Full Text Journal Articles by
Author P Daly

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Leptomeningeal Relapse of Embryonal Rhabdomyosarcoma after 15 years.

S Chew, J P Gleeson, A McCarthy, G A Watson, R O'Dwyer, S Nicholson, M Capra, C Owens, M McDermott, P Daly, C Grant,

Aim Rhabdomyosarcoma (RMS) is the most common malignant soft tissue tumour of childhood. We present the case of a late relapse of RMS to the leptomeninges after 15 years. Methods A 20 year old male presented with a 3 week history of headaches and nausea. He previously had RMS of ... Read more >>

Ir Med J (Irish medical journal)
[2020, 112(10):1026]

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Complement as Prognostic Biomarker and Potential Therapeutic Target in Renal Cell Carcinoma.

Britney Reese, Ashok Silwal, Elizabeth Daugherity, Michael Daugherity, Mahshid Arabi, Pierce Daly, Yvonne Paterson, Layton Woolford, Alana Christie, Roy Elias, James Brugarolas, Tao Wang, Magdalena Karbowniczek, Maciej M Markiewski,

Preclinical studies demonstrated that complement promotes tumor growth. Therefore, we sought to determine the best target for complement-based therapy among common human malignancies. High expression of 11 complement genes was linked to unfavorable prognosis in renal cell carcinoma. Complement protein expression or deposition was observed mainly in stroma, leukocytes, and ... Read more >>

J Immunol (Journal of immunology (Baltimore, Md. : 1950))
[2020, 205(11):3218-3229]

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Serological survey following SARS-COV-2 outbreaks at long-term care facilities in metro Vancouver, British Columbia: Implications for outbreak management and infection control policies.

Rohit Vijh, Cher Ghafari, Althea Hayden, Michael Schwandt, Inna Sekirov, Muhammad Morshed, Paul Levett, Mel Krajden, Suni Boraston, Patricia Daly, Mark Lysyshyn, John Harding, Meghan McLennan, Navdeep Chahil, Annie Mak, Geoff McKee,

A cross-sectional serological survey was carried out in two long-term care facilities that experienced COVID-19 outbreaks in order to evaluate current clinical COVID-19 case definitions. Among individuals with a negative or no previous COVID-19 diagnostic test, myalgias, headache, and loss of appetite were associated with serological reactivity. The US CDC ... Read more >>

Am J Infect Control (American journal of infection control)
[2020, :]

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Seed priming and foliar application with jasmonic acid enhance salinity stress tolerance of soybean (Glycine max L.) seedlings.

Mohamed S Sheteiwy, Hongbo Shao, Weicong Qi, Paul Daly, Anket Sharma, Hiba Shaghaleh, Yousef Alhaj Hamoud, Mohamed A El-Esawi, Ronghui Pan, Qun Wan, Haiying Lu,

BACKGROUND:Jasmonic acid (JA) is an important molecule that has a regulatory effect on many physiological processes in plant growth and development under abiotic stress. This study investigated the effect of 60 μmol L-1 of JA in seed priming (P) at 15 °C in darkness for 24 h, foliar application (F), and/or their combination effect ... Read more >>

J Sci Food Agric (Journal of the science of food and agriculture)
[2020, :]

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A Gaussian Process Model of Human Electrocorticographic Data.

Lucy L W Owen, Tudor A Muntianu, Andrew C Heusser, Patrick M Daly, Katherine W Scangos, Jeremy R Manning,

We present a model-based method for inferring full-brain neural activity at millimeter-scale spatial resolutions and millisecond-scale temporal resolutions using standard human intracranial recordings. Our approach makes the simplifying assumptions that different people's brains exhibit similar correlational structure, and that activity and correlation patterns vary smoothly over space. One can then ... Read more >>

Cereb. Cortex (Cerebral cortex (New York, N.Y. : 1991))
[2020, 30(10):5333-5345]

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Environmental detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from medical equipment in long-term care facilities undergoing COVID-19 outbreaks.

Atiba Nelson, Jennifer Kassimatis, Jay Estoque, Cicely Yang, Geoff McKee, Elizabeth Bryce, Linda Hoang, Patricia Daly, Mark Lysyshyn, Althea S Hayden, John Harding, Suni Boraston, Meena Dawar, Michael Schwandt,

Environmental sampling was conducted at long-term care facilities to determine the extent of surface contamination with severe acute respiratory syndrome coronavirus 2 virus. Medical equipment used throughout the facility was determined to be contaminated. ... Read more >>

Am J Infect Control (American journal of infection control)
[2020, :]

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Patient-reported flare frequency is associated with diminished quality of life and family role functioning in systemic lupus erythematosus.

Patricia Katz, George J Wan, Paola Daly, Lauren Topf, Erin Connolly-Strong, Ryan Bostic, Michael L Reed,

PURPOSE:To understand the influence of the systemic lupus erythematosus (SLE)-related flares on patient's health-related quality of life (HRQoL). METHODS:An online survey included individuals with self-reported physician's diagnosis of SLE or lupus nephritis (LN). Lupus impact tracker (LIT) assessed lupus symptoms and HRQoL, SLE-Family questionnaire measured family role functioning, and Healthy ... Read more >>

Qual Life Res (Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation)
[2020, 29(12):3251-3261]

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A multicentre, randomised controlled trial to compare the clinical and cost-effectiveness of Lee Silverman Voice Treatment versus standard NHS Speech and Language Therapy versus control in Parkinson's disease: a study protocol for a randomised controlled trial.

C M Sackley, C Rick, P Au, M C Brady, G Beaton, C Burton, M Caulfield, S Dickson, F Dowling, M Hughes, N Ives, S Jowett, P Masterson-Algar, A Nicoll, S Patel, C H Smith, R Woolley, C E Clarke, ,

BACKGROUND:Parkinson's disease (PD) affects approximately 145,519 people in the UK. Speech impairments are common with a reported prevalence of 68%, which increase physical and mental demands during conversation, reliance on family and/or carers, and the likelihood of social withdrawal reducing quality of life. In the UK, two approaches to Speech ... Read more >>

Trials (Trials)
[2020, 21(1):436]

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Governmental Power and COVID-19: The Limits of Judicial Review

Paul Daly,

The goal of this Chapter is to explain why those hoping for a high level of judicial engagement with the forms of power being used to combat the cultural, economic, medical, social and other fallout from the current pandemic are likely to be disappointed. In Part I, I explain the ... Read more >>

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Routine HIV testing in acute care hospitals: Changing practice to curb a local HIV epidemic in Vancouver, BC.

Réka Gustafson, S Ellen Demlow, Afshan Nathoo, Geoffrey McKee, Lauren E MacDonald, Tianxin Chu, Jat Sandhu, Eric Grafstein, Mark Hull, Dean Chittock, Ronald Carere, Mel Krajden, Christopher H Sherlock, Scott Harrison, Christopher S Buchner, Julio S G Montaner, Patricia Daly,

Early treatment of HIV infection increases life expectancy and reduces infectivity; however, delayed HIV diagnosis remains common. Implementation and sustainability of hospital-based routine HIV testing in Vancouver, British Columbia, was evaluated to address a local HIV epidemic by facilitating earlier diagnosis and treatment. Public health issued a recommendation in 2011 ... Read more >>

Prev Med (Preventive medicine)
[2020, 137:106132]

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Succession of physiological stages hallmarks the transcriptomic response of the fungus Aspergillus niger to lignocellulose.

Jolanda M van Munster, Paul Daly, Martin J Blythe, Roger Ibbett, Matt Kokolski, Sanyasi Gaddipati, Erika Lindquist, Vasanth R Singan, Kerrie W Barry, Anna Lipzen, Chew Yee Ngan, Christopher J Petzold, Leanne Jade G Chan, Mikko Arvas, Roxane Raulo, Steven T Pullan, Stéphane Delmas, Igor V Grigoriev, Gregory A Tucker, Blake A Simmons, David B Archer,

Background:Understanding how fungi degrade lignocellulose is a cornerstone of improving renewables-based biotechnology, in particular for the production of hydrolytic enzymes. Considerable progress has been made in investigating fungal degradation during time-points where CAZyme expression peaks. However, a robust understanding of the fungal survival strategies over its life time on lignocellulose ... Read more >>

Biotechnol Biofuels (Biotechnology for biofuels)
[2020, 13:69]

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How does small group continuing medical education (CME) impact on practice for rural GPs and their patients, a mixed-methods study.

Stephanie Dowling, J Last, H Finnegan, John Bourke, Pat Daly, Conor Hanrahan, Pat Harrold, Geoff McCoombe, W Cullen,

Studies which report outcomes of continuing medical education (CME) interventions for rural general practitioners (GPs) are limited. This mixed methods study recruited GPs from four CME small group learning (SGL) tutor groups based in different rural locations in the Republic of Ireland. A two-hour teaching module on deprescribing in older ... Read more >>

Educ Prim Care (Education for primary care : an official publication of the Association of Course Organisers, National Association of GP Tutors, World Organisation of Family Doctors)
[2020, 31(3):153-161]

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Biomarkers of Depression Symptoms Defined by Direct Intracranial Neurophysiology

KW Scangos, AN Khambhati, PM Daly, LW Owen, JR Manning, JB Ambrose, Austin, HE Dawes, AD Krystal, EF Chang,

Abstract Quantitative biomarkers of depression are critical for development of rational therapeutics, but limitations of current low-resolution, indirect brain assays may impede their discovery. We applied graph theory and machine learning to a large unique dataset of intracranial electrophysiological recordings to generate a four-dimensional whole-brain model of neural activity. Using ... Read more >>

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Corrigendum to "Mixtures of aromatic compounds induce ligninolytic gene expression in the wood-rotting fungus Dichomitus squalens" [J. Biotechnol. 380 (2020) 35-39].

Paul Daly, Mao Peng, Sara Casado López, Anna Lipzen, Vivian Ng, Vasanth R Singan, Mei Wang, Igor V Grigoriev, Ronald P de Vries, Miia R Mäkelä,

J Biotechnol (Journal of biotechnology)
[2020, 309:142]

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Mixtures of aromatic compounds induce ligninolytic gene expression in the wood-rotting fungus Dichomitus squalens.

Paul Daly, Mao Peng, Sara Casado López, Anna Lipzen, Vivian Ng, Vasanth R Singan, Mei Wang, Igor V Grigoriev, Ronald P de Vries, Miia R Mäkelä,

Heterologous production of fungal ligninolytic cocktails is challenging due to the low yields of catalytically active lignin modifying peroxidases. Production using a natural system, such as a wood-rotting fungus, is a promising alternative if specific or preferential induction of the ligninolytic activities could be achieved. Using transcriptomics, gene expression of ... Read more >>

J. Biotechnol. (Journal of biotechnology)
[2020, 308:35-39]

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Prescription of High-Dose Opioids Among People Living with HIV in British Columbia, Canada.

Jessica Clark, Nadia Fairbairn, Seonaid Nolan, Tian Li, Anthony Wu, Rolando Barrios, Julio Montaner, Lianping Ti, ,

People living with HIV (PLHIV) often experience pain for which opioid medications may be prescribed. Thus, these individuals are particularly vulnerable to opioid-related harms, including overdose, misuse, and addiction, particularly when prescribed at high doses. We used a comprehensive linked population-level database of PLHIV in British Columbia (BC) to identify ... Read more >>

AIDS Behav (AIDS and behavior)
[2019, 23(12):3331-3339]

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Impact of participation in continuing medical education small group learning (CME-SGL) on the stress, morale, and professional isolation of rurally-based GPs: a qualitative study in Ireland.

Stephanie Dowling, Jason Last, Henry Finnegan, Pat Daly, John Bourke, Conor Hanrahan, Pat Harrold, Geoff McCombe, Walter Cullen,

BACKGROUND:The pressures of general practice contribute to high levels of stress, low morale, and burnout in some GPs. In addition, rurally-based doctors may experience significant professional isolation. Participation in continuing medical education (CME) appears to reduce stress, and may improve the retention of rural GPs. AIM:As part of a larger ... Read more >>

BJGP Open (BJGP open)
[2019, :]

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Succession of physiological stages hallmarks the transcriptomic response of fungus Aspergillus niger to lignocellulose

Jolanda van Munster, Paul Daly, Martin Blythe, Roger Ibbett, Matt Kokolski, Sanyasi Gaddipati, Erika Lindquist, Vasanth Singan, Kerrie Barry, Anna Lipzen, Chew Yee Ngan, Christopher Petzold, Leanne Jade Chan, Mikko Arvas, Roxane Raulo, Steven Pullan, Stéphane Delmas, Igor Grigoriev, Gregory Tucker, Blake Simmons, David Archer,

Abstract Background Understanding how fungi degrade lignocellulose is a cornerstone of improving renewables-based biotechnology, in particular for the production of hydrolytic enzymes. Considerable progress has been made in investigating fungal degradation during time-points where CAZyme expression peaks. However, a robust understanding of the fungal survival strategies over its life time ... Read more >>

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Update: Influenza Activity - United States and Worldwide, May 19-September 28, 2019, and Composition of the 2020 Southern Hemisphere Influenza Vaccine.

Scott Epperson, C Todd Davis, Lynnette Brammer, Anwar Isa Abd Elal, Noreen Ajayi, John Barnes, Alicia P Budd, Erin Burns, Peter Daly, Vivien G Dugan, Alicia M Fry, Yunho Jang, Sara Jo Johnson, Krista Kniss, Rebecca Kondor, Lisa A Grohskopf, Larisa Gubareva, Angiezel Merced-Morales, Wendy Sessions, James Stevens, David E Wentworth, Xiyan Xu, Daniel Jernigan,

During May 19-September 28, 2019,* low levels of influenza activity were reported in the United States, with cocirculation of influenza A and influenza B viruses. In the Southern Hemisphere seasonal influenza viruses circulated widely, with influenza A(H3) predominating in many regions; however, influenza A(H1N1)pdm09 and influenza B viruses were predominant ... Read more >>

MMWR Morb Mortal Wkly Rep (MMWR. Morbidity and mortality weekly report)
[2019, 68(40):880-884]

Cited: 3 times

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Geographic variation in the costs of medical care for people living with HIV in British Columbia, Canada.

Benjamin Enns, Jeong Eun Min, Dimitra Panagiotoglou, Julio S G Montaner, Bohdan Nosyk, ,

BACKGROUND:Regional variation in medical care costs can indicate heterogeneity in clinical practice, inequities in access, or inefficiencies in service delivery. We aimed to estimate regional variation in medical costs for people living with HIV (PLHIV), adjusting for demographics and case-mix. METHODS:We conducted a retrospective cohort study using linked health administrative ... Read more >>

BMC Health Serv Res (BMC health services research)
[2019, 19(1):626]

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Reconciling randomized trial evidence on proximal versus distal outcomes, with application to trials of influenza vaccination for healthcare workers.

Reka Gustafson, Paul Gustafson, Patricia Daly,

When synthesizing the body of evidence concerning a clinical intervention, impacts on both proximal and distal outcome variables may be relevant. Assessments will be more defensible if results concerning a proximal outcome align with those concerning a corresponding distal outcome. We present a method to assess the coherence of empirical ... Read more >>

Stat Med (Statistics in medicine)
[2019, 38(22):4323-4333]

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Grounding medical ethics in philosophy of medicine: problematic and potential.

Patrick Daly,

After considering two of Pellegrino's papers that address the relation between philosophy of medicine and medical ethics, I identify several overarching problems in his account that revolve around his self-described essentialism and the lack of a systematic attempt to relate clinical medicine to biomedicine and public health. I address these ... Read more >>

Theor Med Bioeth (Theoretical medicine and bioethics)
[2019, 40(3):169-182]

Cited: 1 time

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Draft Genome Sequences of Three Monokaryotic Isolates of the White-Rot Basidiomycete Fungus Dichomitus squalens.

Sara Casado López, Mao Peng, Paul Daly, Bill Andreopoulos, Jasmyn Pangilinan, Anna Lipzen, Robert Riley, Steven Ahrendt, Vivian Ng, Kerrie Barry, Chris Daum, Igor V Grigoriev, Kristiina S Hildén, Miia R Mäkelä, Ronald P de Vries,

Here, we report the draft genome sequences of three isolates of the wood-decaying white-rot basidiomycete fungus Dichomitus squalens The genomes of these monokaryons were sequenced to provide more information on the intraspecies genomic diversity of this fungus and were compared to the previously sequenced genome of D. squalens LYAD-421 SS1. ... Read more >>

Microbiol Resour Announc (Microbiology resource announcements)
[2019, 8(18):]

Cited: 3 times

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Archaeological evidence that a late 14th-century tsunami devastated the coast of northern Sumatra and redirected history.

Patrick Daly, Kerry Sieh, Tai Yew Seng, Edmund Edwards McKinnon, Andrew C. Parnell, R. Michael Feener, Nazli Ismail, Jedrzej Majewski,

Archaeological evidence shows that a predecessor of the 2004 Indian Ocean tsunami devastated nine distinct communities along a 40-km section of the northern coast of Sumatra in about 1394 CE. Our evidence is the spatial and temporal distribution of tens of thousands of medieval ceramic sherds and over 5,000 carved ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2019, 116(24):11679-11686]

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Impact of personality disorders on leaving hospital against medical advice among people living with HIV in British Columbia, Canada.

Tara Beaulieu, Ashok Krishnamoorthy, Viviane Lima, Tian Li, Anthony Wu, Julio Montaner, Rolando Barrios, Lianping Ti, ,

PURPOSE:Leaving hospital against medical advice (AMA) is a significant source of morbidity, mortality, and a major burden to the healthcare system. Studies have indicated that marginalized populations, including people living with HIV (PLHIV) and those living with a personality disorder (PD), experience high hospitalization rates. We sought to identify whether ... Read more >>

Soc Psychiatry Psychiatr Epidemiol (Social psychiatry and psychiatric epidemiology)
[2019, 54(9):1153-1159]

Cited: 1 time

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