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Addressing unmet basic needs for children with sickle cell disease in the United States: clinic and staff perspectives.

Stephanie Loo, Annelise Brochier, Mikayla Gordon Wexler, Kristin Long, Patricia L Kavanagh, Arvin Garg, Mari-Lynn Drainoni,

<h4>Background</h4>The purpose of this study was to assess pediatric hematology clinic staff's perspectives regarding barriers and facilitators in addressing unmet basic needs for children with sickle cell disease (SCD).<h4>Methodology</h4>Six focus groups were held at four urban pediatric hematology clinics in the Northeastern region of the United States from November to ... Read more >>

BMC Health Serv Res (BMC health services research)
[2021, 21(1):55]

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COVIDiSTRESS Global Survey dataset on psychological and behavioural consequences of the COVID-19 outbreak.

Yuki Yamada, Dominik-Borna Ćepulić, Tao Coll-Martín, Stéphane Debove, Guillaume Gautreau, Hyemin Han, Jesper Rasmussen, Thao P Tran, Giovanni A Travaglino, , Andreas Lieberoth,

This N = 173,426 social science dataset was collected through the collaborative COVIDiSTRESS Global Survey - an open science effort to improve understanding of the human experiences of the 2020 COVID-19 pandemic between 30th March and 30th May, 2020. The dataset allows a cross-cultural study of psychological and behavioural responses to the ... Read more >>

Sci Data (Scientific data)
[2021, 8(1):3]

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Simulation of low dose protocols for myocardial perfusion 82Rubidium imaging.

Martin Lyngby Lassen, Yuka Otaki, Paul Kavanagh, Robert Jack Henry Miller, Daniel S Berman, Piotr J Slomka,

<b>Purpose:</b> Quantification of myocardial perfusion and myocardial blood flow using Rubidium-82 (<sup>82</sup>Rb) positron emission tomography (PET) is increasingly utilized for assessment of coronary artery disease (CAD). Current guidelines suggest injections of 1100-1500MBq. Reducing the injected dose avoids PET system saturation in first-pass flow images and reduces radiation exposure, but the ... Read more >>

J Nucl Med (Journal of nuclear medicine : official publication, Society of Nuclear Medicine)
[2021, :]

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Trial design of comparing patient-specific versus weight-based protocols to treat vaso-occlusive episodes in sickle cell disease (COMPARE-VOE).

Stephanie O Ibemere, Sarah B Dubbs, Huiman X Barnhart, Jacqueline L Brown, Caroline E Freiermuth, Patricia Kavanagh, Judith A Paice, John J Strouse, R Gentry Wilkerson, Paula Tanabe, ,

<h4>Objectives</h4>Painful vaso-occlusive episodes (VOE) are the most common reason for emergency department (ED) visits experienced by patients with sickle cell disease (SCD). The National Heart, Lung and Blood Institute (NHLBI) evidence-based recommendations for VOE treatment are based primarily on expert opinion. In this randomized controlled trial (RCT), we will compare ... Read more >>

Contemp Clin Trials (Contemporary clinical trials)
[2020, 101:106252]

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Association between electronic cigarette use and tobacco cigarette smoking initiation in adolescents: A systematic review and meta-analysis

Doireann O'Brien, Jean Long, Joan Quigley, Caitriona Lee, Anne McCarthy, Paul Kavanagh,

Aim: This systematic review of prospective longitudinal primary studies aimed to explore whether electronic cigarette (e-cigarette) use by adolescents who had never smoked conventional tobacco cigarettes (tobacco cigarettes) at baseline was associated with subsequent initiation of tobacco cigarette smoking. <h4>Methods: </h4> This study followed the principles of a systematic review ... Read more >>

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E-Cigarette-Only and Dual Use among Adolescents in Ireland: Emerging Behaviours with Different Risk Profiles

Andrea K. Bowe, Frank Doyle, Debbi Stanistreet, Emer O’Connell, Michéal Durcan, Emmet Major, Diarmuid O’Donovan, Paul Kavanagh,

E-cigarette-only use and dual-use are emerging behaviours among adolescent nicotine product users which have not yet been sufficiently explored. This study examines the prevalence of, and the factors associated with, nicotine product use in adolescence. The study is a cross-sectional analysis of the 2018 Planet Youth survey completed by 15–16 ... Read more >>

Int J Environ Res Public Health (International journal of environmental research and public health)
[2021, 18(1):]

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Routine testing of close contacts of confirmed COVID-19 cases - National COVID-19 Contact Management Programme, Ireland, May to August 2020.

C Carroll, R Conway, D O'Donnell, C Norton, E Hogan, M Browne, C M Buckley, P Kavanagh, J Martin, S Doyle,

<h4>Objectives</h4>The objective of this study was to inform public health practitioners who are designing, adapting and implementing testing and tracing strategies for Coronavirus disease (COVID-19) control.<h4>Study design</h4>The study design is monitoring and evaluation of a national public health protection programme.<h4>Methods</h4>All close contacts of laboratory-confirmed cases of COVID-19 identified between the ... Read more >>

Public Health (Public health)
[2020, :]

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Routine testing of close contacts of confirmed COVID-19 cases – National COVID-19 Contact Management Programme, Ireland, May to August 2020

C. Carroll, R. Conway, D. O'Donnell, C. Norton, E. Hogan, M. Browne, C.M. Buckley, P. Kavanagh, J. Martin, S. Doyle,

<h4>Objectives</h4> The objective of this study was to inform public health practitioners who are designing, adapting and implementing testing and tracing strategies for Coronavirus disease (COVID-19) control. <h4>Study design</h4> The study design is monitoring and evaluation of a national public health protection programme. <h4>Methods</h4> All close contacts of laboratory-confirmed cases ... Read more >>

Public Health (Public health)
[2020, :]

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Addressing Unmet Basic Needs for Children with Sickle Cell Disease: Clinic and Staff Perspectives

Stephanie Loo, Annelise Brochier, Mikayla Gordon Wexler, Kristin Long, Patricia Kavanagh, Arvin Garg, Mari-Lynn Drainoni,

The purpose of this study was to assess pediatric hematology clinic staff’s perspectives regarding barriers and facilitators in addressing unmet basic needs for children with sickle cell disease (SCD). Six focus groups were held at four urban pediatric hematology clinics in New England from November to December 2019. Discussion questions ... Read more >>

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Analytical profile of N-ethyl-N-cyclopropyl lysergamide (ECPLA), an isomer of lysergic acid 2,4-dimethylazetidide (LSZ).

Simon D Brandt, Pierce V Kavanagh, Folker Westphal, Alexander Stratford, Simon P Elliott, Geraldine Dowling, Adam L Halberstadt,

Recent investigations have shown that N-ethyl-N-cyclopropyl lysergamide (ECPLA) produces LSD-like behavioral effects in mice, which suggests that it may act as a hallucinogen in humans. Although the use of ECPLA as a recreational drug has been limited, key analytical data that can be used to detect ECPLA are required for ... Read more >>

Drug Test Anal (Drug testing and analysis)
[2020, 12(10):1514-1521]

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The Effect of Exercise on Body Composition and Physical Performance in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy (ADT): A Narrative Synthesis.

Lucas Logan, Kellie Toohey, Phillip S Kavanagh, Catherine Paterson, Andrew J McKune,

<h4>Objective</h4>This review sought to synthesize evidence examining the effect of exercise on prostate cancer patients undergoing androgen deprivation therapy (ADT).<h4>Data sources</h4>A systematic literature search was conducted in electronic databases (CINAHL, MEDLINE, APA PsychINFO, Scopus, SPORTDiscus, and Cochrane Library) from their inception to March 31, 2020. Inclusion criteria were randomized controlled ... Read more >>

Semin Oncol Nurs (Seminars in oncology nursing)
[2020, 36(5):151067]

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Health system foundations for Sláintecare implementation in 2020 and beyond – co-producing a Sláintecare Living Implementation Framework with Evaluation: Learning from the Irish health system’s response to COVID-19. A mixed-methods study protocol

Sara Burke, Steve Thomas, Malgorzata Stach, Paul Kavanagh, Laura Magahy, Bridget Johnston, Sarah Barry,

<ns5:p>All over the world, health systems are responding to the major shock of the COVID-19 pandemic. The virus is causing urgent and fast-paced change in the delivery of health and social care as well as highlighting pre-existing deficiencies and inequalities in the health system and broader society. In Ireland, COVID-19 ... Read more >>

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Synthetic cannabinoid receptor agonists: Analytical profiles and development of QMPSB, QMMSB, QMPCB, 2F-QMPSB, QMiPSB, and SGT-233.

Simon D Brandt, Pierce V Kavanagh, Folker Westphal, Wolfgang Dreiseitel, Geraldine Dowling, Matthew J Bowden, James P B Williamson,

A diverse assortment of molecules designed to explore the cannabinoid receptor system and considered new psychoactive substances (NPS) have become known as synthetic cannabinoid receptor agonists (SCRAs). One group of SCRAs that has received little attention involves those exhibiting sulfamoyl benzoate, sulfamoyl benzamide, and N-benzoylpiperidine based structures. In this study, ... Read more >>

Drug Test Anal (Drug testing and analysis)
[2021, 13(1):175-196]

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The psychoactive aminoalkylbenzofuran derivatives, 5-APB and 6-APB, mimic the effects of 3,4-methylenedioxyamphetamine (MDA) on monoamine transmission in male rats.

Simon D Brandt, Hailey M Walters, John S Partilla, Bruce E Blough, Pierce V Kavanagh, Michael H Baumann,

<h4>Rationale</h4>The nonmedical use of new psychoactive substances (NPS) is a worldwide public health concern. The so-called "benzofury" compounds, 5-(2-aminopropyl)benzofuran (5-APB) and 6-(2-aminopropyl)benzofuran (6-APB), are NPS with stimulant-like properties in human users. These substances are known to interact with monoamine transporters and 5-HT receptors in transfected cells, but less is known ... Read more >>

Psychopharmacology (Berl) (Psychopharmacology)
[2020, 237(12):3703-3714]

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EDSC3: Working to Improve Emergency Department Care of Individuals With Sickle Cell Disease.

Patricia L Kavanagh, Jon Mark Hirshon,

Ann Emerg Med (Annals of emergency medicine)
[2020, 76(3S):S80-S82]

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Short-Term Air Pollution as a Risk for Stroke Admission: A Time-Series Analysis.

Colm Patrick Byrne, Kathleen E Bennett, Anne Hickey, Paul Kavanagh, Brian Broderick, Margaret O'Mahony, David J Williams,

BACKGROUND:The harmful effects of outdoor air pollution on stroke incidence are becoming increasingly recognised. We examined the impact of different air pollutants (PM2.5, PM10, NO2, ozone, and SO2) on admission for all strokes in two Irish urban centres from 2013 to 2017. METHODS:Using an ecological time series design with Poisson ... Read more >>

Cerebrovasc Dis (Cerebrovascular diseases (Basel, Switzerland))
[2020, 49(4):404-411]

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Electroactive biofilms on surface functionalized anodes: The anode respiring behavior of a novel electroactive bacterium, Desulfuromonas acetexigens.

Krishna P Katuri, Sirisha Kamireddy, Paul Kavanagh, Ali Muhammad, Peter Ó Conghaile, Amit Kumar, Pascal E Saikaly, Dónal Leech,

Surface chemistry is known to influence the formation, composition, and electroactivity of electron-conducting biofilms. However, understanding of the evolution of microbial composition during biofilm development and its impact on the electrochemical response is limited. Here we present voltammetric, microscopic and microbial community analysis of biofilms formed under fixed applied potential ... Read more >>

Water Res (Water research)
[2020, 185:116284]

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Improving Physical and Mental Health in Patients with Prostate Cancer Undergoing Androgen Deprivation Therapy: Strategies to Promote and Improve Physical Activity Quality and Quantity.

Kellie Toohey, Andrew McKune, Irmina Nahon, Phillip S Kavanagh, Robert U Newton, Catherine Paterson,

<h4>Objective</h4>Prostate cancer continues to be one of the highest-incident cancers among men. Reducing serum testosterone with androgen deprivation therapy (ADT) is a common effective treatment. While well-demonstrated for cancer suppression, there are numerous adverse effects caused by ADT that can contribute to short- and long-term prognosis. Increased levels of physical ... Read more >>

Semin Oncol Nurs (Seminars in oncology nursing)
[2020, 36(4):151051]

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An unusual detection of tert-butyl-4-anilinopiperidine-1-carboxylate in seizures of falsified 'Xanax' tablets and in items in a suspected heroin seizure submitted by Irish law enforcement.

Colette May, Carol Downey, John D Power, Pierce V Kavanagh,

The identification of tert-butyl-4-anilinopiperidine-1-carboxylate (4-anilinopiperdine-t-BOC or 4-AP-t-BOC) in many seized falsified 'Xanax' tablets has been reported after being encountered in forensic casework in late 2019 and early 2020 in Ireland. This substance was also detected in a pink powder submitted for analysis in March 2020. The pink powder was part ... Read more >>

Drug Test Anal (Drug testing and analysis)
[2020, 12(9):1387-1392]

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Tentative identification of the phase I and II metabolites of two synthetic cathinones, MDPHP and α-PBP, in human urine.

Pierce Kavanagh, Mariia Gofenberg, Vadim Shevyrin, Oksana Dvorskaya, Geraldine Dowling, Andrej Grigoryev,

Cathinone derivatives are one of the more prominent groups of new psychoactive substances in terms of the number of forensic case reports and the variety of chemical structures available. These substances often sold as "bath salts" are classified as psychostimulants. Using liquid chromatography-high resolution mass spectrometry, the metabolites of two ... Read more >>

Drug Test Anal (Drug testing and analysis)
[2020, 12(10):1442-1451]

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Teaching Versus Nonteaching Hospitals: Where Children With Sickle Cell Disease Receive Their Emergency Department Care.

David C Brousseau, Cagla S Muslu, Alexis Visotcky, Raphael Fraser, Patricia L Kavanagh, Thomas H Chelius, Abigail M Schuh,

J Pediatr Hematol Oncol (Journal of pediatric hematology/oncology)
[2020, 42(6):412-413]

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A National Measurement Framework to Assess and Improve Sickle Cell Care in 4 US Regions.

Elissa Z Faro, Lisa Shook, Marsha J Treadwell, Allison A King, Lauren N Whiteman, E Donnell Ivy, Mary Hulihan, Patricia L Kavanagh, Sabrina Selk, Suzette Oyeku, Scott D Berns,

OBJECTIVES:Coordinated measurement strategies are needed to inform collaborative approaches to improve access to and quality of care for persons with sickle cell disease (SCD). The objective of our study was to develop a multilevel measurement strategy to assess improvements in access to and quality of care for persons with SCD ... Read more >>

Public Health Rep (Public health reports (Washington, D.C. : 1974))
[2020, 135(4):442-451]

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Syntheses and analytical characterizations of novel (2-aminopropyl)benzo[b]thiophene (APBT) based stimulants.

Simon D Brandt, Laura Carlino, Pierce V Kavanagh, Folker Westphal, Wolfgang Dreiseitel, Geraldine Dowling, Michael H Baumann, Harald H Sitte, Adam L Halberstadt,

Two groups of amphetamine-like drugs with psychostimulant properties that were first developed during the course of scientific studies and later emerged as new psychoactive substances (NPS) are based on the (2-aminopropyl)indole (API) and (2-aminopropyl)benzofuran (APB) structural scaffolds. However, sulfur-based analogs with a benzo[b]thiophene structure (resulting in (2-aminopropyl)benzo[b]thiophene (APBT) derivatives) have ... Read more >>

Drug Test Anal (Drug testing and analysis)
[2020, 12(8):1109-1125]

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The Psilocin (4-hydroxy-N,N-dimethyltryptamine) and Bufotenine (5-hydroxy-N,N-dimethyltryptamine) Case: Ensuring the Correct Isomer has Been Identified.

Tehila Mishraki-Berkowitz, Esti Kochelski, Pierce Kavanagh, John O'Brien, Clodagh Dunne, Brian Talbot, Patricia Ennis, Udi Ehud Wolf,

Psilocin (4-hydroxy-N,N-dimethyltryptamine, 4-HO-DMT) and bufotenine (5-hydroxy-N,N-dimethyltryptamine, 5-HO-DMT), which are both naturally occurring compounds, are classified as controlled substances in numerous countries due to their pharmacological activities and recreational usage. There are two other benzene ring regioisomers, 6-hydroxy-N,N-dimethyltryptamine (6-HO-DMT) and 7-hydroxy-N,N-dimethyltryptamine (7-HO-DMT), which are not classified by name as controlled substances, ... Read more >>

J Forensic Sci (Journal of forensic sciences)
[2020, 65(5):1450-1457]

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Return of the lysergamides. Part VI: Analytical and behavioural characterization of 1-cyclopropanoyl-d-lysergic acid diethylamide (1CP-LSD).

Simon D Brandt, Pierce V Kavanagh, Folker Westphal, Alexander Stratford, Anna U Odland, Adam K Klein, Geraldine Dowling, Nicola M Dempster, Jason Wallach, Torsten Passie, Adam L Halberstadt,

Lysergic acid diethylamide (LSD) is a prototypical serotonergic psychedelic drug and the subject of many clinical investigations. In recent years, a range of lysergamides has emerged with the production of some being inspired by the existing scientific literature. Others, for example various 1-acyl substituted lysergamides, did not exist before their ... Read more >>

Drug Test Anal (Drug testing and analysis)
[2020, 12(6):812-826]

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