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Author P Boers

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Moyamoya disease and moyamoya syndrome in Ireland: patient demographics, mode of presentation and outcomes of EC-IC bypass surgery.

Ronan J Doherty, John Caird, Darach Crimmins, Peter Kelly, Sean Murphy, Christopher McGuigan, Niall Tubridy, Mary D King, Bryan Lynch, David Webb, Desmond O'Neill, Dominick J H McCabe, Peter Boers, Mary O'Regan, Joan Moroney, David J Williams, Simon Cronin, Mohsen Javadpour,

<h4>Background</h4>There are no previously published reports regarding the epidemiology and characteristics of moyamoya disease or syndrome in Ireland.<h4>Aims</h4>To examine patient demographics, mode of presentation and the outcomes of extracranial-intracranial bypass surgery in the treatment of moyamoya disease and syndrome in Ireland.<h4>Methods</h4>All patients with moyamoya disease and syndrome referred to the ... Read more >>

Ir J Med Sci (Irish journal of medical science)
[2020, :]

Cited: 0 times

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Reply to Darcis and Berkhout.

Ingeborg E A Wijting, Cynthia Lungu, Bart J A Rijnders, Marchina E van der Ende, Hanh T Pham, Thibault Mesplede, Suzan D Pas, Jolanda J C Voermans, Rob Schuurman, David A M C van de Vijver, Patrick H M Boers, Rob A Gruters, Charles A B Boucher, Jeroen J A van Kampen,

J Infect Dis (The Journal of infectious diseases)
[2018, 218(12):2020-2021]

Cited: 0 times

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HIV-1 Resistance Dynamics in Patients With Virologic Failure to Dolutegravir Maintenance Monotherapy.

Ingeborg E A Wijting, Cynthia Lungu, Bart J A Rijnders, Marchina E van der Ende, Hanh T Pham, Thibault Mesplede, Suzan D Pas, Jolanda J C Voermans, Rob Schuurman, David A M C van de Vijver, Patrick H M Boers, Rob A Gruters, Charles A B Boucher, Jeroen J A van Kampen,

<h4>Background</h4>A high genetic barrier to resistance to the integrase strand transfer inhibitor (INSTI) dolutegravir has been reported in vitro and in vivo. We describe the dynamics of INSTI resistance-associated mutations (INSTI-RAMs) and mutations in the 3'-polypurine tract (3'-PPT) in relation to virologic failure (VF) observed in the randomized Dolutegravir as ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2018, 218(5):688-697]

Cited: 19 times

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A15 HIV-1 whole-genome NGS analysis to characterize virus evolution following dendritic cell immunotherapy and analytical treatment interruption

C Lungu, P H M Boers, C M E Schapendonk, S L Smits, D A M C van de Vijver, R A Gruters,

Virus Evol (Virus evolution)
[2018, 4(Suppl 1):]

Cited: 0 times

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Ciprofloxacin-associated choreoathetosis in a haemodialysis patient.

Ahad Abdalla, Shazrul Ramly, Peter Boers, Liam Casserly,

This report describes a case of drug-associated choreoathetosis in a patient receiving ciprofloxacin. A 72-year-old haemodialysis patient presented with a 4-day history of progressive weakness, restlessness and involuntary movements of all limbs. He had been prescribed ciprofloxacin 500 mg twice daily for a lower respiratory tract infection 7 days previously. ... Read more >>

BMJ Case Rep (BMJ case reports)
[2013, 2013:]

Cited: 1 time

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Parkinsonism can be cured.

Ronstan Lobo, Alexander Fraser, Patrick Kiely, Peter Boers,

This case describes a woman with a history of rheumatoid arthritis with secondary vasculitic skin ulcers, Sicca syndrome and idiopathic Parkinson's disease that was diagnosed by a neurologist in 2005. The patient's parkinsonian symptoms were difficult to control, despite the use of antiparkinsonian medications. During a regular clinical review in ... Read more >>

BMJ Case Rep (BMJ case reports)
[2013, 2013:]

Cited: 0 times

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The timing, extent, progression and regression of deep vein thrombosis in immobile stroke patients: observational data from the CLOTS multicenter randomized trials.

M Dennis, N Mordi, C Graham, P Sandercock, ,

Deep vein thrombosis (DVT) is an important complication of stroke, but the evidence to support commonly used prophylactic strategies is conflicting.To describe the incidence, extent, associated clinical features and evolution of DVT after stroke.The CLOTS trials 1 and 2 together randomized 5632 immobile stroke patients in 135 hospitals in nine ... Read more >>

J Thromb Haemost (Journal of thrombosis and haemostasis : JTH)
[2011, 9(11):2193-2200]

Cited: 15 times

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Erratum: Profound and persistent painful paclitaxel peripheral neuropathy in a premenopausal patient.

K I Quintyne, P Mainstone, B McNamara, P Boers, F Wallis, R K Gupta,

[This corrects the article DOI: 10.1136/bcr.12.2010.3645.]. ... Read more >>

BMJ Case Rep (BMJ case reports)
[2011, 2011:bcr1220103645corr1]

Cited: 0 times

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Profound and persistent painful paclitaxel peripheral neuropathy in a premenopausal patient.

K I Quintyne, P Mainstone, B McNamara, P Boers, F Wallis, R K Gupta,

The authors herein report the case of a 35-year-old woman undergoing adjuvant therapy for node positive breast cancer, who presented with short and rapidly progressive history of bilateral lower limb symptoms of peripheral neuropathy following therapy with paclitaxel. MRI of her neural axis revealed no leptomeningeal enhancement or focal metastatic ... Read more >>

BMJ Case Rep (BMJ case reports)
[2011, 2011:]

Cited: 0 times

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Characterization of recombinant influenza A virus as a vector for HIV-1 p17Gag.

Anna L de Goede, Patrick H M Boers, Lennard J M Dekker, Albert D M E Osterhaus, Rob A Gruters, Guus F Rimmelzwaan,

We have generated a recombinant influenza A virus with the HIV-1 p17(Gag) (rFlu-p17) gene inserted into the influenza virus neuraminidase (NA) gene. Expression of HIV-1 p17 protein was detected by conventional Western blot analysis and also by liquid chromatography/tandem mass spectrometry (LC-MS/MS) analysis of rFlu-p17 infected cells. The latter method ... Read more >>

Vaccine (Vaccine)
[2009, 27(42):5735-5739]

Cited: 6 times

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Effectiveness of thigh-length graduated compression stockings to reduce the risk of deep vein thrombosis after stroke (CLOTS trial 1): a multicentre, randomised controlled trial.

, M Dennis, P A G Sandercock, J Reid, C Graham, G Murray, G Venables, A Rudd, G Bowler,

<h4>Background</h4>Deep vein thrombosis (DVT) and pulmonary embolism are common after stroke. In small trials of patients undergoing surgery, graduated compression stockings (GCS) reduce the risk of DVT. National stroke guidelines extrapolating from these trials recommend their use in patients with stroke despite insufficient evidence. We assessed the effectiveness of thigh-length ... Read more >>

Lancet (Lancet (London, England))
[2009, 373(9679):1958-1965]

Cited: 154 times

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Triptan-Induced Sensitization of Trigeminovascular Sensation.

Geoffrey A Lambert, Peter Boers, Alessandro S Zagami,

Headache (Headache)
[2017, 57(10):E17-E18]

Cited: 0 times

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CCR5-restricted HIV type 2 variants from long-term aviremic individuals are less sensitive to inhibition by beta-chemokines than low pathogenic HIV type 1 variants.

Hetty Blaak, Patrick H M Boers, Marchina E van der Ende, Hanneke Schuitemaker, Albert D M E Osterhaus,

Many HIV-2-infected individuals maintain low, often undetectable, viral loads for prolonged periods. Virus and/or host factors that contribute to this high level of virus control are largely unknown. Previously we demonstrated that HIV-2 variants from long-term aviremic individuals have relatively low replication kinetics in vitro in comparison to HIV-1 variants. ... Read more >>

AIDS Res Hum Retroviruses (AIDS research and human retroviruses)
[2008, 24(3):473-484]

Cited: 3 times

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Hashimoto's encephalopathy responding to plasmapheresis.

P M Boers, J G Colebatch,

J Neurol Neurosurg Psychiatry (Journal of neurology, neurosurgery, and psychiatry)
[2001, 70(1):132]

Cited: 43 times

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In vitro replication capacity of HIV-2 variants from long-term aviremic individuals.

Hetty Blaak, Marchina E van der Ende, Patrick H M Boers, Hanneke Schuitemaker, Albert D M E Osterhaus,

To establish whether efficient suppression of virus replication in HIV-2-infected individuals is associated with low replicative capacity of HIV-2, replication kinetics of HIV-2 variants from long-term aviremic individuals was analyzed and compared with that of the relatively slow-replicating HIV-1 variants from asymptomatics and long-term nonprogressors (AS/LTNP). On average, HIV-2 from ... Read more >>

Virology (Virology)
[2006, 353(1):144-154]

Cited: 25 times

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Water management strategies against toxic Microcystis blooms in the Dutch delta.

Jolanda M H Verspagen, Jutta Passarge, Klaus D Jöhnk, Petra M Visser, Louis Peperzak, Paul Boers, Hendrikus J Laanbroek, Jef Huisman,

To prevent flooding of the Dutch delta, former estuaries have been impounded by the building of dams and sluices. Some of these water bodies, however, experience major ecological problems. One of the problem areas is the former Volkerak estuary that was turned into a freshwater lake in 1987. From the ... Read more >>

Ecol Appl (Ecological applications : a publication of the Ecological Society of America)
[2006, 16(1):313-327]

Cited: 31 times

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CCR5, GPR15, and CXCR6 are major coreceptors of human immunodeficiency virus type 2 variants isolated from individuals with and without plasma viremia.

H Blaak, P H M Boers, R A Gruters, H Schuitemaker, M E van der Ende, A D M E Osterhaus,

Human immunodeficiency virus type 2 (HIV-2) is generally considered capable of using a broad range of coreceptors. Since HIV-2 variants from individuals with nonprogressive infection were not studied previously, the possibility that broad coreceptor usage is a property of variants associated with progressive infection could not be excluded. To test ... Read more >>

J Virol (Journal of virology)
[2005, 79(3):1686-1700]

Cited: 42 times

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HIV-2-infected individuals with undetectable plasma viremia carry replication-competent virus in peripheral blood lymphocytes.

Hetty Blaak, Patrick H M Boers, Martin Schutten, Marchina E van der Endeñ, Albert D M E Osterhaus,

Using an optimized HIV co-culture protocol it was possible to isolate infectious HIV-2 variants from 6 HIV-2-infected individuals who had undetectable plasma viremia and maintained high CD4 T-cell numbers for prolonged periods. This shows for the first time that HIV-2-infected individuals with no demonstrable in vivo virus production carry replication-competent ... Read more >>

J Acquir Immune Defic Syndr (Journal of acquired immune deficiency syndromes (1999))
[2004, 36(3):777-782]

Cited: 10 times

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Naratriptan has a selective inhibitory effect on trigeminovascular neurones at central 5-HT1A and 5-HT(1B/1D) receptors in the cat: implications for migraine therapy.

P M Boers, C Donaldson, A S Zagami, G A Lambert,

The triptans are agonists at serotonin (5-HT)1B/1D receptors; however, they are also active at 5-HT1A and 5-HT1F receptors. We conducted this series of experiments to further elucidate the site of action of naratriptan using a well-established animal model of trigeminovascular stimulation. Following electrical stimulation of the superior sagittal sinus of ... Read more >>

Cephalalgia (Cephalalgia : an international journal of headache)
[2004, 24(2):99-109]

Cited: 15 times

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Dilatation induced by 5-HT in the middle meningeal artery of the anaesthetised cat.

Geoffrey Andrew Lambert, Cathy Donaldson, Karen Lisa Hoskin, Peter Michael Boers, Alessandro Stefano Zagami,

In chloralose-anaesthetised cats, we studied the effects of intravenous and intra-carotid injections of 5-HT on the middle meningeal artery and the way these were modified by 5-HT antagonists. Cats were prepared for blood pressure recording and intravenous injections and a catheter inserted into one carotid artery via a lingual artery. ... Read more >>

Naunyn Schmiedebergs Arch Pharmacol (Naunyn-Schmiedeberg's archives of pharmacology)
[2004, 369(6):591-601]

Cited: 9 times

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Impact of antigen expression kinetics on the effectiveness of HIV-specific cytotoxic T lymphocytes.

Carel A van Baalen, Christophe Guillon, Minus van Baalen, Esther J Verschuren, Patrick H M Boers, Albert D M E Osterhaus, Rob A Gruters,

Recent studies indicate that the time required for virus-infected cells to become vulnerable for the activity of CTL is of significance for the capacity of CTL to control ongoing viral reproduction. To investigate whether this applies to the effectiveness of HIV-1-specific CTL, we measured virus production in cultures containing CD4(+) ... Read more >>

Eur J Immunol (European journal of immunology)
[2002, 32(9):2644-2652]

Cited: 54 times

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The role of 5-HT1B and 5-HT1D receptors in the selective inhibitory effect of naratriptan on trigeminovascular neurons.

Cathy Donaldson, Peter Michael Boers, Karen Lisa Hoskin, Alessandro Stefano Zagami, Geoffrey Andrew Lambert,

The importance of 5-HT(1B) and 5-HT(1D) receptors in the actions of the anti-migraine drug naratriptan was investigated using the relatively selective 5-HT(1) receptor ligands SB224289 and BRL15572. Electrical stimulation of the superior sagittal sinus (SSS) in cats activated neurones in the trigeminal nucleus caudalis. Facial receptive fields (RF) were also ... Read more >>

Neuropharmacology (Neuropharmacology)
[2002, 42(3):374-385]

Cited: 24 times

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Suppression by eletriptan of the activation of trigeminovascular sensory neurons by glyceryl trinitrate.

G A Lambert, P M Boers, K L Hoskin, C Donaldson, A S Zagami,

The effect of intracarotid arterial infusions of glyceryl trinitrate (GTN), a substance known to precipitate vascular headache, on the spontaneous activity of trigeminal neurons with craniovascular input was studied in cats. Cats were anaesthetised with alpha-chloralose, immobilised and artificially ventilated. The superior sagittal sinus (SSS) was isolated and stimulated electrically. ... Read more >>

Brain Res (Brain research)
[2002, 953(1-2):181-188]

Cited: 18 times

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Construction and characterisation of infectious recombinant HIV-1 clones containing CTL epitopes from structural proteins in Nef.

Christophe Guillon, Carel A van Baalen, Patrick H M Boers, Esther J Verschuren, Rob A Gruters, Albert D M E Osterhaus,

In this study the construction is described of HIV-1 molecular clones in which CTL epitopes from RT or Env late proteins were inserted into the Nef early protein. The ectopic epitopes were efficiently processed from the recombinant Nef proteins, were recognized by their cognate CTL in cytolytic assays, and did ... Read more >>

J Virol Methods (Journal of virological methods)
[2002, 99(1-2):115-121]

Cited: 1 time

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Antibody-mediated enhancement of human immunodeficiency virus type 1 infectivity is determined by the structure of gp120 and depends on modulation of the gp120-CCR5 interaction.

Christophe Guillon, Martin Schutten, Patrick H M Boers, Rob A Gruters, Albert D M E Osterhaus,

In this study, we characterized the viral determinants of coreceptor usage in relation to susceptibility to antibody-mediated neutralization or enhancement of infectivity by using chimeras of three highly related human immunodeficiency virus type 1 (HIV-1) isolates of different phenotypes. We found that the V3 region was the main determinant of ... Read more >>

J Virol (Journal of virology)
[2002, 76(6):2827-2834]

Cited: 20 times

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