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Three vs. Four Cycles of Neoadjuvant Chemotherapy for Localized Muscle Invasive Bladder Cancer Undergoing Radical Cystectomy: A Retrospective Multi-Institutional Analysis.

Matteo Ferro, Ottavio de Cobelli, Gennaro Musi, Giuseppe Lucarelli, Daniela Terracciano, Daniela Pacella, Tommaso Muto, Angelo Porreca, Gian Maria Busetto, Francesco Del Giudice, Francesco Soria, Paolo Gontero, Francesco Cantiello, Rocco Damiano, Fabio Crocerossa, Abdal Rahman Abu Farhan, Riccardo Autorino, Mihai Dorin Vartolomei, Matteo Muto, Michele Marchioni, Andrea Mari, Luca Scafuri, Andrea Minervini, Nicola Longo, Francesco Chiancone, Sisto Perdona, Pietro De Placido, Antonio Verde, Michele Catellani, Stefano Luzzago, Francesco Alessandro Mistretta, Pasquale Ditonno, Vincenzo Francesco Caputo, Michele Battaglia, Stefania Zamboni, Alessandro Antonelli, Francesco Greco, Giorgio Ivan Russo, Rodolfo Hurle, Nicolae Crisan, Matteo Manfredi, Francesco Porpiglia, Giuseppe Di Lorenzo, Felice Crocetto, Carlo Buonerba,

<h4>Background</h4>Three or four cycles of cisplatin-based chemotherapy is the standard neoadjuvant treatment prior to cystectomy in patients with muscle-invasive bladder cancer. Although NCCN guidelines recommend 4 cycles of cisplatin-gemcitabine, three cycles are also commonly administered in clinical practice. In this multicenter retrospective study, we assessed a large and homogenous cohort ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:651745]

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Robot-Assisted, Laparoscopic, and Open Radical Cystectomy (RC): Pre-Operative Data of 1400 Patients From The Italian Radical Cystectomy Registry (RIC)

Angelo Porreca, Gian Maria Busetto, Michele Colicchia, Katie Palmer, Walter Artibani, Alessandro Antonelli, Lorenzo Bianchi, Aldo Bocciardi, Eugenio Brunocilla, Marco Carini, Giuseppe Carrieri, Luigi Cormio, Ugo Giovanni Falagario, Ettore De Berardinis, Alessandro Sciarra, Costantino Leonardo, Francesco Del Giudice, Martina Maggi, Ottavio de Cobelli, Matteo Ferro, Gennaro Musi, Amelio Ercolino, Fabrizio Di Maida, Andrea Gallina, Carlo Introini, Ettore Mearini, Giovanni Cochetti, Andrea Minervini, Francesco Montorsi, Riccardo Schiavina, Sergio Serni, Claudio Simeone, Paolo Parma, Armando Serao, Mario Salvatore Mangano, Giorgio Pomara, Pasquale Ditonno, Alchiede Simonato, Daniele Romagnoli, Alessandro Crestani, Daniele D'Agostino,

<h4>Introduction: </h4> the Italian Radical Cystectomy Registry (RIC) is an observational prospective study aiming to understand clinical variables and patient characteristics associated with short- and long-term outcomes among bladder cancer (BC) patients undergoing radical cystectomy (RC). Moreover, it compares the effectiveness of three RC techniques - open, robotic, and laparoscopic. ... Read more >>

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Oncologic Surveillance for Variant Histology Bladder Cancer after Radical Cystectomy.

Alberto Martini, Luca Afferi, Stefania Zamboni, Julianne G Schultz, Chiara Lonati, Agostino Mattei, R Jeffrey Karnes, Matteo Soligo, Armando Stabile, Ettore Di Trapani, Ottavio De Cobelli, Giuseppe Simone, Claudio Simeone, Mario Alvarez-Maestro, Giorgio Gandaglia, Andrea Gallina, Renzo Colombo, Alberto Briganti, Francesco Montorsi, Evanguelos Xylinas, Shahrokh F Shariat, Marco Moschini,

<h4>Purpose</h4>Presently, major guidelines do not provide specific recommendations on oncologic surveillance for patients who harbor VH BCa at radical cystectomy. We aimed to create a personalized follow-up scheme that dynamically weighs OCM versus the risk of recurrence for VH BCa, and to compare it with a similar one for pUC.<h4>Methods</h4>Within ... Read more >>

J Urol (The Journal of urology)
[2021, :101097JU0000000000001886]

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BRCA Germline Mutations in Prostate Cancer: The Future Is Tailored.

Felice Crocetto, Biagio Barone, Vincenzo Francesco Caputo, Matteo Fontana, Ottavio de Cobelli, Matteo Ferro,

Prostate cancer (PCa) is the second most common neoplasm in men and the fifth leading cause of death worldwide [...]. ... Read more >>

Diagnostics (Basel) (Diagnostics (Basel, Switzerland))
[2021, 11(5):]

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Apparent Diffusion Coefficient and Other Preoperative Magnetic Resonance Imaging Features for the Prediction of Positive Surgical Margins in Prostate Cancer Patients Undergoing Radical Prostatectomy.

Sarah Alessi, Roberta Maggioni, Stefano Luzzago, Alberto Colombo, Paola Pricolo, Paul E Summers, Giulia Saia, Marco Manzoni, Giuseppe Renne, Giulia Marvaso, Ottavio De Cobelli, Massimo Bellomi, Barbara A Jereczek-Fossa, Giuseppe Petralia,

<h4>Purpose</h4>To investigate the use of apparent diffusion coefficient (ADC) values and other MRI features for predicting positive surgical margins (PSMs) in patients undergoing radical prostatectomy.<h4>Materials and methods</h4>We retrospectively identified 400 consecutive patients who underwent surgery for prostate cancer between January 2015 and June 2016. ADC values of the index lesion ... Read more >>

Clin Genitourin Cancer (Clinical genitourinary cancer)
[2021, :]

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Ultrahypofractionated radiotherapy for localized prostate cancer with simultaneous boost to the dominant intraprostatic lesion: a plan comparison.

Raffaella Cambria, Delia Ciardo, Alessia Bazani, Floriana Pansini, Elena Rondi, Davide Maestri, Dario Zerini, Giulia Marvaso, Pola Romanelli, Giorgia Timon, Cristiana Fodor, Giuseppe Petralia, Sarah Alessi, Paola Pricolo, Barbara Vischioni, Piero Fossati, Sivia Molinelli, Stefania Russo, Mario Ciocca, Ottavio De Cobelli, Giuseppe Renne, Roberto Orecchia, Federica Cattani, Barbara A Jereczek-Fossa,

<h4>Objective</h4>To compare different stereotactic body techniques-intensity-modulated radiotherapy with photons and protons, applied to radiotherapy of prostatic cancer-with simultaneous integrated boost (SIB) on the dominant intraprostatic lesion (DIL).<h4>Methods</h4>Ten patients were selected for this planning study. Dosimetric results were compared between volumetric modulated arc therapy, intensity-modulated radiation therapy (IMRT), and intensity-modulated proton ... Read more >>

Tumori (Tumori)
[2021, :3008916211011667]

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Accuracy of Transurethral Resection of the Bladder in Detecting Variant Histology of Bladder Cancer Compared with Radical Cystectomy.

Chiara Lonati, Philipp Baumeister, Paola Irene Ornaghi, Ettore Di Trapani, Ottavio De Cobelli, Michael Rink, Robert Jeffrey Karnes, Cédric Poyet, Giuseppe Simone, Luca Afferi, Andrea Necchi, Alberto Briganti, Francesco Montorsi, Wojciech Krajewski, Alessandro Antonelli, Maria Angela Cerruto, Stefania Zamboni, Claudio Simeone, Livio Mordasini, Agostino Mattei, Marco Moschini, ,

<h4>Background</h4>Correct identification of variant histologies (VHs) of bladder cancer (BCa) at transurethral resection of the bladder (TURB) could drive the subsequent treatment.<h4>Objective</h4>To evaluate the concordance in detecting VHs between TURB and radical cystectomy (RC) specimens in BCa patients.<h4>Design, setting, and participants</h4>We retrospectively analyzed 1881 BCa patients who underwent TURB and ... Read more >>

Eur Urol Focus (European urology focus)
[2021, :]

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Mechanical and Ablative Minimally Invasive Techniques for Male LUTS due to Benign Prostatic Obstruction: A Systematic Review according to BPH-6 Evaluation.

Francesco Cantiello, Deborah Fimognari, Marina Di Mauro, Fabio Crocerossa, Umberto Carbonara, Matteo Ferro, Ottavio De Cobelli, Giuseppe Lucarelli, Cosimo De Nunzio, Giuseppe Morgia, Rocco Damiano, Riccardo Autorino, Francesco Porpiglia, Giorgio Ivan Russo,

The treatment of male lower urinary tract symptoms (LUTS) due to benign prostatic obstruction represents one of the major interesting aspects in urological clinical practice. Although transurethral resection of the prostate is still considered the surgical gold standard for treatment of benign prostatic hyperplasia with prostate volume <80 mL, various ... Read more >>

Urol Int (Urologia internationalis)
[2021, :1-11]

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The emerging landscape of tumor marker panels for the identification of aggressive prostate cancer: the perspective through bibliometric analysis of an Italian translational working group in uro-oncology.

Matteo Ferro, Giuseppe Lucarelli, Ottavio de Cobelli, Francesco Del Giudice, Gennaro Musi, Francesco A Mistretta, Stefano Luzzago, Gian Maria Busetto, Carlo Buonerba, Alessandro Sciarra, Simon Conti, Angelo Porreca, Michele Battaglia, Pasquale Ditonno, Matteo Manfredi, Cristian Fiori, Francesco Porpiglia, Daniela Terracciano,

Molecular heterogeneity and availability of different therapeutic strategies are relevant clinical features of prostate cancer. On this basis, there is an urgent need to identify prognostic and predictive biomarkers for an individualized therapeutic approach. In this context, researchers focused their attention on biomarkers able to discriminate potential life-threatening from organ-confined ... Read more >>

Minerva Urol Nephrol (Minerva urology and nephrology)
[2021, :]

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Continuity of Cancer Care: The Surgical Experience of Two Large Cancer Hubs in London and Milan.

Maria J Monroy-Iglesias, Marta Tagliabue, Harvey Dickinson, Graham Roberts, Rita De Berardinis, Beth Russell, Charlotte Moss, Sophie Irwin, Jonathon Olsburgh, Ivana Maria Francesca Cocco, Alexis Schizas, Sarah McCrindle, Rahul Nath, Aina Brunet, Ricard Simo, Chrysostomos Tornari, Parthi Srinivasan, Andreas Prachalias, Andrew Davies, Jenny Geh, Stephanie Fraser, Tom Routledge, RuJun Ma, Ella Doerge, Ben Challacombe, Raj Nair, Marios Hadjipavlou, Rosaria Scarpinata, Paolo Sorelli, Saoirse Dolly, Francesco Alessandro Mistretta, Gennaro Musi, Monica Casiraghi, Alessia Aloisi, Andrea Dell'Acqua, Donatella Scaglione, Stefania Zanoni, Daniele Rampazio Da Silva, Daniela Brambilla, Raffaella Bertolotti, Giulia Peruzzotti, Angelo Maggioni, Ottavio de Cobelli, Lorenzo Spaggiari, Mohssen Ansarin, Fabrizio Mastrilli, Sara Gandini, Urvashi Jain, Hisham Hamed, Kate Haire, Mieke Van Hemelrijck,

The SARS-CoV-2 (COVID-19) pandemic is having a large effect on the management of cancer patients. This study reports on the approach and outcomes of cancer patients receiving radical surgery with curative intent between March and September 2020 (in comparison to 2019) in the European Institute of Oncology, IRCCS (IEO) in ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(7):]

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Assessment of PSIM (Prostatic Systemic Inflammatory Markers) Score in Predicting Pathologic Features at Robotic Radical Prostatectomy in Patients with Low-Risk Prostate Cancer Who Met the Inclusion Criteria for Active Surveillance.

Matteo Ferro, Gennaro Musi, Deliu Victor Matei, Alessandro Francesco Mistretta, Stefano Luzzago, Gabriele Cozzi, Roberto Bianchi, Ettore Di Trapani, Antonio Cioffi, Giuseppe Lucarelli, Gian Maria Busetto, Francesco Del Giudice, Giorgio Ivan Russo, Marina Di Mauro, Angelo Porreca, Giuseppe Renne, Michele Catellani, Danilo Bottero, Antonio Brescia, Giovanni Cordima, Ottavio de Cobelli,

<h4>Background</h4>circulating levels of lymphocytes, platelets and neutrophils have been identified as factors related to unfavorable clinical outcome for many solid tumors. The aim of this cohort study is to evaluate and validate the use of the Prostatic Systemic Inflammatory Markers (PSIM) score in predicting and improving the detection of clinically ... Read more >>

Diagnostics (Basel) (Diagnostics (Basel, Switzerland))
[2021, 11(2):]

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Liquid Biopsy Biomarkers in Urine: A Route towards Molecular Diagnosis and Personalized Medicine of Bladder Cancer.

Matteo Ferro, Evelina La Civita, Antonietta Liotti, Michele Cennamo, Fabiana Tortora, Carlo Buonerba, Felice Crocetto, Giuseppe Lucarelli, Gian Maria Busetto, Francesco Del Giudice, Ottavio de Cobelli, Giuseppe Carrieri, Angelo Porreca, Amelia Cimmino, Daniela Terracciano,

Bladder cancer (BC) is characterized by high incidence and recurrence rates together with genomic instability and elevated mutation degree. Currently, cystoscopy combined with cytology is routinely used for diagnosis, prognosis and disease surveillance. Such an approach is often associated with several side effects, discomfort for the patient and high economic ... Read more >>

J Pers Med (Journal of personalized medicine)
[2021, 11(3):]

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Systemic combining inflammatory score (SCIS): a new score for prediction of oncologic outcomes in patients with high-risk non-muscle-invasive urothelial bladder cancer.

Matteo Ferro, Marina Di Mauro, Sebastiano Cimino, Giuseppe Morgia, Giuseppe Lucarelli, Abdal Rahman Abu Farhan, Mihai Dorin Vartolomei, Angelo Porreca, Francesco Cantiello, Rocco Damiano, Gian Maria Busetto, Francesco Del Giudice, Rodolfo Hurle, Sisto Perdonà, Marco Borghesi, Pierluigi Bove, Riccardo Autorino, Nicolae Crisan, Michele Marchioni, Luigi Schips, Francesco Soria, Andrea Mari, Andrea Minervini, Alessandro Veccia, Michele Battaglia, Daniela Terracciano, Gennaro Musi, Giovanni Cordima, Matteo Muto, Vincenzo Mirone, Ottavio de Cobelli, Giorgio Ivan Russo,

<h4>Background</h4>An accurate and early diagnosis of bladder cancer (BC) is essential to offer patients the most appropriate treatment and the highest cure rate. For this reason, patients need to be best stratified by class and risk factors. We aimed to develop a score able to better predict cancer outcomes, using ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2021, 10(2):626-635]

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Artificial Intelligence and Machine Learning in Prostate Cancer Patient Management-Current Trends and Future Perspectives.

Octavian Sabin Tătaru, Mihai Dorin Vartolomei, Jens J Rassweiler, Oșan Virgil, Giuseppe Lucarelli, Francesco Porpiglia, Daniele Amparore, Matteo Manfredi, Giuseppe Carrieri, Ugo Falagario, Daniela Terracciano, Ottavio de Cobelli, Gian Maria Busetto, Francesco Del Giudice, Matteo Ferro,

Artificial intelligence (AI) is the field of computer science that aims to build smart devices performing tasks that currently require human intelligence. Through machine learning (ML), the deep learning (DL) model is teaching computers to learn by example, something that human beings are doing naturally. AI is revolutionizing healthcare. Digital ... Read more >>

Diagnostics (Basel) (Diagnostics (Basel, Switzerland))
[2021, 11(2):]

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Impact of Perioperative Immunonutrition on Complications in Patients Undergoing Radical Cystectomy: A Retrospective Analysis.

Gabriele Cozzi, Gennaro Musi, Martina Milani, Costantino Jemos, Sara Gandini, Ludovica Mazzoleni, Matteo Ferro, Stefano Luzzago, Roberto Bianchi, Emanuela Omodeo Salé, Ottavio de Cobelli,

<h4>Introduction</h4>Radical cystectomy (RC) is the gold standard treatment for patients with muscle-invasive or refractory non-muscle invasive bladder cancer. It is estimated that approximately 64% and 13% of RC patients experience any complication and major complications, respectively. Specialized immunonutrition (SIM) aims to reduce the rates of complications after RC. We reported ... Read more >>

Integr Cancer Ther (Integrative cancer therapies)
[2021, 20:15347354211019483]

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Association of statin use and oncological outcomes in patients with first diagnosis of T1 high grade non-muscle invasive urothelial bladder cancer: results from a multicentre study.

Matteo Ferro, Michele Marchioni, Giuseppe Lucarelli, Vartolomei M Dorin, Francesco Soria, Daniela Terracciano, Francesco A Mistretta, Stefano Luzzago, Carlo Buonerba, Francesco Cantiello, Andrea Mari, Andrea Minervini, Alessandro Veccia, Alessandro Antonelli, Gennaro Musi, Rodolfo Hurle, Gian Maria Busetto, Francesco Del Giudice, Benjamin I Chung, Francesco Berardinelli, Sisto Perdonà, Paola Del Prete, Vincenzo Mirone, Marco Borghesi, Angelo Porreca, Pierluigi Bove, Riccardo Autorino, Nicolae Crisan, Abdal R Abu Farhan, Michele Battaglia, Pasquale Ditonno, Giorgio I Russo, Matteo Muto, Rocco Damiano, Matteo Manfredi, Francesco Porpiglia, Ottavio De Cobelli, Luigi Schips,

<h4>Introduction</h4>We aimed to test the hypothesis that the immune-modulatory effect of statins may improve survival outcomes in patients with non-muscle invasive bladder cancer (NMIBC). We focused on a cohort of patients diagnosed with high risk NMIBC, that were treated with intravesical BCG immunotherapy.<h4>Patients and methods</h4>We included patients at first diagnosis ... Read more >>

Minerva Urol Nefrol (Minerva urologica e nefrologica = The Italian journal of urology and nephrology)
[2021, :]

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First-line systemic therapy for metastatic castration-sensitive prostate cancer: An updated systematic review with novel findings.

Matteo Ferro, Giuseppe Lucarelli, Felice Crocetto, Pasquale Dolce, Antonio Verde, Evelina La Civita, Silvia Zappavigna, Ottavio de Cobelli, Giuseppe Di Lorenzo, Bianca Arianna Facchini, Luca Scafuri, Livia Onofrio, Angelo Porreca, Gian Maria Busetto, Guru Sonpavde, Michele Caraglia, Michele Klain, Daniela Terracciano, Sabino De Placido, Carlo Buonerba,

Although both docetaxel and androgen-receptor-axis-targeted (ARAT) agents have yielded survival improvements in combination with androgen deprivation therapy (ADT) compared to ADT alone in metastatic castration-sensitive prostate cancer (mCSPC) patients, the optimal therapeutic choice remains to be established. We analyzed estimates of the hazard ratios for death (OS-HRs) in patients treated ... Read more >>

Crit Rev Oncol Hematol (Critical reviews in oncology/hematology)
[2021, 157:103198]

Cited: 3 times

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Protocol of the Italian Radical Cystectomy Registry (RIC): a non-randomized, 24-month, multicenter study comparing robotic-assisted, laparoscopic, and open surgery for radical cystectomy in bladder cancer.

Angelo Porreca, Katie Palmer, Walter Artibani, Alessandro Antonelli, Lorenzo Bianchi, Eugenio Brunocilla, Aldo Massimo Bocciardi, Maurizio Brausi, Gian Maria Busetto, Marco Carini, Giuseppe Carrieri, Antonio Celia, Luca Cindolo, Giovanni Cochetti, Renzo Colombo, Ettore De Berardinis, Ottavio De Cobelli, Fabrizio Di Maida, Amelio Ercolino, Franco Gaboardi, Antonio Galfano, Andrea Gallina, Michele Gallucci, Carlo Introini, Ettore Mearini, Andrea Minervini, Francesco Montorsi, Gennaro Musi, Giovannalberto Pini, Riccardo Schiavina, Silvia Secco, Sergio Serni, Claudio Simeone, Giovanni Tasso, Daniele D'Agostino,

<h4>Background</h4>Bladder cancer is the ninth most common type of cancer worldwide. In the past, radical cystectomy via open surgery has been considered the gold-standard treatment for muscle invasive bladder cancer. However, in recent years there has been a progressive increase in the use of robot-assisted laparoscopic radical cystectomy. The aim ... Read more >>

BMC Cancer (BMC cancer)
[2021, 21(1):51]

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Impact of uni- or multifocal perineural invasion in prostate cancer at radical prostatectomy.

Alessandro Sciarra, Martina Maggi, Arianna Del Proposto, Fabio Massimo Magliocca, Antonio Ciardi, Valeria Panebianco, Ettore De Berardinis, Stefano Salciccia, Giovanni Battista Di Pierro, Alessandro Gentilucci, Alex M Kasman, Benjamin I Chung, Matteo Ferro, Ottavio de Cobelli, Francesco Del Giudice, Gian Maria Busetto, Michele Gallucci, Marco Frisenda,

<h4>Background</h4>Aim of this study was to correlate perineural invasion (PNI) with other clinical-pathological parameters in terms of prognostic indicators in prostate cancer (PC) cases at the time of radical prostatectomy (RP).<h4>Methods</h4>Prospective study of 288 consecutive PC cases undergoing RP. PNI determination was performed either in biopsy or in RP specimens ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2021, 10(1):66-76]

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Systematic sampling during MRI-US fusion prostate biopsy can overcome errors of targeting-prospective single center experience after 300 cases in first biopsy setting.

Emanuel Cata, Iulia Andras, Matteo Ferro, Pierre Kadula, Daniel Leucuta, Gennaro Musi, Deliu-Victor Matei, Ottavio De Cobelli, Attila Tamas-Szora, Cosmin Caraiani, Andrei Lebovici, Flavia Epure, Maria Bungardean, Radu-Tudor Coman, Nicolae Crisan,

<h4>Background</h4>Multiparametric magnetic resonance imaging (mpMRI) and targeted biopsy have become an integral part of the diagnosis of prostate cancer (PCa), as recommended by the European Association of Urology Guidelines. The aim of the current study was to evaluate the performance of MRI and MRI-transrectal ultrasound (TRUS) fusion prostate biopsy as ... Read more >>

Transl Androl Urol (Translational andrology and urology)
[2020, 9(6):2510-2518]

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Quality of life and psycho-emotional wellbeing in bladder cancer patients and their caregivers: a comparative analysis between urostomy versus ileal orthotopic neobladder.

Marianna Masiero, Derna Busacchio, Paolo Guiddi, Paola Arnaboldi, Gennaro Musi, Ottavio De Cobelli, Florence Didier, Gabriella Pravettoni,

<h4>Background</h4>The impact of neobladder and urostomy on bladder cancer patient's health-related quality of life (HR-QoL) is controversial and many issues currently remain under-investigated. Initial studies pointed out that the emotional responses of caregivers might be '<i>contagious</i>', influencing emotional reactions in bladder cancer patients undergoing radical cystectomy.<h4>Methods</h4>Three hundred and eighty-two bladder ... Read more >>

Ecancermedicalscience (Ecancermedicalscience)
[2021, 15:1163]

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Metabolic syndrome predicts worse perioperative outcomes in patients treated with radical prostatectomy for non-metastatic prostate cancer.

Stefano Luzzago, Carlotta Palumbo, Giuseppe Rosiello, Angela Pecoraro, Marina Deuker, Franziska Stolzenbach, Francesco Alessandro Mistretta, Zhe Tian, Gennaro Musi, Emanuele Montanari, Shahrokh F Shariat, Fred Saad, Alberto Briganti, Ottavio de Cobelli, Pierre I Karakiewicz,

<h4>Objectives</h4>Metabolic syndrome (MetS) and its components (high blood pressure, BMI≥30, altered fasting glucose, low HDL cholesterol and high triglycerides) may undermine early perioperative outcomes after radical prostatectomy (RP). We tested this hypothesis.<h4>Materials & methods</h4>Within the National Inpatient Sample database (2008-2015) we identified RP patients. The effect of MetS was tested ... Read more >>

Surg Oncol (Surgical oncology)
[2021, 37:101519]

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Integration of Lipidomics and Transcriptomics Reveals Reprogramming of the Lipid Metabolism and Composition in Clear Cell Renal Cell Carcinoma.

Giuseppe Lucarelli, Matteo Ferro, Davide Loizzo, Cristina Bianchi, Daniela Terracciano, Francesco Cantiello, Lauren N Bell, Stefano Battaglia, Camillo Porta, Angela Gernone, Roberto A Perego, Eugenio Maiorano, Ottavio de Cobelli, Giuseppe Castellano, Leonardo Vincenti, Pasquale Ditonno, Michele Battaglia,

Clear cell renal cell carcinoma (ccRCC) is fundamentally a metabolic disease. Given the importance of lipids in many cellular processes, in this study we delineated a lipidomic profile of human ccRCC and integrated it with transcriptomic data to connect the variations in cancer lipid metabolism with gene expression changes. Untargeted ... Read more >>

Metabolites (Metabolites)
[2020, 10(12):]

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Contemporary rates and predictors of open conversion during minimally invasive partial nephrectomy for kidney cancer.

Stefano Luzzago, Giuseppe Rosiello, Angela Pecoraro, Marina Deuker, Franziska Stolzenbach, Francesco Alessandro Mistretta, Zhe Tian, Gennaro Musi, Emanuele Montanari, Shahrokh F Shariat, Fred Saad, Alberto Briganti, Ottavio de Cobelli, Pierre I Karakiewicz,

<h4>Objectives</h4>To test contemporary rates and predictors of open conversion at minimally invasive partial nephrectomy (MIPN: laparoscopic or robotic partial nephrectomy).<h4>Materials and methods</h4>Within the National Inpatient Sample database (2008-2015) we identified all MIPN patients and patients that underwent open conversion at MIPN. First, estimated annual percentage changes (EAPC) tested temporal trends ... Read more >>

Surg Oncol (Surgical oncology)
[2021, 36:131-137]

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Effect of Age on Cancer-specific Mortality in Patients With Urothelial Carcinoma of the Urinary Bladder: A Population-based Competing-risks Analysis Across Disease Stages.

Stefano Luzzago, Sophie Knipper, Carlotta Palumbo, Giuseppe Rosiello, Angela Pecoraro, Marina Deuker, Francesco A Mistretta, Zhe Tian, Gennaro Musi, Emanuele Montanari, Shahrokh F Shariat, Fred Saad, Alberto Briganti, Ottavio de Cobelli, Pierre I Karakiewicz,

<h4>Objective</h4>The objective of the study is to test the effect of age on cancer-specific mortality (CSM) in patients with urothelial carcinoma of the urinary bladder (UCUB), across all disease stages.<h4>Materials and methods</h4>Within the Surveillance, Epidemiology, and End Results (SEER) registry (2004-2016), we identified 207,714 patients. Age was categorized as: below ... Read more >>

Am J Clin Oncol (American journal of clinical oncology)
[2020, 43(12):880-888]

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