub>0.17</sub>Co<sub>0.07</sub>O<sub>2</sub> is optimized by fluorine (F)-doped Li<sub>2</sub>SnO<sub>3</sub> coating layer and electrochemical performances are also enhanced accordingly. The results demonstrate that F-doped Li<sub>2</sub>SnO<sub>3</sub>-modified ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2018, 10(48):41802-41813]

Cited: 1 time

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Ablation of MCM10 using CRISPR/Cas9 restrains the growth and migration of esophageal squamous cell carcinoma cells through inhibition of Akt signaling.

Jie Yan, Pan Du, Yongxu Jia, Zhiwei Chang, Silin Gan, Xiaohan Xu, Yaohe Wang, Yanru Qin, Quancheng Kan,

<h4>Introduction</h4>Minichromosome maintenance 10 (MCM10) is deregulated in several malignancies including cervical cancer and urothelial carcinoma. However, the expression and biologic role of MCM10 in esophageal squamous cell carcinoma (ESCC) is still unknown.<h4>Methods</h4>In this study, we performed immunohistochemistry and real-time polymerase chain reaction (PCR) analysis to examine the expression of MCM10 ... Read more >>

Onco Targets Ther (OncoTargets and therapy)
[2018, 11:3323-3333]

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Exploring the methanol decomposition mechanism on the Pt3Ni(100) surface: a periodic density functional theory study.

Pan Du, Yuan Gao, Ping Wu, Chenxin Cai,

The detailed mechanism of the methanol decomposition reaction (MDR) on the Pt3Ni(100) surface is studied based on self-consistent periodic density functional theory calculations. The geometries and energies of methanol and its intermediates involved in MDR are analyzed, and the reaction network is constructed to illustrate the MDR mechanisms. The possible ... Read more >>

Phys Chem Chem Phys (Physical chemistry chemical physics : PCCP)
[2018, 20(15):10132-10141]

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Density Functional Theory Mechanistic Study of Boron-Catalyzed N-Alkylation of Amines with Formic Acid: Formic Acid Activation by Silylation Reaction.

Pan Du, Jiyang Zhao,

New methodology for the alkylation of amines is an intriguing issue in both academia and industry. Recently, several groups reported the metal-free B(C<sub>6</sub> F<sub>5</sub> )<sub>3</sub> -catalyzed N-alkylation of amines, but the mechanistic details of these important reactions are unclear. Herein, a computational study was performed to elucidate the mechanism of ... Read more >>

Chem Asian J (Chemistry, an Asian journal)
[2018, 13(6):701-709]

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Disrupted structure and aberrant function of CHIP mediates the loss of motor and cognitive function in preclinical models of cerebellar CHIPopathy

Chang-he Shi, Carrie Rubel, Sarah Soss, Rebekah Sanchez-Hodge, Shuo Zhang, Donte Stevens, Holly McDonough, Richard Page, Walter Chazin, Cam Patterson, Cheng-yuan Mao, Monte Willis, Hai-Yang Luo, Mi-bo Tang, Pan Du, Yao-he Wang, Zheng-wei Hu, Yu-ming Xu, Jonathan Schisler,

CHIP (carboxyl terminus of heat shock 70-interacting protein) has long been recognized as an active member of the cellular protein quality control system given the ability of CHIP to function as both a co-chaperone and ubiquitin ligase. Mutations in CHIP are the driver of spinocerebellar autosomal recessive 16 (SCAR16), or ... Read more >>

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Advanced Nanostructured Anode Materials for Sodium-Ion Batteries.

Qidi Wang, Chenglong Zhao, Yaxiang Lu, Yunming Li, Yuheng Zheng, Yuruo Qi, Xiaohui Rong, Liwei Jiang, Xinguo Qi, Yuanjun Shao, Du Pan, Baohua Li, Yong-Sheng Hu, Liquan Chen,

Sodium-ion batteries (NIBs), due to the advantages of low cost and relatively high safety, have attracted widespread attention all over the world, making them a promising candidate for large-scale energy storage systems. However, the inherent lower energy density to lithium-ion batteries is the issue that should be further investigated and ... Read more >>

Small (Small (Weinheim an der Bergstrasse, Germany))
[2017, 13(42):]

Cited: 9 times

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Modulation of Salmonella Tumor-Colonization and Intratumoral Anti-angiogenesis by Triptolide and Its Mechanism.

Jianxiang Chen, Yiting Qiao, Bo Tang, Guo Chen, Xiufeng Liu, Bingya Yang, Jing Wei, Xiangyu Zhang, Xiawei Cheng, Pan Du, Wenhui Jiang, Qingang Hu, Zi-Chun Hua,

The weakened tumour colonization of attenuated <i>Salmonella</i> has severely hampered its clinical development. In this study, we investigated whether an anti-inflammation and antiangiogenesis compound triptolide could improve the efficacy of VNP20009, a highly attenuated <i>Salmonella</i> strain, against mice melanoma. By comparing the effects of conventional VNP20009 monotherapy and a combination ... Read more >>

Theranostics (Theranostics)
[2017, 7(8):2250-2260]

Cited: 11 times

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Genomic Variations in Pancreatic Cancer and Potential Opportunities for Development of New Approaches for Diagnosis and Treatment.

Shuangshuang Lu, Tasqeen Ahmed, Pan Du, Yaohe Wang,

Human pancreatic cancer has a very poor prognosis with an overall five-year survival rate of less than 5% and an average median survival time of six months. This is largely due to metastatic disease, which is already present in the majority of patients when diagnosed. Although our understanding of the ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2017, 18(6):]

Cited: 4 times

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Absence of PTHrP nuclear localization and C-terminus sequences leads to abnormal development of T cells.

Kun-Zhi Jia, Shu-Lei Jin, Chun Yao, Rong Rong, Chong Wang, Pan Du, Wen-Hui Jiang, Xiao-Feng Huang, Qin-Gang Hu, Deng-Shun Miao, Zi-Chun Hua,

Parathyroid hormone-related protein (PTHrP), a ubiquitously expressed protein, is composed of four functional domains including N-terminus, mid region, nuclear localization signal (NLS) and C-terminus. Under the direction of NLS, PTHrP can enter cell nucleus from cytoplasm and stimulate mitogenesis. Although PTHrP is considered to have important developmental roles, the role ... Read more >>

Biochimie (Biochimie)
[2017, 138:13-19]

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Enhanced Structural and Electrochemical Stability of Self-Similar Rice-Shaped SnO2 Nanoparticles.

Du Pan, Ning Wan, Yong Ren, Weifeng Zhang, Xia Lu, Yuesheng Wang, Yong-Sheng Hu, Ying Bai,

A facile one-pot hydrothermal strategy is applied to prepare Co and F codoped SnO<sub>2</sub> (Co-F/SnO<sub>2</sub>) nanoparticles, which exhibit a unique rice-shaped self-similar structure. Compared with the pristine and Co-doped counterparts (SnO<sub>2</sub> and Co/SnO<sub>2</sub>), the Co-F/SnO<sub>2</sub> electrode demonstrates higher capacity, better cyclability, and rate capability as anode material for lithium ion ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2017, 9(11):9747-9755]

Cited: 7 times

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[Effects of tillage and nitrogen application rate on soil nitrogen transformation and yield in a winter wheat/summer maize multiple cropping system].

Shi Jie Ding, Shu Ping Xiong, Xin Ming Ma, Juan Juan Zhang, Xiao Chun Wang, Yi Xin Wu, Pan Du, Jie Zhang,

In the winter-wheat and summer-maize multiple cropping system in lime concretion black soil of Huanghuaihai Plain, the effects of three tilling methods (conventional tillage, rotary tillage, subsoiling tillage) in wheat season coupling with three nitrogen treatments (120 kg·hm-2, 225 kg·hm-2, 330 kg·hm-2) before maize sowing on the activities of microorganisms ... Read more >>

Ying Yong Sheng Tai Xue Bao (Ying yong sheng tai xue bao = The journal of applied ecology)
[2017, 28(1):142-150]

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Haploinsufficiency of Hand1 improves mice survival after acute myocardial infarction through preventing cardiac rupture.

Shuangshuang Lu, Pan Du, Congjia Shan, Yaohe Wang, Changsheng Ma, Jianzeng Dong,

Previous studies have demonstrated a significantly lower level of Hand1 in ischemic cardiomyopathy than in normal heart tissue. The role of decreased Hand1 in myocardial infarction remains unclear. This study was designed to investigate the effects of haploinsufficiency of Hand1 on mouse heart after myocardial infarction. 8-10 weeks old male ... Read more >>

Biochem Biophys Res Commun (Biochemical and biophysical research communications)
[2016, 478(4):1726-1731]

Cited: 2 times

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Electrolyzing synthesis of boron-doped graphene quantum dots for fluorescence determination of Fe3+ ions in water samples.

Li Chen, Chuanli Wu, Pan Du, Xiaowei Feng, Ping Wu, Chenxin Cai,

This work reports a facile electrolyzing method to synthesize boron-doped graphene quantum dots (BGQDs) and uses the BGQDs as a fluorescent probe to determine Fe<sup>3+</sup> ion levels in water samples. The BGQDs were produced by oxidizing graphite in an aqueous borax solution at pH 7; then, the borate solution was ... Read more >>

Talanta (Talanta)
[2017, 164:100-109]

Cited: 7 times

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SMPD1 variants in Chinese Han patients with sporadic Parkinson's disease.

Cheng-Yuan Mao, Jing Yang, Hui Wang, Shu-Yu Zhang, Zhi-Hua Yang, Hai-Yang Luo, Fang Li, Mengmeng Shi, Yu-Tao Liu, Zheng-Ping Zhuang, Pan Du, Yao-He Wang, Chang-He Shi, Yu-Ming Xu,

<h4>Introduction</h4>A founder mutation, p.L302P, in sphingomyelin phosphodiesterase 1, acid lysosomal (SMPD1), causing Niemann-Pick disease, a recessive lysosomal storage disorder, was reported to be associated with increased risk of Parkinson's disease (PD) in Ashkenazi Jewish population. Several other studies about the association between SMPD1 variants and PD were performed afterward in ... Read more >>

Parkinsonism Relat Disord (Parkinsonism & related disorders)
[2017, 34:59-61]

Cited: 11 times

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